Detection and Mapping of QTLs Affecting Contents of Pharmaceutical Alkaloids in Leaf and Root of Catharanthus roseus

Agricultural Research

Volumn 2, Issue 1, 2013, Pages 9-23

  Chaudhary, Swati ^a,b   Pandey, Richa ^a   Sharma, Vishakha ^a   Tripathi, Bhumi Nath ^b   Kumar, Sushil ^a  

^a NATIONAL INSTITUTE OF PLANT GENOME RESEARCH   (India)

^b BANASTHALI UNIVERSITY   (India)

Author keywords

Composite interval mapping; Linkage map; Medicinal plant; Simple interval mapping; Single marker analysis; Terpenoid indole alkaloids

Indexed keywords

ALKALOIDS; LIPIDS; MAPPING; POLYCYCLIC AROMATIC HYDROCARBONS; SERPENTINE;

COMPOSITE INTERVAL MAPPING; INTERVAL MAPPING; LINKAGE MAP; MEDICINAL PLANTS; SINGLE MARKER ANALYSIS; TERPENOID INDOLE ALKALOIDS;

PLANTS (BOTANY);

ACCUMULATION; ALKALOID; COMPOSITE; GENETIC ANALYSIS; HERB; LEAF; MAPPING; MEDICINAL PLANT; QUANTITATIVE ANALYSIS; ROOT; SHRUB;

CATHARANTHUS ROSEUS;

EID: 84999163383     PISSN: 2249720X     EISSN: 22497218     Source Type: Journal    
DOI: 10.1007/s40003-013-0050-1     Document Type: Article

References (87)

1. Anonymous (1987) A superior variety of periwinkle resistant to die-bach disease developed. CIMAP Newslett 14: 13.
2. Barleben L, Panjikar S, Ruppert M, Koepke J, Stöckigt J (2007) Molecular architecture of strictosidine glucosidase: the gateway to the biosynthesis of the monoterpenoid indole alkaloid family. Plant Cell 19: 2886-2897.
3. Blom TJM, Sierra M, van Vliet TB, Franke-van Dijk MEI, de Koning P, van Iren F, Verpoorte R, Libbenga KR (1991) Uptake and accumulation of ajmalicine into isolated vacuoles of cultured cells of Catharanthus roseus (L.) G. Don. and its conversion into serpentine. Planta 183: 170-177.
4. Burlat V, Oudin A, Courtois M, Rideau M, St-Pierre B (2004) Co-expression of three MEP pathway genes and geraniol 10-hydroxylase in internal phloem parenchyma of Catharanthus roseus implicates multicellular translocation of intermediates during the biosynthesis of monoterpene indole alkaloids and isoprenoid-derived primary metabolites. Plant J 38: 131-141.
5. Campos-Tamayo F, Hernández-Domínguez E, Vázquez-Flota F (2008) Vindoline formation in shoot cultures of Catharanthus roseus is synchronously activated with morphogenesis through the last biosynthetic step. Ann Bot 102: 409-415.
6. Chaudhary S, Sharma V, Prasad M, Bhatia S, Tripathi BN, Yadav G, Kumar S (2011) Characterization and genetic linkage mapping of the horticulturally important mutation leafless inflorescence (lli) in periwinkle Catharanthus roseus. Sci Hortic 129: 142-153.
7. Chockalingam S, Sundari MSN, Thenmozhi S (1989) Impact of the extract of Catharanthus roseus on feeding and enzymatic digestive activities of Spodoptera litura. J Environ Biol 10: 303-307.
8. Churchill GA, Doerge RW (1994) Empirical threshold values for quantitative trait mapping. Genetics 138: 963-971.
9. Collu G, Unver N, Peltenburg-Looman AM, van der Heijden R, Verpoorte R, Memelink J (2001) Geraniol 10-hydroxylase, a cytochrome P450 enzyme involved in terpenoid indole alkaloid biosynthesis. FEBS Lett 508: 215-220.
10. Costa MMR, Hilliou F, Duarte P, Pereira LG, Almeida I, Leech M, Memelink J, Barceló AR, Sottomayor M (2008) Molecular cloning and characterization of a vacuolar class III peroxidase involved in the metabolism of anticancer alkaloids in Catharanthus roseus. Plant Physiol 146: 403-417.
11. Dekkers JCM, Hospital F (2002) The use of molecular genetics in the improvement of agricultural populations. Nat Rev Genet 3: 22-32.
12. DeLuca V, Marineau C, Brisson N (1989) Molecular cloning and analysis of a cDNA encoding a plant tryptophan decarboxylase. Proc Natl Acad Sci USA 86: 2582-2586.
13. Deorge RW, Churchill GA (1996) Permutation test for multiple loci affecting a quantitative character. Genetics 142: 285-294.
14. El-Sayed M, Verpoorte R (2005) Methyljasmonate accelerates catabolism of monoterpenoid indole alkaloids in Catharanthus roseus during leaf processing. Fitoterapia 76: 83-90.
15. El-Sayed M, Verpoorte R (2007) Catharanthus terpenoid indole alkaloids: biosynthesis and regulation. Phytochem Rev 6: 277-305.
16. Facchini PJ, DeLuca V (2008) Opium poppy and Madagascar periwinkle: model non-model systems to investigate alkaloid biosynthesis in plants. Plant J 54: 763-784.
17. Geerlings A, Hallard D, Marti{dotless}′nez-Caballero A, Lopes-Cardoso I, van der Heijden R, Verpoorte R (1999) Alkaloid production by a Cinchona officinalis 'Ledgeriana' hairy root culture containing constitutive expression constructs for tryptophan decarboxylase and strictosidine synthase cDNAs from Catharanthus roseus. Plant Cell Rep 19: 191-196.
18. Geerlings A, Ibanez MM, Memelink J, van der Heijden R, Verpoorte R (2000) Molecular cloning and analysis of strictosidine b-D-glucosidase, an enzyme in terpenoid indole alkaloid biosynthesis in Catharanthus roseus. J Biol Chem 275: 3051-3056.
19. Guirimand G, Burlat V, Oudin A, Lanoue A, St-Pierre B, Courdavault V (2009) Optimization of the transient transformation of Catharanthus roseus cells by particle bombardment and its application to the subcellular localization of hydroxymethylbutenyl 4-diphosphate synthase and geraniol 10-hydroxylase. Plant Cell Rep 28: 1215-1234.
20. Guirimand G, Courdavault V, St-Pierre B, Burlat V (2010) Biosynthesis and regulation of alkaloids. In: Pua E-C, Dowey MR (eds) Plant developmental biology-biotechnological perspectives, vol 2. Springer, Berlin.
21. Guirimand G, Courdavault V, Lanoue A, Mahroug S, Guihur A, Blanc N, Giglioli-Guivarc'h N, St-Pierre B, Burlat V (2010) Strictosidine activation in Apocynaceae: towards a "nuclear time bomb"? BMC Plant Biol 10: 182-201.
22. Guirimand G, Guihur A, Ginis O, Poutrain P, Héricourt F, Oudin A, Lanoue A, St-Pierre B, Burlat V, Courdavault V (2011) The subcellular organization of strictosidine biosynthesis in Catharanthus roseus epidermis highlights several trans-tonoplast translocations of intermediate metabolites. FEBS J 278: 749-763.
23. Guirimand G, Guihur A, Poutrain P, Héricourt F, Mahroug S, St-Pierre B, Burlat V, Courdavault V (2011) Spatial organization of the vindoline biosynthetic pathway in Catharanthus roseus. J Plant Physiol 168: 549-557.
24. Haley CS, Knott SA (1992) A simple regression method for mapping quantitative trait loci in line crosses using flanking markers. Heredity 69: 315-324.
25. Hedhili S, Courdavault V, Giglioli-Guivarc'h N, Gantet P (2007) Regulation of the terpene moiety biosynthesis of Catharanthus roseus terpene indole alkaloids. Phytochem Rev 6: 341-351.
26. Hemscheidt T, Zenk MH (1985) Partial purification and characterization of a NADPH dependent tetrahydroalstonine synthase from Catharanthus roseus cell suspension cultures. Plant Cell Rep 4: 216-219.
27. Hisinger S, Jolicoeur M (2007) Analysis of Catharanthus roseus alkaloids by HPLC. Phytochem Rev 6: 207-234.
28. Hong SB, Peeble CAM, Shanks JV, San KY, Gibson SI (2006) Expression of the Arabidopsis feedback-insensitive anthranilate synthase holoenzyme and tryptophan decarboxylase genes in Catharanthus roseus hairy roots. J Biotechnol 122: 28-38.
29. Irmler S, Schröder G, St-Pierre G, Crouch NP, Hotze M, Schmidt J, Strack D, Matern U, Schröder J (2000) Indole alkaloid biosynthesis in Catharanthus roseus: new enzyme activities and identification of cytochrome P450 CYP72A1 as secologanin synthase. Plant J 24: 797-804.
30. Ishikawa H, Colby DA, Boger DL (2008) Direct coupling of catharanthine and vindoline to provide vinblastine: total synthesis of (+)-and ent-(-)-vinblastine. J Am Chem Soc 130: 420.
31. Kato D, Sasaki Y, Boger DL (2010) Asymmetric total synthesis of vindoline. J Am Chem Soc 132: 3685-3687.
32. Kruczynsky A, Hill BT (2001) Vinflunine, the latest Vinca alkaloid in clinical development. A review of its preclinical anticancer properties. Crit Rev Oncol Hematol 40: 159-173.
33. Kuboyama T, Yokoshima S, Tokuyama H, Fukuyama T (2004) Stereocontrolled total synthesis of (+)-vincristine. Proc Nat Acad Sci USA 101: 11966-11970.
34. Kulkarni RN, Baskaran K, Chandrashekhara RS, Kumar S (1999) Inheritance of morphological traits of periwinkle mutants with modified contents and yields of leaf and root alkaloids. Plant Breed 118: 71-74.
35. Kulkarni RN, Bhaskaran K, Chandrashekhara RS, Khanuja SPS, Darokar MP, Shasany AK, Kumar S (2003) Dhawal-a high alkaloid producing periwinkle plant. United States Patent 6548746.
36. Kumar S, Rai SP, Rai SK, Singh DV, Srivastava S, Mishra RK (2007) Plant variety of Catharanthus roseus named 'lli'. United States Patent pp 18315.
37. Kumar S, Jaggi M, Taneja J, Sinha AK (2011) Cloning and characterization of two new class III peroxidase genes from Catharanthus roseus. Plant Physiol Biochem 49: 404-412.
38. Laflamme P, St-Pierre B, De Luca V (2001) Molecular and biochemical analysis of a Madagascar periwinkle root specific minovincinine-19-hydroxy-O-acetyltransferase. Plant Physiol 125: 189-198.
39. Lander ES, Botstein D (1989) Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121: 185-199.
40. Lander ES, Green P, Abrahamson J, Barlow A, Daly MJ, Lincoln SE, Newberg LA (1987) MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics 1: 174-181.
41. Lemenager D, Ouelhazi L, Mahroug S, Veau B, St-Pierre B, Rideau M, Aguirreolea J, Burlat V, Clastre M (2005) Purification, molecular cloning and cell-specific gene expression of the alkaloid-accumulation associated protein CrPS in Catharanthus roseus. J Exp Bot 56: 1221-1228.
42. Levac D, Murata J, Kim WS, De Luca V (2008) Application of carborundum abrasion for investigating the leaf epidermis: molecular cloning of Catharanthus roseus 16-hydroxytabersonine-16-O-methyltransferase. Plant J 53: 225-236.
43. Lincoln SE, Daly M, Lander ES (1992) Constructing genetic maps with MAPMAKER/EXP. 3. 0, 3rd edn. Whitehead Institute technical report, Cambridge.
44. Liscombe DK, O' Connor SE (2011) A virus-induced gene silencing approach to understand alkaloid metabolism in Catharanthus roseus. Phytochemistry 72: 1969-1977.
45. Lorz H, Wenzel G (2005) Molecular marker systems in plant breeding and crop improvement. Springer, Berlin.
46. Loyola-Vargas VM, Galas-Avalos RM, Ku-Cauich R (2007) Catharanthus biosynthetic enzymes: the road ahead. Phytochem Rev 6: 307-339.
47. Luijendijk TJC, van der Meijden E, Verpoorte R (1996) Involvement of strictosidine as a defensive chemical in Catharanthus roseus. J Chem Ecol 22: 1355-1366.
48. Ma X, Panjikar S, Koepke J, Loris E, Stöckigt J (2006) The structure of Rauvolfia serpentina strictosidine synthase is a novel six-bladed β-propeller fold in plant proteins. Plant Cell 18: 907-920.
49. Mahroug S, Courdavault V, Thiersault M, St. Pierre B, Burlat V (2006) Epidermis is a pivotal site of at least four secondary metabolic pathways in Catharanthus roseus aerial organs. Planta 223: 1191-1200.
50. Mahroug S, Burlat V, St-Pierre B (2007) Cellular and sub-cellular organization of the monoterpenoid indole alkaloid pathway in Catharanthus roseus. Phytochem Rev 6: 363-381.
51. Mandal S, Maheshwari ML (1986) High pressure liquid chromatographic determination of vindoline, catharanthine, vincaleucoblastine and vincristine in periwinkle leaf. Ind J Pharm Sci 49: 205-209.
52. Meijer AH, Verpoorte R, Hoge JHC (1993) Regulation of enzymes and genes involved in terpenoid indole alkaloid biosynthesis in Catharanthus roseus. J Plant Res 3: 145-164.
53. Meisner J, Weissenberg M, Palevitch D, Aharonson N (1981) Phagodeterrency induced by leaves and leaf extracts of Catharanthus roseus in the larva of Spodoptera littoralis (Lepidoptera, Noctuidae). J Econ Entomol 74: 131-135.
54. Mishra P, Uniyal GC, Sharma S, Kumar S (2001) Pattern of diversity for morphological and yield related traits among the periwinkle Catharanthus roseus accessions collected from in and around Indian subcontinent. Genet Res Crop Evol 48: 273-286.
55. Moreno PRH, van der Heijden R, Verpoorte R (1995) Cell and tissue cultures of Catharanthus roseus: a literature survey II. Updating from 1988 to 1993. Plant Cell Tissue Organ Cult 42: 1-25.
56. Murata J, De Luca V (2005) Localization of tabersonine-16-hydroxylase and 16-OH tabersonine-16-O-methyltransferase to leaf epidermal cells defines them as a major site of precursor biosynthesis in the vindoline pathway in Catharanthus roseus. Plant J 44: 581-594.
57. Murata J, Roepke J, Gordon H, De Luca V (2008) The leaf epidermome of Catharanthus roseus reveals its biochemical specialization. Plant Cell 20: 524-542.
58. Nobel RL (1990) The discovery of vinca alkaloids-chemotherapeutic agents against cancer. Biochem Cell Biol 68: 1344-1351.
59. O'Connor SE, Maresh JJ (2006) Chemistry and biology of monoterpene indole alkaloid biosynthesis. Nat Prod Rep 23: 532-547.
60. Oudin A, Courtois M, Rideau M, Clastre M (2007) The iridoid pathway in Catharanthus roseus alkaloid biosynthesis. Phytochem Res 6: 259-276.
61. Pandey-Rai S, Luthra R, Kumar S (2003) Salt-tolerant mutants in glycophytic salinity response (GSR) genes in Catharanthus roseus. Theor Appl Genet 106: 221-230.
62. Pasquier E, Kavallaris M (2008) Microtubules: a dynamic target in cancer therapy. IUBMB Life 60: 165-170.
63. Peebles CAM, Sander GW, Hughes EH, Peacock R, Shanks JV, San K-Y (2011) The expression of 1-deoxy-D-xylulose synthase and geraniol-10-hydroxylase or anthranilate synthase increases terpenoid indole alkaloid accumulation in Catharanthus roseus hairy roots. Metabol Eng 13: 234-240.
64. Pelt JM (2001) Les nouveaux remedes naturels. Editions Fayard, Paris.
65. Potier P (1980) Is the modified Polonovski reaction biometric? In: Philipson JD, Zenk MH (eds) Indole and biogenetically related alkaloids. Academic, London, pp 159-169.
66. Roepke J, Salim V, Wu M, Thamm AM, Murata J, Ploss K, Boland W, De Luca V (2010) Vinca drug components accumulate exclusively in leaf exudates of Madagascar periwinkle. Proc Natl Acad Sci USA 107: 15287-15292.
67. Roytrakul S, Verpoorte R (2007) Role of vacuolar transporter proteins in plant secondary metabolism: Catharanthus roseus cell culture. Phytochem Rev 6: 383-396.
68. Runguphan W, Maresh JJ, O'Connor SE (2009) Silencing of tryptamine biosynthesis for production of nonnatural alkaloids in plant culture. Proc Natl Acad Sci U S A 106: 13673-13678.
69. Sevon N, Oksman-Caldentey K-M (2002) Agrobacterium rhizogenes-mediated transformation: root cultures as a source of alkaloids. Planta Med 68: 859-868.
70. Shokeen B, Sethy NR, Kumar S, Bhatia S (2007) Isolation and characterization of microsatellites for analysis of molecular variation in medicinal plant Madagascar periwinkle Catharanthus roseus (L.) G. Don. Plant Sci 172: 441-451.
71. Shokeen B, Choudhary S, Sethy NK, Bhatia S (2011) Development of SSR and gene-targeted markers for construction of a framework linkage map of Catharanthus roseus. Ann Bot 108: 321-336.
72. Shukla AK, Shasany AK, Gupta MM, Khanuja SPS (2006) Transcriptome analysis in Catharanthus roseus leaves and roots for comparative terpenoid indole alkaloid profiles. J Exp Bot 57: 3921-3932.
73. Singh DV, Pandey-Rai S, Srivastava S, Rai SK, Mishra RK, Kumar S (2004) Simultaneous quantification of some pharmaceutical Catharanthus roseus leaf and root terpenoid indole alkaloids and their precursors in single runs by reversed-phase liquid chromatography. JAOAC Int 87: 1287-1296.
74. Singh DV, Rai SK, Pandey-Rai S, Srivastava S, Mishra RK, Chaudhary S, Sharma S, Kumar S (2008) Predominance of the serpentine route in monoterpenoid indole alkaloid pathway of Catharanthus roseus. Proc Ind Natl Sci Acad 74: 97-109.
75. St-Pierre B, Laflamme P, Alarco AM, De Luca V (1998) The terminal O-acetyltransferase involved in vindoline biosynthesis defines a new class of proteins responsible for coenzyme A-dependent acyl transfer. Plant J 14: 703-713.
76. St-Pierre B, Vazquez-Flota FA, De Luca V (1999) Multicellular compartmentation of Catharanthus roseus alkaloid biosynthesis predicts intercellular translocation of a pathway intermediate. Plant Cell 11: 887-900.
77. Tam A, Gotoh H, Robertson WM, Boger DL (2010) Catharanthine C16 substituent effects on the biomimetic coupling with vindoline: preparation and evaluation of a key series of vinblastine analogues. Bioorg Med Chem Lett 20: 6408-6410.
78. van der Heijden R, Jacobs DI, Snoeirjer W, Hallard D, Verpoorte R (2004) The Catharanthus roseus alkaloids: pharmacognosy and biotechnology. Curr Med Chem 11: 607-628.
79. Verma P, Mathur AK, Srivastava A, Mathur A (2011) Emerging trends in research on spatial and temporal organization of terpenoid indole alkaloid pathway in Catharanthus roseus: a literature update. Protoplasma. doi: 10. 1007/s00709-011-0291-4.
80. Wang L, Zhang Y, He HP, Zhang Q, Li SF, Hao XJ (2011) Three new terpenoid indole alkaloids from Catharanthus roseus. Planta Med 7: 754-758.
81. Wang SC, Basten CJ, Zeng ZB (2011) Windows QTL Cartographer 2. 5. Department of Statistics, North Carolina State University, Raleigh.
82. Whitmer S, van der Heijden R, Verpoorte R (2002) Effect of precursor feeding on alkaloid accumulation by a tryptophan decarboxylase over-expressing transgenic cell line T22 of Catharanthus roseus. J Biotechnol 96: 193-203.
83. Whitmer S, Canel C, van der Heijden R, Verpoorte R (2003) Longterm instability of alkaloid production by stably transformed cell lines of Catharanthus roseus. Plant Cell Tissue Organ Cult 74: 73-80.
84. Yokoshima S, Ueda T, Kobayashi S, Sato A, Kuboyama T, Tokuyama H, Fukuyama T (2002) Sterocontrolled total synthesis of (+)-vinblastine. J Am Chem Soc 124: 2137-2139.
85. Zarate R, Verpoorte R (2007) Strategies for the genetic modification of the medicinal plant Catharanthus roseus (L.) G. Don. Phytochem Rev 6: 475-491.
86. Zeng ZB (1994) Precision mapping of quantitative trait loci. Genetics 136: 1457-1468.
87. Zhao J, Verpoorte R (2007) Manipulating indole alkaloid production by Catharanthus roseus cell cultures in bioreactors: from biochemical processing to metabolic engineering. Phytochem Rev 6: 435-457.