An iPSC-derived vascular model of Marfan syndrome identifies key mediators of smooth muscle cell death

Nature Genetics

Volumn 49, Issue 1, 2017, Pages 97-109

  Granata, Alessandra ^a   Serrano, Felipe ^a   Bernard, William George ^a   McNamara, Madeline ^a   Low, Lucinda ^a   Sastry, Priya ^a,b   Sinha, Sanjay ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b PAPWORTH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; FIBRILLIN 1; GELATINASE B; KRUPPEL LIKE FACTOR 4; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; SMAD PROTEIN; STROMELYSIN 2; TRANSFORMING GROWTH FACTOR BETA; KRUPPEL LIKE FACTOR;

ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GENE EXPRESSION; GENE MUTATION; GENOTYPE PHENOTYPE CORRELATION; HUMAN; HUMAN CELL; INDUCED PLURIPOTENT STEM CELL; MARFAN SYNDROME; MISSENSE MUTATION; MOUSE; MUSCLE FIBER CONTRACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CELL; AORTIC ANEURYSM; BIOLOGICAL MODEL; GENE EXPRESSION REGULATION; METABOLISM; PATHOLOGY; VASCULAR SMOOTH MUSCLE;

AORTIC ANEURYSM; APOPTOSIS; FIBRILLIN-1; GENE EXPRESSION REGULATION; HUMANS; INDUCED PLURIPOTENT STEM CELLS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MARFAN SYNDROME; MODELS, BIOLOGICAL; MUSCLE, SMOOTH, VASCULAR; P38 MITOGEN-ACTIVATED PROTEIN KINASES; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 84997637149     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.3723     Document Type: Article

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