Loss of elastic fiber integrity and reduction of vascular smooth muscle contraction resulting from the upregulated activities of matrix metalloproteinase-2 and -9 in the thoracic aortic aneurysm in Marfan syndrome

Circulation Research

Volumn 101, Issue 5, 2007, Pages 512-522

  Chung, Ada W Y ^a,b,d   Au Yeung, Karen ^a,b   Sandor, George G S ^b   Judge, Daniel P ^c   Dietz, Harry C ^c   Van Breemen, Cornelis ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Cardiovascular Science   (Canada)

Author keywords

Elastic fiber; Marfan syndrome; Matrix metalloproteinase; Thoracic aortic aneurysm; Vascular smooth muscle contraction

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CYSTEINE; FIBRILLIN 1; GELATINASE A; GELATINASE B; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA WALL; ARTICLE; CONTROLLED STUDY; DEPOLARIZATION; ELASTIC FIBER; ELASTICITY; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; GENE MUTATION; HETEROZYGOSITY; MALE; MARFAN SYNDROME; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOOTH MUSCLE CONTRACTION; THORACIC AORTA ANEURYSM; UPREGULATION; VASCULAR SMOOTH MUSCLE;

ACTINS; ANIMALS; AORTA, THORACIC; AORTIC ANEURYSM, THORACIC; DISEASE MODELS, ANIMAL; ELASTIC TISSUE; FEMALE; MALE; MARFAN SYNDROME; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICE; MICROFILAMENT PROTEINS; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; MUTATION; UP-REGULATION;

EID: 34548437703     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.107.157776     Document Type: Article

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