MEK5 is Activated by Shear Stress, Activates ERK5 and Induces KLF4 to Modulate TNF Responses in Human Dermal Microvascular Endothelial Cells

Microcirculation

Volumn 18, Issue 2, 2011, Pages 102-117

  Clark, Paul R ^a   Jensen, Todd J ^a   Kluger, Martin S ^a   Morelock, Maurice ^b   Hanidu, Adedayo ^b   Qi, Zhenhao ^b   Tatake, Revati J ^b   Pober, Jordan S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

Adhesion molecules; Inflammation; MAP kinases; Skin microvascualture; Vascular leak

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; INTERCELLULAR ADHESION MOLECULE 1; KRUPPEL LIKE FACTOR 4; MITOGEN ACTIVATED PROTEIN KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE KINASE 5; THROMBOMODULIN; TUMOR NECROSIS FACTOR;

ARTERY ENDOTHELIUM; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ELECTRIC RESISTANCE; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME PHOSPHORYLATION; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; INFLAMMATION; MICROVASCULATURE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SHEAR STRESS; SKIN; SKIN BLOOD VESSEL;

BASE SEQUENCE; CELLS, CULTURED; ENDOTHELIAL CELLS; ENZYME ACTIVATION; GENE EXPRESSION PROFILING; GENE KNOCKDOWN TECHNIQUES; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MAP KINASE KINASE 5; MITOGEN-ACTIVATED PROTEIN KINASE 7; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RNA, MESSENGER; RNA, SMALL INTERFERING; SHEAR STRENGTH; STRESS, MECHANICAL; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79551629461     PISSN: 10739688     EISSN: 15498719     Source Type: Journal    
DOI: 10.1111/j.1549-8719.2010.00071.x     Document Type: Article

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