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Volumn 65, Issue 5, 2016, Pages 777-788

Statin-induced changes in mitochondrial respiration in blood platelets in rats and human with dyslipidemia

Author keywords

Mitochondria; Platelet; Statin

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

EID: 84997078023     PISSN: 08628408     EISSN: 18029973     Source Type: Journal    
DOI: 10.33549/physiolres.933264     Document Type: Article
Times cited : (24)

References (75)
  • 1
    • 84879007318 scopus 로고    scopus 로고
    • Mechanisms of the statins cytotoxicity in freshly isolated rat hepatocytes
    • ABDOLI N, HEIDARI R, AZARMI Y, EGHBAL MA: Mechanisms of the statins cytotoxicity in freshly isolated rat hepatocytes. J Biochem Mol Toxicol 27: 287-294, 2013.
    • (2013) J Biochem Mol Toxicol , vol.27 , pp. 287-294
    • Abdoli, N.1    Heidari, R.2    Azarmi, Y.3    Eghbal, M.A.4
  • 3
    • 43249098181 scopus 로고    scopus 로고
    • Potential therapeutic role of statins in neurological disorders
    • BIFULCO M, MALFITANO AM, MARASCO G: Potential therapeutic role of statins in neurological disorders. Expert Rev Neurother 8: 827-837, 2008.
    • (2008) Expert Rev Neurother , vol.8 , pp. 827-837
    • Bifulco, M.1    Malfitano, A.M.2    Marasco, G.3
  • 4
    • 79958723474 scopus 로고    scopus 로고
    • What is a relevant statin concentration in cell experiments claiming pleiotropic effects?
    • BJöRKHEM-BERGMAN L, LINDH JD, BERGMAN P: What is a relevant statin concentration in cell experiments claiming pleiotropic effects? Br J Clin Pharmacol 72: 164-165, 2011.
    • (2011) Br J Clin Pharmacol , vol.72 , pp. 164-165
    • Björkhem-Bergman, L.1    Lindh, J.D.2    Bergman, P.3
  • 5
    • 35348992164 scopus 로고    scopus 로고
    • Activities of respiratory chain complexes in isolated platelets in females with anorexia nervosa
    • BöHM M, PAPEZOVA H, HANSIKOVA H, WENCHICH L, ZEMAN J: Activities of respiratory chain complexes in isolated platelets in females with anorexia nervosa. Int J Eat Disord 40: 659-663, 2007.
    • (2007) Int J Eat Disord , vol.40 , pp. 659-663
    • Böhm, M.1    Papezova, H.2    Hansikova, H.3    Wenchich, L.4    Zeman, J.5
  • 6
    • 84878683397 scopus 로고    scopus 로고
    • Propargylamine-Derived Multitarget-Directed Ligands fighting Alzheimer's disease with monoamine oxidase inhibitors
    • BOLEA I, GELLA A, UNZETA M. Propargylamine-derived multitarget-directed ligands: fighting Alzheimer's disease with monoamine oxidase inhibitors. J Neural Transm (Vienna) 120: 893-902, 2013.
    • (2013) J Neural Transm (Vienna) , vol.120 , pp. 893-902
    • Bolea, I.1    Gella, A.2    Unzeta, M.3
  • 7
    • 0036231792 scopus 로고    scopus 로고
    • Cytochrome c oxidase and mitochondrial F1F0-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer's disease
    • BOSETTI F, BRIZZI F, BAROGI S, MANCUSO M, SICILIANO G, TENDI EA, MURRI L, RAPOPORT SI, SOLAINI G: Cytochrome c oxidase and mitochondrial F1F0-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer's disease. Neurobiol Aging 23: 371-376, 2002.
    • (2002) Neurobiol Aging , vol.23 , pp. 371-376
    • Bosetti, F.1    Brizzi, F.2    Barogi, S.3    Mancuso, M.4    Siciliano, G.5    Tendi, E.A.6    Murri, L.7    Rapoport, S.I.8    Solaini, G.9
  • 8
    • 77952061696 scopus 로고    scopus 로고
    • Statins for primary prevention of cardiovascular mortality in women: a systematic review and meta-analysis
    • BUKKAPATNAM RN, GABLER NB, LEWIS WR: Statins for primary prevention of cardiovascular mortality in women: a systematic review and meta-analysis. Prev Cardiol 13: 84-90, 2010.
    • (2010) Prev Cardiol , vol.13 , pp. 84-90
    • Bukkapatnam, R.N.1    Gabler, N.B.2    Lewis, W.R.3
  • 14
    • 77954503073 scopus 로고    scopus 로고
    • Coenzyme Q10 and statin-induced mitochondrial dysfunction
    • DEICHMANN R, LAVIE C, ANDREWS S: Coenzyme Q10 and statin-induced mitochondrial dysfunction. Ochsner J 10: 16-21, 2010.
    • (2010) Ochsner J , vol.10 , pp. 16-21
    • Deichmann, R.1    Lavie, C.2    Andrews, S.3
  • 16
    • 84904497873 scopus 로고    scopus 로고
    • Non-cardiovascular effects associated with statins
    • DESAI CS, MARTIN SS, BLUMENTHAL RS: Non-cardiovascular effects associated with statins. BMJ 349: g3743, 2014.
    • (2014) BMJ , vol.349
    • Desai, C.S.1    Martin, S.S.2    Blumenthal, R.S.3
  • 20
    • 84872296570 scopus 로고    scopus 로고
    • Protocol for obtaining platelet-rich plasma (PRP), platelet-poor plasma (PPP), and thrombin for autologous use
    • FRANCO D, FRANCO T, SCHETTINO AM, FILHO JM, VENDRAMIN FS: Protocol for obtaining platelet-rich plasma (PRP), platelet-poor plasma (PPP), and thrombin for autologous use. Aesthetic Plast Surg 36: 1254-1259, 2012.
    • (2012) Aesthetic Plast Surg , vol.36 , pp. 1254-1259
    • Franco, D.1    Franco, T.2    Schettino, A.M.3    Filho, J.M.4    Vendramin, F.S.5
  • 24
    • 84938667719 scopus 로고    scopus 로고
    • Mitochondrial pathways and respiratory control
    • 4th ed. Mitochondr Physiol Network 19.12. OROBOROS MiPNet Publications, Innsbruck
    • GNAIGER E: Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 4th ed. Mitochondr Physiol Network 19.12. OROBOROS MiPNet Publications, Innsbruck, 2014, 80 pp. Open Access: www.bioblast.at/index.php/Gnaiger_2014_MitoPathways
    • (2014) An introduction to OXPHOS analysis , pp. 80
    • Gnaiger, E.1
  • 25
    • 59549089180 scopus 로고    scopus 로고
    • Statin adverse effects: a review of the literature and evidence for a mitochondrial mechanism
    • GOLOMB BA, EVANS MA: Statin adverse effects: a review of the literature and evidence for a mitochondrial mechanism. Am J Cardiovasc Drugs 8: 373-418, 2008.
    • (2008) Am J Cardiovasc Drugs , vol.8 , pp. 373-418
    • Golomb, B.A.1    Evans, M.A.2
  • 27
    • 84865197598 scopus 로고    scopus 로고
    • A survey of the FDA's AERS database regarding muscle and tendon adverse events linked to the statin drug class
    • HOFFMAN KB, KRAUS C, DIMBIL M, GOLOMB BA: A survey of the FDA's AERS database regarding muscle and tendon adverse events linked to the statin drug class. PLoS One 7: e42866, 2012.
    • (2012) PLoS One , vol.7
    • Hoffman, K.B.1    Kraus, C.2    Dimbil, M.3    Golomb, B.A.4
  • 29
    • 84938630567 scopus 로고    scopus 로고
    • Reducing Aβ load and tau phosphorylation: Emerging perspective for treating Alzheimer's disease
    • KALRA J, KHAN A: Reducing Aβ load and tau phosphorylation: Emerging perspective for treating Alzheimer's disease. Eur J Pharmacol 764: 571-581, 2015.
    • (2015) Eur J Pharmacol , vol.764 , pp. 571-581
    • Kalra, J.1    Khan, A.2
  • 30
    • 68649109626 scopus 로고    scopus 로고
    • Investigating GABA and its function in platelets as compared to neurons
    • KANEEZ FS, SAEED SA: Investigating GABA and its function in platelets as compared to neurons. Platelets 20: 328-333, 2009.
    • (2009) Platelets , vol.20 , pp. 328-333
    • Kaneez, F.S.1    Saeed, S.A.2
  • 32
    • 0026484964 scopus 로고
    • Platelet mitochondrial function in Parkinson's disease. The Royal Kings and Queens Parkinson Disease Research Group
    • KRIGE D, CARROLL MT, COOPER JM, MARSDEN CD, SCHAPIRA AH: Platelet mitochondrial function in Parkinson's disease. The Royal Kings and Queens Parkinson Disease Research Group. Ann Neurol 32: 782-788, 1992.
    • (1992) Ann Neurol , vol.32 , pp. 782-788
    • Krige, D.1    Carroll, M.T.2    Cooper, J.M.3    Marsden, C.D.4    Schapira, A.H.5
  • 33
    • 84883796067 scopus 로고    scopus 로고
    • Protection of rat skeletal muscle fibers by either L-carnitine or coenzyme Q10 against statins toxicity mediated by mitochondrial reactive oxygen generation
    • LA GUARDIA PG, ALBERICI LC, RAVAGNANI FG, CATHARINO RR, VERCESI AE: Protection of rat skeletal muscle fibers by either L-carnitine or coenzyme Q10 against statins toxicity mediated by mitochondrial reactive oxygen generation. Front Physiol 4: 103, 2013.
    • (2013) Front Physiol , vol.4 , pp. 103
    • La Guardia, P.G.1    Alberici, L.C.2    Ravagnani, F.G.3    Catharino, R.R.4    Vercesi, A.E.5
  • 36
    • 84902154187 scopus 로고    scopus 로고
    • Statins excert neuroprotection on cerebral ischemia independent of their lipid-lowering action: the potential molecular mechanisms
    • LI Q, ZHUANG QK, YANG JN, ZHANG YY: Statins excert neuroprotection on cerebral ischemia independent of their lipid-lowering action: the potential molecular mechanisms. Eur Rev Med Pharmacol Sci 18: 1113-1126, 2014.
    • (2014) Eur Rev Med Pharmacol Sci , vol.18 , pp. 1113-1126
    • Li, Q.1    Zhuang, Q.K.2    Yang, J.N.3    Zhang, Y.Y.4
  • 39
    • 84862769027 scopus 로고    scopus 로고
    • New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates?Nrf2 activators and GSK-3 inhibitors
    • MAES M, FIŠAR Z, MEDINA M, SCAPAGNINI G, NOWAK G, BERK M: New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates?Nrf2 activators and GSK-3 inhibitors. Inflammopharmacology 20: 127-150, 2012.
    • (2012) Inflammopharmacology , vol.20 , pp. 127-150
    • Maes, M.1    Fišar, Z.2    Medina, M.3    Scapagnini, G.4    Nowak, G.5    Berk, M.6
  • 41
    • 79956315187 scopus 로고    scopus 로고
    • Pleiotropic effects of statins: evidence for benefits beyond LDL-cholesterol lowering
    • MARZILLI M: Pleiotropic effects of statins: evidence for benefits beyond LDL-cholesterol lowering. Am J Cardiovasc Drugs 10: 3-9, 2010.
    • (2010) Am J Cardiovasc Drugs , vol.10 , pp. 3-9
    • Marzilli, M.1
  • 43
    • 0034598432 scopus 로고    scopus 로고
    • The current status of the platelet 5-HT2A receptor in depression
    • MENDELSON SD: The current status of the platelet 5-HT2A receptor in depression. J Affect Disord 57: 13-24, 2000.
    • (2000) J Affect Disord , vol.57 , pp. 13-24
    • Mendelson, S.D.1
  • 44
    • 77956034606 scopus 로고    scopus 로고
    • Molecular mechanisms of SERT in platelets: regulation of plasma serotonin levels
    • MERCADO CP, KILIC F: Molecular mechanisms of SERT in platelets: regulation of plasma serotonin levels. Mol Interv 10: 231-241, 2010.
    • (2010) Mol Interv , vol.10 , pp. 231-241
    • Mercado, C.P.1    Kilic, F.2
  • 47
    • 84903209129 scopus 로고    scopus 로고
    • Emerging roles for platelets as immune and inflammatory cells
    • MORRELL CN, AGGREY AA, CHAPMAN LM, MODJESKI KL: Emerging roles for platelets as immune and inflammatory cells. Blood 123: 2759-2767, 2014.
    • (2014) Blood , vol.123 , pp. 2759-2767
    • Morrell, C.N.1    Aggrey, A.A.2    Chapman, L.M.3    Modjeski, K.L.4
  • 48
    • 84884474355 scopus 로고    scopus 로고
    • Comparative tolerability and harms of individual statins: a study-level network metaanalysis of 246 955 participants from 135 randomized, controlled trials
    • NACI H, BRUGTS J, ADES T: Comparative tolerability and harms of individual statins: a study-level network metaanalysis of 246 955 participants from 135 randomized, controlled trials. Circ Cardiovasc Qual Outcomes 6: 390-399, 2013.
    • (2013) Circ Cardiovasc Qual Outcomes , vol.6 , pp. 390-399
    • Naci, H.1    Brugts, J.2    Ades, T.3
  • 49
    • 34548410988 scopus 로고    scopus 로고
    • Mitochondrial impairment by PPAR agonists and statins identified via immunocaptured OXPHOS complex activities and respiration
    • NADANACIVA S, DYKENS JA, BERNAL A, CAPALDI RA, WILL Y: Mitochondrial impairment by PPAR agonists and statins identified via immunocaptured OXPHOS complex activities and respiration. Toxicol Appl Pharmacol 223: 277-287, 2007.
    • (2007) Toxicol Appl Pharmacol , vol.223 , pp. 277-287
    • Nadanaciva, S.1    Dykens, J.A.2    Bernal, A.3    Capaldi, R.A.4    Will, Y.5
  • 51
    • 84867403473 scopus 로고    scopus 로고
    • The effect of HMG-CoA reductase inhibitors on cognition in patients with Alzheimer's dementia: a prospective withdrawal and rechallenge pilot study
    • PADALA KP, PADALA PR, MCNEILLY DP, GESKE JA, SULLIVAN DH, POTTER JF: The effect of HMG-CoA reductase inhibitors on cognition in patients with Alzheimer's dementia: a prospective withdrawal and rechallenge pilot study. Am J Geriatr Pharmacother 10: 296-302, 2012.
    • (2012) Am J Geriatr Pharmacother , vol.10 , pp. 296-302
    • Padala, K.P.1    Padala, P.R.2    Mcneilly, D.P.3    Geske, J.A.4    Sullivan, D.H.5    Potter, J.F.6
  • 52
    • 84860471028 scopus 로고    scopus 로고
    • Statins lower calcium-induced oxidative stress in isolated mitochondria
    • PARIHAR A, PARIHAR MS, ZENEBE WJ, GHAFOURIFAR P: Statins lower calcium-induced oxidative stress in isolated mitochondria. Hum Exp Toxicol 31: 355-363, 2012.
    • (2012) Hum Exp Toxicol , vol.31 , pp. 355-363
    • Parihar, A.1    Parihar, M.S.2    Zenebe, W.J.3    Ghafourifar, P.4
  • 53
    • 82355161907 scopus 로고    scopus 로고
    • High-resolution respirometry: OXPHOS protocols for human cells and permeabilized fibers from small biopsies of human muscle
    • PESTA D, GNAIGER E: High-resolution respirometry: OXPHOS protocols for human cells and permeabilized fibers from small biopsies of human muscle. Methods Mol Biol 810: 25-58, 2012.
    • (2012) Methods Mol Biol , vol.810 , pp. 25-58
    • Pesta, D.1    Gnaiger, E.2
  • 55
    • 77954179995 scopus 로고    scopus 로고
    • Statins and all-cause mortality in high-risk primary prevention: a meta-analysis of 11 randomized controlled trials involving 65,229 participants
    • RAY KK, SESHASAI SR, ERQOU S, SEVER P, JUKEMA JW, FORD I, SATTAR N: Statins and all-cause mortality in high-risk primary prevention: a meta-analysis of 11 randomized controlled trials involving 65,229 participants. Arch Intern Med 170: 1024-1031, 2010.
    • (2010) Arch Intern Med , vol.170 , pp. 1024-1031
    • Ray, K.K.1    Seshasai, S.R.2    Erqou, S.3    Sever, P.4    Jukema, J.W.5    Ford, I.6    Sattar, N.7
  • 57
    • 84860532398 scopus 로고    scopus 로고
    • Statin induced myotoxicity
    • SATHASIVAM S: Statin induced myotoxicity. Eur J Intern Med 23: 317-324, 2012.
    • (2012) Eur J Intern Med , vol.23 , pp. 317-324
    • Sathasivam, S.1
  • 58
    • 35248900346 scopus 로고    scopus 로고
    • The metabolism of serotonin in neuronal cells in culture and platelets
    • SHAD KF, SAEED SA: The metabolism of serotonin in neuronal cells in culture and platelets. Exp Brain Res 183: 411-416, 2007.
    • (2007) Exp Brain Res , vol.183 , pp. 411-416
    • Shad, K.F.1    Saeed, S.A.2
  • 59
    • 80053928598 scopus 로고    scopus 로고
    • Cholesterol level and statin use in Alzheimer disease: I. Review of epidemiological and preclinical studies
    • SHEPARDSON NE, SHANKAR GM, SELKOE DJ: Cholesterol level and statin use in Alzheimer disease: I. Review of epidemiological and preclinical studies. Arch Neurol 68: 1239-1244, 2011.
    • (2011) Arch Neurol , vol.68 , pp. 1239-1244
    • Shepardson, N.E.1    Shankar, G.M.2    Selkoe, D.J.3
  • 60
    • 43649092320 scopus 로고    scopus 로고
    • Effects of ageing and Alzheimer's disease on mitochondrial function of human platelets
    • SHI C, GUO K, YEW DT, YAO Z, FORSTER EL, WANG H, XU J: Effects of ageing and Alzheimer's disease on mitochondrial function of human platelets. Exp Gerontol 43: 589-594, 2008.
    • (2008) Exp Gerontol , vol.43 , pp. 589-594
    • Shi, C.1    Guo, K.2    Yew, D.T.3    Yao, Z.4    Forster, E.L.5    Wang, H.6    Xu, J.7
  • 63
    • 78549296744 scopus 로고    scopus 로고
    • Temporal increase of platelet mitochondrial respiration is negatively associated with clinical outcome in patients with sepsis
    • SJöVALL F, MOROTA S, HANSSON MJ, FRIBERG H, GNAIGER E, ELMéR E: Temporal increase of platelet mitochondrial respiration is negatively associated with clinical outcome in patients with sepsis. Crit Care 14: R214, 2010.
    • (2010) Crit Care , vol.14 , pp. R214
    • Sjövall, F.1    Morota, S.2    Hansson, M.J.3    Friberg, H.4    Gnaiger, E.5    Elmér, E.6
  • 65
    • 84920861405 scopus 로고    scopus 로고
    • Treatment of vascular risk factors in patients with a diagnosis of Alzheimer's disease: a systematic review
    • VALENTI R, PANTONI L, MARKUS HS: Treatment of vascular risk factors in patients with a diagnosis of Alzheimer's disease: a systematic review. BMC Med 12: 160, 2014.
    • (2014) BMC Med , vol.12 , pp. 160
    • Valenti, R.1    Pantoni, L.2    Markus, H.S.3
  • 67
    • 84877866735 scopus 로고    scopus 로고
    • Ubiquinol rescues simvastatinsuppression of mitochondrial content, function and metabolism: Implications for statin-induced rhabdomyolysis
    • VAUGHAN RA, GARCIA-SMITH R, BISOFFI M, CONN CA, TRUJILLO KA: Ubiquinol rescues simvastatinsuppression of mitochondrial content, function and metabolism: Implications for statin-induced rhabdomyolysis. Eur J Pharmacol 711: 1-9, 2013.
    • (2013) Eur J Pharmacol , vol.711 , pp. 1-9
    • Vaughan, R.A.1    Garcia-Smith, R.2    Bisoffi, M.3    Conn, C.A.4    Trujillo, K.A.5
  • 69
    • 84959288136 scopus 로고    scopus 로고
    • The effect of prolonged simvastatin application on serotonin uptake, membrane microviscosity and behavioral changes in the animal model
    • VEVERA J, VALEŠ K, FIŠAR Z, HROUDOVá J, SINGH N, STUCHLíK A, KACER P, NEKOVáROVá T: The effect of prolonged simvastatin application on serotonin uptake, membrane microviscosity and behavioral changes in the animal model. Physiol Behav 158: 112-120, 2016.
    • (2016) Physiol Behav , vol.158 , pp. 112-120
    • Vevera, J.1    Valeš, K.2    Fišar, Z.3    Hroudová, J.4    Singh, N.5    Stuchlík, A.6    Kacer, P.7    Nekovárová, T.8
  • 70
    • 33746233393 scopus 로고    scopus 로고
    • Identification of small-molecule inhibitors of the Aβ-ABAD interaction
    • XIE Y, DENG S, CHEN Z, YAN S, LANDRY DW: Identification of small-molecule inhibitors of the Aβ-ABAD interaction. Bioorg Med Chem Lett 16: 4657-4660, 2006.
    • (2006) Bioorg Med Chem Lett , vol.16 , pp. 4657-4660
    • Xie, Y.1    Deng, S.2    Chen, Z.3    Yan, S.4    Landry, D.W.5
  • 71
    • 34249909201 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in platelets and hippocampi of senescence-accelerated mice
    • XU J, SHI C, LI Q, WU J, FORSTER EL, YEW DT: Mitochondrial dysfunction in platelets and hippocampi of senescence-accelerated mice. J Bioenerg Biomembr 39: 195-202, 2007.
    • (2007) J Bioenerg Biomembr , vol.39 , pp. 195-202
    • Xu, J.1    Shi, C.2    Li, Q.3    Wu, J.4    Forster, E.L.5    Yew, D.T.6
  • 72
    • 0023864743 scopus 로고
    • Platelet monoamine oxidase B: use and misuse
    • YOUDIM MB: Platelet monoamine oxidase B: use and misuse. Experientia 44: 137-141, 1988.
    • (1988) Experientia , vol.44 , pp. 137-141
    • Youdim, M.B.1
  • 73
    • 84879623987 scopus 로고    scopus 로고
    • Simvastatin inhibits proliferation and induces apoptosis in human lung cancer cells
    • YU X, PAN Y, MA H, LI W: Simvastatin inhibits proliferation and induces apoptosis in human lung cancer cells. Oncol Res 20: 351-357, 2013.
    • (2013) Oncol Res , vol.20 , pp. 351-357
    • Yu, X.1    Pan, Y.2    Ma, H.3    Li, W.4
  • 74
    • 84877945218 scopus 로고    scopus 로고
    • Platelet SERT as a peripheral biomarker of serotonergic neurotransmission in the central nervous system
    • YUBERO-LAHOZ S, ROBLEDO P, FARRé M, DE LATORRE R: Platelet SERT as a peripheral biomarker of serotonergic neurotransmission in the central nervous system. Curr Med Chem 20: 1382-1396, 2013.
    • (2013) Curr Med Chem , vol.20 , pp. 1382-1396
    • Yubero-Lahoz, S.1    Robledo, P.2    Farré, M.3    De Latorre, R.4
  • 75
    • 84923180985 scopus 로고    scopus 로고
    • Pre-treatment of a single high-dose of atorvastatin provided cardioprotection in different ischaemia/reperfusion models via activating mitochondrial KATP channel
    • ZHAO Z, CUI W, ZHANG H, GAO H, LI X, WANG Y, HU H, LI B: Pre-treatment of a single high-dose of atorvastatin provided cardioprotection in different ischaemia/reperfusion models via activating mitochondrial KATP channel. Eur J Pharmacol 751: 89-98, 2015.
    • (2015) Eur J Pharmacol , vol.751 , pp. 89-98
    • Zhao, Z.1    Cui, W.2    Zhang, H.3    Gao, H.4    Li, X.5    Wang, Y.6    Hu, H.7    Li, B.8


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