Investigating GABA and its function in platelets as compared to neurons

Platelets

Volumn 20, Issue 5, 2009, Pages 328-333

  Kaneez, Fatima Shad ^a   Saeed, Sheikh Arshad ^a  

^a UNIVERSITY OF KARACHI   (Pakistan)

Author keywords

Benzodiazepine; Calcium ionophore A23187; GABA; GABA transaminase; PK11195; Platelet aggregation; Wortmannin

Indexed keywords

4 AMINOBUTYRATE AMINOTRANSFERASE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR; BENZODIAZEPINE; CALCIUM CHANNEL BLOCKING AGENT; PHOSPHATIDYLINOSITOL 3 KINASE; WORTMANNIN;

4 AMINOBUTYRIC ACID METABOLISM; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CEREBELLUM CORTEX; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPILEPSY; GABAERGIC SYSTEM; HIPPOCAMPUS; HUMAN; HUMAN CELL; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SCHIZOPHRENIA; THROMBOCYTE; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BLOOD PLATELETS; CALCIUM; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; GAMMA-AMINOBUTYRIC ACID; HUMANS; MICE; NEURONS; PLATELET AGGREGATION; RECEPTORS, GABA;

EID: 68649109626     PISSN: 09537104     EISSN: 13691635     Source Type: Journal    
DOI: 10.1080/09537100903047752     Document Type: Article

References (27)

1. Bowery NG. GABA-B Receptor Pharmacology. An Rev Pharmacol Toxicol 1993;33:109-147.
2. Oset-gasque MJ, Launay JM, Gonzalez MP. GABAergic mechanisms in blood cells: Their possible role in GABAergic mechanisms in the mammalian periphery, In: Erdo SL, Bowery NG, editors. GABAergic mechanisms in the mammalian periphery, New York: Raven Press; 1986. pp 305-324.
3. Fatima-Shad K. Effect of d-serine on the serotonin receptors of human platelets. Exp Brain Res 2006;173:353-356.
4. Fatima Shad K, Sheikh Saeed. The metabolism of serotonin in neuronal cells in culture and platelets. Exp Brain Res 2007;183:1791-2506.
5. Wang JKT, Taniguchi T, Spector S. Properties of (3H) diazepam binding sites on rat blood platelets. Life Sci 1980;27:1881-1888.
6. Taniguchi K, Wang JKT, Spector S. Changes in platelets and renal benzodiazepine binding in spontaneously hypertensive rats. Eur J Pharmacol 1981;70:587-588. (Pubitemid 11152796)
7. O'Berine GB, Williams DC. Binding of benzodiazepines to blood platelets from various species. Biochem Pharmacol 1984;33:1568-1571. (Pubitemid 14105038)
8. Fatima-Shad K, Barry PH. Heterogeneous current responses to GABA and glycine are present in post-natal cultured hippocampal neurons. Brain Res 1995;704:246-255. (Pubitemid 26009943)
9. Heemskerk JWM, Sage O. Calcium signaling in platelets and other cells. Platelets 1994;5:295-316.
10. ++ signalling pathways. Exp Mol Med 1999;31:42-46.
11. Ui M, Okada T, Hazeki K, Hazeki O. Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase. Trends Biochem Sci 1995;20:303-306.
12. Fatima-Shad K, Barry PH. Morphological and electrical characteristics of post-natal hippocampal neurons in culture: The presence of bicuculline- and strychnine-sensitive IPSPs. Tissue Cell 1998;30:236-250. (Pubitemid 28211881)
13. Saeed SA, Aleem F, Naqvi A, Jafarey M, Suria A. Synergistic actions of platelet-activating factor and 5-HT in platelet aggregation: Effect of 5-HT blockers and anti-asthma drugs. Br J Pharmacol 1989;97:544-556.
14. Saeed SA, Nasreen R, Suria A. Synergistic actions of 5-HT and arachidonic acid in platelet aggregation. Effect of 5-HT blockers. Br J Pharmacol 1988;88:330-338.
15. Rainesalo S, Saransaari P, Peltola J, Tapani K. Uptake of GABA and activity of GABA-transaminase in platelets from epileptic patients. Epilep Res 2003;53:233-239. (Pubitemid 36419617)
16. Valdizan EM, Garcia AP, Armijo JA. Effects of increasing doses of vigabatrin on platelet γ-aminobutyric acid-transaminase and brain γ-aminobutyric acid in rats. Eur J Pharmacol 1999;369:169-173.
17. +2 dependent tyrosine phosphorylation. Biochem J 1993;294:675-680.
18. Zorumsky CF, Isenberg KE. Insights into the stricter and function of GABA-benzodiazepine receptors: Ion channels and psychiatry. Am J Psychiat 1991;149:162-173.
19. Johnson MR, Marazziti D, Brawman-mintzer O, Emmanuel NP, Ware MR, Morton WA, Rossi A, Cassano GB, Lydiard RB. Abnormal peripheral benzodiazepine receptor density associated with generalized social phobia. Biol Psychiat 1998;43:306-309. (Pubitemid 28085679)
20. Rittenhouse SE. Regulation of phosphatidylinositide 3-kinase, a potential signaling enzyme in platelets. Semin Hematol 1995;32:120-125.
21. Berridge MJ. Inositol trisphosphate and calcium signaling. Nature 1993;361:315-325.
22. Saeed SA, Shamim G, Nawaz Z, Gilani AH, Shah BH. Role of phosphatidylinositol 3-kinase in platelet aggregation. J Chem Soc Pak 1999;21:289-294.
23. Shah BH, Saeed SA. Phosphatidylinositol 3-kinase inhibitor, wortmannin, inhibits 5-hydroxytryptamine-mediated potentiation of platelet aggregation induced by epinephrine. Res Comm. Mol Pathol Pharmacol 1995;89:57-164.
24. Rainesalo S, Keränen T, Saransaari P, Honkaniemi J. GABA and glutamate transporters are expressed in human platelets. Mol Brain Res 2005;141:161-165. (Pubitemid 41608697)
25. Freson K, Labarque V, Thys C, Wittevrongel C, Van Geet C. What's new in using platelet research? To unravel thrombopathies and other human disorders. Eur J Pediatr 2007;166:1203-1210. (Pubitemid 350029482)
26. Begni B, Tremolizzo L, D'Orlando C, Serena Bono M, Garofolo R, Longoni M, Ferrarese C. Substrate-induced modulation of glutamate uptake in human platelets. Br J Pharmacol 2005;145:792-799. (Pubitemid 41076286)
27. Yatomi Y, Hazeki O, Kume S, Ui M. Suppression by Wortmannin of platelet responses to stimuli due to inhibition of pleckstrin phosphorylation. Biochem. J 1992;285:745-751.