메뉴 건너뛰기




Volumn 2, Issue , 2016, Pages

Molecular evidence of synaptic pathology in the CA1 region in schizophrenia

Author keywords

[No Author keywords available]

Indexed keywords

METABOTROPIC RECEPTOR 1; POSTSYNAPTIC DENSITY PROTEIN 95; PROTEIN HOMER 1; PROTEIN HOMER 1A; PROTEIN HOMER 1B; PROTEIN HOMER 1C; SYNAPTOPHYSIN;

EID: 84996734038     PISSN: None     EISSN: 2334265X     Source Type: Journal    
DOI: 10.1038/npjschz.2016.22     Document Type: Article
Times cited : (67)

References (75)
  • 1
    • 77957952253 scopus 로고    scopus 로고
    • The hippocampal formation in schizophrenia
    • Tamminga, C. A., Stan, A. D., Wagner, A. D. The hippocampal formation in schizophrenia. Am. J. Psychiatry 167, 1178-1193 (2010).
    • (2010) Am. J. Psychiatry , vol.167 , pp. 1178-1193
    • Tamminga, C.A.1    Stan, A.D.2    Wagner, A.D.3
  • 2
    • 44749094779 scopus 로고    scopus 로고
    • The cognitive neuroscience of memory function and dysfunction in schizophrenia
    • Ranganath, C., Minzenberg, M. J., Ragland, J. D. The cognitive neuroscience of memory function and dysfunction in schizophrenia. Biol. Psychiatry 64, 18-25 (2008).
    • (2008) Biol. Psychiatry , vol.64 , pp. 18-25
    • Ranganath, C.1    Minzenberg, M.J.2    Ragland, J.D.3
  • 3
    • 84866001607 scopus 로고    scopus 로고
    • A single microcircuit with multiple functions: State dependent information processing in the hippocampus
    • Carr, M. F., Frank, L. M. A single microcircuit with multiple functions: state dependent information processing in the hippocampus. Curr. Opin. Neurobiol. 22, 704-708 (2012).
    • (2012) Curr. Opin. Neurobiol. , vol.22 , pp. 704-708
    • Carr, M.F.1    Frank, L.M.2
  • 4
    • 84920646061 scopus 로고    scopus 로고
    • Genetic risk for schizophrenia: Convergence on synaptic pathways involved in plasticity
    • Hall, J., Trent, S., Thomas, K. L., O'Donovan, M. C., Owen, M. J. Genetic risk for schizophrenia: convergence on synaptic pathways involved in plasticity. Biol. Psychiatry 77, 52-58 (2015).
    • (2015) Biol. Psychiatry , vol.77 , pp. 52-58
    • Hall, J.1    Trent, S.2    Thomas, K.L.3    O'Donovan, M.C.4    Owen, M.J.5
  • 5
    • 5044224260 scopus 로고    scopus 로고
    • PDZ domain proteins of synapses
    • Kim, E., Sheng, M. PDZ domain proteins of synapses. Nat. Rev. Neurosci. 5, 771-781 (2004).
    • (2004) Nat. Rev. Neurosci. , vol.5 , pp. 771-781
    • Kim, E.1    Sheng, M.2
  • 6
    • 79955775549 scopus 로고    scopus 로고
    • PSD-95 Is required to sustain the molecular organization of the postsynaptic density
    • Chen, X. et al. PSD-95 Is required to sustain the molecular organization of the postsynaptic density. J. Neurosci. 31, 6329-6338 (2011).
    • (2011) J. Neurosci. , vol.31 , pp. 6329-6338
    • Chen, X.1
  • 7
    • 34247237148 scopus 로고    scopus 로고
    • PSD-95 is required for activity-driven synapse stabilization
    • Ehrlich, I., Klein, M., Rumpel, S., Malinow, R. PSD-95 is required for activity-driven synapse stabilization. Proc. Natl Acad. Sci. USA 104, 4176-4181 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 4176-4181
    • Ehrlich, I.1    Klein, M.2    Rumpel, S.3    Malinow, R.4
  • 8
    • 0034727417 scopus 로고    scopus 로고
    • Gene expression of PSD95 in prefrontal cortex and hippocampus in schizophrenia
    • Ohnuma, T. et al. Gene expression of PSD95 in prefrontal cortex and hippocampus in schizophrenia. NeuroReport 11, 3133-3137 (2000).
    • (2000) NeuroReport , vol.11 , pp. 3133-3137
    • Ohnuma, T.1
  • 9
    • 18744366911 scopus 로고    scopus 로고
    • Selective reduction of a PDZ protein, SAP-97, in the prefrontal cortex of patients with chronic schizophrenia
    • Toyooka, K. et al. Selective reduction of a PDZ protein, SAP-97, in the prefrontal cortex of patients with chronic schizophrenia. J. Neurochem. 83, 797-806 (2002).
    • (2002) J. Neurochem. , vol.83 , pp. 797-806
    • Toyooka, K.1
  • 10
    • 33746526525 scopus 로고    scopus 로고
    • Changes in NMDA receptor subunits and interacting PSD proteins in dorsolateral prefrontal and anterior cingulate cortex indicate abnormal regional expression in schizophrenia
    • Kristiansen, L. V., Beneyto, M., Haroutunian, V., Meador-Woodruff, J. H. Changes in NMDA receptor subunits and interacting PSD proteins in dorsolateral prefrontal and anterior cingulate cortex indicate abnormal regional expression in schizophrenia. Mol. Psychiatry 11, 737-747 (2006).
    • (2006) Mol. Psychiatry , vol.11 , pp. 737-747
    • Kristiansen, L.V.1    Beneyto, M.2    Haroutunian, V.3    Meador-Woodruff, J.H.4
  • 11
    • 79960309911 scopus 로고    scopus 로고
    • Endosomal trafficking of AMPA receptors in frontal cortex of elderly patients with schizophrenia
    • Hammond, J. C., McCullumsmith, R. E., Haroutunian, V., Meador-Woodruff, J. H. Endosomal trafficking of AMPA receptors in frontal cortex of elderly patients with schizophrenia. Schizophr. Res. 130, 260-265 (2011).
    • (2011) Schizophr. Res. , vol.130 , pp. 260-265
    • Hammond, J.C.1    McCullumsmith, R.E.2    Haroutunian, V.3    Meador-Woodruff, J.H.4
  • 12
    • 1242283944 scopus 로고    scopus 로고
    • Expression of the ionotropic glutamate receptor subunits and NMDA receptor-associated intracellular proteins in the substantia nigra in schizophrenia
    • Mueller, H. T., Haroutunian, V., Davis, K. L., Meador-Woodruff, J. H. Expression of the ionotropic glutamate receptor subunits and NMDA receptor-associated intracellular proteins in the substantia nigra in schizophrenia. Mol. Brain Res. 121, 60-69 (2004).
    • (2004) Mol. Brain Res. , vol.121 , pp. 60-69
    • Mueller, H.T.1    Haroutunian, V.2    Davis, K.L.3    Meador-Woodruff, J.H.4
  • 13
    • 0642338932 scopus 로고    scopus 로고
    • Synapse-associated protein 90/postsynaptic density-95-associated protein (SAPAP) is expressed differentially in phencyclidine-treated rats and is increased in the nucleus accumbens of patients with schizophrenia
    • Kajimoto, Y. et al. Synapse-associated protein 90/postsynaptic density-95-associated protein (SAPAP) is expressed differentially in phencyclidine-treated rats and is increased in the nucleus accumbens of patients with schizophrenia. Neuropsychopharmacology 28, 1831-1839 (2003).
    • (2003) Neuropsychopharmacology , vol.28 , pp. 1831-1839
    • Kajimoto, Y.1
  • 14
    • 2942666210 scopus 로고    scopus 로고
    • Abnormalities of the NMDA receptor and associated intracellular molecules in the thalamus in schizophrenia and bipolar disorder
    • Clinton, S. M., Meador-Woodruff, J. H. Abnormalities of the NMDA receptor and associated intracellular molecules in the thalamus in schizophrenia and bipolar disorder. Neuropsychopharmacology 29, 1353-1362 (2004).
    • (2004) Neuropsychopharmacology , vol.29 , pp. 1353-1362
    • Clinton, S.M.1    Meador-Woodruff, J.H.2
  • 15
    • 33746391983 scopus 로고    scopus 로고
    • Up-regulation of NMDA receptor subunit and post-synaptic density protein expression in the thalamus of elderly patients with schizophrenia
    • Clinton, S. M., Haroutunian, V., Meador-Woodruff, J. H. Up-regulation of NMDA receptor subunit and post-synaptic density protein expression in the thalamus of elderly patients with schizophrenia. J. Neurochem. 98, 1114-1125 (2006).
    • (2006) J. Neurochem. , vol.98 , pp. 1114-1125
    • Clinton, S.M.1    Haroutunian, V.2    Meador-Woodruff, J.H.3
  • 16
    • 0038488293 scopus 로고    scopus 로고
    • Altered transcript expression of NMDA receptor-associated postsynaptic proteins in the thalamus of subjects with schizophrenia
    • Clinton, S. M., Haroutunian, V., Davis, K. L., Meador-Woodruff, J. H. Altered transcript expression of NMDA receptor-associated postsynaptic proteins in the thalamus of subjects with schizophrenia. Am. J. Psychiatry 160, 1100-1109 (2003).
    • (2003) Am. J. Psychiatry , vol.160 , pp. 1100-1109
    • Clinton, S.M.1    Haroutunian, V.2    Davis, K.L.3    Meador-Woodruff, J.H.4
  • 17
    • 67749130803 scopus 로고    scopus 로고
    • Decreased expression of NMDA receptor-associated proteins in frontal cortex of elderly patients with schizophrenia
    • Funk, A. J., Rumbaugh, G., Harotunian, V., McCullumsmith, R. E., Meador-Woodruff, J. H. Decreased expression of NMDA receptor-associated proteins in frontal cortex of elderly patients with schizophrenia. Neuroreport 20, 1019 (2009).
    • (2009) Neuroreport , vol.20 , pp. 1019
    • Funk, A.J.1    Rumbaugh, G.2    Harotunian, V.3    McCullumsmith, R.E.4    Meador-Woodruff, J.H.5
  • 18
    • 47249164327 scopus 로고    scopus 로고
    • Lamina-specific abnormalities of NMDA receptor-associated postsynaptic protein transcripts in the prefrontal cortex in schizophrenia and bipolar disorder
    • Beneyto, M., Meador-Woodruff, J. H. Lamina-specific abnormalities of NMDA receptor-associated postsynaptic protein transcripts in the prefrontal cortex in schizophrenia and bipolar disorder. Neuropsychopharmacology 33, 2175-2186 (2008).
    • (2008) Neuropsychopharmacology , vol.33 , pp. 2175-2186
    • Beneyto, M.1    Meador-Woodruff, J.H.2
  • 19
    • 84964303784 scopus 로고    scopus 로고
    • Synaptic proteins in schizophrenia hippocampus indicate increased neuronal activity in CA3
    • Li, W. et al. Synaptic proteins in schizophrenia hippocampus indicate increased neuronal activity in CA3. Am. J. Psychiatry 172, 373-382 (2015).
    • (2015) Am. J. Psychiatry , vol.172 , pp. 373-382
    • Li, W.1
  • 20
    • 33845223257 scopus 로고    scopus 로고
    • Decreased NR1 NR2A and SAP102 transcript expression in the hippocampus in bipolar disorder
    • McCullumsmith, R. E., et al. Decreased NR1, NR2A, and SAP102 transcript expression in the hippocampus in bipolar disorder. Brain Res. 1127, 108-118 (2007).
    • (2007) Brain Res. , vol.1127 , pp. 108-118
    • McCullumsmith, R.E.1
  • 21
    • 28244433460 scopus 로고    scopus 로고
    • NMDA receptor subunit NRI and postsynaptic protein PSD-95 in hippocampus and orbitofrontal cortex in schizophrenia and mood disorder
    • Toro, C., Deakin, J. F. W. NMDA receptor subunit NRI and postsynaptic protein PSD-95 in hippocampus and orbitofrontal cortex in schizophrenia and mood disorder. Schizophr Res. 80, 323-330 (2005).
    • (2005) Schizophr Res. , vol.80 , pp. 323-330
    • Toro, C.1    Deakin, J.F.W.2
  • 22
    • 80051966439 scopus 로고    scopus 로고
    • Schizophrenia is associated with dysregulation of a Cdk5 activator that regulates synaptic protein expression and cognition
    • Engmann, O. et al. Schizophrenia is associated with dysregulation of a Cdk5 activator that regulates synaptic protein expression and cognition. Brain 134, 2408-2421 (2011).
    • (2011) Brain , vol.134 , pp. 2408-2421
    • Engmann, O.1
  • 23
    • 84955176919 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor 5, and its trafficking molecules Norbin and Tamalin, are increased in the CA1 hippocampal region of subjects with schizophrenia
    • Matosin, N. et al. Metabotropic glutamate receptor 5, and its trafficking molecules Norbin and Tamalin, are increased in the CA1 hippocampal region of subjects with schizophrenia. Schizophr Res. 166, 212-218 (2015).
    • (2015) Schizophr Res. , vol.166 , pp. 212-218
    • Matosin, N.1
  • 24
    • 84861539413 scopus 로고    scopus 로고
    • Preso1 dynamically regulates group i metabotropic glutamate receptors
    • Hu, J.-H. et al. Preso1 dynamically regulates group I metabotropic glutamate receptors. Nat. Neurosci. 15, 836-844 (2012).
    • (2012) Nat. Neurosci. , vol.15 , pp. 836-844
    • Hu, J.-H.1
  • 25
    • 58149392098 scopus 로고    scopus 로고
    • Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis
    • Lee, H. W. et al. Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis. J. Neurosci. 28, 14546-14556 (2008).
    • (2008) J. Neurosci. , vol.28 , pp. 14546-14556
    • Lee, H.W.1
  • 26
    • 84931006931 scopus 로고    scopus 로고
    • Alterations of mGluR5 and its endogenous regulators Norbin Tamalin and Preso1 in schizophrenia: Towards a model of mGluR5 dysregulation
    • Matosin, N. et al. Alterations of mGluR5 and its endogenous regulators Norbin, Tamalin and Preso1 in schizophrenia: towards a model of mGluR5 dysregulation. Acta Neuropathol. 130, 119-129 (2015).
    • (2015) Acta Neuropathol. , vol.130 , pp. 119-129
    • Matosin, N.1
  • 27
    • 50449101830 scopus 로고    scopus 로고
    • Structural plasticity with preserved topology in the postsynaptic protein network
    • Blanpied, T. A., Kerr, J. M., Ehlers, M. D. Structural plasticity with preserved topology in the postsynaptic protein network. Proc. Natl Acad. Sci. USA 105, 12587-12592 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 12587-12592
    • Blanpied, T.A.1    Kerr, J.M.2    Ehlers, M.D.3
  • 28
    • 70350448399 scopus 로고    scopus 로고
    • Distinct Domains within PSD-95 mediate synaptic incorporation, stabilization, and activity-dependent trafficking
    • Sturgill, J. F., Steiner, P., Czervionke, B. L., Sabatini, B. L. Distinct Domains within PSD-95 mediate synaptic incorporation, stabilization, and activity-dependent trafficking. J. Neurosci. 29, 12845-12854 (2009).
    • (2009) J. Neurosci. , vol.29 , pp. 12845-12854
    • Sturgill, J.F.1    Steiner, P.2    Czervionke, B.L.3    Sabatini, B.L.4
  • 29
    • 0037083370 scopus 로고    scopus 로고
    • Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins
    • Kitano, J. et al. Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins. J. Neurosci. 22, 1280-1289 (2002).
    • (2002) J. Neurosci. , vol.22 , pp. 1280-1289
    • Kitano, J.1
  • 30
    • 0033166537 scopus 로고    scopus 로고
    • Coupling of mGluR/Homer and PSD-95 complexes by the shank family of postsynaptic density proteins
    • Tu, J. C. et al. Coupling of mGluR/Homer and PSD-95 complexes by the shank family of postsynaptic density proteins. Neuron 23, 583-592 (1999).
    • (1999) Neuron , vol.23 , pp. 583-592
    • Tu, J.C.1
  • 31
    • 0038013863 scopus 로고    scopus 로고
    • Tamalin is a scaffold protein that interacts with multiple neuronal proteins in distinct modes of protein-protein association
    • Kitano, J. et al. Tamalin is a scaffold protein that interacts with multiple neuronal proteins in distinct modes of protein-protein association. J. Biol. Chem. 278, 14762-14768 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 14762-14768
    • Kitano, J.1
  • 32
    • 22544449233 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor protein expression in the prefrontal cortex and striatum in schizophrenia
    • Gupta, D. S. et al. Metabotropic glutamate receptor protein expression in the prefrontal cortex and striatum in schizophrenia. Synapse 57, 123-131 (2005).
    • (2005) Synapse , vol.57 , pp. 123-131
    • Gupta, D.S.1
  • 33
    • 78649743311 scopus 로고    scopus 로고
    • Alterations in metabotropic glutamate receptor 1a and regulator of G protein signaling 4 in the prefrontal cortex in schizophrenia
    • Volk, D. W., Eggan, S. M., Lewis, D. A. Alterations in metabotropic glutamate receptor 1a and regulator of G protein signaling 4 in the prefrontal cortex in schizophrenia. Am. J. Psychiatry 167, 1489-1498 (2010).
    • (2010) Am. J. Psychiatry , vol.167 , pp. 1489-1498
    • Volk, D.W.1    Eggan, S.M.2    Lewis, D.A.3
  • 34
    • 11144357852 scopus 로고    scopus 로고
    • Regional specificity of hippocampal volume reductions in firstepisode schizophrenia
    • Narr, K. L. et al. Regional specificity of hippocampal volume reductions in firstepisode schizophrenia. NeuroImage 21, 1563-1575 (2004).
    • (2004) NeuroImage , vol.21 , pp. 1563-1575
    • Narr, K.L.1
  • 35
    • 84874926157 scopus 로고    scopus 로고
    • Hippocampal CA1 deformity is related to symptom severity and antipsychotic dosage in schizophrenia
    • Zierhut K. C. et al. Hippocampal CA1 deformity is related to symptom severity and antipsychotic dosage in schizophrenia. Brain 2013; 1-11.
    • (2013) Brain , pp. 1-11
    • Zierhut, K.C.1
  • 36
    • 0026438129 scopus 로고
    • Regional cerebral blood-flow in patients with schizophrenia-A preliminary-report
    • Kawasaki, Y. et al. Regional cerebral blood-flow in patients with schizophrenia-a preliminary-report. Eur. Arch. Psychiatry Clin. Neurosci. 241, 195-200 (1992).
    • (1992) Eur. Arch. Psychiatry Clin. Neurosci. , vol.241 , pp. 195-200
    • Kawasaki, Y.1
  • 37
    • 84924977090 scopus 로고    scopus 로고
    • The glutamate hypothesis of schizophrenia: Evidence from human brain tissue studies
    • Hu, W., MacDonald, M. L., Elswick, D. E., Sweet, R. A. The glutamate hypothesis of schizophrenia: evidence from human brain tissue studies. Ann. N Y Acad. Sci. 1338, 38-57 (2014).
    • (2014) Ann. N y Acad. Sci. , vol.1338 , pp. 38-57
    • Hu, W.1    MacDonald, M.L.2    Elswick, D.E.3    Sweet, R.A.4
  • 38
    • 33745220274 scopus 로고    scopus 로고
    • Homer proteins: Implications for neuropsychiatric disorders
    • Szumlinski, K. K., Kalivas, P. W., Worley, P. F. Homer proteins: implications for neuropsychiatric disorders. Curr. Opin. Neurobiol. 16, 251-257 (2006).
    • (2006) Curr. Opin. Neurobiol. , vol.16 , pp. 251-257
    • Szumlinski, K.K.1    Kalivas, P.W.2    Worley, P.F.3
  • 39
    • 77956176457 scopus 로고    scopus 로고
    • The role of hippocampus dysfunction in deficient memory encoding and positive symptoms in schizophrenia
    • Zierhut, K. et al. The role of hippocampus dysfunction in deficient memory encoding and positive symptoms in schizophrenia. Psychiatry Res. Neuroimaging 183, 187-194 (2010).
    • (2010) Psychiatry Res. Neuroimaging , vol.183 , pp. 187-194
    • Zierhut, K.1
  • 40
    • 84929514877 scopus 로고    scopus 로고
    • Increased hippocampal blood volume and normal blood flow in schizophrenia
    • Talati, P., Rane, S., Skinner, J., Gore, J., Heckers, S. Increased hippocampal blood volume and normal blood flow in schizophrenia. Psychiatry Res. 232, 219-225 (2015).
    • (2015) Psychiatry Res. , vol.232 , pp. 219-225
    • Talati, P.1    Rane, S.2    Skinner, J.3    Gore, J.4    Heckers, S.5
  • 41
    • 69949176721 scopus 로고    scopus 로고
    • Differential targeting of the CA1 subfield of the hippocampal formation by schizophrenia and related psychotic disorders
    • Schobel, S. A. et al. Differential targeting of the CA1 subfield of the hippocampal formation by schizophrenia and related psychotic disorders. Arch. Gen. Psychiatry 66, 938 (2009).
    • (2009) Arch. Gen. Psychiatry , vol.66 , pp. 938
    • Schobel, S.A.1
  • 42
    • 0029098119 scopus 로고
    • Resting cerebral glucose-metabolism in first-episode and previously treated patients with schizophrenia relates to clinical-features
    • Gur, R. et al. Resting cerebral glucose-metabolism in first-episode and previously treated patients with schizophrenia relates to clinical-features. Arch. Gen. Psychiatry 52, 657-667 (1995).
    • (1995) Arch. Gen. Psychiatry , vol.52 , pp. 657-667
    • Gur, R.1
  • 43
    • 0032129718 scopus 로고    scopus 로고
    • Impaired recruitment of the hippocampus during conscious recollection in schizophrenia
    • Heckers, S. et al. Impaired recruitment of the hippocampus during conscious recollection in schizophrenia. Nat. Neurosci. 1, 318-323 (1998).
    • (1998) Nat. Neurosci. , vol.1 , pp. 318-323
    • Heckers, S.1
  • 44
    • 84916623535 scopus 로고    scopus 로고
    • Live imaging of endogenous PSD-95 using ENABLED: A conditional strategy to fluorescently label endogenous proteins
    • Fortin, D. A. et al. Live imaging of endogenous PSD-95 using ENABLED: a conditional strategy to fluorescently label endogenous proteins. J. Neurosci. 34, 16698-16712 (2014).
    • (2014) J. Neurosci. , vol.34 , pp. 16698-16712
    • Fortin, D.A.1
  • 45
    • 0025330775 scopus 로고
    • Quantitative immunohistochemistry of synaptophysin in human neocortex: An alternative method to estimate density of presynaptic terminals in paraffin sections
    • Masliah, E., Terry, R. D., Alford, M., DeTeresa, R. Quantitative immunohistochemistry of synaptophysin in human neocortex: an alternative method to estimate density of presynaptic terminals in paraffin sections. J. Histochem. Cytochem. 38, 837-844 (1990).
    • (1990) J. Histochem. Cytochem. , vol.38 , pp. 837-844
    • Masliah, E.1    Terry, R.D.2    Alford, M.3    DeTeresa, R.4
  • 46
    • 62649174753 scopus 로고    scopus 로고
    • Oligomeric amyloid ? Associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques
    • Koffie, R. M. et al. Oligomeric amyloid ? associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques. Proc. Natl Acad. Sci. USA 106, 4012-4017 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 4012-4017
    • Koffie, R.M.1
  • 47
    • 2342508828 scopus 로고    scopus 로고
    • Reduced spinophilin but not microtubule-associated protein 2 expression in the hippocampal formation in schizophrenia and mood disorders: Molecular evidence for a pathology of dendritic spines
    • Law, A. J., Weickert, C. S., Hyde, T. M., Kleinman, J. E., Harrison, P. J. Reduced spinophilin but not microtubule-associated protein 2 expression in the hippocampal formation in schizophrenia and mood disorders: molecular evidence for a pathology of dendritic spines. Am. J. Psychiatry 161, 1848-1855 (2004).
    • (2004) Am. J. Psychiatry , vol.161 , pp. 1848-1855
    • Law, A.J.1    Weickert, C.S.2    Hyde, T.M.3    Kleinman, J.E.4    Harrison, P.J.5
  • 48
    • 84878459382 scopus 로고    scopus 로고
    • Nanoscale scaffolding domains within the postsynaptic density concentrate synaptic AMPA receptors
    • MacGillavry, H. D., Song, Y., Raghavachari, S., Blanpied, T. A. Nanoscale scaffolding domains within the postsynaptic density concentrate synaptic AMPA receptors. Neuron 78, 615-622 (2013).
    • (2013) Neuron , vol.78 , pp. 615-622
    • MacGillavry, H.D.1    Song, Y.2    Raghavachari, S.3    Blanpied, T.A.4
  • 49
    • 84892604040 scopus 로고    scopus 로고
    • Homer-1a immediate early gene expression correlates with better cognitive performance in aging
    • Kaja, S. et al. Homer-1a immediate early gene expression correlates with better cognitive performance in aging. Age Dordr. Neth. 35, 1799-1808 (2013).
    • (2013) Age Dordr. Neth. , vol.35 , pp. 1799-1808
    • Kaja, S.1
  • 50
    • 84904122388 scopus 로고    scopus 로고
    • Endoplasmic reticulum calcium stores in dendritic spines
    • Segal, M., Korkotian, E. Endoplasmic reticulum calcium stores in dendritic spines. Front. Neuroanat. 8, 1-7 (2014).
    • (2014) Front. Neuroanat. , vol.8 , pp. 1-7
    • Segal, M.1    Korkotian, E.2
  • 51
    • 51649103854 scopus 로고    scopus 로고
    • Endogenous homer proteins regulate metabotropic glutamate receptor signaling in neurons
    • Kammermeier, P. J. Endogenous homer proteins regulate metabotropic glutamate receptor signaling in neurons. J. Neurosci. 28, 8560-8567 (2008).
    • (2008) J. Neurosci. , vol.28 , pp. 8560-8567
    • Kammermeier, P.J.1
  • 52
    • 0036382868 scopus 로고    scopus 로고
    • An N-terminal sequence specific for a novel Homer1 isoform controls trafficking of group i metabotropic glutamate receptor in mammalian cells
    • Saito, H., Kimura, M., Inanobe, A., Ohe, T., Kurachi, Y. An N-terminal sequence specific for a novel Homer1 isoform controls trafficking of group I metabotropic glutamate receptor in mammalian cells. Biochem. Biophys. Res. Commun. 296, 523-529 (2002).
    • (2002) Biochem. Biophys. Res. Commun. , vol.296 , pp. 523-529
    • Saito, H.1    Kimura, M.2    Inanobe, A.3    Ohe, T.4    Kurachi, Y.5
  • 53
    • 42749095376 scopus 로고    scopus 로고
    • Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia
    • Lisman, J. E. et al. Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia. Trends Neurosci. 31, 234-242 (2008).
    • (2008) Trends Neurosci. , vol.31 , pp. 234-242
    • Lisman, J.E.1
  • 54
    • 0025885689 scopus 로고
    • Hippocampal neuron number in schizophrenia: A stereological study
    • Heckers, S., Heinsen, H., Geiger, B., Beckmann, H. Hippocampal neuron number in schizophrenia: a stereological study. Arch. Gen. Psychiatry 48, 1002 (1991).
    • (1991) Arch. Gen. Psychiatry , vol.48 , pp. 1002
    • Heckers, S.1    Heinsen, H.2    Geiger, B.3    Beckmann, H.4
  • 55
    • 80051816613 scopus 로고    scopus 로고
    • Hippocampal interneurons are abnormal in schizophrenia
    • Konradi, C. et al. Hippocampal interneurons are abnormal in schizophrenia. Schizophr. Res. 131, 165-173 (2011).
    • (2011) Schizophr. Res. , vol.131 , pp. 165-173
    • Konradi, C.1
  • 56
    • 65649125260 scopus 로고    scopus 로고
    • Stereologic investigation of the posterior part of the hippocampus in schizophrenia
    • Schmitt, A. et al. Stereologic investigation of the posterior part of the hippocampus in schizophrenia. Acta Neuropathol. 117, 395-407 (2009).
    • (2009) Acta Neuropathol. , vol.117 , pp. 395-407
    • Schmitt, A.1
  • 57
    • 0036242135 scopus 로고    scopus 로고
    • Estimated neuronal populations and volumes of the hippocampus and its subfields in schizophrenia
    • Walker, M. A. et al. Estimated neuronal populations and volumes of the hippocampus and its subfields in schizophrenia. Am. J. Psychiatry 159, 821-828 (2002).
    • (2002) Am. J. Psychiatry , vol.159 , pp. 821-828
    • Walker, M.A.1
  • 58
    • 84959105976 scopus 로고    scopus 로고
    • GABAergic system impairment in the hippocampus and superior temporal gyrus of patients with paranoid schizophrenia: A post-mortem study
    • Feb 24, pii: S0920-9964(16)30074-3 (Epub ahead of print)
    • Steiner, J. et al. GABAergic system impairment in the hippocampus and superior temporal gyrus of patients with paranoid schizophrenia: a post-mortem study. Schizophr. Res. 2016 Feb 24. pii: S0920-9964(16)30074-3. doi: 10.1016/j. schres.2016.02.018 (Epub ahead of print).
    • (2016) Schizophr. Res.
    • Steiner, J.1
  • 59
    • 0036569197 scopus 로고    scopus 로고
    • A selective decrease in the relative density of parvalbumin-immunoreactive neurons in the hippocampus in schizophrenia
    • Zhang, Z. J., Reynolds, G. P. A selective decrease in the relative density of parvalbumin-immunoreactive neurons in the hippocampus in schizophrenia. Schizophr. Res. 55, 1-10 (2002).
    • (2002) Schizophr. Res. , vol.55 , pp. 1-10
    • Zhang, Z.J.1    Reynolds, G.P.2
  • 60
    • 0032527572 scopus 로고    scopus 로고
    • A reduction of nonpyramidal cells in sector CA2 of schizophrenics and manic depressives
    • Benes, F. M., Kwok, E. W., Vincent, S. L., Todtenkopf, M. S. A reduction of nonpyramidal cells in sector CA2 of schizophrenics and manic depressives. Biol. Psychiatry 44, 88-97 (1998).
    • (1998) Biol. Psychiatry , vol.44 , pp. 88-97
    • Benes, F.M.1    Kwok, E.W.2    Vincent, S.L.3    Todtenkopf, M.S.4
  • 61
    • 0036269901 scopus 로고    scopus 로고
    • DIfferential hippocampal expression of glutamic acid decarboxylase 65 and 67 messenger RNA in bipolar disorder and schizophrenia
    • Heckers, S. et al. DIfferential hippocampal expression of glutamic acid decarboxylase 65 and 67 messenger RNA in bipolar disorder and schizophrenia. Arch. Gen. Psychiatry 59, 521-529 (2002).
    • (2002) Arch. Gen. Psychiatry , vol.59 , pp. 521-529
    • Heckers, S.1
  • 62
    • 84942102160 scopus 로고    scopus 로고
    • GABAergic mechanisms of hippocampal hyperactivity in schizophrenia
    • Heckers, S., Konradi, C. GABAergic mechanisms of hippocampal hyperactivity in schizophrenia. Schizophr. Res. 167, 4-11 (2015).
    • (2015) Schizophr. Res. , vol.167 , pp. 4-11
    • Heckers, S.1    Konradi, C.2
  • 63
    • 0035882474 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors 1 and 5 differentially regulate CA1 pyramidal cell function
    • Mannaioni, G., Marino, M. J., Valenti, O., Traynelis, S. F., Conn, P. J. Metabotropic glutamate receptors 1 and 5 differentially regulate CA1 pyramidal cell function. J. Neurosci. 21, 5925-5934 (2001).
    • (2001) J. Neurosci. , vol.21 , pp. 5925-5934
    • Mannaioni, G.1    Marino, M.J.2    Valenti, O.3    Traynelis, S.F.4    Conn, P.J.5
  • 64
    • 1242268027 scopus 로고    scopus 로고
    • Immunolocalization of metabotropic glutamate receptor 1? (mGluR1?) in distinct classes of interneuron in the CA1 region of the rat hippocampus
    • Ferraguti, F. et al. Immunolocalization of metabotropic glutamate receptor 1? (mGluR1?) in distinct classes of interneuron in the CA1 region of the rat hippocampus. Hippocampus 14, 193-215 (2004).
    • (2004) Hippocampus , vol.14 , pp. 193-215
    • Ferraguti, F.1
  • 65
    • 0037756817 scopus 로고    scopus 로고
    • Species, strain and developmental variations in hippocampal neuronal and endothelial nitric oxide synthase clarify discrepancies in nitric oxide-dependent synaptic plasticity
    • Blackshaw, S. et al. Species, strain and developmental variations in hippocampal neuronal and endothelial nitric oxide synthase clarify discrepancies in nitric oxide-dependent synaptic plasticity. Neuroscience 119, 979-990 (2003).
    • (2003) Neuroscience , vol.119 , pp. 979-990
    • Blackshaw, S.1
  • 66
    • 57649230076 scopus 로고    scopus 로고
    • Genomic anatomy of the hippocampus
    • Thompson, C. L. et al. Genomic anatomy of the hippocampus. Neuron 60, 1010-1021 (2008).
    • (2008) Neuron , vol.60 , pp. 1010-1021
    • Thompson, C.L.1
  • 67
    • 33747613561 scopus 로고    scopus 로고
    • Enriched environments, experiencedependent plasticity and disorders of the nervous system
    • Nithianantharajah, J., Hannan, A. J. Enriched environments, experiencedependent plasticity and disorders of the nervous system. Nat. Rev. Neurosci. 7, 697-709 (2006).
    • (2006) Nat. Rev. Neurosci. , vol.7 , pp. 697-709
    • Nithianantharajah, J.1    Hannan, A.J.2
  • 68
    • 0036896810 scopus 로고    scopus 로고
    • Experience-dependent coincident expression of the effector immediate-early genes arc and Homer 1a in hippocampal and neocortical neuronal networks
    • Vazdarjanova, A., McNaughton, B. L., Barnes, C. A., Worley, P. F., Guzowski, J. F. Experience-dependent coincident expression of the effector immediate-early genes arc and Homer 1a in hippocampal and neocortical neuronal networks. J. Neurosci. 22, 10067-10071 (2002).
    • (2002) J. Neurosci. , vol.22 , pp. 10067-10071
    • Vazdarjanova, A.1    McNaughton, B.L.2    Barnes, C.A.3    Worley, P.F.4    Guzowski, J.F.5
  • 70
    • 84894376429 scopus 로고    scopus 로고
    • Glutamatergic postsynaptic density protein dysfunctions in synaptic plasticity and dendritic spines morphology: Relevance to schizophrenia and other behavioral disorders pathophysiology, and implications for novel therapeutic approaches
    • de Bartolomeis, A., Latte, G., Tomasetti, C., Iasevoli, F. Glutamatergic postsynaptic density protein dysfunctions in synaptic plasticity and dendritic spines morphology: relevance to schizophrenia and other behavioral disorders pathophysiology, and implications for novel therapeutic approaches. Mol. Neurobiol. 49, 484-511 (2014).
    • (2014) Mol. Neurobiol. , vol.49 , pp. 484-511
    • De Bartolomeis, A.1    Latte, G.2    Tomasetti, C.3    Iasevoli, F.4
  • 71
    • 33745516540 scopus 로고    scopus 로고
    • Selective effects of typical antipsychotic drugs on SNAP-25 and synaptophysin in the hippocampal trisynaptic pathway
    • Barr, A. M., Young, C. E., Phillips, A. G., Honer, W. G. Selective effects of typical antipsychotic drugs on SNAP-25 and synaptophysin in the hippocampal trisynaptic pathway. Int. J. Neuropsychopharmacol. 9, 457 (2006).
    • (2006) Int. J. Neuropsychopharmacol. , vol.9 , pp. 457
    • Barr, A.M.1    Young, C.E.2    Phillips, A.G.3    Honer, W.G.4
  • 73
    • 58149357209 scopus 로고    scopus 로고
    • Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression
    • Feyissa, A. M., Chandran, A., Stockmeier, C. A., Karolewicz, B. Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression. Prog. Neuropsychopharmacol. Biol. Psychiatry 33, 70-75 (2009).
    • (2009) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.33 , pp. 70-75
    • Feyissa, A.M.1    Chandran, A.2    Stockmeier, C.A.3    Karolewicz, B.4
  • 74
    • 75149163414 scopus 로고    scopus 로고
    • Selection of reference gene expression in a schizophrenia brain cohort
    • Weickert, C. S. et al. Selection of reference gene expression in a schizophrenia brain cohort. Aust. N Z J. Psychiatry 44, 59-70 (2010).
    • (2010) Aust. N Z J. Psychiatry , vol.44 , pp. 59-70
    • Weickert, C.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.