Alterations of mGluR5 and its endogenous regulators Norbin, Tamalin and Preso1 in schizophrenia: towards a model of mGluR5 dysregulation

Acta Neuropathologica

Volumn 130, Issue 1, 2015, Pages 119-129

  Matosin, Natalie ^a,b   Fernandez Enright, Francesca ^a,b   Fung, Samantha Jane ^b,c,d   Lum, Jeremy Stephen ^a,b   Engel, Martin ^a,b   Andrews, Jessica Lee ^a,b   Huang, Xu Feng ^a,b   Weickert, Cynthia Shannon ^b,c,d   Newell, Kelly Anne ^a,b  

^a UNIVERSITY OF WOLLONGONG   (Australia)

^b SCHIZOPHRENIA RESEARCH INSTITUTE   (Australia)

^c NEUROSCIENCE RESEARCH AUSTRALIA   (Australia)

^d UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Antipsychotic; GRM5; Human brain; Immunoblot; Metabotropic glutamate receptor; Schizophrenia

Indexed keywords

HALOPERIDOL; MESSENGER RNA; METABOTROPIC RECEPTOR 5; NORBIN; OLANZAPINE; PRESO 1 PROTEIN; REGULATOR PROTEIN; TAMALIN; UNCLASSIFIED DRUG; CARRIER PROTEIN; GRASP PROTEIN, HUMAN; GRM5 PROTEIN, HUMAN; GRM5 PROTEIN, RAT; GRP1-ASSOCIATED SCAFFOLD PROTEIN, RAT; MEMBRANE PROTEIN; NERVE PROTEIN; NEUROCHONDRIN-1; NEUROLEPTIC AGENT; NEUROPEPTIDE; PRESO PROTEIN, HUMAN; PRESO PROTEIN, RAT; SIGNAL PEPTIDE;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; BRAIN LEVEL; CONTROLLED STUDY; DORSOLATERAL PREFRONTAL CORTEX; FEMALE; HUMAN; HUMAN TISSUE; MALE; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; PSYCHOPHARMACOTHERAPY; RAT; SCHIZOPHRENIA; ADOLESCENT; ANIMAL; COHORT ANALYSIS; DISEASE MODEL; DRUG EFFECTS; METABOLISM; MIDDLE AGED; SPRAGUE DAWLEY RAT; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ANIMALS; ANTIPSYCHOTIC AGENTS; CARRIER PROTEINS; COHORT STUDIES; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; NERVE TISSUE PROTEINS; NEUROPEPTIDES; PREFRONTAL CORTEX; RATS, SPRAGUE-DAWLEY; RECEPTOR, METABOTROPIC GLUTAMATE 5; RNA, MESSENGER; SCHIZOPHRENIA; YOUNG ADULT;

EID: 84931006931     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-015-1411-6     Document Type: Article

References (41)

1. Beneyto M, Meador-Woodruff JH (2007) Lamina-specific abnormalities of NMDA receptor-associated postsynaptic protein transcripts in the prefrontal cortex in schizophrenia and bipolar disorder. Neuropsychopharmacology 33:2175–2186
2. Catts VS, Fung SJ, Long LE, Joshi D, Vercammen A, Allen KM, Fillman SG, Rothmond DA, Sinclair D, Tiwari Y, Tsai S-Y, Weickert TW, Shannon Weickert C (2013) Rethinking schizophrenia in the context of normal neurodevelopment. Front Cell Neurosci 7:60
3. Corti C, Crepaldi L, Mion S, Roth AL, Xuereb JH, Ferraguti F (2007) Altered dimerization of metabotropic glutamate receptor 3 in schizophrenia. Biol Psychiatry 62:747–755
4. Corti C, Xuereb JH, Crepaldi L, Corsi M, Michielin F, Ferraguti F (2011) Altered levels of glutamatergic receptors and Na +/K + ATPase-α1 in the prefrontal cortex of subjects with schizophrenia. Schizophr Res 128:7–14
5. El Moustaine D, Granier S, Doumazane E, Scholler P, Rahmeh R, Bron P, Mouillac B, Banères J-L, Rondard P, Pin J-P (2012) Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling. Proc Natl Acad Sci USA 109:16342–16347
6. Engmann O, Hortobágyi T, Pidsley R, Troakes C, Bernstein H-G, Kreutz MR, Mill J, Nikolic M, Giese KP (2011) Schizophrenia is associated with dysregulation of a Cdk5 activator that regulates synaptic protein expression and cognition. Brain 134:2408–2421
7. Fatemi SH, Folsom TD (2014) Existence of monomer and dimer forms of mGluR5, under reducing conditions in studies of postmortem brain in various psychiatric disorders. Schizophr Res 158:270–271
8. Fatemi SH, Folsom TD, Rooney RJ, Thuras PD (2013) mRNA and protein expression for novel GABAA receptors θ and ρ2 are altered in schizophrenia and mood disorders; relevance to FMRP-mGluR5 signaling pathway. Transl Psychiatry 3:e271.
9. Fuxe K, Marcellino D, Rivera A, Diaz-Cabiale Z, Filip M, Gago B, Roberts DCS, Langel U, Genedani S, Ferraro L, de la Calle A, Narvaez J, Tanganelli S, Woods A, Agnati LF (2008) Receptor-receptor interactions within receptor mosaics. Impact on neuropsychopharmacology. Brain Res Rev 58:415–452
10. Greenbaum D, Colangelo C, Williams K, Gerstein M (2003) Comparing protein abundance and mRNA expression levels on a genomic scale. Genome Biol 4:117
11. Han M, Newell K, Zavitsanou K, Deng C, Huang XF (2008) Effects of antipsychotic medication on muscarinic M1 receptor mRNA expression in the rat brain. J Neurosci Res 86:457–464
12. Hu J-H, Yang L, Kammermeier PJ, Moore CG, Brakeman PR, Tu J, Yu S, Petralia RS, Li Z, Zhang P-W, Park JM, Dong X, Xiao B, Worley PF (2012) Preso1 dynamically regulates group I metabotropic glutamate receptors. Nat Neurosci 15:836–844
13. Javitt DC (2012) Twenty-five years of glutamate in schizophrenia: are we there yet? Schizophr Bull 38:911–913
14. Kitano J, Kimura K, Yamazaki Y, Soda T, Shigemoto R, Nakajima Y, Nakanishi S (2002) Tamalin, a PDZ domain-containing protein, Links a Protein Complex Formation of Group 1 Metabotropic Glutamate Receptors and the Guanine Nucleotide Exchange Factor Cytohesins. J Neurosci 22:1280–1289
15. Kitano J, Yamazaki Y, Kimura K, Masukado T, Nakajima Y, Nakanishi S (2003) Tamalin is a scaffold protein that interacts with multiple neuronal proteins in distinct modes of protein-protein association. J Biol Chem 278:14762–14768
16. Lee HW, Choi J, Shin H, Kim K, Yang J, Na M, Choi SY, Kang GB, Eom SH, Kim H et al (2008) Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis. J Neurosci 28:14546–14556
17. Matosin N, Frank E, Deng C, Huang X-F, Newell KA (2013) Metabotropic glutamate receptor 5 binding and protein expression in schizophrenia and following antipsychotic drug treatment. Schizophr Res 146:170–176
18. Matosin N, Newell KA (2013) Metabotropic glutamate receptor 5 in the pathology and treatment of schizophrenia. Neurosci Biobehav Rev 37:256–268
19. McCullumsmith RE, Hammond JH, Shan D, Meador-Woodruff JH (2014) Postmortem brain: an underutilized substrate for studying severe mental illness. Neuropsychopharmacology 39:65–87
20. Milligan G (2004) G protein-coupled receptor dimerization: function and ligand pharmacology. Mol Pharmacol 66:1–7
21. Miyamoto S, Miyake N, Jarskog LF, Fleischhacker WW, Lieberman JA (2012) Pharmacological treatment of schizophrenia: a critical review of the pharmacology and clinical effects of current and future therapeutic agents. Mol Psychiatry 17:1206–1227
22. Mochizuki R, Ishizuka Y, Yanai K, Koga Y, Fukamizu A (1999) Molecular cloning and expression of human neurochondrin-1 and -2. Biochim Biophys Acta BBA 1446:397–402
23. Newell KA, Matosin N (2014) Rethinking metabotropic glutamate receptor 5 pathological findings in psychiatric disorders: implications for the future of novel therapeutics. BMC Psychiatry 14:23
24. Newell KA, Matosin N, Lum JS (2014) Metabotropic glutamate receptors in the pathophysiology and treatment of schizophrenia and major depression. In: Olive MF (ed) Metabotropic glutamate receptors. Molecular mechanisms, role in neurological disorders and pharmacological effects. Nova Science, New York, pp 73–106
25. Ohnuma T, Augood SJ, Arai H, McKenna PJ, Emson PC (1998) Expression of the human excitatory amino acid transporter 2 and metabotropic glutamate receptors 3 and 5 in the prefrontal cortex from normal individuals and patients with schizophrenia. Mol Brain Res 56:207–217
26. Paxinos G, Watson C (2007) The rat brain in stereotaxic coordinates: hard cover edition, 6th edn. Academic press, London
27. Piton A, Gauthier J, Hamdan FF, Lafrenière RG, Yang Y, Henrion E, Laurent S, Noreau A, Thibodeau P, Karemera L, Spiegelman D, Kuku F, Duguay J, Destroismaisons L, Jolivet P, Côté M, Lachapelle K, Diallo O, Raymond A, Marineau C, Champagne N, Xiong L, Gaspar C, Rivière J-B, Tarabeux J, Cossette P, Krebs M-O, Rapoport JL, Addington A, DeLisi LE, Mottron L, Joober R, Fombonne E, Drapeau P, Rouleau GA (2010) Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia. Mol Psychiatry 16:867–880
28. Radulovic J, Tronson NC (2012) Preso1, mGluR5 and the machinery of pain. Nat Neurosci 15:805–807
29. Romano C, Yang W-L, O’Malley KL (1996) Metabotropic glutamate receptor 5 is a disulfide-linked dimer. J Biol Chem 271:28612–28616
30. Shinozaki K, Maruyama K, Kume H, Kuzume H, Obata K (1997) A novel brain gene, Norbin, induced by treatment of tetraethylammonium in rat hippocampal slice and accompanied with neurite-outgrowth in neuro 2a cells. Biochem Biophys Res Commun 240:766–771
31. Spellmann I, Rujescu D, Musil R, Mayr A, Giegling I, Genius J, Zill P, Dehning S, Opgen-Rhein M, Cerovecki A, Hartmann AM, Schäfer M, Bondy B, Müller N, Möller H-J, Riedel M (2011) Homer-1 polymorphisms are associated with psychopathology and response to treatment in schizophrenic patients. J Psychiatr Res 45:234–241
32. Tai H-C, Besche H, Goldberg AL, Schuman EM (2010) Characterization of the brain 26S proteasome and its interacting proteins. Front Mol Neurosci 3:1–19
33. Tandon R, Nasrallah HA, Keshavan MS (2010) Schizophrenia, “just the facts” 5. treatment and prevention. Past, present, and future. Schizophr Res 122:1–23
34. Timms AE, Dorschner MO, Wechsler J, Choi KY, Kirkwood R, Girirajan S, Baker C, Eichler EE, Korvatska O, Roche KW, Horwitz MS, Tsuang DW (2013) Support for the N-methyl-d-aspartate receptor hypofunction hypothesis of schizophrenia from exome sequencing in multiplex families. JAMA Psychiatry Chic Ill 70:582–590
35. Ting JT, Peça J, Feng G (2012) functional consequences of mutations in postsynaptic scaffolding proteins and relevance to psychiatric disorders. Annu Rev Neurosci 35:49–71
36. Volk DW, Eggan SM, Lewis DA (2010) Alterations in metabotropic glutamate receptor 1a and regulator of G protein signaling 4 in the prefrontal cortex in schizophrenia. Am J Psychiatry 167:1489–1498
37. Wang H, Nong Y, Bazan F, Greengard P, Flajolet M (2010) Norbin: a promising central nervous system regulator. Commun Integr Biol 3:487
38. Wang H, Westin L, Nong Y, Birnbaum S, Bendor J, Brismar H, Nestler E, Aperia A, Flajolet M, Greengard P (2009) Norbin Is an endogenous regulator of metabotropic glutamate receptor 5 signaling. Science 326:1554–1557
39. Weickert CS, Fung SJ, Catts VS, Schofield PR, Allen KM, Moore LT, Newell KA, Pellen D, Huang X-F, Catts SV, Weickert TW (2012) Molecular evidence of N-methyl-d-aspartate receptor hypofunction in schizophrenia. Mol Psychiatry 18(11):1185–1192
40. Weickert CS, Sheedy D, Rothmond DA, Dedova I, Fung S, Garrick T, Wong J, Harding AJ, Sivagnanansundaram S, Hunt C, Duncan C, Sundqvist N, Tsai SY, Anand J, Draganic D, Harper C (2010) Selection of reference gene expression in a schizophrenia brain cohort. Aust N Z J Psychiatry 44:59–70
41. Weston-Green K, Huang XF, Lian J, Deng C (2012) Effects of olanzapine on muscarinic M3 receptor binding density in the brain relates to weight gain, plasma insulin and metabolic hormone levels. Eur Neuropsychopharmacol 22:364–373