Low heritability in pharmacokinetics of talinolol: A pharmacogenetic twin study on the heritability of the pharmacokinetics of talinolol, a putative probe drug of MDR1 and other membrane transporters

Genome Medicine

Volumn 8, Issue 1, 2016, Pages

  Matthaei, Johannes ^a   Tzvetkov, Mladen V ^a   Gal, Valerie ^a   Sachse Seeboth, Cordula ^a   Sehrt, Daniel ^a   Hjelmborg, Jakob B ^b   Hofmann, Ute ^c   Schwab, Matthias ^c,d   Kerb, Reinhold ^c   Brockmöller, Jürgen ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

ABCB1; ABCC2; BCRP; Heritability; MDR1; MDR5; MRP2; P glycoprotein; Talinolol; Twin study

Indexed keywords

CARRIER PROTEIN; MEMBRANE TRANSPORTER; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 5; ORGANIC CATION TRANSPORTER 1; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1B1; TALINOLOL; UNCLASSIFIED DRUG; ABCB1 PROTEIN, HUMAN; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 2; PROPANOLAMINE DERIVATIVE;

ARTICLE; BODY MASS; CONTROLLED STUDY; DIZYGOTIC TWINS; DRUG CLEARANCE; ENVIRONMENTAL FACTOR; FOOD INTAKE; GENETIC POLYMORPHISM; HERITABILITY; HUMAN; MAXIMUM PLASMA CONCENTRATION; MONOZYGOTIC TWINS; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN INTAKE; PROTEIN POLYMORPHISM; SEX DIFFERENCE; CLINICAL TRIAL; FEMALE; GENETICS; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; MALE; PHARMACOGENETICS; TWIN STUDY;

BODY MASS INDEX; FEMALE; GENE-ENVIRONMENT INTERACTION; GENOTYPE; HUMANS; MALE; MEMBRANE TRANSPORT PROTEINS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEINS; PHARMACOGENETICS; PROPANOLAMINES; SEX FACTORS; TWIN STUDIES AS TOPIC; TWINS, DIZYGOTIC; TWINS, MONOZYGOTIC;

EID: 84996590308     PISSN: None     EISSN: 1756994X     Source Type: Journal    
DOI: 10.1186/s13073-016-0372-2     Document Type: Article

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