메뉴 건너뛰기




Volumn 14, Issue 5, 1999, Pages 405-412

Molecular aspects of organic compound transport across the plasma membrane of hepatocytes

Author keywords

ATP binding cassette transporters; Bile acids; Bilirubin; Hepatic excretion; Hepatic uptake

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; CARRIER PROTEIN; ORGANIC COMPOUND;

EID: 0032986770     PISSN: 08159319     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1746.1999.01886.x     Document Type: Review
Times cited : (22)

References (75)
  • 1
    • 0020464777 scopus 로고
    • Taurocholate transport by rat liver sinusoidal membrane vesicles: Evidence of sodium cotransport
    • 1 Inoue M, Kinne R, Tran T, Arias IM. Taurocholate transport by rat liver sinusoidal membrane vesicles: Evidence of sodium cotransport. Hepatology 1982; 2: 572-9.
    • (1982) Hepatology , vol.2 , pp. 572-579
    • Inoue, M.1    Kinne, R.2    Tran, T.3    Arias, I.M.4
  • 2
    • 0022981885 scopus 로고
    • Purification and reconstitution of the bile acid transport system from hepatocyte sinusoidal plasma membrane
    • 2 Von Dippe P, Ananthanarayanan M, Drain P, Levy D. Purification and reconstitution of the bile acid transport system from hepatocyte sinusoidal plasma membrane. Biochim. Biophys. Acta 1986; 862: 352-60.
    • (1986) Biochim. Biophys. Acta , vol.862 , pp. 352-360
    • Von Dippe, P.1    Ananthanarayanan, M.2    Drain, P.3    Levy, D.4
  • 3
    • 0025161557 scopus 로고
    • Reconstitution of the immunopurified 49 kDa sodium-dependent bile acid transporter protein derived from hepatocyte sinusoidal membrane
    • 3 Von Dippe P, Levy D. Reconstitution of the immunopurified 49 kDa sodium-dependent bile acid transporter protein derived from hepatocyte sinusoidal membrane. J. Biol. Chem. 1990; 265: G14812-16.
    • (1990) J. Biol. Chem. , vol.265
    • Von Dippe, P.1    Levy, D.2
  • 4
    • 0028046387 scopus 로고
    • Characterization of cloned rat liver Na(+)-bile acid cotransporter using peptide and fusion protein antibodies
    • 4 Ananthanarayanan M, Ng OC, Boyer JL, Suchy FJ. Characterization of cloned rat liver Na(+)-bile acid cotransporter using peptide and fusion protein antibodies. Am. J. Physiol. 1994; 267: G637-43.
    • (1994) Am. J. Physiol. , vol.267
    • Ananthanarayanan, M.1    Ng, O.C.2    Boyer, J.L.3    Suchy, F.J.4
  • 5
    • 0029615982 scopus 로고
    • Molecular mechanisms of hepatic bile salt transport from sinusoidal blood into bile
    • 5 Meier PJ. Molecular mechanisms of hepatic bile salt transport from sinusoidal blood into bile. Am. J. Physiol. 1995; 269: G801-12.
    • (1995) Am. J. Physiol. , vol.269
    • Meier, P.J.1
  • 7
    • 0029870313 scopus 로고    scopus 로고
    • Molecular and functional characterization of bile acid transport in human hepatoblastoma HepG2 cells
    • 7 Kullack-Ublick GA, Beuers U, Paumgartner G. Molecular and functional characterization of bile acid transport in human hepatoblastoma HepG2 cells. Hepatology 1996; 23: 1053-60.
    • (1996) Hepatology , vol.23 , pp. 1053-1060
    • Kullack-Ublick, G.A.1    Beuers, U.2    Paumgartner, G.3
  • 8
    • 84895704781 scopus 로고    scopus 로고
    • +/taurocholate transporter (ntcp) promoter activity via rat GH and prolactin (PRL) receptors by inducing Sat5
    • +/taurocholate transporter (ntcp) promoter activity via rat GH and prolactin (PRL) receptors by inducing Sat5. Hepatology 1997; 26: 262A (Abstract).
    • (1997) Hepatology , vol.26
    • Ganguly, T.C.1    Karpen, S.2    Vore, M.3
  • 9
    • 0030994363 scopus 로고    scopus 로고
    • Regulation of the rat liver sodium-dependent bile acid transporter gene by prolactin. Modulation of transcriptional activation by Sat5
    • 9 Ganguly TC, O'Brien ML, Karpen SJ, Hyde JF, Suchy FJ, Vore M. Regulation of the rat liver sodium-dependent bile acid transporter gene by prolactin. Modulation of transcriptional activation by Sat5. J. Clin. Invest. 1997; 99: 2906-14.
    • (1997) J. Clin. Invest. , vol.99 , pp. 2906-2914
    • Ganguly, T.C.1    O'Brien, M.L.2    Karpen, S.J.3    Hyde, J.F.4    Suchy, F.J.5    Vore, M.6
  • 10
    • 0029886277 scopus 로고    scopus 로고
    • Regulation of hepatocyte bile salt transporters by endotoxin and inflammatory cytokines in rodents
    • 10 Green RM, Beier D, Gollan JL. Regulation of hepatocyte bile salt transporters by endotoxin and inflammatory cytokines in rodents. Gastroenterology 1996; 111: 193-8.
    • (1996) Gastroenterology , vol.111 , pp. 193-198
    • Green, R.M.1    Beier, D.2    Gollan, J.L.3
  • 11
    • 0032524012 scopus 로고    scopus 로고
    • Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors
    • 11 Trauner M, Arrese M, Lee H, Boyer JL, Karpen SJ. Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors. J. Clin. Invest. 1998; 101: 2092-100.
    • (1998) J. Clin. Invest. , vol.101 , pp. 2092-2100
    • Trauner, M.1    Arrese, M.2    Lee, H.3    Boyer, J.L.4    Karpen, S.J.5
  • 13
    • 0028866988 scopus 로고
    • Identification of a mutation in the ileal sodium-dependent bile acid transporter gene that abolishes transport activity
    • 13 Wong MH, Oelkers P, Dawson PA. Identification of a mutation in the ileal sodium-dependent bile acid transporter gene that abolishes transport activity. J. Biol. Chem. 1995; 270: 27228-34.
    • (1995) J. Biol. Chem. , vol.270 , pp. 27228-27234
    • Wong, M.H.1    Oelkers, P.2    Dawson, P.A.3
  • 14
    • 0025721848 scopus 로고
    • Functional expression, cloning and characterization of the hepatocyte Na/bile acid cotransport system
    • 14 Hagenbuch B, Stieger B, Foguet M, Lubbert H, Meier PJ. Functional expression, cloning and characterization of the hepatocyte Na/bile acid cotransport system. Proc. Natl Acad. Sci. USA 1991; 88: 10629-33.
    • (1991) Proc. Natl Acad. Sci. USA , vol.88 , pp. 10629-10633
    • Hagenbuch, B.1    Stieger, B.2    Foguet, M.3    Lubbert, H.4    Meier, P.J.5
  • 15
    • 0028108370 scopus 로고
    • Functional characterization of the basolateral rat liver organic anion transporting polypeptide
    • 15 Kullak-Ublick GA, Hagenbuch B, Stieger B et al. Functional characterization of the basolateral rat liver organic anion transporting polypeptide. Hepatology 1994; 20: 411-16.
    • (1994) Hepatology , vol.20 , pp. 411-416
    • Kullak-Ublick, G.A.1    Hagenbuch, B.2    Stieger, B.3
  • 16
    • 0029091022 scopus 로고
    • Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver
    • 16 Kullak-Ublick GA, Hagenbuch B, Stieger B et al. Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. Gastroenterology 1995; 109: 1274-82.
    • (1995) Gastroenterology , vol.109 , pp. 1274-1282
    • Kullak-Ublick, G.A.1    Hagenbuch, B.2    Stieger, B.3
  • 17
    • 0027296876 scopus 로고
    • Bilitranslocase and sulfobromophthalein/bilirubin-binding protein are both involved in the hepatic uptake of organic unions
    • 17 Torres AM, Lunazzi GC, Stremmel W, Tiribelli C. Bilitranslocase and sulfobromophthalein/bilirubin-binding protein are both involved in the hepatic uptake of organic unions. Proc. Natl Acad. Sci. USA 1993, 90: 8136-9.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 8136-8139
    • Torres, A.M.1    Lunazzi, G.C.2    Stremmel, W.3    Tiribelli, C.4
  • 18
    • 0029889501 scopus 로고    scopus 로고
    • Hepatocellular sinusoidal membrane organic anion transport and transporters
    • 18 Wolkoff AW. Hepatocellular sinusoidal membrane organic anion transport and transporters. Semin. Liver Dis. 1996; 16: 121-7.
    • (1996) Semin. Liver Dis. , vol.16 , pp. 121-127
    • Wolkoff, A.W.1
  • 19
    • 0030098277 scopus 로고    scopus 로고
    • Polyspecific drug and steroid clearance by an organic anion transporter of mammalian liver
    • 19 Bossuyt X, Mueller M, Hagenbuch B, Meier PJ. Polyspecific drug and steroid clearance by an organic anion transporter of mammalian liver. J. Pharmacol. Exp. Ther. 1996; 276: 891-6.
    • (1996) J. Pharmacol. Exp. Ther. , vol.276 , pp. 891-896
    • Bossuyt, X.1    Mueller, M.2    Hagenbuch, B.3    Meier, P.J.4
  • 20
    • 0030437929 scopus 로고    scopus 로고
    • Uptake of the mycotoxin ochratoxin A in liver cells occurs via the cloned organic anion transporting polypeptide
    • 20 Kontaxi M, Echkardt U, Hagenbuch B, Stieger B, Meier PJ, Petzinger E. Uptake of the mycotoxin ochratoxin A in liver cells occurs via the cloned organic anion transporting polypeptide. J. Pharmacol. Exp. Ther. 1996; 279: 1507-13.
    • (1996) J. Pharmacol. Exp. Ther. , vol.279 , pp. 1507-1513
    • Kontaxi, M.1    Echkardt, U.2    Hagenbuch, B.3    Stieger, B.4    Meier, P.J.5    Petzinger, E.6
  • 22
    • 0031589135 scopus 로고    scopus 로고
    • mRNA distribution and membrane localisation of the OAT-K1 organic anion transporter in rat renal tubules
    • 22 Masuda S, Saito H, Nonoguchi H, Tomita K, Inui K. mRNA distribution and membrane localisation of the OAT-K1 organic anion transporter in rat renal tubules. FEBS Lett. 1997; 407: 127-31.
    • (1997) FEBS Lett. , vol.407 , pp. 127-131
    • Masuda, S.1    Saito, H.2    Nonoguchi, H.3    Tomita, K.4    Inui, K.5
  • 24
    • 0029739973 scopus 로고    scopus 로고
    • Cloning, in vitro expression and tissue distribution of human prostaglandin transporter cDNA (hPGT)
    • 24 Lu R, Kanai N, Bao Y, Schuster VL. Cloning, in vitro expression and tissue distribution of human prostaglandin transporter cDNA (hPGT). J. Clin. Invest. 1996; 98: 1142-9.
    • (1996) J. Clin. Invest. , vol.98 , pp. 1142-1149
    • Lu, R.1    Kanai, N.2    Bao, Y.3    Schuster, V.L.4
  • 25
    • 0030886124 scopus 로고    scopus 로고
    • Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain
    • 25 Noe B, Hagenbuch B, Stieger B, Meier PJ. Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain. Proc. Natl Acad. Sci. USA 1997; 94: 10 346-50.
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 10346-10350
    • Noe, B.1    Hagenbuch, B.2    Stieger, B.3    Meier, P.J.4
  • 26
    • 0029876334 scopus 로고    scopus 로고
    • Transient expression of oatp organic anion transporter in mammalian cells: Identification of candidate substrate
    • 26 Kanai N, Lu R, Bao Y, Wolkoff AW, Schuster VL. Transient expression of oatp organic anion transporter in mammalian cells: Identification of candidate substrate. Am. J. Physiol. 1996; 270: F319-25.
    • (1996) Am. J. Physiol. , vol.270
    • Kanai, N.1    Lu, R.2    Bao, Y.3    Wolkoff, A.W.4    Schuster, V.L.5
  • 27
    • 0000753743 scopus 로고    scopus 로고
    • Oatp family proteins expressed in oocytes are not involved in the uptake of unconjugated bilirubin
    • 27 Noe B, Pascolo L, Ostrow JD, Tiribelli C, Meier PJ. Oatp family proteins expressed in oocytes are not involved in the uptake of unconjugated bilirubin (Abstract). Hepatology 1997; 26: 572A.
    • (1997) Hepatology , vol.26
    • Noe, B.1    Pascolo, L.2    Ostrow, J.D.3    Tiribelli, C.4    Meier, P.J.5
  • 28
    • 0024327501 scopus 로고
    • Zonal compartmentation of perfused rat liver: Plasma reappearance of rhodamine B explained
    • 28 Braakman I, Groothius GMM, Meijer DKF. Zonal compartmentation of perfused rat liver: Plasma reappearance of rhodamine B explained. J. Pharmacol. Exp. Ther. 1989; 249: 869-73.
    • (1989) J. Pharmacol. Exp. Ther. , vol.249 , pp. 869-873
    • Braakman, I.1    Groothius, G.M.M.2    Meijer, D.K.F.3
  • 29
  • 30
    • 0028063302 scopus 로고
    • Drug excretion mediated by a new prototype of polyspecific transporter
    • 30 Gruendemann D, Gorboulev V, Gambaryan S, Veyhl M, Koepsell H. Drug excretion mediated by a new prototype of polyspecific transporter. Nature 1994; 372: 549-52.
    • (1994) Nature , vol.372 , pp. 549-552
    • Gruendemann, D.1    Gorboulev, V.2    Gambaryan, S.3    Veyhl, M.4    Koepsell, H.5
  • 31
    • 0030590117 scopus 로고    scopus 로고
    • cDNA cloning and functional expression of a novel rat kidney organic cation transporter
    • 31 Okuda M, Saito H, Urakami Y, Takano M, Inui K. cDNA cloning and functional expression of a novel rat kidney organic cation transporter. Biochim. Biophys. Res. Commun. 1996; 224: 500-7.
    • (1996) Biochim. Biophys. Res. Commun. , vol.224 , pp. 500-507
    • Okuda, M.1    Saito, H.2    Urakami, Y.3    Takano, M.4    Inui, K.5
  • 33
    • 0021804301 scopus 로고
    • Hereditary chronic conjugated hyperbilirubinemia in mutant rats caused by defective hepatic anion transporter
    • 33 Jansen PLM, Peters WH, Lamers WHL. Hereditary chronic conjugated hyperbilirubinemia in mutant rats caused by defective hepatic anion transporter. Hepatology 1985; 5: 573-9.
    • (1985) Hepatology , vol.5 , pp. 573-579
    • Jansen, P.L.M.1    Peters, W.H.2    Lamers, W.H.L.3
  • 34
    • 0025744687 scopus 로고
    • Biliary excretion of bile acid conjugates in a hyperbilirubinemic mutant Sprague-Dawley rat
    • 34 Takikawa H, Sano N, Narita T et al. Biliary excretion of bile acid conjugates in a hyperbilirubinemic mutant Sprague-Dawley rat. Hepatology 1991; 14: 352-60.
    • (1991) Hepatology , vol.14 , pp. 352-360
    • Takikawa, H.1    Sano, N.2    Narita, T.3
  • 35
    • 0024235239 scopus 로고
    • ATP stimulates the uptake of S-dinitrophenyl glutathione by rat liver plasma membrane vesicles
    • 35 Kobayashi K, Sogame Y, Hayashi K, Nicotera P, Orrenius S. ATP stimulates the uptake of S-dinitrophenyl glutathione by rat liver plasma membrane vesicles. FEBS Lett. 1988; 240: 55-8.
    • (1988) FEBS Lett. , vol.240 , pp. 55-58
    • Kobayashi, K.1    Sogame, Y.2    Hayashi, K.3    Nicotera, P.4    Orrenius, S.5
  • 36
    • 0025132673 scopus 로고
    • ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. Role of the ATP-dependent transport system for glutathione S-conjugates
    • 36 Ishikawa T, Mueller M, Klunemann C, Schaub T, Keppler D. ATP-depcndent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. Role of the ATP-dependent transport system for glutathione S-conjugates. J. Biol. Chem. 1990; 265: 19 279-86.
    • (1990) J. Biol. Chem. , vol.265 , pp. 19279-19286
    • Ishikawa, T.1    Mueller, M.2    Klunemann, C.3    Schaub, T.4    Keppler, D.5
  • 37
    • 0026490803 scopus 로고
    • Two distinct mechanisms for bilirubin glucuronide transport by rat bile canalicular membrane vesicles. Demonstration of defective ATP-dependent transport in rats (TR-) with inherited conjugated hyperbilirubinemia
    • 37 Nishida T, Gatmaitan Z, Roy-Chowdhury J, Arias IM. Two distinct mechanisms for bilirubin glucuronide transport by rat bile canalicular membrane vesicles. Demonstration of defective ATP-dependent transport in rats (TR-) with inherited conjugated hyperbilirubinemia. J. Clin. Invest. 1992; 90: 2130-5.
    • (1992) J. Clin. Invest. , vol.90 , pp. 2130-2135
    • Nishida, T.1    Gatmaitan, Z.2    Roy-Chowdhury, J.3    Arias, I.M.4
  • 38
    • 0027984511 scopus 로고
    • The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates
    • 38 Leier I, Jedlitschky G, Buchholz U, Cole SP, Deeley RG, Keppler D. The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. J. Biol. Chem. 1994; 269: 27 807-10.
    • (1994) J. Biol. Chem. , vol.269 , pp. 27807-27810
    • Leier, I.1    Jedlitschky, G.2    Buchholz, U.3    Cole, S.P.4    Deeley, R.G.5    Keppler, D.6
  • 39
    • 0028578004 scopus 로고
    • Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport
    • 39 Müller M, Meijer C, Zaman GJ et al. Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. Proc. Natl Acad. Sci. USA 1994; 91: 13 033-7.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 13033-13037
    • Müller, M.1    Meijer, C.2    Zaman, G.J.3
  • 40
    • 0029981430 scopus 로고    scopus 로고
    • Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene
    • 40 Paulusma CC, Bosma PJ, Zaman GJ et al. Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene. Science 1996; 271: 1126-8.
    • (1996) Science , vol.271 , pp. 1126-1128
    • Paulusma, C.C.1    Bosma, P.J.2    Zaman, G.J.3
  • 41
    • 9544233652 scopus 로고    scopus 로고
    • A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation
    • 41 Taniguchi K, Wada M, Kohno K at al. A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation. Cancer Res. 1996; 56: 4126-9.
    • (1996) Cancer Res. , vol.56 , pp. 4126-4129
    • Taniguchi, K.1    Wada, M.2    Kohno, K.3
  • 42
    • 0029849789 scopus 로고    scopus 로고
    • The canalicular conjugate export pump encoded by the cmrp/cmoat gene
    • 42 Keppler D, Kartenbeck J. The canalicular conjugate export pump encoded by the cmrp/cmoat gene. Prog. Liver Dis. 1996, 14: 55-67.
    • (1996) Prog. Liver Dis. , vol.14 , pp. 55-67
    • Keppler, D.1    Kartenbeck, J.2
  • 43
    • 0030906434 scopus 로고    scopus 로고
    • Multiplicity of biliary excretion mechanisms for irinotecan, CPT-11, and its metabolites in rats
    • 43 Chu XY, Kato Y, Sugiyama Y. Multiplicity of biliary excretion mechanisms for irinotecan, CPT-11, and its metabolites in rats. Cancer Res. 1997; 57: 1934-8.
    • (1997) Cancer Res. , vol.57 , pp. 1934-1938
    • Chu, X.Y.1    Kato, Y.2    Sugiyama, Y.3
  • 44
    • 0030841332 scopus 로고    scopus 로고
    • Analysis of expression of cMOAT (MRP2), MRP3, MRP4 and MRP5 homologues of multidrug resistance-associated protein gene (MRP1) in human cancer cells
    • 44 Kool M, de Haas M, Scheffer GL et al. Analysis of expression of cMOAT (MRP2), MRP3, MRP4 and MRP5 homologues of multidrug resistance-associated protein gene (MRP1) in human cancer cells. Cancer Res. 1997; 57: 3537-47.
    • (1997) Cancer Res. , vol.57 , pp. 3537-3547
    • Kool, M.1    De Haas, M.2    Scheffer, G.L.3
  • 45
    • 4243455996 scopus 로고    scopus 로고
    • Identification of a novel multidrug resistance-associated protein (mrp6) at the lateral plasma membrane of rat hepatocytes
    • Abstract
    • 45 Madon J, Hagenbuch B, Gerloff T, Landmann L, Meier PJ, Stiegen B. Identification of a novel multidrug resistance-associated protein (mrp6) at the lateral plasma membrane of rat hepatocytes. Hepatology 1998; 28: 400A (Abstract).
    • (1998) Hepatology , vol.28
    • Madon, J.1    Hagenbuch, B.2    Gerloff, T.3    Landmann, L.4    Meier, P.J.5    Stiegen, B.6
  • 46
    • 0029986408 scopus 로고    scopus 로고
    • Absence of canalicular isoform of MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome
    • 46 Kartenbeck J, Leuschner U, Mayer R, Keppler D. Absence of canalicular isoform of MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome. Hepatology 1996; 23: 1061-6.
    • (1996) Hepatology , vol.23 , pp. 1061-1066
    • Kartenbeck, J.1    Leuschner, U.2    Mayer, R.3    Keppler, D.4
  • 47
    • 0026320338 scopus 로고
    • Bilirubin diglucuronide transport by rat liver canalicular membrane vesicles: Stimulation by bicarbonate ion
    • 47 Adachi Y, Kobayashi H, Kurumi Y, Shouji M, Kitano M, Yamamoto T. Bilirubin diglucuronide transport by rat liver canalicular membrane vesicles: Stimulation by bicarbonate ion. Hepatology 1991, 14: 1251-8.
    • (1991) Hepatology , vol.14 , pp. 1251-1258
    • Adachi, Y.1    Kobayashi, H.2    Kurumi, Y.3    Shouji, M.4    Kitano, M.5    Yamamoto, T.6
  • 48
    • 0030090846 scopus 로고    scopus 로고
    • Intrahepatic cholestasis
    • in Japanese with English abstract
    • 48 Adachi Y, Kamisako T, Okuyama Y, Miya H. Intrahepatic cholestasis. Jpn. J. Clin. Med. 1996; 54: 788-93 (in Japanese with English abstract).
    • (1996) Jpn. J. Clin. Med. , vol.54 , pp. 788-793
    • Adachi, Y.1    Kamisako, T.2    Okuyama, Y.3    Miya, H.4
  • 49
    • 0030963906 scopus 로고    scopus 로고
    • The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis
    • 49 Trauner M, Arrese M, Soroka CJ et al. The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis. Gastroenterology 1997; 113: 255-64.
    • (1997) Gastroenterology , vol.113 , pp. 255-264
    • Trauner, M.1    Arrese, M.2    Soroka, C.J.3
  • 50
    • 0030994468 scopus 로고    scopus 로고
    • A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin Johnson syndrome
    • 50 Paulusma CC, Kool M, Bosma PJ et al. A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin Johnson syndrome. Hepatalogy 1997; 25: 1539-42.
    • (1997) Hepatalogy , vol.25 , pp. 1539-1542
    • Paulusma, C.C.1    Kool, M.2    Bosma, P.J.3
  • 51
    • 6844250107 scopus 로고    scopus 로고
    • Mutations in the canalicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome
    • 51 Wada M, Toh S, Taniguchi K et al. Mutations in the canalicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome. Hum. Mol. Genet. 1998; 7: 203-97.
    • (1998) Hum. Mol. Genet. , vol.7 , pp. 203-297
    • Wada, M.1    Toh, S.2    Taniguchi, K.3
  • 52
    • 0021328118 scopus 로고
    • Taurocholate transport by rat canalicular membrane vesicles. Evidence for the presence of an Na-independent transport system
    • 52 Inoue M, Kinne R, Tran T, Arias IM. Taurocholate transport by rat canalicular membrane vesicles. Evidence for the presence of an Na-independent transport system. J. Clin. Invest. 1984; 73: 659-63.
    • (1984) J. Clin. Invest. , vol.73 , pp. 659-663
    • Inoue, M.1    Kinne, R.2    Tran, T.3    Arias, I.M.4
  • 53
    • 0027984777 scopus 로고
    • Hepatocellular transport of bile acids. Evidence for distinct sub-cellular localization of electrogenic and ATP-dependent taurocholate transport in rat hepatocytes
    • 53 Kast C, Stieger B, Winterhalter KH, Meier PJ. Hepatocellular transport of bile acids. Evidence for distinct sub-cellular localization of electrogenic and ATP-dependent taurocholate transport in rat hepatocytes. J. Biol. Chem. 1994; 269: 5179-86.
    • (1994) J. Biol. Chem. , vol.269 , pp. 5179-5186
    • Kast, C.1    Stieger, B.2    Winterhalter, K.H.3    Meier, P.J.4
  • 54
    • 0026077224 scopus 로고
    • ATP-dependent taurocholate transport by rat liver canalicular membrane vesicles
    • 54 Adachi Y, Koboyashi H, Kurumi Y, Shouji M, Kitano M, Yamamoto T. ATP-dependent taurocholate transport by rat liver canalicular membrane vesicles. Hepatology 1991; 14: 655-9.
    • (1991) Hepatology , vol.14 , pp. 655-659
    • Adachi, Y.1    Koboyashi, H.2    Kurumi, Y.3    Shouji, M.4    Kitano, M.5    Yamamoto, T.6
  • 55
    • 0027522810 scopus 로고
    • The bilology of the bile canaliculus, 1993
    • 55 Arias IM. The bilology of the bile canaliculus, 1993. Hepatology 1993; 17: 318-29.
    • (1993) Hepatology , vol.17 , pp. 318-329
    • Arias, I.M.1
  • 56
    • 0026516095 scopus 로고
    • ATP-dependent organic anion transporting system in normal and TR-rat liver canalicular membranes
    • 56 Nishida T, Hardenbrook C, Gatmaitan Z, Arias IM. ATP-dependent organic anion transporting system in normal and TR-rat liver canalicular membranes. Am. J. Physiol. 1992; 262: G629-35.
    • (1992) Am. J. Physiol. , vol.262
    • Nishida, T.1    Hardenbrook, C.2    Gatmaitan, Z.3    Arias, I.M.4
  • 57
    • 0027225501 scopus 로고
    • Ethinylestradiol treatment induces multiple canalicular transport alterations in rat liver
    • 57 Bossard R, Stieger B, O'Neill B, Fricker G, Meier PJ. Ethinylestradiol treatment induces multiple canalicular transport alterations in rat liver. J. Clin. Invest. 1993; 91: 2714-20.
    • (1993) J. Clin. Invest. , vol.91 , pp. 2714-2720
    • Bossard, R.1    Stieger, B.2    O'Neill, B.3    Fricker, G.4    Meier, P.J.5
  • 58
  • 59
    • 0026044685 scopus 로고
    • ATP-dependent transport of taurocholate across the hepatocyte canalicular membrane mediated by a 110 kDa glycoprotein binding ATP and bile salt
    • 59 Mueller M, Ishikawa T, Berger U et al. ATP-dependent transport of taurocholate across the hepatocyte canalicular membrane mediated by a 110 kDa glycoprotein binding ATP and bile salt. J. Biol. Chem. 1991; 266: 18 920-6.
    • (1991) J. Biol. Chem. , vol.266 , pp. 18920-18926
    • Mueller, M.1    Ishikawa, T.2    Berger, U.3
  • 60
  • 61
    • 0030950640 scopus 로고    scopus 로고
    • A yeast ATP-binding cassette-type protein mediating ATP-dependent bile acid transport
    • 61 Ortiz DF, St Pierre MV, Abdulmessih A, Arias IM. A yeast ATP-binding cassette-type protein mediating ATP-dependent bile acid transport. J. Biol. Chem. 1997; 272: 15 358-65.
    • (1997) J. Biol. Chem. , vol.272 , pp. 15358-15365
    • Ortiz, D.F.1    St Pierre, M.V.2    Abdulmessih, A.3    Arias, I.M.4
  • 62
    • 0029022589 scopus 로고
    • Identification of a sister gene to P-glycoprotein
    • 62 Childs S, Yeh R, Georges E, Ling V. Identification of a sister gene to P-glycoprotein. Cancer Res. 1995; 55: 2029-34.
    • (1995) Cancer Res. , vol.55 , pp. 2029-2034
    • Childs, S.1    Yeh, R.2    Georges, E.3    Ling, V.4
  • 63
    • 0032540277 scopus 로고    scopus 로고
    • The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver
    • 63 Gerloff T, Stieger B, Hagenbuch B et al. The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver. J. Biol. Chem. 1998; 273: 10 046-50.
    • (1998) J. Biol. Chem. , vol.273 , pp. 10046-10050
    • Gerloff, T.1    Stieger, B.2    Hagenbuch, B.3
  • 65
    • 0024371025 scopus 로고
    • The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles
    • 65 Kamimoto Y, Gatmaitan Z, Hsu J, Arias IM. The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles. J. Biol. Chem. 1989; 264: 11 693-8.
    • (1989) J. Biol. Chem. , vol.264 , pp. 11693-11698
    • Kamimoto, Y.1    Gatmaitan, Z.2    Hsu, J.3    Arias, I.M.4
  • 66
    • 0030753125 scopus 로고    scopus 로고
    • Molecular aspects of hepatobiliary transport
    • 66 Mueller M, Jansen PL. Molecular aspects of hepatobiliary transport. Am. J. Physiol. 1997; 272: G1285-303.
    • (1997) Am. J. Physiol. , vol.272
    • Mueller, M.1    Jansen, P.L.2
  • 67
    • 0028060570 scopus 로고
    • The inability of the mouse mdr2 gene to confer multidrug resistance is linked to reduced drug binding to the protein
    • 67 Buschman E, Gros P. The inability of the mouse mdr2 gene to confer multidrug resistance is linked to reduced drug binding to the protein. Cancer Res. 1994; 54: 4892-8.
    • (1994) Cancer Res. , vol.54 , pp. 4892-4898
    • Buschman, E.1    Gros, P.2
  • 68
    • 0025893114 scopus 로고
    • Characterization of the human MDR3 P-glycoprotein and its recognition by P-glycoprotein-specific monoclonal antibodies
    • 68 Schinkel AH, Roelofs EM, Borst P. Characterization of the human MDR3 P-glycoprotein and its recognition by P-glycoprotein-specific monoclonal antibodies. Cancer Res. 1991; 51: 2628-35.
    • (1991) Cancer Res. , vol.51 , pp. 2628-2635
    • Schinkel, A.H.1    Roelofs, E.M.2    Borst, P.3
  • 69
    • 0026640274 scopus 로고
    • Mdr2 encodes P-glycoprotein expressed in the bile canalicular membrane as determined by isoform-specific antibodies
    • 69 Buschman E, Arceci RJ, Croop JM et al. Mdr2 encodes P-glycoprotein expressed in the bile canalicular membrane as determined by isoform-specific antibodies. J. Biol. Chem. 1992; 267: 18 093-9.
    • (1992) J. Biol. Chem. , vol.267 , pp. 18093-18099
    • Buschman, E.1    Arceci, R.J.2    Croop, J.M.3
  • 70
    • 0028112934 scopus 로고
    • Tissue distribution of the human MDR3 P-glycoprotein
    • 70 Smit JJM, Schinkel AH, Mol CA et al. Tissue distribution of the human MDR3 P-glycoprotein. Lab Invest 1994; 71: 638-49.
    • (1994) Lab Invest , vol.71 , pp. 638-649
    • Smit, J.J.M.1    Schinkel, A.H.2    Mol, C.A.3
  • 71
    • 0027363563 scopus 로고
    • Homozygous disruption of murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease
    • 71 Smit JJM, Schinkel AH, Oude Elierink RP et al. Homozygous disruption of murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease. Cell 1993; 75: 451-62.
    • (1993) Cell , vol.75 , pp. 451-462
    • Smit, J.J.M.1    Schinkel, A.H.2    Oude Elierink, R.P.3
  • 72
    • 0029990296 scopus 로고    scopus 로고
    • Defect of multidrug resistance 3 gene expression in subtype of progressive familial intrahepatic cholestasis
    • 72 Deleuze JF, Jacquemin E, Dubuisson C et al. Defect of multidrug resistance 3 gene expression in subtype of progressive familial intrahepatic cholestasis. Hepatology 1996; 23: 904-8.
    • (1996) Hepatology , vol.23 , pp. 904-908
    • Deleuze, J.F.1    Jacquemin, E.2    Dubuisson, C.3
  • 73
    • 0040284751 scopus 로고    scopus 로고
    • Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis
    • 73 De Vree JML, Jacquemin E, Sturm E et al. Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis. Proc. Natl Acad. Sci. USA 1998; 95: 282-7.
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 282-287
    • De Vree, J.M.L.1    Jacquemin, E.2    Sturm, E.3
  • 74
    • 84895676467 scopus 로고    scopus 로고
    • Strong induction of MDR2 P-glycoprotein expression in livers of simvastatin-treated rats
    • Abstract
    • 74 Mueller M, Hooiveld GJEJ, Vos TA et al. Strong induction of MDR2 P-glycoprotein expression in livers of simvastatin-treated rats. Hepatology 1997; 26: 379A (Abstract).
    • (1997) Hepatology , vol.26
    • Mueller, M.1    Hooiveld, G.J.E.J.2    Vos, T.A.3
  • 75
    • 0029055416 scopus 로고
    • Marked improvement of cholestasis and hypercholesterolemia with simvastatin in a patient with primary biliary cirrhosis
    • 75 Kamisako T, Adachi Y. Marked improvement of cholestasis and hypercholesterolemia with simvastatin in a patient with primary biliary cirrhosis. Am. J. Gastroenterol. 1995; 90: 1187-8.
    • (1995) Am. J. Gastroenterol. , vol.90 , pp. 1187-1188
    • Kamisako, T.1    Adachi, Y.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.