Amyloid-β peptide nitrotyrosination stabilizes oligomers and enhances NMDAR-mediated toxicity

Journal of Neuroscience

Volumn 36, Issue 46, 2016, Pages 11693-11703

  Guivernau, Biuse ^a   Bonet, Jaume ^a   Valls Comamala, Victòria ^a   Bosch Morató, Mònica ^a   Godoy, Juan A ^b   Inestrosa, Nibaldo C ^b,c   Perálvarez Marín, Alex ^d   Fernández Busquets, Xavier ^e   Andreu, David ^a   Oliva, Baldomero ^a   Muñoz, Francisco J ^a  

^a UNIVERSITAT POMPEU FABRA   (Spain)

^b PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

^d UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^e CENTRE FOR RESEARCH IN ENVIRONMENTAL EPIDEMIOLOGY CREAL   (Spain)

Author keywords

Alzheimer; Amyloid; Nitrotyrosination; NMDA Rc; Oligomers; Peroxynitrite

Indexed keywords

AMYLOID BETA PROTEIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; THIOFLAVINE; AMYLOID; NITRO DERIVATIVE; PROTEIN BINDING; TYROSINE;

ARTICLE; ATOMIC FORCE MICROSCOPY; BINDING ASSAY; BRAIN TOXICITY; CALCIUM HOMEOSTASIS; CELL VIABILITY; CIRCULAR DICHROISM; CONFOCAL LASER SCANNING MICROSCOPY; CONTROLLED STUDY; DOT HYBRIDIZATION; HIPPOCAMPUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; IMMUNOPRECIPITATION; IMMUNOREACTIVITY; INFRARED SPECTROSCOPY; MOLECULAR WEIGHT; MTT ASSAY; NEURONAL TOXICITY; NITRATIVE STRESS; NITROTYROSINATION; PARTICLE SIZE; PHOTON CORRELATION SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN MODIFICATION; PROTEIN STRUCTURE; SENILE PLAQUE; TRANSMISSION ELECTRON MICROSCOPY; TUNEL ASSAY; WESTERN BLOTTING; ANIMAL; BINDING SITE; CELL CULTURE; CELL SURVIVAL; CHEMICAL MODEL; CHEMISTRY; COMPUTER SIMULATION; CYTOLOGY; METABOLISM; MOLECULAR MODEL; MOUSE; NERVE CELL; PHYSIOLOGY; PROTEIN MULTIMERIZATION; ULTRASTRUCTURE;

AMYLOID; AMYLOID BETA-PEPTIDES; ANIMALS; BINDING SITES; CELL SURVIVAL; CELLS, CULTURED; COMPUTER SIMULATION; MICE; MODELS, CHEMICAL; MODELS, MOLECULAR; NEURONS; NITRO COMPOUNDS; PROTEIN BINDING; PROTEIN MULTIMERIZATION; RECEPTORS, N-METHYL-D-ASPARTATE; TYROSINE;

EID: 84996555462     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1081-16.2016     Document Type: Article

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