메뉴 건너뛰기




Volumn 60, Issue 2, 2017, Pages 296-305

Adipocyte STAT5 deficiency promotes adiposity and impairs lipid mobilisation in mice

Author keywords

Adipose tissue; Energy metabolism; Lipolysis; STAT5

Indexed keywords

CRE RECOMBINASE; FATTY ACID; GLUCOSE; GLYCEROL; MESSENGER RNA; PROTEIN; PROTEIN PNPLA2; STAT5 PROTEIN; STAT5A PROTEIN; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

EID: 84995771489     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-016-4152-8     Document Type: Article
Times cited : (49)

References (38)
  • 1
    • 84892727198 scopus 로고    scopus 로고
    • What we talk about when we talk about fat
    • COI: 1:CAS:528:DC%2BC2cXhtF2ht78%3D, PID: 24439368
    • Rosen ED, Spiegelman BM (2014) What we talk about when we talk about fat. Cell 156:20–44
    • (2014) Cell , vol.156 , pp. 20-44
    • Rosen, E.D.1    Spiegelman, B.M.2
  • 2
    • 84858020291 scopus 로고    scopus 로고
    • Fat signals – lipases and lipolysis in lipid metabolism and signaling
    • COI: 1:CAS:528:DC%2BC38XjsFOmsb0%3D, PID: 22405066
    • Zechner R, Zimmermann R, Eichmann TO et al (2012) Fat signals – lipases and lipolysis in lipid metabolism and signaling. Cell Metab 15:279–291
    • (2012) Cell Metab , vol.15 , pp. 279-291
    • Zechner, R.1    Zimmermann, R.2    Eichmann, T.O.3
  • 3
    • 78650107057 scopus 로고    scopus 로고
    • Lipolysis – a highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores
    • COI: 1:CAS:528:DC%2BC3cXhs1WktL7N, PID: 21087632
    • Lass A, Zimmermann R, Oberer M, Zechner R (2011) Lipolysis – a highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores. Prog Lipid Res 50:14–27
    • (2011) Prog Lipid Res , vol.50 , pp. 14-27
    • Lass, A.1    Zimmermann, R.2    Oberer, M.3    Zechner, R.4
  • 4
    • 84893046863 scopus 로고    scopus 로고
    • Adipocytokines in obesity and metabolic disease
    • COI: 1:CAS:528:DC%2BC2cXjtlSls7s%3D, PID: 24403378
    • Cao H (2014) Adipocytokines in obesity and metabolic disease. J Endocrinol 220:T47–T59
    • (2014) J Endocrinol , vol.220 , pp. T47-T59
    • Cao, H.1
  • 5
    • 80054986457 scopus 로고    scopus 로고
    • The effects of glucocorticoids on adipose tissue lipid metabolism
    • COI: 1:CAS:528:DC%2BC3MXhtlKjsLbO, PID: 21864867
    • Peckett AJ, Wright DC, Riddell MC (2011) The effects of glucocorticoids on adipose tissue lipid metabolism. Metabolism 60:1500–1510
    • (2011) Metabolism , vol.60 , pp. 1500-1510
    • Peckett, A.J.1    Wright, D.C.2    Riddell, M.C.3
  • 6
    • 33645863768 scopus 로고    scopus 로고
    • Transcriptional regulation of metabolism
    • COI: 1:CAS:528:DC%2BD28Xktlylu7o%3D, PID: 16601267
    • Desvergne B, Michalik L, Wahli W (2006) Transcriptional regulation of metabolism. Physiol Rev 86:465–514
    • (2006) Physiol Rev , vol.86 , pp. 465-514
    • Desvergne, B.1    Michalik, L.2    Wahli, W.3
  • 7
    • 84875908666 scopus 로고    scopus 로고
    • Transcriptional cofactor TBLR1 controls lipid mobilization in white adipose tissue
    • COI: 1:CAS:528:DC%2BC3sXktFantLo%3D, PID: 23499424
    • Rohm M, Sommerfeld A, Strzoda D et al (2013) Transcriptional cofactor TBLR1 controls lipid mobilization in white adipose tissue. Cell Metab 17:575–585
    • (2013) Cell Metab , vol.17 , pp. 575-585
    • Rohm, M.1    Sommerfeld, A.2    Strzoda, D.3
  • 8
    • 79952155359 scopus 로고    scopus 로고
    • Transcriptional control of adipose lipid handling by IRF4
    • COI: 1:CAS:528:DC%2BC3MXisFGrsr4%3D, PID: 21356515
    • Eguchi J, Wang X, Yu S et al (2011) Transcriptional control of adipose lipid handling by IRF4. Cell Metab 13:249–259
    • (2011) Cell Metab , vol.13 , pp. 249-259
    • Eguchi, J.1    Wang, X.2    Yu, S.3
  • 9
    • 41549123672 scopus 로고    scopus 로고
    • Adipose-specific disruption of signal transducer and activator of transcription 3 increases body weight and adiposity
    • COI: 1:CAS:528:DC%2BD1cXktVeru7g%3D, PID: 18096662
    • Cernkovich ER, Deng J, Bond MC, Combs TP, Harp JB (2008) Adipose-specific disruption of signal transducer and activator of transcription 3 increases body weight and adiposity. Endocrinology 149:1581–1590
    • (2008) Endocrinology , vol.149 , pp. 1581-1590
    • Cernkovich, E.R.1    Deng, J.2    Bond, M.C.3    Combs, T.P.4    Harp, J.B.5
  • 10
    • 84870484174 scopus 로고    scopus 로고
    • Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity
    • COI: 1:CAS:528:DC%2BC38Xhslymsb%2FM, PID: 23217260
    • Derecka M, Gornicka A, Koralov SB et al (2012) Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity. Cell Metab 16:814–824
    • (2012) Cell Metab , vol.16 , pp. 814-824
    • Derecka, M.1    Gornicka, A.2    Koralov, S.B.3
  • 11
    • 84899747167 scopus 로고    scopus 로고
    • Depletion of white adipose tissue in cancer cachexia syndrome is associated with inflammatory signaling and disrupted circadian regulation
    • PID: 24667661
    • Tsoli M, Schweiger M, Vanniasinghe AS et al (2014) Depletion of white adipose tissue in cancer cachexia syndrome is associated with inflammatory signaling and disrupted circadian regulation. PLoS One 9:e92966
    • (2014) PLoS One , vol.9
    • Tsoli, M.1    Schweiger, M.2    Vanniasinghe, A.S.3
  • 12
    • 84925857018 scopus 로고    scopus 로고
    • White-to-brown metabolic conversion of human adipocytes by JAK inhibition
    • COI: 1:CAS:528:DC%2BC2cXitV2nsrnK, PID: 25487280
    • Moisan A, Lee YK, Zhang JD et al (2015) White-to-brown metabolic conversion of human adipocytes by JAK inhibition. Nat Cell Biol 17:57–67
    • (2015) Nat Cell Biol , vol.17 , pp. 57-67
    • Moisan, A.1    Lee, Y.K.2    Zhang, J.D.3
  • 13
    • 84893712870 scopus 로고    scopus 로고
    • The role of JAK-STAT signaling in adipose tissue function
    • COI: 1:CAS:528:DC%2BC3sXhtVCgt7fI, PID: 23735217
    • Richard AJ, Stephens JM (2014) The role of JAK-STAT signaling in adipose tissue function. Biochim Biophys Acta 1842:431–439
    • (2014) Biochim Biophys Acta , vol.1842 , pp. 431-439
    • Richard, A.J.1    Stephens, J.M.2
  • 14
    • 84898599467 scopus 로고    scopus 로고
    • Adipocyte-specific deficiency of Janus kinase (JAK) 2 in mice impairs lipolysis and increases body weight, and leads to insulin resistance with ageing
    • COI: 1:CAS:528:DC%2BC2cXivF2ntbw%3D, PID: 24531222
    • Shi SY, Luk CT, Brunt JJ et al (2014) Adipocyte-specific deficiency of Janus kinase (JAK) 2 in mice impairs lipolysis and increases body weight, and leads to insulin resistance with ageing. Diabetologia 57:1016–1026
    • (2014) Diabetologia , vol.57 , pp. 1016-1026
    • Shi, S.Y.1    Luk, C.T.2    Brunt, J.J.3
  • 15
    • 84863038179 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma/signal transducers and activators of transcription 5A pathway plays a key factor in adipogenesis of human bone marrow-derived stromal cells and 3T3-L1 preadipocytes
    • COI: 1:CAS:528:DC%2BC38XhslGiurY%3D, PID: 21542777
    • Jung HS, Lee YJ, Kim YH, Paik S, Kim JW, Lee JW (2012) Peroxisome proliferator-activated receptor gamma/signal transducers and activators of transcription 5A pathway plays a key factor in adipogenesis of human bone marrow-derived stromal cells and 3T3-L1 preadipocytes. Stem Cells Dev 21:465–475
    • (2012) Stem Cells Dev , vol.21 , pp. 465-475
    • Jung, H.S.1    Lee, Y.J.2    Kim, Y.H.3    Paik, S.4    Kim, J.W.5    Lee, J.W.6
  • 16
    • 33847684669 scopus 로고    scopus 로고
    • Growth hormone stimulates adipogenesis of 3T3-L1 cells through activation of the Stat5A/5B-PPARγ pathway
    • COI: 1:CAS:528:DC%2BD2sXjt1GjtL4%3D, PID: 17242167
    • Kawai M, Namba N, Mushiake S et al (2007) Growth hormone stimulates adipogenesis of 3T3-L1 cells through activation of the Stat5A/5B-PPARγ pathway. J Mol Endocrinol 38:19–34
    • (2007) J Mol Endocrinol , vol.38 , pp. 19-34
    • Kawai, M.1    Namba, N.2    Mushiake, S.3
  • 17
    • 70449382436 scopus 로고    scopus 로고
    • Impact of growth hormone receptor blockade on substrate metabolism during fasting in healthy subjects
    • COI: 1:CAS:528:DC%2BD1MXhsVejtb%2FP, PID: 19820031
    • Moller L, Norrelund H, Jessen N et al (2009) Impact of growth hormone receptor blockade on substrate metabolism during fasting in healthy subjects. J Clin Endocrinol Metab 94:4524–4532
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 4524-4532
    • Moller, L.1    Norrelund, H.2    Jessen, N.3
  • 18
    • 65249171425 scopus 로고    scopus 로고
    • Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects
    • PID: 19240267
    • Moller N, Jorgensen JO (2009) Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects. Endocr Rev 30:152–177
    • (2009) Endocr Rev , vol.30 , pp. 152-177
    • Moller, N.1    Jorgensen, J.O.2
  • 19
    • 84879117813 scopus 로고    scopus 로고
    • The GH/IGF-1 axis in obesity: pathophysiology and therapeutic considerations
    • COI: 1:CAS:528:DC%2BC3sXot1ejs7k%3D, PID: 23568441
    • Berryman DE, Glad CA, List EO, Johannsson G (2013) The GH/IGF-1 axis in obesity: pathophysiology and therapeutic considerations. Nat Rev Endocrinol 9:346–356
    • (2013) Nat Rev Endocrinol , vol.9 , pp. 346-356
    • Berryman, D.E.1    Glad, C.A.2    List, E.O.3    Johannsson, G.4
  • 20
    • 84885630101 scopus 로고    scopus 로고
    • The metabolic effects of growth hormone in adipose tissue
    • COI: 1:CAS:528:DC%2BC3sXivFeks7k%3D, PID: 23430368
    • Chaves VE, Junior FM, Bertolini GL (2013) The metabolic effects of growth hormone in adipose tissue. Endocrine 44:293–302
    • (2013) Endocrine , vol.44 , pp. 293-302
    • Chaves, V.E.1    Junior, F.M.2    Bertolini, G.L.3
  • 21
    • 84880836117 scopus 로고    scopus 로고
    • Disruption of JAK2 in adipocytes impairs lipolysis and improves fatty liver in mice with elevated GH
    • COI: 1:CAS:528:DC%2BC3sXht1aqs7zF, PID: 23782652
    • Nordstrom SM, Tran JL, Sos BC, Wagner KU, Weiss EJ (2013) Disruption of JAK2 in adipocytes impairs lipolysis and improves fatty liver in mice with elevated GH. Mol Endocrinol 27:1333–1342
    • (2013) Mol Endocrinol , vol.27 , pp. 1333-1342
    • Nordstrom, S.M.1    Tran, J.L.2    Sos, B.C.3    Wagner, K.U.4    Weiss, E.J.5
  • 22
    • 84874657953 scopus 로고    scopus 로고
    • Characterization of the adipocyte cellular lineage in vivo
    • COI: 1:CAS:528:DC%2BC3sXivFygtLY%3D, PID: 23434825
    • Berry R, Rodeheffer MS (2013) Characterization of the adipocyte cellular lineage in vivo. Nat Cell Biol 15:302–308
    • (2013) Nat Cell Biol , vol.15 , pp. 302-308
    • Berry, R.1    Rodeheffer, M.S.2
  • 23
    • 4444268818 scopus 로고    scopus 로고
    • Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation
    • COI: 1:CAS:528:DC%2BD2cXnslCrsLs%3D, PID: 15340066
    • Cui Y, Riedlinger G, Miyoshi K et al (2004) Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation. Mol Cell Biol 24:8037–8047
    • (2004) Mol Cell Biol , vol.24 , pp. 8037-8047
    • Cui, Y.1    Riedlinger, G.2    Miyoshi, K.3
  • 24
    • 84904270166 scopus 로고    scopus 로고
    • Reliable quantification of protein expression and cellular localization in histological sections
    • PID: 25013898
    • Schlederer M, Mueller KM, Haybaeck J et al (2014) Reliable quantification of protein expression and cellular localization in histological sections. PLoS One 9:e100822
    • (2014) PLoS One , vol.9
    • Schlederer, M.1    Mueller, K.M.2    Haybaeck, J.3
  • 25
    • 34249070257 scopus 로고    scopus 로고
    • Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression
    • COI: 1:CAS:528:DC%2BD2sXls1aqu74%3D, PID: 17504935
    • Engblom D, Kornfeld JW, Schwake L et al (2007) Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression. Genes Dev 21:1157–1162
    • (2007) Genes Dev , vol.21 , pp. 1157-1162
    • Engblom, D.1    Kornfeld, J.W.2    Schwake, L.3
  • 27
    • 84924185168 scopus 로고    scopus 로고
    • Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis
    • COI: 1:CAS:528:DC%2BC2MXotlais78%3D, PID: 25734337
    • Grabner B, Schramek D, Mueller KM et al (2015) Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis. Nat Commun 6:6285
    • (2015) Nat Commun , vol.6 , pp. 6285
    • Grabner, B.1    Schramek, D.2    Mueller, K.M.3
  • 28
    • 33745849713 scopus 로고    scopus 로고
    • The adipose tissue triglyceride lipase ATGL/PNPLA2 is downregulated by insulin and TNF-α in 3T3-L1 adipocytes and is a target for transactivation by PPARγ
    • COI: 1:CAS:528:DC%2BD28XntFGitr0%3D
    • Kim JY, Tillison K, Lee JH, Rearick DA, Smas CM (2006) The adipose tissue triglyceride lipase ATGL/PNPLA2 is downregulated by insulin and TNF-α in 3T3-L1 adipocytes and is a target for transactivation by PPARγ. Am J Phys Endocrinol Metab 291:E115–E127
    • (2006) Am J Phys Endocrinol Metab , vol.291 , pp. E115-E127
    • Kim, J.Y.1    Tillison, K.2    Lee, J.H.3    Rearick, D.A.4    Smas, C.M.5
  • 29
    • 84874507612 scopus 로고    scopus 로고
    • The role of GH in adipose tissue: lessons from adipose-specific GH receptor gene-disrupted mice
    • COI: 1:CAS:528:DC%2BC3sXjvVyjs7g%3D, PID: 23349524
    • List EO, Berryman DE, Funk K et al (2013) The role of GH in adipose tissue: lessons from adipose-specific GH receptor gene-disrupted mice. Mol Endocrinol 27:524–535
    • (2013) Mol Endocrinol , vol.27 , pp. 524-535
    • List, E.O.1    Berryman, D.E.2    Funk, K.3
  • 31
    • 84965185580 scopus 로고    scopus 로고
    • Coupling of lipolysis and de novo lipogenesis in brown, beige, and white adipose tissues during chronic β3-adrenergic receptor activation
    • COI: 1:CAS:528:DC%2BC2cXhvVartr7I, PID: 25193997
    • Mottillo EP, Balasubramanian P, Lee YH, Weng C, Kershaw EE, Granneman JG (2014) Coupling of lipolysis and de novo lipogenesis in brown, beige, and white adipose tissues during chronic β3-adrenergic receptor activation. J Lipid Res 55:2276–2286
    • (2014) J Lipid Res , vol.55 , pp. 2276-2286
    • Mottillo, E.P.1    Balasubramanian, P.2    Lee, Y.H.3    Weng, C.4    Kershaw, E.E.5    Granneman, J.G.6
  • 32
    • 84954546692 scopus 로고    scopus 로고
    • Gsalpha deficiency in adipose tissue improves glucose metabolism and insulin sensitivity without an effect on body weight
    • COI: 1:CAS:528:DC%2BC2MXitV2isL7J, PID: 26712027
    • Li YQ, Shrestha YB, Chen M, Chanturiya T, Gavrilova O, Weinstein LS (2016) Gsalpha deficiency in adipose tissue improves glucose metabolism and insulin sensitivity without an effect on body weight. Proc Natl Acad Sci U S A 113:446–451
    • (2016) Proc Natl Acad Sci U S A , vol.113 , pp. 446-451
    • Li, Y.Q.1    Shrestha, Y.B.2    Chen, M.3    Chanturiya, T.4    Gavrilova, O.5    Weinstein, L.S.6
  • 33
    • 84946926584 scopus 로고    scopus 로고
    • Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity
    • COI: 1:CAS:528:DC%2BC2MXhsleksbvL, PID: 26508640
    • Schreiber R, Hofer P, Taschler U et al (2015) Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity. Proc Natl Acad Sci U S A 112:13850–13855
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. 13850-13855
    • Schreiber, R.1    Hofer, P.2    Taschler, U.3
  • 34
    • 77249118270 scopus 로고    scopus 로고
    • 1 switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase
    • COI: 1:CAS:528:DC%2BC3cXlsVajurc%3D, PID: 20197052
    • 1 switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase. Cell Metab 11:194–205
    • (2010) Cell Metab , vol.11 , pp. 194-205
    • Yang, X.1    Lu, X.2    Lombes, M.3
  • 35
    • 67649403606 scopus 로고    scopus 로고
    • FoxO1 controls insulin-dependent adipose triglyceride lipase (ATGL) expression and lipolysis in adipocytes
    • COI: 1:CAS:528:DC%2BD1MXls1Kjur4%3D, PID: 19297333
    • Chakrabarti P, Kandror KV (2009) FoxO1 controls insulin-dependent adipose triglyceride lipase (ATGL) expression and lipolysis in adipocytes. J Biol Chem 284:13296–13300
    • (2009) J Biol Chem , vol.284 , pp. 13296-13300
    • Chakrabarti, P.1    Kandror, K.V.2
  • 36
    • 84956666350 scopus 로고    scopus 로고
    • The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux
    • PID: 26727229
    • Samuel VT, Shulman GI (2016) The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux. J Clin Invest 126:12–22
    • (2016) J Clin Invest , vol.126 , pp. 12-22
    • Samuel, V.T.1    Shulman, G.I.2
  • 37
    • 0028825129 scopus 로고
    • Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin
    • COI: 1:CAS:528:DyaK2MXotVGhurg%3D, PID: 7657026
    • Rebrin K, Steil GM, Getty L, Bergman RN (1995) Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin. Diabetes 44:1038–1045
    • (1995) Diabetes , vol.44 , pp. 1038-1045
    • Rebrin, K.1    Steil, G.M.2    Getty, L.3    Bergman, R.N.4
  • 38
    • 84904000735 scopus 로고    scopus 로고
    • Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis
    • COI: 1:CAS:528:DC%2BC2cXpslGis70%3D, PID: 24929951
    • Perry RJ, Zhang XM, Zhang D et al (2014) Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis. Nat Med 20:759–763
    • (2014) Nat Med , vol.20 , pp. 759-763
    • Perry, R.J.1    Zhang, X.M.2    Zhang, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.