-
1
-
-
79958243025
-
Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse
-
List EO, Sackmann-Sala L, Berryman DE, et al. Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse. Endocr Rev. 2011;32:356-386.
-
(2011)
Endocr Rev
, vol.32
, pp. 356-386
-
-
List, E.O.1
Sackmann-Sala, L.2
Berryman, D.E.3
-
2
-
-
12644257576
-
A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse)
-
Zhou Y, Xu BC, Maheshwari HG, et al. A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse). Proc Natl Acad Sci USA. 1997;94:13215-13220.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 13215-13220
-
-
Zhou, Y.1
Xu, B.C.2
Maheshwari, H.G.3
-
3
-
-
0033835911
-
Compensatory alterations of insulin signal transduction in liver of growth hormone receptor knockout mice
-
Dominici FP, Arostegui Diaz G, Bartke A, Kopchick JJ, Turyn D. Compensatory alterations of insulin signal transduction in liver of growth hormone receptor knockout mice. J Endocrinol. 2000;166: 579-590.
-
(2000)
J Endocrinol
, vol.166
, pp. 579-590
-
-
Dominici, F.P.1
Arostegui Diaz, G.2
Bartke, A.3
Kopchick, J.J.4
Turyn, D.5
-
4
-
-
0041419437
-
Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin and IGF-1 levels and increased lifespan
-
Coschigano KT, Holland AN, Riders ME, List EO, Flyvbjerg A, Kopchick JJ. Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin and IGF-1 levels and increased lifespan. Endocrinology. 2003; 144:3799-3810.
-
(2003)
Endocrinology
, vol.144
, pp. 3799-3810
-
-
Coschigano, K.T.1
Holland, A.N.2
Riders, M.E.3
List, E.O.4
Flyvbjerg, A.5
Kopchick, J.J.6
-
5
-
-
84887212549
-
Disruption of growth hormone receptor prevents calorie restriction from improving insulin action and longevity
-
Bonkowski MS, Dominici FP, Arum O, et al. Disruption of growth hormone receptor prevents calorie restriction from improving insulin action and longevity. PLoS ONE. 2009;4:e4567.
-
(2009)
PLoS ONE
, vol.4
-
-
Bonkowski, M.S.1
Dominici, F.P.2
Arum, O.3
-
6
-
-
65549149453
-
Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/ binding protein knockout mice
-
Ikeno Y, Hubbard GB, Lee S, et al. Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/ binding protein knockout mice. J Gerontol A Biol Sci Med Sci. 2009;64:522-529.
-
(2009)
J Gerontol A Biol Sci Med Sci
, vol.64
, pp. 522-529
-
-
Ikeno, Y.1
Hubbard, G.B.2
Lee, S.3
-
7
-
-
79951938474
-
Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans
-
Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, et al. Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med. 2011;3:70ra13.
-
(2011)
Sci Transl Med
, vol.3
-
-
Guevara-Aguirre, J.1
Balasubramanian, P.2
Guevara-Aguirre, M.3
-
9
-
-
33644855561
-
Growth hormone receptor deficiency results in blunted ghrelin feeding response, obesity, and hypolipidemia in mice
-
Egecioglu E, Bjursell M, Ljungberg A, et al. Growth hormone receptor deficiency results in blunted ghrelin feeding response, obesity, and hypolipidemia in mice. Am J Physiol Endocrinol Metab. 2006;290:E317-E325.
-
(2006)
Am J Physiol Endocrinol Metab
, vol.290
-
-
Egecioglu, E.1
Bjursell, M.2
Ljungberg, A.3
-
10
-
-
79958153897
-
Growth hormone and adipose tissue: Beyond the adipocyte
-
Berryman DE, List EO, Sackmann-Sala L, Lubbers E, Munn R, Kopchick JJ. Growth hormone and adipose tissue: beyond the adipocyte. Growth Horm IGF Res. 2011;21:113-123.
-
(2011)
Growth Horm IGF Res
, vol.21
, pp. 113-123
-
-
Berryman, D.E.1
List, E.O.2
Sackmann-Sala, L.3
Lubbers, E.4
Munn, R.5
Kopchick, J.J.6
-
12
-
-
3042815659
-
Comparing adiposity profiles in three mouse models with altered GH signaling
-
Berryman DE, List EO, Coschigano KT, Behar K, Kim JK, Kopchick JJ. Comparing adiposity profiles in three mouse models with altered GH signaling. Growth Horm IGF Res. 2004;14:309-318.
-
(2004)
Growth Horm IGF Res
, vol.14
, pp. 309-318
-
-
Berryman, D.E.1
List, E.O.2
Coschigano, K.T.3
Behar, K.4
Kim, J.K.5
Kopchick, J.J.6
-
13
-
-
70349308403
-
Adiponectin-a predictor of higher mortality in cardiovascular disease or a factor contributing to longer life?
-
Bik W, Baranowska B. Adiponectin-a predictor of higher mortality in cardiovascular disease or a factor contributing to longer life? Neuro Endocrinol Lett. 2009;30:180-184.
-
(2009)
Neuro Endocrinol Lett
, vol.30
, pp. 180-184
-
-
Bik, W.1
Baranowska, B.2
-
14
-
-
77952777084
-
Growth hormone therapy in short children born small for gestational age: Effects on abdominal fat partitioning and circulating follistatin and high-molecular-weight adiponectin
-
Ibanez L, Lopez-Bermejo A, Diaz M, Jaramillo A, Marin S, de Zegher F. Growth hormone therapy in short children born small for gestational age: effects on abdominal fat partitioning and circulating follistatin and high-molecular-weight adiponectin. J Clin Endocrinol Metab. 2010;95:2234-2239.
-
(2010)
J Clin Endocrinol Metab
, vol.95
, pp. 2234-2239
-
-
Ibanez, L.1
Lopez-Bermejo, A.2
Diaz, M.3
Jaramillo, A.4
Marin, S.5
de Zegher, F.6
-
15
-
-
21044455602
-
Prolactin and growth hormone regulate adiponectin secretion and receptor expression in adipose tissue
-
Nilsson L, Binart N, Bohlooly YM, et al. Prolactin and growth hormone regulate adiponectin secretion and receptor expression in adipose tissue. Biochem Biophys Res Commun. 2005;331:1120-1126.
-
(2005)
Biochem Biophys Res Commun
, vol.331
, pp. 1120-1126
-
-
Nilsson, L.1
Binart, N.2
Bohlooly, Y.M.3
-
16
-
-
33745196434
-
Body composition in untreated adult patients with Laron syndrome (primary GH insensitivity)
-
Laron Z, Ginsberg S, Lilos P, Arbiv M, Vaisman N. Body composition in untreated adult patients with Laron syndrome (primary GH insensitivity). Clin Endocrinol (Oxf). 2006;65:114-117.
-
(2006)
Clin Endocrinol (Oxf)
, vol.65
, pp. 114-117
-
-
Laron, Z.1
Ginsberg, S.2
Lilos, P.3
Arbiv, M.4
Vaisman, N.5
-
17
-
-
67749111843
-
Liver-specific deletion of the growth hormone receptor reveals essential role of GH signaling in hepatic lipid metabolism
-
Fan Y, Menon RK, Cohen P, et al. Liver-specific deletion of the growth hormone receptor reveals essential role of GH signaling in hepatic lipid metabolism. J Biol Chem. 2009;284(30):19937-19944.
-
(2009)
J Biol Chem.
, vol.284
, Issue.30
, pp. 19937-19944
-
-
Fan, Y.1
Menon, R.K.2
Cohen, P.3
-
18
-
-
78049429504
-
Distinct growth hormone receptor signaling modes regulate skeletal muscle development and insulin sensitivity in mice
-
Mavalli MD, DiGirolamo DJ, Fan Y, et al. Distinct growth hormone receptor signaling modes regulate skeletal muscle development and insulin sensitivity in mice. J Clin Invest. 2010;120:4007-4020.
-
(2010)
J Clin Invest
, vol.120
, pp. 4007-4020
-
-
Mavalli, M.D.1
DiGirolamo, D.J.2
Fan, Y.3
-
19
-
-
84555195115
-
Targeted loss ofGHRsignaling in mouse skeletal muscle protects against high-fat diet-induced metabolic deterioration
-
Vijayakumar A, WuY, Sun H, et al. Targeted loss ofGHRsignaling in mouse skeletal muscle protects against high-fat diet-induced metabolic deterioration. Diabetes. 2012;61:94-103.
-
(2012)
Diabetes
, vol.61
, pp. 94-103
-
-
Vijayakumar, A.1
Wu, Y.2
Sun, H.3
-
20
-
-
79957887666
-
Growth hormone receptor regulates β cell hyperplasia and glucose-stimulated insulin secretion in obese mice
-
Wu Y, Liu C, Sun H, et al. Growth hormone receptor regulates β cell hyperplasia and glucose-stimulated insulin secretion in obese mice. J Clin Invest. 2011;121:2422-2426.
-
(2011)
J Clin Invest
, vol.121
, pp. 2422-2426
-
-
Wu, Y.1
Liu, C.2
Sun, H.3
-
21
-
-
79959210305
-
A conditional knockout resource for the genome-wide study of mouse gene function
-
Skarnes WC, Rosen B, West AP, et al. A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011;474:337-342.
-
(2011)
Nature
, vol.474
, pp. 337-342
-
-
Skarnes, W.C.1
Rosen, B.2
West, A.P.3
-
22
-
-
27744445115
-
Caloric restriction results in decreased expression of peroxisome proliferator-activated receptor superfamily in muscle of normal and long-lived growth hormone receptor/binding protein knockout mice
-
Masternak MM, Al-Regaiey KA, Del Rosario Lim MM, et al. Caloric restriction results in decreased expression of peroxisome proliferator-activated receptor superfamily in muscle of normal and long-lived growth hormone receptor/binding protein knockout mice. J Gerontol A Biol Sci Med Sci. 2005;60:1238-1245.
-
(2005)
J Gerontol A Biol Sci Med Sci
, vol.60
, pp. 1238-1245
-
-
Masternak, M.M.1
Masternak, M.M.2
Al-Regaiey, K.A.3
Del Rosario Lim, M.M.4
Al-Regaiey, K.A.5
Del Rosario Lim, M.M.6
-
23
-
-
0035816531
-
Growth hormone (GH)-induced dimerization inhibits phorbol ester-stimulated GH receptor proteolysis
-
Zhang Y, Guan R, Jiang J, et al. Growth hormone (GH)-induced dimerization inhibits phorbol ester-stimulated GH receptor proteolysis. J Biol Chem. 2001;276:24565-24573.
-
(2001)
J Biol Chem
, vol.276
, pp. 24565-24573
-
-
Zhang, Y.1
Guan, R.2
Jiang, J.3
-
24
-
-
67650649523
-
Growth hormone improves body composition, fasting blood glucose, glucose tolerance and liver triacylglycerol in a mouse model of diet-induced obesity and type 2 diabetes
-
List EO, Palmer AJ, Berryman DE, Bower B, Kelder B, Kopchick JJ. Growth hormone improves body composition, fasting blood glucose, glucose tolerance and liver triacylglycerol in a mouse model of diet-induced obesity and type 2 diabetes. Diabetologia. 2009;52: 1647-1655.
-
(2009)
Diabetologia
, vol.52
, pp. 1647-1655
-
-
List, E.O.1
Palmer, A.J.2
Berryman, D.E.3
Bower, B.4
Kelder, B.5
Kopchick, J.J.6
-
25
-
-
0022345789
-
Effect of dietary fat content on the incidence of obesity among ad libitum fed mice
-
Salmon DM, Flatt JP. Effect of dietary fat content on the incidence of obesity among ad libitum fed mice. Int J Obes. 1985;9:443-449.
-
(1985)
Int J Obes
, vol.9
, pp. 443-449
-
-
Salmon, D.M.1
Flatt, J.P.2
-
26
-
-
77957173657
-
Sex-and depotdependent differences in adipogenesis in normal-weight humans
-
Tchoukalova YD, Koutsari C, Votruba SB, et al. Sex-and depotdependent differences in adipogenesis in normal-weight humans. Obesity (Silver Spring). 2010;18:1875-1880.
-
(2010)
Obesity (Silver Spring)
, vol.18
, pp. 1875-1880
-
-
Tchoukalova, Y.D.1
Koutsari, C.2
Votruba, S.B.3
-
27
-
-
74949138985
-
Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice
-
Wueest S, Rapold RA, Schumann DM, et al. Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice. J Clin Invest. 2010;120:191-202.
-
(2010)
J Clin Invest
, vol.120
, pp. 191-202
-
-
Wueest, S.1
Rapold, R.A.2
Schumann, D.M.3
-
28
-
-
77953200528
-
Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism
-
Kumar A, Lawrence JC Jr, Jung DY, et al. Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism. Diabetes. 2010;59:1397-1406.
-
(2010)
Diabetes
, vol.59
, pp. 1397-1406
-
-
Kumar, A.1
Lawrence Jr., J.C.2
Jung, D.Y.3
-
29
-
-
9144229185
-
Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle
-
He W, Barak Y, Hevener A, et al. Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci USA. 2003; 100:15712-15717.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 15712-15717
-
-
He, W.1
Barak, Y.2
Hevener, A.3
-
30
-
-
0035825643
-
Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
-
Abel ED, Peroni O, Kim JK, et al. Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature. 2001;409:729-733.
-
(2001)
Nature
, vol.409
, pp. 729-733
-
-
Abel, E.D.1
Peroni, O.2
Kim, J.K.3
-
31
-
-
33748747113
-
Selective expression of an aP2/fatty acid binding protein 4-Cre transgene in non-adipogenic tissues during embryonic development
-
Urs S, Harrington A, Liaw L, Small D. Selective expression of an aP2/fatty acid binding protein 4-Cre transgene in non-adipogenic tissues during embryonic development. Transgenic Res. 2006;15: 647-653.
-
(2006)
Transgenic Res
, vol.15
, pp. 647-653
-
-
Urs, S.1
Harrington, A.2
Liaw, L.3
Small, D.4
-
32
-
-
0034959752
-
Lack of macrophage fattyacid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis
-
Makowski L, Boord JB, Maeda K, et al. Lack of macrophage fattyacid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis. Nat Med. 2001;7:699-705.
-
(2001)
Nat Med
, vol.7
, pp. 699-705
-
-
Makowski, L.1
Boord, J.B.2
Maeda, K.3
-
33
-
-
0028154380
-
Growth hormone treatment of obese women for 5 wk: Effect on body composition and adipose tissue LPL activity
-
Richelsen B, Pedersen SB, Borglum JD, Moller-Pedersen T, Jorgensen J, Jorgensen JO. Growth hormone treatment of obese women for 5 wk: effect on body composition and adipose tissue LPL activity. Am J Physiol. 1994;266:E211-E216.
-
(1994)
Am J Physiol
, vol.266
-
-
Richelsen, B.1
Pedersen, S.B.2
Borglum, J.D.3
Moller-Pedersen, T.4
Jorgensen, J.5
Jorgensen, J.O.6
-
34
-
-
0034773602
-
Porcine growth hormone: A central metabolic hormone involved in the regulation of adipose tissue growth
-
Etherton TD. Porcine growth hormone: a central metabolic hormone involved in the regulation of adipose tissue growth. Nutrition. 2001;17:789-792.
-
(2001)
Nutrition
, vol.17
, pp. 789-792
-
-
Etherton, T.D.1
-
35
-
-
4143085927
-
Disruption of growth hormone receptor gene causes diminished pancreatic islet size and increased insulin sensitivity in mice
-
Liu JL, Coschigano KT, Robertson K, et al. Disruption of growth hormone receptor gene causes diminished pancreatic islet size and increased insulin sensitivity in mice. Am J Physiol Endocrinol Metab. 2004;287:E405-E413.
-
(2004)
Am J Physiol Endocrinol Metab
, vol.287
-
-
Liu, J.L.1
Coschigano, K.T.2
Robertson, K.3
-
36
-
-
84864009689
-
Leptin as a link between the immune system and kidney-related diseases: Leading actor or just a coadjuvant?
-
Moraes-Vieira PM, Bassi EJ, Araujo RC, Camara NO. Leptin as a link between the immune system and kidney-related diseases: leading actor or just a coadjuvant? Obes Rev. 2012;13:733-743.
-
(2012)
Obes Rev
, vol.13
, pp. 733-743
-
-
Moraes-Vieira, P.M.1
Bassi, E.J.2
Araujo, R.C.3
Camara, N.O.4
-
38
-
-
79959409408
-
Efficacy of metreleptin in obese patients with type 2 diabetes: Cellular and molecular pathways underlying leptin tolerance
-
Moon HS, Matarese G, Brennan AM, et al. Efficacy of metreleptin in obese patients with type 2 diabetes: cellular and molecular pathways underlying leptin tolerance. Diabetes. 2011;60:1647-1656.
-
(2011)
Diabetes
, vol.60
, pp. 1647-1656
-
-
Moon, H.S.1
Matarese, G.2
Brennan, A.M.3
-
39
-
-
0033515761
-
Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity
-
Arita Y, Kihara S, Ouchi N, et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun. 1999;257:79-83.
-
(1999)
Biochem Biophys Res Commun
, vol.257
, pp. 79-83
-
-
Arita, Y.1
Kihara, S.2
Ouchi, N.3
-
40
-
-
39449087257
-
Interfering effects of insulin, growth hormone and glucose on adipokine secretion
-
Wolfing B, Neumeier M, Buechler C, Aslanidis C, Scholmerich J, Schaffler A. Interfering effects of insulin, growth hormone and glucose on adipokine secretion. Exp Clin Endocrinol Diabetes. 2008; 116:47-52.
-
(2008)
Exp Clin Endocrinol Diabetes
, vol.116
, pp. 47-52
-
-
Wolfing, B.1
Neumeier, M.2
Buechler, C.3
Aslanidis, C.4
Scholmerich, J.5
Schaffler, A.6
-
42
-
-
77953019823
-
Innate immunity and adipose tissue biology
-
Schaffler A, Scholmerich J. Innate immunity and adipose tissue biology. Trends Immunol. 2010;31:228-235.
-
(2010)
Trends Immunol
, vol.31
, pp. 228-235
-
-
Schaffler, A.1
Scholmerich, J.2
-
43
-
-
0030724591
-
Pathogenesis of type 2 diabetes: Metabolic and molecular implications for identifying diabetes genes
-
DeFronzo RA. Pathogenesis of type 2 diabetes: metabolic and molecular implications for identifying diabetes genes. Diabetes Rev. 1997;5:177-269.
-
(1997)
Diabetes Rev
, vol.5
, pp. 177-269
-
-
DeFronzo, R.A.1
-
44
-
-
23044440661
-
Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle
-
Carvalho E, Kotani K, Peroni OD, Kahn BB. Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle. AmJ Physiol Endocrinol Metab. 2005;289:E551-E561.
-
(2005)
Am J Physiol Endocrinol Metab
, vol.289
-
-
Carvalho, E.1
Kotani, K.2
Peroni, O.D.3
Kahn, B.B.4
-
45
-
-
0036068133
-
Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance
-
Bluher M, Michael MD, Peroni OD, et al. Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Dev Cell. 2002;3:25-38.
-
(2002)
Dev Cell
, vol.3
, pp. 25-38
-
-
Bluher, M.1
Michael, M.D.2
Peroni, O.D.3
|