Differential white blood cell count and type 2 diabetes: Systematic review and meta-analysis of cross-sectional and prospective studies

PLoS ONE

Volumn 5, Issue 10, 2010, Pages

  Gkrania Klotsas, Effrossyni ^a   Ye, Zheng ^a   Cooper, Andrew J ^a   Sharp, Stephen J ^a   Luben, Robert ^b   Biggs, Mary L ^c   Chen, Liang Kung ^d   Gokulakrishnan, Kuppan ^e   Hanefeld, Markolf ^f   Ingelsson, Erik ^g   Lai, Wen An ^h   Lin, Shih Yi ⁱ   Lind, Lars ^j   Lohsoonthorn, Vitool ^k   Mohan, Viswanathan ^e   Muscari, Antonio ^l   Nilsson, Goran ^m   Ohrvik, John ^g   Qiang, Jiang Chao ⁿ   Jenny, Nancy Swords ^o   Tamakoshi, Koji ^p   Temelkova Kurktschiev, Theodora ^f,q   Wang, Ya Yu ^h   Yajnik, Chittaranjan Sakerlal ^r   Zoli, Marco ^l   Khaw, Kay Tee ^b   Forouhi, Nita G ^a   Wareham, Nicholas J ^a   Langenberg, Claudia ^a   more..

^a INSTITUTE OF METABOLIC SCIENCE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF WASHINGTON   (United States)

^d TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^e MADRAS DIABETES RESEARCH FOUNDATION   (India)

^f DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^g KAROLINSKA INSTITUTE   (Sweden)

^h KUANG TIEN GENERAL HOSPITAL   (Taiwan)

ⁱ TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^j UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^k CHULALONGKORN UNIVERSITY   (Thailand)

^l UNIVERSITY OF BOLOGNA   (Italy)

^m UPPSALA UNIVERSITY   (Sweden)

ⁿ Guangzhou No 12 Hospital   (China)

^o UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^p NAGOYA UNIVERSITY   (Japan)

^q National Sports Academy V Levski   (Bulgaria)

^r KEM HOSPITAL   (India)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AGE; ARTICLE; BODY MASS; CROSS-SECTIONAL STUDY; EDUCATION; FAMILY HISTORY; GRANULOCYTE; HUMAN; INCIDENCE; LEUKOCYTE DIFFERENTIAL COUNT; LYMPHOCYTE COUNT; MONOCYTE; NON INSULIN DEPENDENT DIABETES MELLITUS; PHYSICAL ACTIVITY; PROSPECTIVE STUDY; RISK FACTOR; SEX; SMOKING; SYSTEMATIC REVIEW; WAIST CIRCUMFERENCE; ADULT; AGED; BLOOD; FEMALE; LEUKOCYTE COUNT; MALE; META ANALYSIS; MIDDLE AGED; REVIEW;

ADULT; AGED; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; LEUKOCYTE COUNT; MALE; MIDDLE AGED; PROSPECTIVE STUDIES;

EID: 78149438990     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0013405     Document Type: Article

References (60)

1. Pradhan, AD, Manson JE, Rifai N, Buring JE, Ridker PM (2001) C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 286: 327-334.
2. Pickup JC, Mattock MB, Chusney GD, Burt D (1997) NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X. Diabetologia 40: 1286-1292.
3. Hotamisligil, GS (2006) Inflammation and metabolic disorders. Nature 444: 860-867.
4. Hak AE, Stehouwer CD, Bots ML, Polderman KH, Schalkwijk CG, et al. (1999) Associations of C-reactive protein with measures of obesity, insulin resistance, and subclinical atherosclerosis in healthy, middle-aged women. Arterioscler Thromb Vasc Biol 19: 1986-1991.
5. Duncan BB, Schmidt MI, Pankow JS, Ballantyne CM, Couper D, et al. (2003) Low-grade systemic inflammation and the development of type 2 diabetes: the atherosclerosis risk in communities study. Diabetes 52: 1799-1805.
6. Mohamed-Ali V, Goodrick S, Rawesh A, Katz DR, Miles JM, et al. (1997) Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo. J Clin Endocrinol Metab 82: 4196-4200.
7. Lundgren CH, Brown SL, Nordt TK, Sobel BE, Fujii Setal (1996) Elaboration of type-1 plasminogen activator inhibitor from adipocytes. A potential pathogenetic link between obesity and cardiovascular disease. Circulation 93: 106-110.
8. Donath MY, Ehses JA, Maedler K, Schumann DM, Ellingsgaard H, et al. (2005) Mechanisms of Beta-Cell Death in Type 2 Diabetes. Diabetes 54: S108-S113.
9. Schmidt MI, Duncan BB, Sharrett AR, Lindberg G, Savage PJ, et al. (1999) Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study. The Lancet 353: 1649-1652.
10. Vozarova B, Weyer C, Lindsay RS, Pratley RE, Bogardus C, et al. (2002) High white blood cell count is associated with a worsening of insulin sensitivity and predicts the development of type 2 diabetes. Diabetes 51: 455-461.
11. WHO (2006) Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia: A report of the World Health Organization and International Diabetes Federation. Geneva, Switzerland. pp 1-46.
12. Danesh J, Collins R, Appleby P, Peto R, et al. (1998) Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: meta-analyses of prospective studies. JAMA 279: 1477-1482.
13. Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327: 557-560.
14. Whitehead A, Whitehead J (1991) A general parametric approach to the metaanalysis of randomized clinical trials. Stat Med 10: 1665-1677.
15. Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50: 1088-1101.
16. Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315: 629-634.
17. Day NE, Oakes S, Luben R, Khaw KT, Bingham SA, et al. (1999) EPICNorfolk: Study design and characteristics of the cohort. British Journal of Cancer 80: 95-103.
18. Smith MR, Kinmonth AL, Luben RN, Bingham S, Day NE, et al. (2003) Smoking status and differential white cell count in men and women in the EPICNorfolk population. Atherosclerosis 169: 331-337.
19. Khaw KT, Wareham N, Bingham S, Welch A, Luben R, et al. (2008) Combined impact of health behaviours and mortality in men and women: the EPICNorfolk prospective population study. PLoS Med 5: e12.
20. Ford, ES (2002) Leukocyte count, erythrocyte sedimentation rate, and diabetes incidence in a national sample of US adults. Am J Epidemiol 155: 57-64.
21. Chien K, Cai T, Hsu H, Su T, Chang W, et al. (2009) A prediction model for type 2 diabetes risk among Chinese people. Diabetologia 52: 443-450.
22. Kim DJ, Noh JH, Lee BW, Choi YH, Chung JH, et al. (2008) The associations of total and differential white blood cell counts with obesity, hypertension, dyslipidemia and glucose intolerance in a Korean population. J Korean Med Sci 23: 193-198.
23. Muntner P, He J, Chen J, Fonseca V, Whelton PK (2004) Prevalence of nontraditional cardiovascular disease risk factors among persons with impaired fasting glucose, impaired glucose tolerance, diabetes, and the metabolic syndrome: analysis of the Third National Health and Nutrition Examination Survey (NHANES III). Ann Epidemiol 14: 686-695.
24. Stranges S, Rafalson LB, Dmochowski J, Rejman K, Tracy RP, et al. (2008) Additional contribution of emerging risk factors to the prediction of the risk of type 2 diabetes: evidence from the Western New York Study. Obesity (Silver Spring) 16: 1370-1376.
25. Barzilay JI, Abraham L, Heckbert SR, Cushman M, Kuller LH, et al. (2001) The relation of markers of inflammation to the development of glucose disorders in the elderly: the Cardiovascular Health Study. Diabetes 50: 2384-2389.
26. Chen LK, Lin MH, Chen ZJ, Hwang SJ, Chiou ST (2006) Association of insulin resistance and hematologic parameters: study of a middle-aged and elderly Chinese population in Taiwan. J Chin Med Assoc 69: 248-253.
27. Chuo SK, Li JC, Tsai WC, Wu DA, Kuo SW, et al. (2005) Correlations between white blood cell count and metabolic syndrome in middle-age Taiwanese. Endocr Res 31: 39-50.
28. Gokulakrishnan K, Deepa R, Sampathkumar R, Balasubramanyam M, Mohan V (2009) Association of leukocyte count with varying degrees of glucose intolerance in Asian Indians: the Chennai Urban Rural Epidemiology Study (CURES-26). Metab Syndr Relat Disord 7: 205-210.
29. Ingelsson E, Hulthe J, Lind L (2008) Inflammatory markers in relation to insulin resistance and the metabolic syndrome. Eur J Clin Invest 38: 502-509.
30. shizaka N, Ishizaka Y, Toda E, Nagai R, Yamakado M (2006) Association between smoking, hematological parameters, and metabolic syndrome in Japanese men. Diabetes Care 29: 741.
31. Ishizaka N, Ishizaka Y, Toda E, Nagai R, Yamakado M (2007) Association between cigarette smoking, white blood cell count, and metabolic syndrome as defined by the Japanese criteria. Intern Med 46: 1167-1170.
32. Kim JA, Choi YS, Hong JI, Kim SH, Jung HH, et al. (2006) Association of metabolic syndrome with white blood cell subtype and red blood cells. Endocr J 53: 133-139.
33. Lao XQ, Neil Thomas G, Jiang C, Zhang W, Adab P, et al. (2008) White blood cell count and the metabolic syndrome in older Chinese: the Guangzhou Biobank Cohort Study. Atherosclerosis 201: 418-424.
34. Lohsoonthorn V, Dhanamun B, Williams MA (2006) Prevalence of metabolic syndrome and its relationship to white blood cell count in a population of Thai men and women receiving routine health examinations. Am J Hypertens 19: 339-345.
35. Marques-Vidal P, Mazoyer E, Bongard V, Gourdy P, Ruidavets JB, et al. (2002) Prevalence of insulin resistance syndrome in southwestern France and its relationship with inflammatory and hemostatic markers. Diabetes Care 25: 1371-1377.
36. Muscari A, Antonelli S, Bianchi G, Cavrini G, Dapporto S, et al. (2007) Serum C3 is a stronger inflammatory marker of insulin resistance than C-reactive protein, leukocyte count, and erythrocyte sedimentation rate: comparison study in an elderly population. Diabetes Care 30: 2362-2368.
37. Nagasawa N, Tamakoshi K, Yatsuya H, Hori Y, Ishikawa M, et al. (2004) Association of white blood cell count and clustered components of metabolic syndrome in Japanese men. Circ J 68: 892-897.
38. Nakanishi N, Sato M, Shirai K, Nakajima K, Murakami S, et al. (2002) Associations between white blood cell count and features of the metabolic syndrome in Japanese male office workers. Ind Health 40: 273-277.
39. Nilsson G, Hedberg P, Jonason T, Lonnberg I, Tenerz A, et al. (2007) White blood cell counts associate more strongly to the metabolic syndrome in 75-yearold women than in men: a population based study. Metab Syndr Relat Disord 5: 359-364.
40. Temelkova-Kurktschiev T, Siegert G, Bergmann S, Henkel E, Koehler C, et al. (2002) Subclinical inflammation is strongly related to insulin resistance but not to impaired insulin secretion in a high risk population for diabetes. Metabolism 51: 743-749.
41. Tian JY, Yang Y, Cheng Q, Huang HE, Li R, et al. (2008) Association of WBC count and glucose metabolism among Chinese population aged 40 years and over. Diabetes Res Clin Pract 82: 132-138.
42. Wang YY, Lin SY, Liu PH, Cheung BM, Lai WA (2004) Association between hematological parameters and metabolic syndrome components in a Chinese population. J Diabetes Complications 18: 322-327.
43. Wannamethee SG, Lowe GD, Shaper AG, Rumley A, Lennon L, et al. (2005) The metabolic syndrome and insulin resistance: relationship to haemostatic and inflammatory markers in older non-diabetic men. Atherosclerosis 181: 101-108.
44. Yajnik CS, Joglekar CV, Lubree HG, Rege SS, Naik SS, et al. (2008) Adiposity, inflammation and hyperglycaemia in rural and urban Indian men: Coronary Risk of Insulin Sensitivity in Indian Subjects (CRISIS) Study. Diabetologia 51: 39-46.
45. McCarthy DA, Dale MM (1988) The leucocytosis of exercise. A review and model. Sports Med 6: 333-363.
46. Natale VM, Brenner IK, Moldoveanu AI, Vasiliou P, Shek P, et al. (2003) Effects of three different types of exercise on blood leukocyte count during and following exercise. Sao Paulo Med J 121: 9-14.
47. Pannacciulli N, Giorgino F, Martina RA, Resta O, Giorgino R, et al. (2003) Effect of family history of type 2 diabetes on white blood cell count in adult women. Obes Res 11: 1232-1237.
48. Pollitt RA, Kaufman JS, Rose KM, Diez-Roux AV, Zeng D, et al. (2007) Earlylife and adult socioeconomic status and inflammatory risk markers in adulthood. Eur J Epidemiol 22: 55-66.
49. Duncan BB, Schmidt MI, Chambless LE, Folsom AR, Carpenter M, et al. (2000) Fibrinogen, other putative markers of inflammation, and weight gain in middle-aged adults-the ARIC study. Atherosclerosis Risk in Communities. Obes Res 8: 279-286.
50. Yeh HC, Duncan BB, Schmidt MI, Wang NY, Brancati FL (2010) Smoking, Smoking Cessation, and Risk for Type 2 Diabetes Mellitus. Annals of Internal Medicine. 152: 10-17.
51. Van Furth R, Diesselhoff-den Dulk MMC, Mattie H (1973) QUANTITATIVE STUDY ON THE PRODUCTION AND KINETICS OF MONONUCLEAR PHAGOCYTES DURING AN ACUTE INFLAMMATORY REACTION. The Journal of Experimental Medicine 138: 1314-1330.
52. Senn JJ, Klover PJ, Nowak IA, Mooney RA (2002) Interleukin-6 induces cellular insulin resistance in hepatocytes. Diabetes 51: 3391-3399.
53. Dandona P, Aljada A, Mohanty P, Ghanim H, Hamouda W, et al. (2001) Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect? J Clin Endocrinol Metab 86: 3257-3265.
54. Dandona P, Aljada A, Bandyopadhyay A (2004) Inflammation: the link between insulin resistance, obesity and diabetes. Trends Immunol 25: 4-7.
55. Dandona P, Aljada A, Chaudhuri A, Mohanty P (2004) Endothelial dysfunction, inflammation and diabetes. Rev Endocr Metab Disord 5: 189-197.
56. Yudkin JS, Stehouwer CD, Emeis JJ, Coppack SW (1999) C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol 19: 972-978.
57. Haffner SM, Greenberg AS, Weston WM, Chen H, Williams K, et al. (2002) Effect of rosiglitazone treatment on nontraditional markers of cardiovascular disease in patients with type 2 diabetes mellitus. Circulation 106: 679-684.
58. Van Wijk JP, Cabezas MC, Coll B, Joven J, Rabelink TJ, et al. (2006) Effects of rosiglitazone on postprandial leukocytes and cytokines in type 2 diabetes. Atherosclerosis 186: 152-159.
59. Hanefeld M, Schaper F, Koehler C, Bergmann S, Ugocsai P, et al. (2009) Effect of acarbose on postmeal mononuclear blood cell response in patients with early type 2 diabetes: the AI(I)DA study. Horm Metab Res 41: 132-136.
60. Kim JA, Park HS (2008) White blood cell count and abdominal fat distribution in female obese adolescents. Metabolism 57: 1375-1359.