메뉴 건너뛰기




Volumn 99, Issue 1, 2016, Pages 40-55

Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals

(113)  Eicher, John D a   Chami, Nathalie b,c   Kacprowski, Tim d,e   Nomura, Akihiro f,g,h,i   Chen, Ming Huei a   Yanek, Lisa R j   Tajuddin, Salman M k   Schick, Ursula M l   Slater, Andrew J m,n   Pankratz, Nathan o   Polfus, Linda p   Schurmann, Claudia l   Giri, Ayush q   Brody, Jennifer A r   Lange, Leslie A s   Manichaikul, Ani t   Hill, W David u   Pazoki, Raha v   Elliot, Paul w   Evangelou, Evangelos w,x   more..


Author keywords

[No Author keywords available]

Indexed keywords

ARFGAP3 GENE; ARTICLE; ERYTHROCYTE; FCER1A GENE; GENE; GENE EXPRESSION; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; IQGAP2 GENE; LEUKOCYTE; LY75 GENE; MAP1A GENE; META ANALYSIS; MRVI1 GENE; PACSIN2 GENE; PEAR1 GENE; PLATELET REACTIVITY; PRIORITY JOURNAL; PTGES3 GENE; SINGLE NUCLEOTIDE POLYMORPHISM; SMG6 GENE; THROMBOCYTE; THROMBOCYTE COUNT; THROMBOCYTE VOLUME; TMPRSS6 GENE; ZMIZ2 GENE; EXOME; FEMALE; GENETIC VARIATION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; MALE; METABOLISM;

EID: 84989952555     PISSN: 00029297     EISSN: 15376605     Source Type: Journal    
DOI: 10.1016/j.ajhg.2016.05.005     Document Type: Article
Times cited : (71)

References (77)
  • 3
    • 0030773146 scopus 로고    scopus 로고
    • Aspirin as a therapeutic agent in cardiovascular disease: a statement for healthcare professionals from the American Heart Association
    • 3 Hennekens, C.H., Dyken, M.L., Fuster, V., Aspirin as a therapeutic agent in cardiovascular disease: a statement for healthcare professionals from the American Heart Association. Circulation 96 (1997), 2751–2753.
    • (1997) Circulation , vol.96 , pp. 2751-2753
    • Hennekens, C.H.1    Dyken, M.L.2    Fuster, V.3
  • 6
    • 84891858260 scopus 로고    scopus 로고
    • A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects
    • 6 Shameer, K., Denny, J.C., Ding, K., Jouni, H., Crosslin, D.R., de Andrade, M., Chute, C.G., Peissig, P., Pacheco, J.A., Li, R., et al. A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects. Hum. Genet. 133 (2014), 95–109.
    • (2014) Hum. Genet. , vol.133 , pp. 95-109
    • Shameer, K.1    Denny, J.C.2    Ding, K.3    Jouni, H.4    Crosslin, D.R.5    de Andrade, M.6    Chute, C.G.7    Peissig, P.8    Pacheco, J.A.9    Li, R.10
  • 7
    • 84859224216 scopus 로고    scopus 로고
    • A meta-analysis and genome-wide association study of platelet count and mean platelet volume in African Americans
    • 7 Qayyum, R., Snively, B.M., Ziv, E., Nalls, M.A., Liu, Y., Tang, W., Yanek, L.R., Lange, L., Evans, M.K., Ganesh, S., et al. A meta-analysis and genome-wide association study of platelet count and mean platelet volume in African Americans. PLoS Genet., 8, 2012, e1002491.
    • (2012) PLoS Genet. , vol.8 , pp. e1002491
    • Qayyum, R.1    Snively, B.M.2    Ziv, E.3    Nalls, M.A.4    Liu, Y.5    Tang, W.6    Yanek, L.R.7    Lange, L.8    Evans, M.K.9    Ganesh, S.10
  • 9
    • 70350644759 scopus 로고    scopus 로고
    • A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium
    • 9 Soranzo, N., Spector, T.D., Mangino, M., Kühnel, B., Rendon, A., Teumer, A., Willenborg, C., Wright, B., Chen, L., Li, M., et al. A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat. Genet. 41 (2009), 1182–1190.
    • (2009) Nat. Genet. , vol.41 , pp. 1182-1190
    • Soranzo, N.1    Spector, T.D.2    Mangino, M.3    Kühnel, B.4    Rendon, A.5    Teumer, A.6    Willenborg, C.7    Wright, B.8    Chen, L.9    Li, M.10
  • 11
    • 84983227901 scopus 로고    scopus 로고
    • Genome-wide association study identifies candidate loci associated with platelet count in Koreans
    • 11 Oh, J.H., Kim, Y.K., Moon, S., Kim, Y.J., Kim, B.J., Genome-wide association study identifies candidate loci associated with platelet count in Koreans. Genomics Inform. 12 (2014), 225–230.
    • (2014) Genomics Inform. , vol.12 , pp. 225-230
    • Oh, J.H.1    Kim, Y.K.2    Moon, S.3    Kim, Y.J.4    Kim, B.J.5
  • 12
    • 84875271874 scopus 로고    scopus 로고
    • GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children
    • 12 Li, J., Glessner, J.T., Zhang, H., Hou, C., Wei, Z., Bradfield, J.P., Mentch, F.D., Guo, Y., Kim, C., Xia, Q., et al. GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Hum. Mol. Genet. 22 (2013), 1457–1464.
    • (2013) Hum. Mol. Genet. , vol.22 , pp. 1457-1464
    • Li, J.1    Glessner, J.T.2    Zhang, H.3    Hou, C.4    Wei, Z.5    Bradfield, J.P.6    Mentch, F.D.7    Guo, Y.8    Kim, C.9    Xia, Q.10
  • 15
    • 79960638531 scopus 로고    scopus 로고
    • The genetics of common variation affecting platelet development, function and pharmaceutical targeting
    • 15 Johnson, A.D., The genetics of common variation affecting platelet development, function and pharmaceutical targeting. J. Thromb. Haemost. 9:Suppl 1 (2011), 246–257.
    • (2011) J. Thromb. Haemost. , vol.9 , pp. 246-257
    • Johnson, A.D.1
  • 16
    • 84868502906 scopus 로고    scopus 로고
    • Imputation of exome sequence variants into population- based samples and blood-cell-trait-associated loci in African Americans: NHLBI GO Exome Sequencing Project
    • 16 Auer, P.L., Johnsen, J.M., Johnson, A.D., Logsdon, B.A., Lange, L.A., Nalls, M.A., Zhang, G., Franceschini, N., Fox, K., Lange, E.M., et al. Imputation of exome sequence variants into population- based samples and blood-cell-trait-associated loci in African Americans: NHLBI GO Exome Sequencing Project. Am. J. Hum. Genet. 91 (2012), 794–808.
    • (2012) Am. J. Hum. Genet. , vol.91 , pp. 794-808
    • Auer, P.L.1    Johnsen, J.M.2    Johnson, A.D.3    Logsdon, B.A.4    Lange, L.A.5    Nalls, M.A.6    Zhang, G.7    Franceschini, N.8    Fox, K.9    Lange, E.M.10
  • 23
    • 77955894071 scopus 로고    scopus 로고
    • METAL: fast and efficient meta-analysis of genomewide association scans
    • 23 Willer, C.J., Li, Y., Abecasis, G.R., METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics 26 (2010), 2190–2191.
    • (2010) Bioinformatics , vol.26 , pp. 2190-2191
    • Willer, C.J.1    Li, Y.2    Abecasis, G.R.3
  • 25
    • 80051499915 scopus 로고    scopus 로고
    • Rare-variant association testing for sequencing data with the sequence kernel association test
    • 25 Wu, M.C., Lee, S., Cai, T., Li, Y., Boehnke, M., Lin, X., Rare-variant association testing for sequencing data with the sequence kernel association test. Am. J. Hum. Genet. 89 (2011), 82–93.
    • (2011) Am. J. Hum. Genet. , vol.89 , pp. 82-93
    • Wu, M.C.1    Lee, S.2    Cai, T.3    Li, Y.4    Boehnke, M.5    Lin, X.6
  • 28
    • 84895858942 scopus 로고    scopus 로고
    • A general framework for estimating the relative pathogenicity of human genetic variants
    • 28 Kircher, M., Witten, D.M., Jain, P., O'Roak, B.J., Cooper, G.M., Shendure, J., A general framework for estimating the relative pathogenicity of human genetic variants. Nat. Genet. 46 (2014), 310–315.
    • (2014) Nat. Genet. , vol.46 , pp. 310-315
    • Kircher, M.1    Witten, D.M.2    Jain, P.3    O'Roak, B.J.4    Cooper, G.M.5    Shendure, J.6
  • 29
    • 84962230620 scopus 로고    scopus 로고
    • Coding variation in ANGPTL4, LPL, and SVEP1 and the risk of coronary disease
    • 29 Coding variation in ANGPTL4, LPL, and SVEP1 and the risk of coronary disease. N. Engl. J. Med., 374, 2016, 1898.
    • (2016) N. Engl. J. Med. , vol.374 , pp. 1898
  • 33
    • 80052322958 scopus 로고    scopus 로고
    • Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA
    • 33 Fehrmann, R.S., Jansen, R.C., Veldink, J.H., Westra, H.J., Arends, D., Bonder, M.J., Fu, J., Deelen, P., Groen, H.J., Smolonska, A., et al. Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA. PLoS Genet., 7, 2011, e1002197.
    • (2011) PLoS Genet. , vol.7 , pp. e1002197
    • Fehrmann, R.S.1    Jansen, R.C.2    Veldink, J.H.3    Westra, H.J.4    Arends, D.5    Bonder, M.J.6    Fu, J.7    Deelen, P.8    Groen, H.J.9    Smolonska, A.10
  • 34
    • 70349462818 scopus 로고    scopus 로고
    • IgE-binding properties and selectivity of peptide mimics of the FcvarepsilonRI binding site
    • 34 Sandomenico, A., Monti, S.M., Marasco, D., Dathan, N., Palumbo, R., Saviano, M., Ruvo, M., IgE-binding properties and selectivity of peptide mimics of the FcvarepsilonRI binding site. Mol. Immunol. 46 (2009), 3300–3309.
    • (2009) Mol. Immunol. , vol.46 , pp. 3300-3309
    • Sandomenico, A.1    Monti, S.M.2    Marasco, D.3    Dathan, N.4    Palumbo, R.5    Saviano, M.6    Ruvo, M.7
  • 36
    • 0031470237 scopus 로고    scopus 로고
    • Identification of contact residues in the IgE binding site of human FcepsilonRIalpha
    • 36 Cook, J.P., Henry, A.J., McDonnell, J.M., Owens, R.J., Sutton, B.J., Gould, H.J., Identification of contact residues in the IgE binding site of human FcepsilonRIalpha. Biochemistry 36 (1997), 15579–15588.
    • (1997) Biochemistry , vol.36 , pp. 15579-15588
    • Cook, J.P.1    Henry, A.J.2    McDonnell, J.M.3    Owens, R.J.4    Sutton, B.J.5    Gould, H.J.6
  • 37
    • 0032969286 scopus 로고    scopus 로고
    • The crystal structure of the human high-affinity IgE receptor (Fc epsilon RI alpha)
    • 37 Garman, S.C., Kinet, J.P., Jardetzky, T.S., The crystal structure of the human high-affinity IgE receptor (Fc epsilon RI alpha). Annu. Rev. Immunol. 17 (1999), 973–976.
    • (1999) Annu. Rev. Immunol. , vol.17 , pp. 973-976
    • Garman, S.C.1    Kinet, J.P.2    Jardetzky, T.S.3
  • 39
    • 79959812503 scopus 로고    scopus 로고
    • Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT)
    • 39 Reiner, A.P., Lettre, G., Nalls, M.A., Ganesh, S.K., Mathias, R., Austin, M.A., Dean, E., Arepalli, S., Britton, A., Chen, Z., et al. Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT). PLoS Genet., 7, 2011, e1002108.
    • (2011) PLoS Genet. , vol.7 , pp. e1002108
    • Reiner, A.P.1    Lettre, G.2    Nalls, M.A.3    Ganesh, S.K.4    Mathias, R.5    Austin, M.A.6    Dean, E.7    Arepalli, S.8    Britton, A.9    Chen, Z.10
  • 40
    • 84904697807 scopus 로고    scopus 로고
    • Platelets and allergic inflammation
    • 40 Page, C., Pitchford, S., Platelets and allergic inflammation. Clin. Exp. Allergy 44 (2014), 901–913.
    • (2014) Clin. Exp. Allergy , vol.44 , pp. 901-913
    • Page, C.1    Pitchford, S.2
  • 41
    • 0038620337 scopus 로고    scopus 로고
    • IQGAP2 functions as a GTP-dependent effector protein in thrombin-induced platelet cytoskeletal reorganization
    • 41 Schmidt, V.A., Scudder, L., Devoe, C.E., Bernards, A., Cupit, L.D., Bahou, W.F., IQGAP2 functions as a GTP-dependent effector protein in thrombin-induced platelet cytoskeletal reorganization. Blood 101 (2003), 3021–3028.
    • (2003) Blood , vol.101 , pp. 3021-3028
    • Schmidt, V.A.1    Scudder, L.2    Devoe, C.E.3    Bernards, A.4    Cupit, L.D.5    Bahou, W.F.6
  • 43
    • 81755178910 scopus 로고    scopus 로고
    • Glanzmann thrombasthenia-like syndromes associated with macrothrombocytopenias and mutations in the genes encoding the αIIbβ3 integrin
    • 43 Nurden, A.T., Pillois, X., Fiore, M., Heilig, R., Nurden, P., Glanzmann thrombasthenia-like syndromes associated with macrothrombocytopenias and mutations in the genes encoding the αIIbβ3 integrin. Semin. Thromb. Hemost. 37 (2011), 698–706.
    • (2011) Semin. Thromb. Hemost. , vol.37 , pp. 698-706
    • Nurden, A.T.1    Pillois, X.2    Fiore, M.3    Heilig, R.4    Nurden, P.5
  • 49
    • 33846900261 scopus 로고    scopus 로고
    • Altered expression and endocytic function of CD205 in human dendritic cells, and detection of a CD205-DCL-1 fusion protein upon dendritic cell maturation
    • 49 Butler, M., Morel, A.S., Jordan, W.J., Eren, E., Hue, S., Shrimpton, R.E., Ritter, M.A., Altered expression and endocytic function of CD205 in human dendritic cells, and detection of a CD205-DCL-1 fusion protein upon dendritic cell maturation. Immunology 120 (2007), 362–371.
    • (2007) Immunology , vol.120 , pp. 362-371
    • Butler, M.1    Morel, A.S.2    Jordan, W.J.3    Eren, E.4    Hue, S.5    Shrimpton, R.E.6    Ritter, M.A.7
  • 50
    • 84931275201 scopus 로고    scopus 로고
    • pH-dependent recognition of apoptotic and necrotic cells by the human dendritic cell receptor DEC205
    • 50 Cao, L., Shi, X., Chang, H., Zhang, Q., He, Y., pH-dependent recognition of apoptotic and necrotic cells by the human dendritic cell receptor DEC205. Proc. Natl. Acad. Sci. USA 112 (2015), 7237–7242.
    • (2015) Proc. Natl. Acad. Sci. USA , vol.112 , pp. 7237-7242
    • Cao, L.1    Shi, X.2    Chang, H.3    Zhang, Q.4    He, Y.5
  • 51
    • 0017848247 scopus 로고
    • Heterogeneity of human platelets. VI. Correlation of platelet function with platelet volume
    • 51 Karpatkin, S., Heterogeneity of human platelets. VI. Correlation of platelet function with platelet volume. Blood 51 (1978), 307–316.
    • (1978) Blood , vol.51 , pp. 307-316
    • Karpatkin, S.1
  • 53
    • 18244396105 scopus 로고    scopus 로고
    • Platelet homeostasis is regulated by platelet expression of CD47 under normal conditions and in passive immune thrombocytopenia
    • 53 Olsson, M., Bruhns, P., Frazier, W.A., Ravetch, J.V., Oldenborg, P.A., Platelet homeostasis is regulated by platelet expression of CD47 under normal conditions and in passive immune thrombocytopenia. Blood 105 (2005), 3577–3582.
    • (2005) Blood , vol.105 , pp. 3577-3582
    • Olsson, M.1    Bruhns, P.2    Frazier, W.A.3    Ravetch, J.V.4    Oldenborg, P.A.5
  • 57
    • 84956932581 scopus 로고    scopus 로고
    • Replication and hematological characterization of human platelet reactivity genetic associations in men from the Caerphilly Prospective Study (CaPS)
    • 57 Eicher, J.D., Xue, L., Ben-Shlomo, Y., Beswick, A.D., Johnson, A.D., Replication and hematological characterization of human platelet reactivity genetic associations in men from the Caerphilly Prospective Study (CaPS). J. Thromb. Thrombolysis 41 (2016), 343–350.
    • (2016) J. Thromb. Thrombolysis , vol.41 , pp. 343-350
    • Eicher, J.D.1    Xue, L.2    Ben-Shlomo, Y.3    Beswick, A.D.4    Johnson, A.D.5
  • 58
    • 79960044081 scopus 로고    scopus 로고
    • Regulation and function of the RasGRP family of Ras activators in blood cells
    • 58 Stone, J.C., Regulation and function of the RasGRP family of Ras activators in blood cells. Genes Cancer 2 (2011), 320–334.
    • (2011) Genes Cancer , vol.2 , pp. 320-334
    • Stone, J.C.1
  • 59
    • 0032974078 scopus 로고    scopus 로고
    • A role for changes in platelet production in the cause of acute coronary syndromes
    • 59 van der Loo, B., Martin, J.F., A role for changes in platelet production in the cause of acute coronary syndromes. Arterioscler. Thromb. Vasc. Biol. 19 (1999), 672–679.
    • (1999) Arterioscler. Thromb. Vasc. Biol. , vol.19 , pp. 672-679
    • van der Loo, B.1    Martin, J.F.2
  • 63
    • 84930040363 scopus 로고    scopus 로고
    • Cardiovascular correlates of platelet count and volume in the Framingham Heart Study
    • 63 Sloan, A., Gona, P., Johnson, A.D., Cardiovascular correlates of platelet count and volume in the Framingham Heart Study. Ann. Epidemiol. 25 (2015), 492–498.
    • (2015) Ann. Epidemiol. , vol.25 , pp. 492-498
    • Sloan, A.1    Gona, P.2    Johnson, A.D.3
  • 65
    • 78650985681 scopus 로고    scopus 로고
    • Determinants of platelet count in humans
    • 65 Daly, M.E., Determinants of platelet count in humans. Haematologica 96 (2011), 10–13.
    • (2011) Haematologica , vol.96 , pp. 10-13
    • Daly, M.E.1
  • 66
    • 84931561183 scopus 로고    scopus 로고
    • PIAS-like protein Zimp7 is required for the restriction of the zebrafish organizer and mesoderm development
    • 66 Moreno-Ayala, R., Schnabel, D., Salas-Vidal, E., Lomelí, H., PIAS-like protein Zimp7 is required for the restriction of the zebrafish organizer and mesoderm development. Dev. Biol. 403 (2015), 89–100.
    • (2015) Dev. Biol. , vol.403 , pp. 89-100
    • Moreno-Ayala, R.1    Schnabel, D.2    Salas-Vidal, E.3    Lomelí, H.4
  • 67
    • 77951243909 scopus 로고    scopus 로고
    • A novel role for protein inhibitor of activated STAT (PIAS) proteins in modulating the activity of Zimp7, a novel PIAS-like protein, in androgen receptor-mediated transcription
    • 67 Peng, Y., Lee, J., Zhu, C., Sun, Z., A novel role for protein inhibitor of activated STAT (PIAS) proteins in modulating the activity of Zimp7, a novel PIAS-like protein, in androgen receptor-mediated transcription. J. Biol. Chem. 285 (2010), 11465–11475.
    • (2010) J. Biol. Chem. , vol.285 , pp. 11465-11475
    • Peng, Y.1    Lee, J.2    Zhu, C.3    Sun, Z.4
  • 68
    • 84925068250 scopus 로고    scopus 로고
    • Mutations in the microtubule-associated protein 1A (Map1a) gene cause Purkinje cell degeneration
    • 68 Liu, Y., Lee, J.W., Ackerman, S.L., Mutations in the microtubule-associated protein 1A (Map1a) gene cause Purkinje cell degeneration. J. Neurosci. 35 (2015), 4587–4598.
    • (2015) J. Neurosci. , vol.35 , pp. 4587-4598
    • Liu, Y.1    Lee, J.W.2    Ackerman, S.L.3
  • 72
    • 84887008398 scopus 로고    scopus 로고
    • The large non-coding RNA ANRIL, which is associated with atherosclerosis, periodontitis and several forms of cancer, regulates ADIPOR1, VAMP3 and C11ORF10
    • 72 Bochenek, G., Häsler, R., El Mokhtari, N.E., König, I.R., Loos, B.G., Jepsen, S., Rosenstiel, P., Schreiber, S., Schaefer, A.S., The large non-coding RNA ANRIL, which is associated with atherosclerosis, periodontitis and several forms of cancer, regulates ADIPOR1, VAMP3 and C11ORF10. Hum. Mol. Genet. 22 (2013), 4516–4527.
    • (2013) Hum. Mol. Genet. , vol.22 , pp. 4516-4527
    • Bochenek, G.1    Häsler, R.2    El Mokhtari, N.E.3    König, I.R.4    Loos, B.G.5    Jepsen, S.6    Rosenstiel, P.7    Schreiber, S.8    Schaefer, A.S.9
  • 74
    • 77952978623 scopus 로고    scopus 로고
    • Hypercholesterolemia promotes bone marrow cell mobilization by perturbing the SDF-1:CXCR4 axis
    • 74 Gomes, A.L., Carvalho, T., Serpa, J., Torre, C., Dias, S., Hypercholesterolemia promotes bone marrow cell mobilization by perturbing the SDF-1:CXCR4 axis. Blood 115 (2010), 3886–3894.
    • (2010) Blood , vol.115 , pp. 3886-3894
    • Gomes, A.L.1    Carvalho, T.2    Serpa, J.3    Torre, C.4    Dias, S.5
  • 75
    • 33749991315 scopus 로고    scopus 로고
    • Clinical and molecular genetic analysis of a family with sitosterolemia and co-existing erythrocyte and platelet abnormalities
    • 75 Su, Y., Wang, Z., Yang, H., Cao, L., Liu, F., Bai, X., Ruan, C., Clinical and molecular genetic analysis of a family with sitosterolemia and co-existing erythrocyte and platelet abnormalities. Haematologica 91 (2006), 1392–1395.
    • (2006) Haematologica , vol.91 , pp. 1392-1395
    • Su, Y.1    Wang, Z.2    Yang, H.3    Cao, L.4    Liu, F.5    Bai, X.6    Ruan, C.7
  • 76
    • 84896813122 scopus 로고    scopus 로고
    • Specific macrothrombocytopenia/hemolytic anemia associated with sitosterolemia
    • 76 Wang, Z., Cao, L., Su, Y., Wang, G., Wang, R., Yu, Z., Bai, X., Ruan, C., Specific macrothrombocytopenia/hemolytic anemia associated with sitosterolemia. Am. J. Hematol. 89 (2014), 320–324.
    • (2014) Am. J. Hematol. , vol.89 , pp. 320-324
    • Wang, Z.1    Cao, L.2    Su, Y.3    Wang, G.4    Wang, R.5    Yu, Z.6    Bai, X.7    Ruan, C.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.