Cell entry of porcine epidemic diarrhea coronavirus is activated by lysosomal proteases

Journal of Biological Chemistry

Volumn 291, Issue 47, 2016, Pages 24779-24786

  Liu, Chang ^a   Ma, Yuanmei ^b   Yang, Yang ^a   Zheng, Yuan ^a   Shang, Jian ^a   Zhou, Yusen ^c   Jiang, Shibo ^d,e   Du, Lanying ^d   Li, Jianrong ^b   Li, Fang ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^d NEW YORK BLOOD CENTER   (United States)

^e FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACCIDENT PREVENTION; AMINO ACIDS; CELL MEMBRANES; PROTEINS; VIRUSES;

CELL SURFACES; CORONAVIRUSES; CYSTEINE PROTEASE; EXTRACELLULAR; FATALITY RATES; MOLECULAR MECHANISM; SERINE PROTEASE; SPIKE PROTEIN;

ENZYME ACTIVITY;

ALOXISTATIN; BAFILOMYCIN A1; CATHEPSIN B; CATHEPSIN L; CYSTEINE PROTEINASE; PROTEINASE; SERINE PROTEINASE; TRYPSIN; CORONAVIRUS SPIKE GLYCOPROTEIN; CTSB PROTEIN, HUMAN; CTSL1 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CORONAVIRIDAE; CYTOTOXICITY; DOSE RESPONSE; EMBRYO; ENDOCYTOSIS; HUMAN; HUMAN CELL; NONHUMAN; PORCINE EPIDEMIC DIARRHEA CORONAVIRUS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN FUNCTION; VIRUS ACTIVATION; VIRUS ENTRY; VIRUS INFECTION; VIRUS REPLICATION; ANIMAL; CELL LINE; ENZYMOLOGY; LYSOSOME; METABOLISM; PHYSIOLOGY; PIG; PORCINE EPIDEMIC DIARRHEA VIRUS; VIROLOGY;

ANIMALS; CATHEPSIN B; CATHEPSIN L; CELL LINE; HUMANS; LYSOSOMES; PORCINE EPIDEMIC DIARRHEA VIRUS; SPIKE GLYCOPROTEIN, CORONAVIRUS; SWINE; VIRUS INTERNALIZATION;

EID: 84995747398     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.740746     Document Type: Article

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