BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 46, 2016, Pages 13057-13062

  Hayashi, Yohei ^a,b   Hsiao, Edward C ^c   Sami, Salma ^a   Lancero, Mariselle ^a   Schlieve, Christopher R ^a,d   Nguyen, Trieu ^a   Yano, Koyori ^e   Nagahashi, Ayako ^e   Ikeya, Makoto ^e   Matsumoto, Yoshihisa ^e,f,g   Nishimura, Ken ^b   Fukuda, Aya ^b   Hisatake, Koji ^b   Tomoda, Kiichiro ^a   Asaka, Isao ^e   Toguchida, Junya ^e,f,h   Conklin, Bruce R ^a,c   Yamanaka, Shinya ^a,e  

^a GLADSTONE INSTITUTE OF CARDIOVASCULAR DISEASE   (United States)

^b UNIVERSITY OF TSUKUBA   (Japan)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d CHILDREN S HOSPITAL LOS ANGELES   (United States)

^e KYOTO UNIVERSITY   (Japan)

^f KYOTO UNIVERSITY   (Japan)

^g NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^h KYOTO UNIVERSITY   (Japan)

Author keywords

BMP; FOP; Pluripotency; Reprogramming; Senescence

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; RECOMBINANT BONE MORPHOGENETIC PROTEIN 4; SMAD PROTEIN; ACTIVIN RECEPTOR 1; ACVR1 PROTEIN, HUMAN; BONE MORPHOGENETIC PROTEIN;

ARTICLE; CONTROLLED STUDY; FIBROBLAST; FIBRODYSPLASIA OSSIFICANS PROGRESSIVA; GENE; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; NUCLEAR REPROGRAMMING; OSSIFYING MYOSITIS; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; SENESCENCE; SIGNAL TRANSDUCTION; ADOLESCENT; ADULT; ANIMAL; CELL AGING; CELL LINE; CHILD; CYTOLOGY; FEMALE; GENETICS; INDUCED PLURIPOTENT STEM CELL; MALE; METABOLISM; MIDDLE AGED; MUTATION; TRANSGENIC MOUSE;

ACTIVIN RECEPTORS, TYPE I; ADOLESCENT; ADULT; ANIMALS; BONE MORPHOGENETIC PROTEINS; CELL LINE; CELLULAR REPROGRAMMING; CELLULAR SENESCENCE; CHILD; CYCLIN-DEPENDENT KINASE INHIBITOR P16; FEMALE; FIBROBLASTS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MALE; MICE, TRANSGENIC; MIDDLE AGED; MUTATION; MYOSITIS OSSIFICANS; SIGNAL TRANSDUCTION; SMAD PROTEINS;

EID: 84995698722     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1603668113     Document Type: Article

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