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Volumn 6, Issue , 2016, Pages

Aflibercept and Ang1 supplementation improve neoadjuvant or adjuvant chemotherapy in a preclinical model of resectable breast cancer

Author keywords

[No Author keywords available]

Indexed keywords

AFLIBERCEPT; ANGIOPOIETIN 1; ANGPT1 PROTEIN, HUMAN; HYBRID PROTEIN; VASCULOTROPIN RECEPTOR;

EID: 84995400193     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep36694     Document Type: Article
Times cited : (14)

References (54)
  • 1
    • 84989159343 scopus 로고    scopus 로고
    • Antiangiogenic therapy in oncology: Current status and future directions
    • Jayson, G. C., Kerbel, R., Ellis, L. M. & Harris, A. L. Antiangiogenic therapy in oncology: current status and future directions. Lancet 388, 518-529 (2016).
    • (2016) Lancet , vol.388 , pp. 518-529
    • Jayson, G.C.1    Kerbel, R.2    Ellis, L.M.3    Harris, A.L.4
  • 2
    • 80054864382 scopus 로고    scopus 로고
    • Reappraising antiangiogenic therapy for breast cancer
    • Kerbel, R. S. Reappraising antiangiogenic therapy for breast cancer. Breast 20, S56-S60 (2011).
    • (2011) Breast , vol.20 , pp. S56-S60
    • Kerbel, R.S.1
  • 3
    • 84856263234 scopus 로고    scopus 로고
    • Fighting fire with fire: Rekindling the bevacizumab debate
    • Montero, A. J. & Vogel, C. Fighting fire with fire: rekindling the bevacizumab debate. N. Engl. J. Med. 366, 374-375 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , pp. 374-375
    • Montero, A.J.1    Vogel, C.2
  • 4
    • 84940600482 scopus 로고    scopus 로고
    • Bevacizumab: No comeback in early breast cancer?
    • Bartsch, R., Gnant, M. & Steger, G. G. Bevacizumab: no comeback in early breast cancer? Lancet Oncol. 16, 1001 1003 (2015).
    • (2015) Lancet Oncol. , vol.16 , pp. 1001-1003
    • Bartsch, R.1    Gnant, M.2    Steger, G.G.3
  • 5
    • 84984754122 scopus 로고    scopus 로고
    • Antiangiogenic therapy: Impact on invasion, disease progression, and metastasis
    • Ebos, J. M. & Kerbel, R. S. Antiangiogenic therapy: impact on invasion, disease progression, and metastasis. Nat. Rev. Clin. Oncol. 8, 210-221 (2011).
    • (2011) Nat. Rev. Clin. Oncol. , vol.8 , pp. 210-221
    • Ebos, J.M.1    Kerbel, R.S.2
  • 6
    • 37549040613 scopus 로고    scopus 로고
    • Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
    • Miller, K. et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N. Engl. J. Med. 357, 2666-2676 (2007).
    • (2007) N. Engl. J. Med. , vol.357 , pp. 2666-2676
    • Miller, K.1
  • 7
    • 77954700380 scopus 로고    scopus 로고
    • Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the first-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer
    • Miles, D. W. et al. Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the first-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer. J. Clin. Oncol. 28, 3239-3247 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 3239-3247
    • Miles, D.W.1
  • 8
    • 79953874259 scopus 로고    scopus 로고
    • RIBBON-1: Randomized, double-blind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor 2-negative, locally recurrent or metastatic breast cancer
    • Robert, N. J. et al. RIBBON-1: randomized, double-blind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor 2-negative, locally recurrent or metastatic breast cancer. J. Clin. Oncol. 29, 1252-1260 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , pp. 1252-1260
    • Robert, N.J.1
  • 9
    • 84908126746 scopus 로고    scopus 로고
    • Bevacizumab plus chemotherapy versus chemotherapy alone as second-line treatment for patients with HER2-negative locally recurrent or metastatic breast cancer after first-line treatment with bevacizumab plus chemotherapy (TANIA): An open-label, randomised phase 3 trial
    • von Minckwitz, G. et al. Bevacizumab plus chemotherapy versus chemotherapy alone as second-line treatment for patients with HER2-negative locally recurrent or metastatic breast cancer after first-line treatment with bevacizumab plus chemotherapy (TANIA): an open-label, randomised phase 3 trial. Lancet Oncol. 15, 1269-1278 (2014).
    • (2014) Lancet Oncol. , vol.15 , pp. 1269-1278
    • Von Minckwitz, G.1
  • 10
    • 84856291930 scopus 로고    scopus 로고
    • Neoadjuvant chemotherapy and bevacizumab for HER2-negative breast cancer
    • von Minckwitz, G. et al. Neoadjuvant chemotherapy and bevacizumab for HER2-negative breast cancer. N. Engl. J. Med. 366, 299-309 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , pp. 299-309
    • Von Minckwitz, G.1
  • 11
    • 84856253589 scopus 로고    scopus 로고
    • Bevacizumab added to neoadjuvant chemotherapy for breast cancer
    • Bear, H. D. et al. Bevacizumab added to neoadjuvant chemotherapy for breast cancer. N. Engl. J. Med. 366, 310-320 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , pp. 310-320
    • Bear, H.D.1
  • 12
    • 84930273565 scopus 로고    scopus 로고
    • Efficacy of neoadjuvant bevacizumab added to docetaxel followed by fluorouracil, epirubicin, and cyclophosphamide, for women with HER2-negative early breast cancer (ARTemis): An open-label, randomised, phase 3 trial
    • Earl, H. M. et al. Efficacy of neoadjuvant bevacizumab added to docetaxel followed by fluorouracil, epirubicin, and cyclophosphamide, for women with HER2-negative early breast cancer (ARTemis): an open-label, randomised, phase 3 trial. Lancet Oncol. 16, 656-666 (2015).
    • (2015) Lancet Oncol. , vol.16 , pp. 656-666
    • Earl, H.M.1
  • 13
    • 84883050174 scopus 로고    scopus 로고
    • Adjuvant bevacizumab-containing therapy in triple-negative breast cancer (BEATRICE): Primary results of a randomised, phase 3 trial
    • Cameron, D. et al. Adjuvant bevacizumab-containing therapy in triple-negative breast cancer (BEATRICE): primary results of a randomised, phase 3 trial. Lancet Oncol. 14, 933-942 (2013).
    • (2013) Lancet Oncol. , vol.14 , pp. 933-942
    • Cameron, D.1
  • 14
    • 84920917423 scopus 로고    scopus 로고
    • Bevacizumab (Bv) in the adjuvant treatment of HER2-negative breast cancer: Final results from Eastern Cooperative Oncology Group E5103
    • [Abstract] In: 2014 ASCO Annual Meeting. (abstr 500)
    • Miller, K. et al. Bevacizumab (Bv) in the adjuvant treatment of HER2-negative breast cancer: Final results from Eastern Cooperative Oncology Group E5103. [Abstract] In: 2014 ASCO Annual Meeting. J Clin Oncol 32, 5s suppl., (abstr 500) (2014).
    • (2014) J Clin Oncol , vol.32 , Issue.5 S
    • Miller, K.1
  • 15
    • 84899906863 scopus 로고    scopus 로고
    • Primary results from BETH, a phase 3 controlled study of adjuvant chemotherapy and trastuzumab ± bevacizumab in patients with HER2-positive, node-positive or high risk node-negative breast cancer
    • [Abstract] In: 2013 San Antonio Breast Cancer Symposium. (abstr S1-03)
    • Slamon, D. J. et al. Primary results from BETH, a phase 3 controlled study of adjuvant chemotherapy and trastuzumab ± bevacizumab in patients with HER2-positive, node-positive or high risk node-negative breast cancer. [Abstract] In: 2013 San Antonio Breast Cancer Symposium. Cancer Res 73, (abstr S1-03) (2013).
    • (2013) Cancer Res , vol.73
    • Slamon, D.J.1
  • 16
    • 84940606731 scopus 로고    scopus 로고
    • Neoadjuvant plus adjuvant bevacizumab in early breast cancer (NSABP B-40 [NRG Oncology]): Secondary outcomes of a phase 3, randomised controlled trial
    • Bear, H. D. et al. Neoadjuvant plus adjuvant bevacizumab in early breast cancer (NSABP B-40 [NRG Oncology]): secondary outcomes of a phase 3, randomised controlled trial. Lancet Oncol. 16, 1037-1048 (2015).
    • (2015) Lancet Oncol. , vol.16 , pp. 1037-1048
    • Bear, H.D.1
  • 17
    • 33645744835 scopus 로고    scopus 로고
    • Highly efficacious nontoxic preclinical treatment for advanced metastatic breast cancer using combination oral UFT-cyclophosphamide metronomic chemotherapy
    • Munoz, R. et al. Highly efficacious nontoxic preclinical treatment for advanced metastatic breast cancer using combination oral UFT-cyclophosphamide metronomic chemotherapy. Cancer Res. 66, 3386-3391 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 3386-3391
    • Munoz, R.1
  • 18
    • 36148954658 scopus 로고    scopus 로고
    • On the development of models in mice of advanced visceral metastatic disease for anti-cancer drug testing
    • Man, S., Munoz, R. & Kerbel, R. S. On the development of models in mice of advanced visceral metastatic disease for anti-cancer drug testing. Cancer Metastasis Rev. 26, 737-747 (2007).
    • (2007) Cancer Metastasis Rev. , vol.26 , pp. 737-747
    • Man, S.1    Munoz, R.2    Kerbel, R.S.3
  • 19
    • 60649087564 scopus 로고    scopus 로고
    • Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
    • Ebos, J. M. et al. Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell. 15, 232-239 (2009).
    • (2009) Cancer Cell. , vol.15 , pp. 232-239
    • Ebos, J.M.1
  • 20
    • 85003028819 scopus 로고    scopus 로고
    • Efficacy of co-targeting Angiopoietin-2 and the VEGF pathway in the adjuvant postsurgical setting for early breast, colorectal and renal cancers
    • CAN-16-0888 (published online, Sep 20)
    • Wu, F. T. H. et al. Efficacy of co-targeting Angiopoietin-2 and the VEGF pathway in the adjuvant postsurgical setting for early breast, colorectal and renal cancers. Cancer Res, doi: 10.1158/0008-5472. CAN-16-0888 (published online, 2016 Sep 20).
    • (2016) Cancer Res
    • Wu, F.T.H.1
  • 21
    • 84877746890 scopus 로고    scopus 로고
    • A model of postsurgical advanced metastatic breast cancer more accurately replicates the clinical efficacy of antiangiogenic drugs
    • Guerin, E., Man, S., Xu, P. & Kerbel, R. S. A model of postsurgical advanced metastatic breast cancer more accurately replicates the clinical efficacy of antiangiogenic drugs. Cancer Res. 73, 2743-2748 (2013).
    • (2013) Cancer Res. , vol.73 , pp. 2743-2748
    • Guerin, E.1    Man, S.2    Xu, P.3    Kerbel, R.S.4
  • 22
    • 84918578552 scopus 로고    scopus 로고
    • Neoadjuvant antiangiogenic therapy reveals contrasts in primary and metastatic tumor efficacy
    • Ebos, J. M. et al. Neoadjuvant antiangiogenic therapy reveals contrasts in primary and metastatic tumor efficacy. EMBO Mol. Med. 6, 1561-1576 (2014).
    • (2014) EMBO Mol. Med. , vol.6 , pp. 1561-1576
    • Ebos, J.M.1
  • 23
    • 84938657323 scopus 로고    scopus 로고
    • Potential pro-invasive or metastatic effects of preclinical antiangiogenic therapy are prevented by concurrent chemotherapy
    • Paez-Ribes, M., Man, S., Xu, P. & Kerbel, R. S. Potential Pro-invasive or Metastatic Effects of Preclinical Antiangiogenic Therapy Are Prevented by Concurrent Chemotherapy. Clin. Cancer Res. 21, 5488-5498 (2015).
    • (2015) Clin. Cancer Res. , vol.21 , pp. 5488-5498
    • Paez-Ribes, M.1    Man, S.2    Xu, P.3    Kerbel, R.S.4
  • 24
    • 84942115515 scopus 로고    scopus 로고
    • Amgen's angiopoietin blocker fails in ovarian cancer
    • Sheridan, C. Amgen's angiopoietin blocker fails in ovarian cancer. Nat. Biotechnol. 33, 5-6 (2015).
    • (2015) Nat. Biotechnol. , vol.33 , pp. 5-6
    • Sheridan, C.1
  • 25
    • 84937641865 scopus 로고    scopus 로고
    • Trebananib (AMG 386) plus weekly paclitaxel with or without bevacizumab as first-line therapy for HER2-negative locally recurrent or metastatic breast cancer: A phase 2 randomized study
    • Dieras, V. et al. Trebananib (AMG 386) plus weekly paclitaxel with or without bevacizumab as first-line therapy for HER2-negative locally recurrent or metastatic breast cancer: A phase 2 randomized study. Breast 24, 182-190 (2015).
    • (2015) Breast , vol.24 , pp. 182-190
    • Dieras, V.1
  • 26
    • 77954890371 scopus 로고    scopus 로고
    • Targeting the ANGPT-TIE2 pathway in malignancy
    • Huang, H., Bhat, A., Woodnutt, G. & Lappe, R. Targeting the ANGPT-TIE2 pathway in malignancy. Nat. Rev. Cancer. 10, 575-585 (2010).
    • (2010) Nat. Rev. Cancer. , vol.10 , pp. 575-585
    • Huang, H.1    Bhat, A.2    Woodnutt, G.3    Lappe, R.4
  • 27
    • 84957837077 scopus 로고    scopus 로고
    • Biomarkers of residual disease after neoadjuvant therapy for breast cancer
    • Penault-Llorca, F. & Radosevic-Robin, N. Biomarkers of residual disease after neoadjuvant therapy for breast cancer. Nat. Rev. Clin. Oncol. (2016).
    • (2016) Nat. Rev. Clin. Oncol.
    • Penault-Llorca, F.1    Radosevic-Robin, N.2
  • 28
    • 84873328631 scopus 로고    scopus 로고
    • Bevacizumab in stage II-III colon cancer: 5-year update of the National Surgical adjuvant breast and bowel project C-08 trial
    • Allegra, C. J. et al. Bevacizumab in stage II-III colon cancer: 5-year update of the National Surgical Adjuvant Breast and Bowel Project C-08 trial. J. Clin. Oncol. 31, 359-364 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , pp. 359-364
    • Allegra, C.J.1
  • 29
    • 84870244259 scopus 로고    scopus 로고
    • Bevacizumab plus oxaliplatin-based chemotherapy as adjuvant treatment for colon cancer (AVANT): A phase 3 randomised controlled trial
    • de Gramont, A. et al. Bevacizumab plus oxaliplatin-based chemotherapy as adjuvant treatment for colon cancer (AVANT): a phase 3 randomised controlled trial. Lancet Oncol. 13, 1225-1233 (2012).
    • (2012) Lancet Oncol. , vol.13 , pp. 1225-1233
    • De Gramont, A.1
  • 30
    • 84959932876 scopus 로고    scopus 로고
    • Adjuvant sunitinib or sorafenib for high-risk, non-metastatic renal-cell carcinoma (ECOG-ACRIN E2805): A double-blind, placebo-controlled, randomised, phase 3 trial
    • Haas, N. B. et al. Adjuvant sunitinib or sorafenib for high-risk, non-metastatic renal-cell carcinoma (ECOG-ACRIN E2805): a double-blind, placebo-controlled, randomised, phase 3 trial. Lancet 387, 2008-2016 (2016).
    • (2016) Lancet , vol.387 , pp. 2008-2016
    • Haas, N.B.1
  • 31
    • 0037143764 scopus 로고    scopus 로고
    • VEGF-Trap: A VEGF blocker with potent antitumor effects
    • Holash, J. et al. VEGF-Trap: a VEGF blocker with potent antitumor effects. Proc. Natl. Acad. Sci. USA. 99, 11393-11398 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 11393-11398
    • Holash, J.1
  • 32
    • 66149086950 scopus 로고    scopus 로고
    • Positive and negative modulation of angiogenesis by VEGFR1 ligands
    • Cao, Y. Positive and negative modulation of angiogenesis by VEGFR1 ligands. Sci. Signal. 2, re1 (2009).
    • (2009) Sci. Signal. , vol.2 , pp. re1
    • Cao, Y.1
  • 33
    • 84942306942 scopus 로고    scopus 로고
    • VEGFR-1 pseudogene expression and regulatory function in human colorectal cancer cells
    • Ye, X. et al. VEGFR-1 Pseudogene Expression and Regulatory Function in Human Colorectal Cancer Cells. Mol. Cancer. Res. 13, 1274-1282 (2015).
    • (2015) Mol. Cancer. Res. , vol.13 , pp. 1274-1282
    • Ye, X.1
  • 34
    • 84961145493 scopus 로고    scopus 로고
    • FLT1 signaling in metastasis-associated macrophages activates an inflammatory signature that promotes breast cancer metastasis
    • Qian, B. Z. et al. FLT1 signaling in metastasis-associated macrophages activates an inflammatory signature that promotes breast cancer metastasis. J. Exp. Med. 212, 1433-1448 (2015).
    • (2015) J. Exp. Med. , vol.212 , pp. 1433-1448
    • Qian, B.Z.1
  • 35
    • 84995491674 scopus 로고    scopus 로고
    • Blockade of angiopoietin-2 or Tie2 is equally effective at inhibiting tumor growth and reducing tumor vessel density in most human tumor xenograft models
    • [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Abstract nr 4492
    • Adler, A. P. et al. Blockade of angiopoietin-2 or Tie2 is equally effective at inhibiting tumor growth and reducing tumor vessel density in most human tumor xenograft models. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Cancer Research 74 (19 Suppl), Abstract nr 4492 (2014).
    • (2014) Cancer Research , vol.74 , Issue.19
    • Adler, A.P.1
  • 36
    • 84919466750 scopus 로고    scopus 로고
    • Postsurgical adjuvant tumor therapy by combining anti-angiopoietin-2 and metronomic chemotherapy limits metastatic growth
    • Srivastava, K. et al. Postsurgical adjuvant tumor therapy by combining anti-angiopoietin-2 and metronomic chemotherapy limits metastatic growth. Cancer Cell. 26, 880-895 (2014).
    • (2014) Cancer Cell. , vol.26 , pp. 880-895
    • Srivastava, K.1
  • 37
    • 0034730784 scopus 로고    scopus 로고
    • Angiopoietin-1 is an antipermeability and anti-inflammatory agent in vitro and targets cell junctions
    • Gamble, J. R. et al. Angiopoietin-1 is an antipermeability and anti-inflammatory agent in vitro and targets cell junctions. Circ. Res. 87, 603-607 (2000).
    • (2000) Circ. Res. , vol.87 , pp. 603-607
    • Gamble, J.R.1
  • 38
    • 16644388788 scopus 로고    scopus 로고
    • The anti-inflammatory actions of angiopoietin-1
    • Thurston, G. et al. The anti-inflammatory actions of angiopoietin-1. EXS (94), 233-245 (2005).
    • (2005) EXS , Issue.94 , pp. 233-245
    • Thurston, G.1
  • 39
    • 37848998838 scopus 로고    scopus 로고
    • Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia
    • Gavard, J., Patel, V. & Gutkind, J. S. Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia. Dev. Cell. 14, 25-36 (2008).
    • (2008) Dev. Cell. , vol.14 , pp. 25-36
    • Gavard, J.1    Patel, V.2    Gutkind, J.S.3
  • 40
    • 84871954875 scopus 로고    scopus 로고
    • VEGF and Angiopoietin-1 exert opposing effects on cell junctions by regulating the Rho GEF Syx
    • Ngok, S. P. et al. VEGF and Angiopoietin-1 exert opposing effects on cell junctions by regulating the Rho GEF Syx. J. Cell Biol. 199, 1103-15 (2012).
    • (2012) J. Cell Biol. , vol.199 , pp. 1103-1115
    • Ngok, S.P.1
  • 41
    • 84871719489 scopus 로고    scopus 로고
    • Orchestral actions of angiopoietin-1 in vascular regeneration
    • Koh, G. Y. Orchestral actions of angiopoietin-1 in vascular regeneration. Trends Mol. Med. 19, 31-39 (2013).
    • (2013) Trends Mol. Med. , vol.19 , pp. 31-39
    • Koh, G.Y.1
  • 42
    • 0035866389 scopus 로고    scopus 로고
    • The effects of angiopoietin-1 and -2 on tumor growth and angiogenesis in human colon cancer
    • Ahmad, S. A. et al. The effects of angiopoietin-1 and -2 on tumor growth and angiogenesis in human colon cancer. Cancer Res. 61, 1255-1259 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 1255-1259
    • Ahmad, S.A.1
  • 43
    • 0038407310 scopus 로고    scopus 로고
    • Angiopoietin-1 inhibits vascular permeability, angiogenesis, and growth of hepatic colon cancer tumors
    • Stoeltzing, O. et al. Angiopoietin-1 inhibits vascular permeability, angiogenesis, and growth of hepatic colon cancer tumors. Cancer Res. 63, 3370-3377 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 3370-3377
    • Stoeltzing, O.1
  • 44
    • 0036112626 scopus 로고    scopus 로고
    • Activation of the tie2 receptor by angiopoietin-1 enhances tumor vessel maturation and impairs squamous cell carcinoma growth
    • Hawighorst, T. et al. Activation of the tie2 receptor by angiopoietin-1 enhances tumor vessel maturation and impairs squamous cell carcinoma growth. Am. J. Pathol. 160, 1381-1392 (2002).
    • (2002) Am. J. Pathol. , vol.160 , pp. 1381-1392
    • Hawighorst, T.1
  • 45
    • 0037065969 scopus 로고    scopus 로고
    • Stabilization of breast cancer xenograft tumour neovasculature by angiopoietin-1
    • Tian, S., Hayes, A. J., Metheny-Barlow, L. J. & Li, L. Y. Stabilization of breast cancer xenograft tumour neovasculature by angiopoietin-1. Br. J. Cancer 86, 645-651 (2002).
    • (2002) Br. J. Cancer , vol.86 , pp. 645-651
    • Tian, S.1    Hayes, A.J.2    Metheny-Barlow, L.J.3    Li, L.Y.4
  • 46
    • 0036405427 scopus 로고    scopus 로고
    • Angiopoietin 1 promotes tumor angiogenesis and tumor vessel plasticity of human cervical cancer in mice
    • Shim, W. S. et al. Angiopoietin 1 promotes tumor angiogenesis and tumor vessel plasticity of human cervical cancer in mice. Exp. Cell Res. 279, 299-309 (2002).
    • (2002) Exp. Cell Res. , vol.279 , pp. 299-309
    • Shim, W.S.1
  • 47
    • 7244229595 scopus 로고    scopus 로고
    • Angiopoietin-1 promotes tumor angiogenesis in a rat glioma model
    • Machein, M. R. et al. Angiopoietin-1 promotes tumor angiogenesis in a rat glioma model. Am. J. Pathol. 165, 1557-1570 (2004).
    • (2004) Am. J. Pathol. , vol.165 , pp. 1557-1570
    • Machein, M.R.1
  • 48
    • 66349133061 scopus 로고    scopus 로고
    • Angiopoietin-1 overexpression modulates vascular endothelium to facilitate tumor cell dissemination and metastasis establishment
    • Holopainen, T. et al. Angiopoietin-1 overexpression modulates vascular endothelium to facilitate tumor cell dissemination and metastasis establishment. Cancer Res. 69, 4656-4664 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 4656-4664
    • Holopainen, T.1
  • 49
    • 84871989305 scopus 로고    scopus 로고
    • Angiopoietin-2 functions as a tie2 agonist in tumor models, where it limits the effects of VEGF inhibition
    • Daly, C. et al. Angiopoietin-2 functions as a tie2 agonist in tumor models, where it limits the effects of VEGF inhibition. Cancer Res. 73, 108-118 (2013).
    • (2013) Cancer Res. , vol.73 , pp. 108-118
    • Daly, C.1
  • 50
    • 60749124285 scopus 로고    scopus 로고
    • Angiopoietin-1/Tie-2 activation contributes to vascular survival and tumor growth during VEGF blockade
    • Huang, J. et al. Angiopoietin-1/Tie-2 activation contributes to vascular survival and tumor growth during VEGF blockade. Int. J. Oncol. 34, 79-87 (2009).
    • (2009) Int. J. Oncol. , vol.34 , pp. 79-87
    • Huang, J.1
  • 51
    • 60649106195 scopus 로고    scopus 로고
    • Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
    • Paez-Ribes, M. et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell. 15, 220-231 (2009).
    • (2009) Cancer Cell. , vol.15 , pp. 220-231
    • Paez-Ribes, M.1
  • 52
    • 84865129521 scopus 로고    scopus 로고
    • Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab
    • Papadopoulos, N. et al. Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab. Angiogenesis 15, 171-185 (2012).
    • (2012) Angiogenesis , vol.15 , pp. 171-185
    • Papadopoulos, N.1
  • 53
    • 84962232352 scopus 로고    scopus 로고
    • A phase I first-in-human study of nesvacumab (REGN910), a fully human anti-angiopoietin-2 (Ang2) monoclonal antibody, in patients with advanced solid tumors
    • Papadopoulos, K. P. et al. A Phase I First-in-Human Study of Nesvacumab (REGN910), a Fully Human Anti-Angiopoietin-2 (Ang2) Monoclonal Antibody, in Patients with Advanced Solid Tumors. Clin. Cancer Res. 22, 1348-55 (2016).
    • (2016) Clin. Cancer Res. , vol.22 , pp. 1348-1355
    • Papadopoulos, K.P.1
  • 54
    • 0037219502 scopus 로고    scopus 로고
    • Angiopoietins have distinct modular domains essential for receptor binding, dimerization and superclustering
    • Davis, S. et al. Angiopoietins have distinct modular domains essential for receptor binding, dimerization and superclustering. Nat. Struct. Biol. 10, 38-44 (2003).
    • (2003) Nat. Struct. Biol. , vol.10 , pp. 38-44
    • Davis, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.