Blockade of NF-κB and MAPK pathways by ulinastatin attenuates wear particle-stimulated osteoclast differentiation in vitro and in vivo

Bioscience Reports

Volumn 36, Issue 5, 2016, Pages

  Ru, Jiang Ying ^a   Xu, Hai Dong ^b   Shi, Dai ^a   Pan, Jun Bo ^a   Pan, Xiao Jin ^a   Wang, Yan Fen ^a  

^a YANGZHOU UNIVERSITY   (China)

^b NANJING UNIVERSITY   (China)

Author keywords

Aseptic loosening (AL); Lipopolysaccharide (LPS); Mitogen activated protein kinase (MAPK); Nuclear factor kappa B (NF B); Osteoclast; Osteolysis; Polymethyl methacrylate (PMMA); Ulinastatin

Indexed keywords

CATHEPSIN K; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; POLY(METHYL METHACRYLATE); STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR; ULINASTATIN; GLYCOPROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PATHOGEN ASSOCIATED MOLECULAR PATTERN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE MASS; CELL COUNT; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE RELEASE; DISTAL FEMUR; DOWN REGULATION; ENZYME INHIBITION; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATORY CELL; MALE; MOUSE; NONHUMAN; OSTEOCLASTOGENESIS; OSTEOLYSIS; PROTEIN PHOSPHORYLATION; TRABECULAR BONE; ANIMAL; BIOSYNTHESIS; BONE DEVELOPMENT; CELL DIFFERENTIATION; CHEMICALLY INDUCED; DRUG EFFECTS; INFLAMMATION; OSTEOCLAST; PATHOLOGY; RAW 264.7 CELL LINE; SIGNAL TRANSDUCTION;

ANIMALS; CELL DIFFERENTIATION; GLYCOPROTEINS; INFLAMMATION; LIPOPOLYSACCHARIDES; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NF-KAPPA B; OSTEOCLASTS; OSTEOGENESIS; OSTEOLYSIS; PATHOGEN-ASSOCIATED MOLECULAR PATTERN MOLECULES; RAW 264.7 CELLS; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84995380187     PISSN: 01448463     EISSN: 15734935     Source Type: Journal    
DOI: 10.1042/BSR20160234     Document Type: Article

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