Antitumour activity of cordycepin in mice

Clinical and Experimental Pharmacology and Physiology

Volumn 31, Issue SUPPL.2, 2004, Pages

  Yoshikawa, Noriko ^a   Nakamura, Kazuki ^a   Yamaguchi, Yu ^a   Kagota, Satomi ^a   Shinozuka, Kazumasa ^a,b   Kunitomo, Masaru ^a,b  

^a Department of Pharmacology   (Japan)

^b MUKOGAWA WOMEN'S UNIVERSITY   (Japan)

Author keywords

Antitumour; B16 mouse melanoma cells; Cordycepin (3' deoxyadenosine)

Indexed keywords

ANTINEOPLASTIC AGENT; CORDYCEPIN; DEOXYADENOSINE DERIVATIVE;

ANIMAL; ARTICLE; C57BL MOUSE; CANCER TRANSPLANTATION; DRUG EFFECT; DRUG SCREENING; EXPERIMENTAL MELANOMA; FEMALE; MOUSE; PATHOLOGY; SKIN TUMOR; TUMOR CELL LINE; TUMOR VOLUME;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DEOXYADENOSINES; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; NEOPLASM TRANSPLANTATION; SKIN NEOPLASMS; TUMOR BURDEN;

EID: 28644450230     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2004.04108.x     Document Type: Article

References (8)

1. Nakamura K, Yamaguchi Y, Kagota S, Kwon YM, Shinozuka K, Kunitomo M. Inhibitory effect of Cordyceps sinensis on spontaneous liver metastasis of Lewis lung carcinoma and B16 melanoma cells in syngeneic mice. Jpn J. Pharmacol. 1999; 79: 335-41.DOI: 10.1254/jjp.79.335
2. Nakamura K, Konoha K, Yamaguchi Y, Kagota S, Shinozuka K, Kunitomo M. Combined effects of Cordyceps sinensis and Methotrexate on hematogenic lung metastasis in mice. Receptors Channels 2003; 9: 329-34.
3. Cunningham KG, Mason W, Spring FS, Hutchinson SA. Cordycepin, a metabolic product isolated from cultures of Cordyceps militaris (Linn.) Link. Nature 1950; 166: 949.
4. Kredich NM. Inhibition of nucleic acid methylation by cordycepin. In vivo synthesis of S-3'-deoxyadenosylmethionine by WI-L2 human lymphoblasts. J. Biol. Chem. 1980; 255: 7380-5.
5. Zeevi M, Nevins JR, Darnell JE. Nuclear RNA is spliced in the absence of poly (A) addition. Cell 1981; 26: 39-46.
6. Zhou X, Meyer CU, Schmidtke P, Zepp F. Effect of cordycepin on interleukin-10 production of human peripheral blood mononuclear cells. Eur. J. Pharmacol. 2002; 453: 309-17.DOI: 10.1016/S0014-2999(02)02359-2
7. Montefiori DC, Sobol RW, Li SW et al. Phosphorothioate and cordycepin analogues of 2', 5'-oligoadenylate. Inhibition of human immunodeficiency virus type 1 reverse transcriptase and infection in vitro. Proc. Natl. Acad. Sci. USA 1989; 86: 7191-4.
8. Müller WEG, Weiler BE, Charubala R et al. Cordycepin analogues of 2', 5'-oligoadenylate inhibit human immunodeficiency virus infection via inhibition of reverse transcriptase. Biochemistry 1991; 30: 2027-33.