Do hematopoietic stem cells get old?

Leukemia

Volumn 31, Issue 3, 2017, Pages 529-531

  Jung, J J ^a   Buisman, S C ^a   De Haan, G ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANEMIA; ARTERIOSCLEROSIS; CELL AGING; ERYTHROCYTE; GRANULOCYTE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; INTESTINAL STEM CELL; MACROPHAGE; MUSCLE STEM CELL; PRIORITY JOURNAL; PROGENY; REVIEW; AGE; AGING; ANIMAL; BLOOD; CYTOLOGY; DISEASE PREDISPOSITION;

AGE FACTORS; AGING; ANIMALS; DISEASE SUSCEPTIBILITY; HEMATOPOIETIC STEM CELLS; HUMANS;

EID: 84994784751     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2016.301     Document Type: Review

References (38)

1. Heron MAR. Changes in the leading cause of death: recent patterns in heart disease and cancer mortality. NCHS Data Brief 2016; 254.
2. Frasca D, Landin AM, Lechner SC, Ryan JG, Schwartz R, Riley RL, et al. Aging downregulates the transcription factor e2a, activation-induced cytidine deaminase, Ig class switch in human B cells. J Immunol 2008; 180: 5283-5290.
3. Goodwin K, Viboud C, Simonsen L. Antibody response to influenza vaccination in the elderly: a quantitative review. Vaccine 2006; 24: 1159-1169.
4. Tettamanti M, Lucca U, Gandini F, Recchia A, Mosconi P, Apolone G, et al. Prevalence, incidence and types of mild anemia in the elderly: the 'Health and Anemia' population-based study. Haematologica 2010; 95: 1849-1856.
5. Mosher KI, Wyss-Coray T. Microglial dysfunction in brain aging and Alzheimer's disease. Biochem Pharmacol 2014; 88: 594-604.
6. Harrison DE. Mouse erythropoietic stem cell lines function normally 100 months: loss related to number of transplantations. Mech Ageing Dev 1979; 9: 427-433.
7. Dykstra B, Olthof S, Schreuder J, Ritsema M, de Haan G. Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells. J Exp Med 2011; 208: 2691-2703.
8. Beerman I, Bhattacharya D, Zandi S, Sigvardsson M, Weissman IL, Bryder D, et al. Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion. Proc Natl Acad Sci 2010; 107: 5465-5470.
9. Walter D, Lier A, Geiselhart A, Thalheimer FB, Huntscha S, Sobotta MC, et al. Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells. Nature 2015; 520: 549-552.
10. Clevers H. The intestinal crypt, a prototype stem cell compartment. Cell 2013; 154: 274-284.
11. Brack AS, Conboy MJ, Roy S, Lee M, Kuo CJ, Keller C, et al. Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science 2007; 317: 807.
12. Rossi DJ, Bryder D, Zahn JM, Ahlenius H, Sonu R, Wagers AJ, et al. Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc Natl Acad Sci USA 2005; 102: 9194-9199.
13. Rozman C, Feliu E, Berga L, Reverter JC, Climent C, Ferran MJ. Age-related variations of fat tissue fraction in normal human bone marrow depend both on size and number of adipocytes: a stereological study. Exp Hematol 1989; 17: 34-37.
14. Birbrair A, Frenette PS. Niche heterogeneity in the bone marrow. Ann NY Acad Sci 2016; 1370: 82-96.
15. Busque L, Mio R, Mattioli J, Brais E, Blais N, Lalonde Y, et al. Nonrandom X-inactivation patterns in normal females: lyonization ratios vary with age. Blood 1996; 88: 59-65.
16. Genovese G, Kähler AK, Handsaker RE, Lindberg J, Rose SA, Bakhoum SF, et al. Clonal Hematopoiesis and blood-cancer risk inferred from blood DNA sequence. N Engl J Med 2014; 371: 2477-2487.
17. Xie M, Lu C, Wang J, McLellan MD, Johnson KJ, Wendl MC, et al. Age-related mutations associated with clonal hematopoietic expansion and malignancies. Nat Med 2014; 20: 1472-1478.
18. Jaiswal S, Fontanillas P, Flannick J, Manning A, Grauman PV, Mar BG, et al. Agerelated clonal hematopoiesis associated with adverse outcomes. N Engl J Med 2014; 371: 2488-2498.
19. Busque L, Patel JP, Figueroa ME, Vasanthakumar A, Provost S, Hamilou Z, et al. Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis. Nat Genet 2012; 44: 1179-1181.
20. van den Akker EB, Pitts SJ, Deelen J, Moed MH, Potluri S, van Rooij J, et al. Uncompromised 10-year survival of oldest old carrying somatic mutations in DNMT3A and TET2. Blood 2016; 127: 1512-1515.
21. Wahlestedt M, Norddahl GL, Sten G, Ugale A, Frisk M-AM, Mattsson R, et al. An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state. Blood 2013; 121: 4257-4264.
22. Beerman I, Seita J, Inlay MA, Weissman IL, Rossi DJ. Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle. Cell Stem Cell 2014; 15: 37-50.
23. Zhang S, Yajima H, Huynh H, Zheng J, Callen E, Chen H-T, et al. Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair. J Cell Biol 2011; 193: 295-305.
24. Salob SP, Webb DKH, Atherton DJ. A child with xeroderma pigmentosum and bone marrow failure. Br J Dermatol 1992; 126: 372-374.
25. Kamminga LM, Bystrykh LV, de Boer A, Houwer S, Douma J, Weersing E, et al. The Polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion. Blood 2006; 107: 2170-2179.
26. Rizo A, Olthof S, Han L, Vellenga E, de Haan G, Schuringa JJ. Repression of BMI1 in normal and leukemic human CD34+ cells impairs self-renewal and induces apoptosis. Blood 2009; 114: 1498-1505.
27. Rizo A, Dontje B, Vellenga E, de Haan G, Schuringa JJ. Long-term maintenance of human hematopoietic stem/progenitor cells by expression of BMI1. Blood 2008; 111: 2621-2630.
28. Klauke K, Radulovic V, Broekhuis M, Weersing E, Zwart E, Olthof S, et al. Polycomb Cbx family members mediate the balance between haematopoietic stem cell selfrenewal and differentiation. Nat Cell Biol 2013; 15: 353-362.
29. Challen GA, Sun D, Jeong M, Luo M, Jelinek J, Berg JS, et al. Dnmt3a is essential for hematopoietic stem cell differentiation. Nat Genet 2012; 44: 23-31.
30. Bowie MB, Kent DG, Dykstra B, McKnight KD, McCaffrey L, Hoodless PA, et al. Identification of a new intrinsically timed developmental checkpoint that reprograms key hematopoietic stem cell properties. Proc Natl Acad Sci 2007; 104: 5878-5882.
31. Rebel V, Miller C, Eaves C, Lansdorp P. The repopulation potential of fetal liver hematopoietic stem cells in mice exceeds that of their liver adult bone marrow counterparts. Blood 1996; 87: 3500-3507.
32. Copley MR, Babovic S, Benz C, Knapp DJHF, Beer PA, Kent DG, et al. The Lin28b-let-7-Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells. Nat Cell Biol 2013; 15: 916-925.
33. Kim I, Saunders TL, Morrison SJ. Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell 2007; 130: 470-483.
34. Morin RD, Johnson NA, Severson TM, Mungall AJ, An J, Goya R, et al. Somatic mutation of EZH2 (Y641) in follicular and diffuse large B-cell lymphomas of germinal center origin. Nat Genet 2010; 42: 181-185.
35. Kandoth C, McLellan MD, Vandin F, Ye K, Niu B, Lu C, et al. Mutational landscape and significance across 12 major cancer types. Nature 2013; 502: 333-339.
36. Langemeijer SMC, Jansen JH, Hooijer J, van Hoogen P, Stevens-Linders E, Massop M, et al. TET2 mutations in childhood leukemia. Leukemia 2011; 25: 189-192.
37. Jung J, Buisman S, de Haan G. Hematopoiesis during development, aging, disease. Exp Hematol 2016; 44: 689-695.
38. Signer RAJ, Montecino-Rodriguez E, Witte ON, McLaughlin J, Dorshkind K. Agerelated defects in B lymphopoiesis underlie the myeloid dominance of adult leukemia. Blood 2007; 110: 1831-1839.