Niemann-Pick C1 (NPC1)/NPC1-like1 chimeras define sequences critical for NPC1's function as a filovirus entry receptor

Viruses

Volumn 4, Issue 11, 2012, Pages 2471-2484

  Krishnan, Anuja ^a,d   Miller, Emily Happy ^a   Herbert, Andrew S ^b   Ng, Melinda ^a   Ndungo, Esther ^a   Whelan, Sean P ^c   Dye, John M ^b   Chandran, Kartik ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d Institute of Molecular Medicine   (India)

Author keywords

Ebola virus; Filovirus; Host factor; Marburg virus; Niemann Pick C1; Niemann Pick C1 like1; NPC1; NPC1L1; Viral entry; Viral receptor

Indexed keywords

CELL MEMBRANE PROTEIN; NIEMANN PICK C1 LIKE 1 PROTEIN; NIEMANN PICK C1 PROTEIN; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN; VIRUS RECEPTOR;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CHIMERA; CONTROLLED STUDY; FEMALE; FILOVIRUS; FILOVIRUS INFECTION; NONHUMAN; PARALOGY; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; VIRUS CELL INTERACTION; VIRUS ENTRY; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CRICETINAE; FILOVIRIDAE; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; RECEPTORS, VIRUS; SEQUENCE ALIGNMENT; VIRAL ENVELOPE PROTEINS; VIRUS INTERNALIZATION;

EBOLA VIRUS; HEPATITIS C VIRUS; LAKE VICTORIA MARBURGVIRUS; MARBURGVIRUS;

EID: 84870613982     PISSN: 19994915     EISSN: None     Source Type: Journal    
DOI: 10.3390/v4112471     Document Type: Article

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