Caspase-3 Deletion Promotes Necrosis in Atherosclerotic Plaques of ApoE Knockout Mice

Oxidative Medicine and Cellular Longevity

Volumn 2016, Issue , 2016, Pages

  Grootaert, Mandy O J ^a   Schrijvers, Dorien M ^a   Hermans, Marthe ^a   Van Hoof, Viviane O ^b   De Meyer, Guido R Y ^a   Martinet, Wim ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b ANTWERP UNIVERSITY HOSPITAL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; CHOLESTEROL; MACROPHAGES;

APOLIPOPROTEIN E; APOPTOTIC PATHWAYS; ATHEROSCLEROTIC PLAQUE; COLLAGEN CONTENT; LDL CHOLESTEROL; PLAQUE PROGRESSION; PLASMA CHOLESTEROL; VASCULAR SMOOTH MUSCLE CELLS;

MAMMALS;

APOLIPOPROTEIN E; CASPASE 3; CASPASE 7; CHOLESTEROL; COLLAGEN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PROTEIN; RIP1 PROTEIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATHEROGENESIS; ATHEROSCLEROTIC PLAQUE; BONE MARROW DERIVED MACROPHAGE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; GENE DELETION; GENE EXPRESSION; HISTOPATHOLOGY; KNOCKOUT MOUSE; MALE; MOUSE; NECROPTOSIS; NONHUMAN; TRIACYLGLYCEROL BLOOD LEVEL; VASCULAR SMOOTH MUSCLE CELL; WESTERN DIET; ANIMAL; DEFICIENCY; METABOLISM; NECROSIS;

ANIMALS; APOLIPOPROTEINS E; APOPTOSIS; CASPASE 3; MICE; MICE, KNOCKOUT; NECROSIS; PLAQUE, ATHEROSCLEROTIC;

EID: 84994603227     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2016/3087469     Document Type: Article

References (50)

1. M. M. Kockx, "Apoptosis in the atherosclerotic plaque: quantitative and qualitative aspects, " Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 18, no. 10, pp. 1519-1522, 1998.
2. Z. Mallat and A. Tedgui, "Current perspective on the role of apoptosis in atherothrombotic disease, " Circulation Research, vol. 88, no. 10, pp. 998-1003, 2001.
3. V. E. A. Stoneman and M. R. Bennett, "Role of apoptosis in atherosclerosis and its therapeutic implications, " Clinical Science, vol. 107, no. 4, pp. 343-354, 2004.
4. F. D. Kolodgie, J. Narula, A. P. Burke et al., "Localization of apoptotic macrophages at the site of plaque rupture in sudden coronary death, "The American Journal of Pathology, vol. 157, no. 4, pp. 1259-1268, 2000.
5. Y.-J. Geng and P. Libby, "Progression of atheroma: a struggle between death and procreation, " Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 22, no. 9, pp. 1370-1380, 2002.
6. D. W. Nicholson and N. A. Thornberry, "Caspases: killer proteases, " Trends in Biochemical Sciences, vol. 22, no. 8, pp. 299-306, 1997.
7. J. F. Kerr, A. H. Wyllie, and A. R. Currie, "Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics, " British Journal of Cancer, vol. 26, no. 4, pp. 239-257, 1972.
8. M. M. Kockx and A. G. Herman, "Apoptosis in atherosclerosis: beneficial or detrimental" Cardiovascular Research, vol. 45, no. 3, pp. 736-746, 2000.
9. Z. Mallat and A. Tedgui, "Apoptosis in the vasculature: mechanisms and functional importance, " British Journal of Pharmacology, vol. 130, no. 5, pp. 947-962, 2000.
10. M. C. H. Clarke, N. Figg, J. J. Maguire et al., "Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis, " Nature Medicine, vol. 12, no. 9, pp. 1075-1080, 2006.
11. S. Arai, J. M. Shelton, M. Chen et al., "A role for the apoptosis inhibitory factor AIM/Spα/Api6 in atherosclerosis development, " Cell Metabolism, vol. 1, no. 3, pp. 201-213, 2005.
12. V. Stoneman, D. Braganza, N. Figg et al., "Monocyte/ macrophage suppression in CD11b diphtheria toxin receptor transgenic mice differentially affects atherogenesis and established plaques, " Circulation Research, vol. 100, no. 6, pp. 884-893, 2007.
13. E. L. Gautier, T. Huby, J. L. Witztum et al., "Macrophage apoptosis exerts divergent effects on atherogenesis as a function of lesion stage, " Circulation, vol. 119, no. 13, pp. 1795-1804, 2009.
14. D. M. Schrijvers, G. R. Y. De Meyer, A. G. Herman, and W. Martinet, "Phagocytosis in atherosclerosis: molecular mechanisms and implications for plaque progression and stability, " Cardiovascular Research, vol. 73, no. 3, pp. 470-480, 2007.
15. T. Seimon and I. Tabas, "Mechanisms and consequences of macrophage apoptosis in atherosclerosis, " The Journal of Lipid Research, vol. 50, supplement, pp. S382-S387, 2009.
16. E. A. Van Vré, H. Ait-Oufella, A. Tedgui, and Z. Mallat, "Apoptotic cell death and efferocytosis in atherosclerosis, " Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 32, no. 4, pp. 887-893, 2012.
17. S. A. Schreyer, J. J. Peschon, and R. C. LeBoeuf, "Accelerated atherosclerosis in mice lacking tumor necrosis factor receptor p55, " The Journal of Biological Chemistry, vol. 271, no. 42, pp. 26174-26178, 1996.
18. T. Aprahamian, I. Rifkin, R. Bonegio et al., "Impaired clearance of apoptotic cells promotes synergy between atherogenesis and autoimmune disease, " The Journal of Experimental Medicine, vol. 199, no. 8, pp. 1121-1131, 2004.
19. L. Branén, L. Hovgaard, M. Nitulescu, E. Bengtsson, J. Nilsson, and S. Jovinge, "Inhibition of tumor necrosis factor-β reduces atherosclerosis in apolipoprotein E knockout mice, " Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 24, no. 11, pp. 2137-2142, 2004.
20. X. Feng, H. Li, A. A. Rumbin et al., "ApoE/Fas/ C57BL/6 mice: a novel murine model simultaneously exhibits lupus nephritis, atherosclerosis, and osteopenia, " Journal of Lipid Research, vol. 48, no. 4, pp. 794-805, 2007.
21. J. Liu, D. P. Thewke, Y. R. Su, M. F. Linton, S. Fazio, and M. S. Sinensky, "Reduced macrophage apoptosis is associated with accelerated atherosclerosis in low-density lipoprotein receptornull mice, " Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 25, no. 1, pp. 174-179, 2005.
22. N. V. Guevara, H.-S. Kim, E. I. Antonova, and L. Chan, "The absence of p53 accelerates atherosclerosis by increasing cell proliferation in vivo, " NatureMedicine, vol. 5, no. 3, pp. 335-339, 1999.
23. B. J. M. van Vlijmen, G. Gerritsen, A. L. Franken et al., "Macrophage p53 deficiency leads to enhanced atherosclerosis in APOE3-Leiden transgenic mice, " Circulation Research, vol. 88, no. 8, pp. 780-786, 2001.
24. A. J. Merched, E. Williams, and L. Chan, "Macrophage-specific p53 expression plays a crucial role in atherosclerosis development and plaque remodeling, " Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 23, no. 9, pp. 1608-1614, 2003.
25. J. Mercer, N. Figg, V. Stoneman, D. Braganza, and M. R. Bennett, "Endogenous p53 protects vascular smooth muscle cells from apoptosis and reduces atherosclerosis in ApoE knockout mice, " Circulation Research, vol. 96, no. 6, pp. 667-674, 2005.
26. L. S. M. Boesten, A. S. M. Zadelaar, A. van Nieuwkoop et al., "Macrophage p53 controlsmacrophage death in atherosclerotic lesions of apolipoprotein E deficient mice, " Atherosclerosis, vol. 207, no. 2, pp. 399-404, 2009.
27. H. González-Navarro, Y. N. Abu Nabah, á. Vinué et al., "p19ARF deficiency reduces macrophage and vascular smooth muscle cell apoptosis and aggravates atherosclerosis, " Journal of the American College of Cardiology, vol. 55, no. 20, pp. 2258-2268, 2010.
28. Z. Mallat, J. Ohan, G. Lesèche, and A. Tedgui, "Colocalization of CPP-32 with apoptotic cells in human atherosclerotic plaques, " Circulation, vol. 96, no. 2, pp. 424-428, 1997.
29. T. Q. Nhan, W. C. Liles, A. Chait, J. T. Fallon, and S. M. Schwartz, "The p17 cleaved form of caspase-3 is present within viable macrophages in vitro and in atherosclerotic plaque, " Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 23, no. 7, pp. 1276-1282, 2003.
30. R. Hutter, C. Valdiviezo, B. V. Sauter et al., "Caspase-3 and tissue factor expression in lipid-rich plaque macrophages: evidence for apoptosis as link between inflammation and atherothrombosis, " Circulation, vol. 109, no. 16, pp. 2001-2008, 2004.
31. G. K. Owens, A. Loeb, D. Gordon, and M. M. Thompson, "Expression of smooth muscle-specific α-isoactin in cultured vascular smooth muscle cells: relationship between growth and cytodifferentiation, " Journal of Cell Biology, vol. 102, no. 2, pp. 343-352, 1986.
32. A. A. T. Geisterfer and M. J. G. K. PeachOwens, "Angiotensin II induces hypertrophy, not hyperplasia, of cultured rat aortic smooth muscle cells, " Circulation Research, vol. 62, no. 4, pp. 749-756, 1988.
33. M. O. Grootaert, P. A. da Costa Martins, N. Bitsch et al., "Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis, " Autophagy, vol. 11, no. 11, pp. 2014-2032, 2015.
34. T. A. Seimon, Y. Wang, S. Han et al., "Macrophage deficiency of p38α MAPK promotes apoptosis and plaque necrosis in advanced atherosclerotic lesions in mice, " Journal of Clinical Investigation, vol. 119, no. 4, pp. 886-898, 2009.
35. V. Croons, W. Martinet, A. G. Herman, J.-P. Timmermans, and G. R. Y. De Meyer, "Selective clearance of macrophages in atherosclerotic plaques by the protein synthesis inhibitor cycloheximide, " Journal of Pharmacology and Experimental Therapeutics, vol. 320, no. 3, pp. 986-993, 2007.
36. V. Croons, W. Martinet, A. G. Herman, and G. R. Y. De Meyer, "Differential effect of the protein synthesis inhibitors puromycin and cycloheximide on vascular smooth muscle cell viability, " Journal of Pharmacology and ExperimentalTherapeutics, vol. 325, no. 3, pp. 824-832, 2008.
37. C. Scheller, J. Knöferle, A. Ullrich et al., "Caspase inhibition in apoptotic T cells triggers necrotic cell death depending on the cell type and the proapoptotic stimulus, " Journal of Cellular Biochemistry, vol. 97, no. 6, pp. 1350-1361, 2006.
38. C. Lemaire, K. Andréau, V. Souvannavong, and A. Adam, "Inhibition of caspase activity induces a switch from apoptosis to necrosis, " FEBS Letters, vol. 425, no. 2, pp. 266-270, 1998.
39. O. Meilhac, I. Escargueil-Blanc, J.-C. Thiers, R. Salvayre, and A. Nègre-Salvayre, "Bcl-2 alters the balance between apoptosis and necrosis, but does not prevent cell death induced by oxidized low density lipoproteins, " FASEB Journal, vol. 13, no. 3, pp. 485-494, 1999.
40. N. Auge, M.-T. Pieraggi, J.-C. Thiers, A. Negre-Salvayre, and R. Salvayre, "Proliferative and cytotoxic effects of mildly oxidized low-density lipoproteins on vascular smooth-muscle cells, " Biochemical Journal, vol. 309, no. 3, pp. 1015-1020, 1995.
41. B. Björkerud and S. Björkerud, "Contrary effects of lightly and strongly oxidized LDL with potent promotion of growth versus apoptosis on arterial smooth muscle cells, macrophages, and fibroblasts, " Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 16, no. 3, pp. 416-424, 1996.
42. J. A. Dubland and G. A. Francis, "So Much Cholesterol: the unrecognized importance of smoothmuscle cells in atherosclerotic foam cell formation, " Current Opinion in Lipidology, vol. 27, no. 2, pp. 155-161, 2016.
43. N. Vanlangenakker, M. J. M. Bertrand, P. Bogaert, P. Vandenabeele, and T. Vanden Berghe, "TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex i and II members, " Cell Death and Disease, vol. 2, article e230, 2011.
44. B. Yang, D. Ye, and Y. Wang, "Caspase-3 as a therapeutic target for heart failure, " ExpertOpinion onTherapeutic Targets, vol. 17, no. 3, pp. 255-263, 2013.
45. U. Fischer and K. Schulze-Osthoff, "Apoptosis-based therapies and drug targets, " Cell Death and Differentiation, vol. 12, no. 1, pp. 942-961, 2005.
46. H. Yaoita, K. Ogawa, K. Maehara, and Y. Maruyama, "Attenuation of ischemia/reperfusion injury in rats by a caspase inhibitor, " Circulation, vol. 97, no. 3, pp. 276-281, 1998.
47. T. A. Holly, A. Drincic, Y. Byun et al., "Caspase inhibition reduces myocyte cell death induced by myocardial ischemia and reperfusion in vivo, " Journal of Molecular and Cellular Cardiology, vol. 31, no. 9, pp. 1709-1715, 1999.
48. J.-Q. Huang, S. Radinovic, P. Rezaiefar, and S. C. Black, "In vivo myocardial infarct size reduction by a caspase inhibitor administered after the onset of ischemia, " European Journal of Pharmacology, vol. 402, no. 1-2, pp. 139-142, 2000.
49. G. Condorelli, R. Roncarati, J. Ross Jr. et al., "Heart-targeted overexpression of caspase3 in mice increases infarct size and depresses cardiac function, " Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 17, pp. 9977-9982, 2001.
50. W. Martinet, D. M. Schrijvers, and G. R. Y. DeMeyer, "Necrotic cell death in atherosclerosis, " Basic Research in Cardiology, vol. 106, no. 5, pp. 749-760, 2011.