The p17 cleaved form of caspase-3 is present within viable macrophages in vitro and in atherosclerotic plaque

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 23, Issue 7, 2003, Pages 1276-1282

  Nhan, Thomas Q ^a   Liles, W Conrad ^a   Chait, Alan ^a   Fallon, John T ^b   Schwartz, Stephen M ^a,c  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Apoptosis; Caspases; CD95; LDL; Macrophages

Indexed keywords

ACETYL LOW DENSITY LIPOPROTEIN; APOLIPOPROTEIN E; CASPASE 3; DNA FRAGMENT; FAS ANTIGEN; FAS LIGAND; OXIDIZED LOW DENSITY LIPOPROTEIN; PHOSPHATIDYLSERINE; PROTEIN P17; THIOGLYCOLIC ACID; UNCLASSIFIED DRUG;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CELL DEATH; CELL SURFACE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DISEASE ASSOCIATION; ENZYME ACTIVITY; FOAM CELL; MACROPHAGE; MALE; MOUSE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; ANTIGENS, CD95; APOPTOSIS; ARTERIOSCLEROSIS; CASPASE 3; CASPASES; CYSTEINE PROTEINASE INHIBITORS; DNA FRAGMENTATION; ENZYME ACTIVATION; ENZYME INHIBITORS; FAS LIGAND PROTEIN; FOAM CELLS; IN SITU NICK-END LABELING; LIPOPROTEINS, LDL; MACROPHAGES, PERITONEAL; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; OLIGOPEPTIDES;

EID: 0038447969     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000078602.54433.07     Document Type: Article

References (47)

1. Stary HC, Chandler AB, Dinsmore RE. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis: a report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Arterioscler Thromb Vasc Biol. 1995;15:1512-1531.
2. Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM. Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2000;20:1262-1275.
3. Gutstein DE, Fuster V. Pathophysiology and clinical significance of atherosclerotic plaque rupture. Cardiovasc Res. 1999;41:323-333.
4. Johnson JL, Jackson CL. Atherosclerotic plaque rupture in the apolipoprotein E knockout mouse. Atherosclerosis. 2001;154:399-406.
5. Davies MJ, Richardson PD, Woolf N, Katz DR, Mann J. Risk of thrombosis in human atherosclerotic plaques: role of extracellular lipid, macrophage, and smooth muscle cell content. Br Heart J. 1993;69:377-381.
6. Bjorkerud S, Bjorkerud B. Apoptosis is abundant in human atherosclerotic lesions, especially in inflammatory cells (macrophages and T cells), and may contribute to the accumulation of gruel and plaque instability. Am J Pathol. 1996;149:367-380.
7. Carpenter KL, van der Veen C, Taylor SE, Hardwick SJ, Clare K, Hegyi L, Mitchinson MJ. Macrophages, lipid oxidation, ceroid accumulation and α-tocopherol depletion in human atherosclerotic lesions. Gerontology. 1995;41(suppl 2):53-67.
8. Hakamata H, Miyazaki A, Sakai M, Sakamoto YI, Horiuchi S. Cytotoxic effect of oxidized low density lipoprotein on macrophages. J Atheroscler Thromb. 1998;5:66-75.
9. Harada K, Chen Z, Ishibashi S, Osuga J, Yagyu H, Ohashi K, Yahagi N, Shionoiri F, Sun L, Yazaki Y, Yamada N. Apoptotic cell death in atherosclerotic plaques of hyperlipidemic knockout mice. Atherosclerosis. 1997;135:235-239.
10. Bjorkerud B, Bjorkerud S. Contrary effects of lightly and strongly oxidized LDL with potent promotion of growth versus apoptosis on arterial smooth muscle cells, macrophages, and fibroblasts. Arterioscler Thromb Vasc Biol. 1996;16:416-424.
11. Glass CK, Witztum JL. Atherosclerosis: the road ahead. Cell. 2001;104:503-516.
12. Yao PM, Tabas I. Free cholesterol loading of macrophages induces apoptosis involving the Fas pathway. J Biol Chem. 2000;275:23807-23813.
13. Fazio S, Babaev VR, Murray AB, Hasty AH, Carter KJ, Gleaves LA, Atkinson JB, Linton MF. Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages. Proc Natl Acad Sci U SA. 1997;94:4647-4652.
14. Dhaliwal BS, Steinbrecher UP. Cholesterol delivered to macrophages by oxidized low density lipoprotein is sequestered in lysosomes and fails to efflux normally. J Lipid Res. 2000;41:1658-1665.
15. Han CY, Pak YK. Oxidation-dependent effects of oxidized LDL: proliferation or cell death. Exp Mol Med. 1999;31:165-173.
16. Harada K, Ishibashi S, Miyashita T, Osuga J, Yagyu H, Ohashi K, Yazaki Y, Yamada N. Bcl-2 protein inhibits oxysterol-induced apoptosis through suppressing CPP32-mediated pathway. FEBS Lett. 1997;411:63-66.
17. Hardwick SJ, Hegyi L, Clare K, Law NS, Carpenter KL, Mitchinson MJ, Skepper JN. Apoptosis in human monocyte-macrophages exposed to oxidized low density lipoprotein. J Pathol. 1996;179:294-302.
18. Li W, Yuan XM, Olsson AG, Brunk UT. Uptake of oxidized LDL by macrophages results in partial lysosomal enzyme inactivation and relocation. Arterioscler Thromb Vasc Biol. 1998;18:177-184.
19. Marchant CE, Law NS, van der Veen C, Hardwick SJ, Carpenter KL, Mitchinson MJ. Oxidized low-density lipoprotein is cytotoxic to human monocyte-macrophages: protection with lipophilic antioxidants. FEBS Lett. 1995;358:175-178.
20. Yuan XM, Li W, Olsson AG, Brunk UT. The toxicity to macrophages of oxidized low-density lipoprotein is mediated through lysosomal damage. Atherosclerosis. 1997;133:153-161.
21. Imanishi T, Han DKM, Hofstra L, Hano T, Nishio I, Liles WC, Gorden AM, Schwartz SM. Apoptosis of vascular smooth muscle cells is induced by Fas ligand derived from monocytes/macrophage. Atherosclerosis. 2002;161:143-151.
22. Kockx MM, Knaapen MW. The role of apoptosis in vascular disease. J Pathol. 2000;190:267-280.
23. Kiener PA, Davis PM, Starling GC, Mehlin C, Klebanoff SJ, Ledbetter JA, Liles WC. Differential induction of apoptosis by Fas-Fas ligand interactions in human monocytes and macrophages. J Exp Med. 1997;195:1511-1516.
24. Heinecke JW, Baker L, Rosen H, Chait A. Superoxide-mediated modification of low density lipoprotein by arterial smooth muscle cells. J Clin Invest. 1986;77:757-761.
25. Esterbauer H, Striegl G, Puhl H, Rotheneder M. Continuous monitoring of in vitro oxidation of human low density lipoprotein. Free Radic Res Commun. 1989;6:67-75.
26. Rosenfeld ME, Polinsky P, Virmani R, Kauser K, Rubanyi G, Schwartz SM. Advanced atherosclerotic lesions in the innominate artery of the ApoE knockout mouse. Arterioscler Thromb Vasc Biol. 2000;20:2587-2592.
27. Liles WC, Kiener PA, Ledbetter JA, Aruffo A, Klebanoff SJ. Differential expression of Fas (CD95) and Fas ligand on normal human phagocytes: implications for the regulation of apoptosis in neutrophils. J Exp Med. 1996;184:429-440.
28. Greenspan P, Lou P. Spectrofluorometric studies of Nile red treated native and oxidized low density lipoprotein. Int J Biochem. 1993;25:987-991.
29. Ashkenazi A, Dixit VM. Death receptors: signaling and modulation. Science. 1998;281:1305-1308.
30. Crispe IN. Fatal interactions: Fas-induced apoptosis of mature T cells. Immunity. 1994;1:347-349.
31. Kojima H, Shinohara N, Hanaoka S, Someya-Shirota Y, Takagaki Y, Katayama T, Yagita H, Okumura K, Shinkai Y, Alt FW, Matsuzawa A, Yonehara S, Takayama H. Two distinct pathways of specific killing revealed by perform mutant cytotoxic T lymphocytes. Immunity. 1994;1:357-364.
32. Wu JC, Fritz LC. Irreversible caspase inhibitors: tools for studying apoptosis. Methods. 1999;17:320-328.
33. Linton MF, Fazio S. Macrophages, lipoprotein metabolism, and atherosclerosis: insights from murine bone marrow transplantation studies. Curr Opin Lipidol. 1999;10:97-105.
34. Xue D, Horvitz HR. Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein. Nature. 1995;377:248-251.
35. Tedgui A, Mallat Z. Apoptosis as a determinant of atherothrombosis. Thromb Haemost. 2001;86:420-426.
36. Alam A, Cohen LY, Aouad S, Sekaly RP. Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells. J Exp Med. 1999;190:1879-1890.
37. Kennedy NJ, Kataoka T, Tschopp J, Budd RC. Caspase activation is required for T cell proliferation. J Exp Med. 1999;190:1725-1727.
38. Fernando P, Kelly JF, Balazsi K, Slack RS, Megeney LA. Caspase 3 activity is required for skeletal muscle differentiation. Proc Natl Acad Sci USA. 2002;99:11025-11030.
39. De Maria R, Zeuner A, Eramo A, Domenichelli C, Bonci D, Grignani F, Srinivasula SM, Alnemri ES, Testa U, Peschle C. Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1. Nature. 1999;401:489-493.
40. De Maria R, Testa U, Luchetti L, Zeuner A, Stassi G, Pelosi E, Riccioni R, Felli N, Samoggia P, Peschle C. Apoptotic role of Fas/Fas ligand system in the regulation of erythropoiesis. Blood. 1999;93:796-803.
41. Zermati Y, Garrido C, Amsellem S, Fishelson S, Bouscary D, Valensi F, Varet B, Solary E, Hermine O. Caspase activation is required for terminal erythroid differentiation. J Exp Med. 2001;193:247-254.
42. Schneider DB, Vassalli G, Wen S, Driscoll RM, Sassani AB, DeYoung MB, Linnemann R, Virmani R, Dichek DA. Expression of Fas ligand in arteries of hypercholesterolemic rabbits accelerates atherosclerotic lesion formation. Arterioscler Thromb Vasc Biol. 2000;20:298-308.
43. Panini SR, Sinensky MS. Mechanisms of oxysterol-induced apoptosis. Curr Opin Lipidol. 2001;12:529-533.
44. Verhagen AM, Ekert PG, Pakusch M, Silke J, Connolly LM, Reid GE, Moritz RL, Simpson RJ, Vaux DL. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell. 2000;102:43-53.
45. Joza N, Susin SA, Daugas E, Stanford WL, Cho SK, Li CY, Sasaki T, Elia AJ, Cheng HY, Ravagnan L, Ferri KF, Zamzami N, Wakeham A, Hakem R, Yoshida H, Kong YY, Mak TW, Zuniga-Pflucker JC, Kroemer G, Penninger JM. Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature. 2001;410:549-554.
46. Lougheed M, Steinbrecher UP. Mechanism of uptake of copper-oxidized low density lipoprotein in macrophages is dependent on its extent of oxidation. J Biol Chem. 1996;271:11798-11805.
47. Fazio S, Major AS, Swift LL, Gleaves LA, Accad M, Linton MF, Farese RV Jr. Increased atherosclerosis in LDL receptor-null mice lacking ACAT1 in macrophages. J Clin Invest. 2001;107:163-171.