Oxidized phospholipid OxPAPC activates TRPA1 and contributes to chronic inflammatory pain in mice

PLoS ONE

Volumn 11, Issue 11, 2016, Pages

  Liu, Boyi ^a   Tai, Yan ^a,b   Caceres, Ana I ^b   Achanta, Satyanarayana ^b   Balakrishna, Shrilatha ^c   Shao, Xiaomei ^a   Fang, Junfan ^a   Jordt, Sven Eric ^b  

^a ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 PALMITOYL 2 ARACHIDONOYL SN GLYCEROL 3 PHOSPHATIDYLCHOLINE; ALLYL ISOTHIOCYANATE; CALCIUM; CYSTEINE; LYSINE; N (4 ISOPROPYLPHENYL) 2 (1,2,3,6 TETRAHYDRO 1,3 DIMETHYL 2,6 DIOXO 7H PURIN 7 YL)ACETAMIDE; PHOSPHOLIPID; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 4; CALCIUM CHANNEL; NERVE PROTEIN; OXIDIZED-L-ALPHA-1-PALMITOYL-2-ARACHIDONOYL-SN-GLYCERO-3-PHOSPHORYLCHOLINE; PHOSPHATIDYLCHOLINE; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRPA1 PROTEIN, HUMAN;

ADULT; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM TRANSPORT; CHRONIC INFLAMMATORY PAIN; CONTROLLED STUDY; EMBRYO; HEK293 CELL LINE; HIND PAW; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PROTEIN ACTIVATION; PROTEIN EXPRESSION; PROTEIN MODIFICATION; SENSORY NERVE CELL; AGONISTS; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; CHRONIC PAIN; COMPLICATION; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; INFLAMMATION; METABOLISM; NOCICEPTION; PATHOLOGY; SPINAL GANGLION;

ANIMALS; CALCIUM CHANNELS; CHRONIC PAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; GANGLIA, SPINAL; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; MALE; MICE; MICE, INBRED C57BL; NERVE TISSUE PROTEINS; NOCICEPTION; PHOSPHATIDYLCHOLINES; SENSORY RECEPTOR CELLS; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 84994274950     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0165200     Document Type: Article

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