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Volumn 32, Issue 12, 2016, Pages 763-773

Update: Mechanisms Underlying N6-Methyladenosine Modification of Eukaryotic mRNA

Author keywords

[No Author keywords available]

Indexed keywords

6 N METHYLADENOSINE; BINDING PROTEIN; MESSENGER RNA; MICRORNA; ADENOSINE; DNA BINDING PROTEIN; N(6)-METHYLADENOSINE;

EID: 84994143420     PISSN: 01689525     EISSN: 13624555     Source Type: Journal    
DOI: 10.1016/j.tig.2016.09.006     Document Type: Review
Times cited : (42)

References (83)
  • 1
    • 0016285746 scopus 로고
    • Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells
    • 1 Desrosiers, R., et al. Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells. Proc. Natl. Acad. Sci. U.S.A. 71 (1974), 3971–3975.
    • (1974) Proc. Natl. Acad. Sci. U.S.A. , vol.71 , pp. 3971-3975
    • Desrosiers, R.1
  • 2
    • 0016793057 scopus 로고
    • Modified nucleosides and bizarre 5’-termini in mouse myeloma mRNA
    • 2 Adams, J.M., Cory, S., Modified nucleosides and bizarre 5’-termini in mouse myeloma mRNA. Nature 255 (1975), 28–33.
    • (1975) Nature , vol.255 , pp. 28-33
    • Adams, J.M.1    Cory, S.2
  • 3
    • 0016809932 scopus 로고
    • The methylated constituents of L cell messenger RNA: evidence for an unusual cluster at the 5’ terminus
    • 3 Perry, R.P., et al. The methylated constituents of L cell messenger RNA: evidence for an unusual cluster at the 5’ terminus. Cell 4 (1975), 387–394.
    • (1975) Cell , vol.4 , pp. 387-394
    • Perry, R.P.1
  • 4
    • 0017296194 scopus 로고
    • 5’-Terminal and internal methylated nucleotide sequences in HeLa cell mRNA
    • 4 Wei, C.M., et al. 5’-Terminal and internal methylated nucleotide sequences in HeLa cell mRNA. Biochemistry 15 (1976), 397–401.
    • (1976) Biochemistry , vol.15 , pp. 397-401
    • Wei, C.M.1
  • 5
    • 0028936082 scopus 로고
    • Mobilities of modified ribonucleotides on two-dimensional cellulose thin-layer chromatography
    • 5 Keith, G., Mobilities of modified ribonucleotides on two-dimensional cellulose thin-layer chromatography. Biochimie 77 (1995), 142–144.
    • (1995) Biochimie , vol.77 , pp. 142-144
    • Keith, G.1
  • 6
    • 57749089784 scopus 로고    scopus 로고
    • MTA is an Arabidopsis messenger RNA adenosine methylase and interacts with a homolog of a sex-specific splicing factor
    • 6 Zhong, S., et al. MTA is an Arabidopsis messenger RNA adenosine methylase and interacts with a homolog of a sex-specific splicing factor. Plant Cell 20 (2008), 1278–1288.
    • (2008) Plant Cell , vol.20 , pp. 1278-1288
    • Zhong, S.1
  • 7
    • 81355146483 scopus 로고    scopus 로고
    • N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
    • 7 Jia, G., et al. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat. Chem. Biol. 7 (2011), 885–887.
    • (2011) Nat. Chem. Biol. , vol.7 , pp. 885-887
    • Jia, G.1
  • 8
    • 0016629559 scopus 로고
    • 5’-Terminal m-7G(5’)ppp(5’)G-m-p in vivo: identification in reovirus genome RNA
    • 8 Furuichi, Y., et al. 5’-Terminal m-7G(5’)ppp(5’)G-m-p in vivo: identification in reovirus genome RNA. Proc. Natl. Acad. Sci. U.S.A. 72 (1975), 742–745.
    • (1975) Proc. Natl. Acad. Sci. U.S.A. , vol.72 , pp. 742-745
    • Furuichi, Y.1
  • 9
    • 0016770156 scopus 로고
    • Methylated nucleotides block 5’ terminus of HeLa cell messenger RNA
    • 9 Wei, C.M., et al. Methylated nucleotides block 5’ terminus of HeLa cell messenger RNA. Cell 4 (1975), 379–386.
    • (1975) Cell , vol.4 , pp. 379-386
    • Wei, C.M.1
  • 10
    • 82255168340 scopus 로고    scopus 로고
    • The biosynthesis and functional roles of methylated nucleosides in eukaryotic mRNA
    • 10 Bokar, J.A., The biosynthesis and functional roles of methylated nucleosides in eukaryotic mRNA. Topics Curr. Genet. 12 (2005), 141–177.
    • (2005) Topics Curr. Genet. , vol.12 , pp. 141-177
    • Bokar, J.A.1
  • 11
    • 34548726200 scopus 로고    scopus 로고
    • Identification of modified residues in RNAs by reverse transcription-based methods
    • 11 Motorin, Y., et al. Identification of modified residues in RNAs by reverse transcription-based methods. Methods Enzymol. 425 (2007), 21–53.
    • (2007) Methods Enzymol. , vol.425 , pp. 21-53
    • Motorin, Y.1
  • 12
    • 0026546877 scopus 로고
    • A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands
    • 12 Frommer, M., et al. A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands. Proc. Natl. Acad. Sci. U.S.A. 89 (1992), 1827–1831.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 1827-1831
    • Frommer, M.1
  • 13
    • 84862649489 scopus 로고    scopus 로고
    • Comprehensive analysis of mRNA methylation reveals enrichment in 3’ UTRs and near stop codons
    • 13 Meyer, K.D., et al. Comprehensive analysis of mRNA methylation reveals enrichment in 3’ UTRs and near stop codons. Cell 149 (2012), 1635–1646.
    • (2012) Cell , vol.149 , pp. 1635-1646
    • Meyer, K.D.1
  • 14
    • 84860779086 scopus 로고    scopus 로고
    • Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
    • 14 Dominissini, D., et al. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature 485 (2012), 201–206.
    • (2012) Nature , vol.485 , pp. 201-206
    • Dominissini, D.1
  • 15
    • 84890107723 scopus 로고    scopus 로고
    • High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis
    • 15 Schwartz, S., et al. High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis. Cell 155 (2013), 1409–1421.
    • (2013) Cell , vol.155 , pp. 1409-1421
    • Schwartz, S.1
  • 16
    • 84919457819 scopus 로고    scopus 로고
    • m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells
    • 16 Batista, P.J., et al. m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells. Cell Stem Cell 15 (2014), 707–719.
    • (2014) Cell Stem Cell , vol.15 , pp. 707-719
    • Batista, P.J.1
  • 17
    • 84904035764 scopus 로고    scopus 로고
    • Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5’ sites
    • 17 Schwartz, S., et al. Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5’ sites. Cell Rep. 8 (2014), 284–296.
    • (2014) Cell Rep. , vol.8 , pp. 284-296
    • Schwartz, S.1
  • 18
    • 84892372347 scopus 로고    scopus 로고
    • N6-methyladenosine-dependent regulation of messenger RNA stability
    • 18 Wang, X., et al. N6-methyladenosine-dependent regulation of messenger RNA stability. Nature 505 (2014), 117–120.
    • (2014) Nature , vol.505 , pp. 117-120
    • Wang, X.1
  • 19
    • 84893310526 scopus 로고    scopus 로고
    • N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells
    • 19 Wang, Y., et al. N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells. Nat. Cell Biol. 16 (2014), 191–198.
    • (2014) Nat. Cell Biol. , vol.16 , pp. 191-198
    • Wang, Y.1
  • 20
    • 84921512407 scopus 로고    scopus 로고
    • High-resolution N(6) -methyladenosine (m(6) A) map using photo-crosslinking-assisted m(6) A sequencing
    • 20 Chen, K., et al. High-resolution N(6) -methyladenosine (m(6) A) map using photo-crosslinking-assisted m(6) A sequencing. Angew. Chem. 54 (2015), 1587–1590.
    • (2015) Angew. Chem. , vol.54 , pp. 1587-1590
    • Chen, K.1
  • 21
    • 84943570207 scopus 로고    scopus 로고
    • A majority of m6A residues are in the last exons, allowing the potential for 3’ UTR regulation
    • 21 Ke, S., et al. A majority of m6A residues are in the last exons, allowing the potential for 3’ UTR regulation. Genes Dev. 29 (2015), 2037–2053.
    • (2015) Genes Dev. , vol.29 , pp. 2037-2053
    • Ke, S.1
  • 22
    • 84938417580 scopus 로고    scopus 로고
    • Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome
    • 22 Linder, B., et al. Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome. Nat. Methods 12 (2015), 767–772.
    • (2015) Nat. Methods , vol.12 , pp. 767-772
    • Linder, B.1
  • 23
    • 84976908747 scopus 로고    scopus 로고
    • m(6)A-LAIC-seq reveals the census and complexity of the m(6)A epitranscriptome
    • 23 Molinie, B., et al. m(6)A-LAIC-seq reveals the census and complexity of the m(6)A epitranscriptome. Nat. Methods 13 (2016), 692–698.
    • (2016) Nat. Methods , vol.13 , pp. 692-698
    • Molinie, B.1
  • 24
    • 0025245501 scopus 로고
    • Sequence specificity of mRNA N6-adenosine methyltransferase
    • 24 Csepany, T., et al. Sequence specificity of mRNA N6-adenosine methyltransferase. J. Biol. Chem. 265 (1990), 20117–20122.
    • (1990) J. Biol. Chem. , vol.265 , pp. 20117-20122
    • Csepany, T.1
  • 25
    • 0025084945 scopus 로고
    • Sequence specificity of the human mRNA N6-adenosine methylase in vitro
    • 25 Harper, J.E., et al. Sequence specificity of the human mRNA N6-adenosine methylase in vitro. Nucleic Acids Res. 18 (1990), 5735–5741.
    • (1990) Nucleic Acids Res. , vol.18 , pp. 5735-5741
    • Harper, J.E.1
  • 26
    • 0028670846 scopus 로고
    • N6-adenosine methylation in mRNA: substrate specificity and enzyme complexity
    • 26 Rottman, F.M., et al. N6-adenosine methylation in mRNA: substrate specificity and enzyme complexity. Biochimie 76 (1994), 1109–1114.
    • (1994) Biochimie , vol.76 , pp. 1109-1114
    • Rottman, F.M.1
  • 27
    • 84920273757 scopus 로고    scopus 로고
    • FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis
    • 27 Zhao, X., et al. FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis. Cell Res. 24 (2014), 1403–1419.
    • (2014) Cell Res. , vol.24 , pp. 1403-1419
    • Zhao, X.1
  • 28
    • 84893746230 scopus 로고    scopus 로고
    • Mammalian WTAP is a regulatory subunit of the RNA N6–methyladenosine methyltransferase
    • 28 Ping, X.L., et al. Mammalian WTAP is a regulatory subunit of the RNA N6–methyladenosine methyltransferase. Cell Res. 24 (2014), 177–189.
    • (2014) Cell Res. , vol.24 , pp. 177-189
    • Ping, X.L.1
  • 29
    • 0017621466 scopus 로고
    • The 5’-termini of heterogeneous nuclear RNA: a comparison among molecules of different sizes and ages
    • 29 Schibler, U., Perry, R.P., The 5’-termini of heterogeneous nuclear RNA: a comparison among molecules of different sizes and ages. Nucleic Acids Res. 4 (1977), 4133–4149.
    • (1977) Nucleic Acids Res. , vol.4 , pp. 4133-4149
    • Schibler, U.1    Perry, R.P.2
  • 30
    • 84946228509 scopus 로고    scopus 로고
    • 5’ UTR m(6)A promotes cap-independent translation
    • 30 Meyer, K.D., et al. 5’ UTR m(6)A promotes cap-independent translation. Cell 163 (2015), 999–1010.
    • (2015) Cell , vol.163 , pp. 999-1010
    • Meyer, K.D.1
  • 31
    • 84937884118 scopus 로고    scopus 로고
    • Genome-wide detection of high abundance N6-methyladenosine sites by microarray
    • 31 Li, Y., et al. Genome-wide detection of high abundance N6-methyladenosine sites by microarray. RNA 21 (2015), 1511–1518.
    • (2015) RNA , vol.21 , pp. 1511-1518
    • Li, Y.1
  • 32
    • 0016297552 scopus 로고
    • Effects of methylation on the stability of nucleic acid conformations: studies at the monomer level
    • 32 Engel, J.D., von Hippel, P.H., Effects of methylation on the stability of nucleic acid conformations: studies at the monomer level. Biochemistry 13 (1974), 4143–4158.
    • (1974) Biochemistry , vol.13 , pp. 4143-4158
    • Engel, J.D.1    von Hippel, P.H.2
  • 33
    • 0017871219 scopus 로고
    • Effects of methylation on the stability of nucleic acid conformations. Studies at the polymer level
    • 33 Engel, J.D., von Hippel, P.H., Effects of methylation on the stability of nucleic acid conformations. Studies at the polymer level. J. Biol. Chem. 253 (1978), 927–934.
    • (1978) J. Biol. Chem. , vol.253 , pp. 927-934
    • Engel, J.D.1    von Hippel, P.H.2
  • 34
    • 0035476599 scopus 로고    scopus 로고
    • Methylation of the nucleobases in RNA oligonucleotides mediates duplex-hairpin conversion
    • 34 Micura, R., et al. Methylation of the nucleobases in RNA oligonucleotides mediates duplex-hairpin conversion. Nucleic Acids Res. 29 (2001), 3997–4005.
    • (2001) Nucleic Acids Res. , vol.29 , pp. 3997-4005
    • Micura, R.1
  • 35
    • 0042161864 scopus 로고    scopus 로고
    • The thermodynamic stability of RNA duplexes and hairpins containing N6-alkyladenosines and 2-methylthio-N6-alkyladenosines
    • 35 Kierzek, E., The thermodynamic stability of RNA duplexes and hairpins containing N6-alkyladenosines and 2-methylthio-N6-alkyladenosines. Nucleic Acids Res. 31 (2003), 4472–4480.
    • (2003) Nucleic Acids Res. , vol.31 , pp. 4472-4480
    • Kierzek, E.1
  • 36
    • 84922780316 scopus 로고    scopus 로고
    • Structure and thermodynamics of N6-methyladenosine in RNA: a spring-loaded base modification
    • 36 Roost, C., et al. Structure and thermodynamics of N6-methyladenosine in RNA: a spring-loaded base modification. J. Am. Chem. Soc. 137 (2015), 2107–2715.
    • (2015) J. Am. Chem. Soc. , vol.137 , pp. 2107-2715
    • Roost, C.1
  • 37
    • 84891280075 scopus 로고    scopus 로고
    • Identification of a selective polymerase enables detection of N(6)-methyladenosine in RNA
    • 37 Harcourt, E.M., et al. Identification of a selective polymerase enables detection of N(6)-methyladenosine in RNA. J Am Chem Soc 135 (2013), 19079–19082.
    • (2013) J Am Chem Soc , vol.135 , pp. 19079-19082
    • Harcourt, E.M.1
  • 38
    • 84875649230 scopus 로고    scopus 로고
    • Analysis of RNA base modification and structural rearrangement by single-molecule real–time detection of reverse transcription
    • 38 Vilfan, I.D., et al. Analysis of RNA base modification and structural rearrangement by single-molecule real–time detection of reverse transcription. J. Nanobiotechnol., 11, 2013, 8.
    • (2013) J. Nanobiotechnol. , vol.11 , pp. 8
    • Vilfan, I.D.1
  • 39
    • 35549008047 scopus 로고    scopus 로고
    • Identification of recognition residues for ligation-based detection and quantitation of pseudouridine and N6-methyladenosine
    • 39 Dai, Q., et al. Identification of recognition residues for ligation-based detection and quantitation of pseudouridine and N6-methyladenosine. Nucleic Acids Res. 35 (2007), 6322–6329.
    • (2007) Nucleic Acids Res. , vol.35 , pp. 6322-6329
    • Dai, Q.1
  • 40
    • 84888423912 scopus 로고    scopus 로고
    • Probing N6-methyladenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNA
    • 40 Liu, N., et al. Probing N6-methyladenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNA. RNA 19 (2013), 1848–1856.
    • (2013) RNA , vol.19 , pp. 1848-1856
    • Liu, N.1
  • 41
    • 0026463886 scopus 로고
    • Partial purification of a 6-methyladenine mRNA methyltransferase which modifies internal adenine residues
    • 41 Tuck, M.T., Partial purification of a 6-methyladenine mRNA methyltransferase which modifies internal adenine residues. Biochem. J. 288 (1992), 233–240.
    • (1992) Biochem. J. , vol.288 , pp. 233-240
    • Tuck, M.T.1
  • 42
    • 0028242885 scopus 로고
    • Characterization and partial purification of mRNA N6-adenosine methyltransferase from HeLa cell nuclei. Internal mRNA methylation requires a multisubunit complex
    • 42 Bokar, J.A., et al. Characterization and partial purification of mRNA N6-adenosine methyltransferase from HeLa cell nuclei. Internal mRNA methylation requires a multisubunit complex. J. Biol. Chem. 269 (1994), 17697–17704.
    • (1994) J. Biol. Chem. , vol.269 , pp. 17697-17704
    • Bokar, J.A.1
  • 43
    • 0030712151 scopus 로고    scopus 로고
    • Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase
    • 43 Bokar, J.A., et al. Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase. RNA 3 (1997), 1233–1247.
    • (1997) RNA , vol.3 , pp. 1233-1247
    • Bokar, J.A.1
  • 44
    • 84897110592 scopus 로고    scopus 로고
    • A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
    • 44 Liu, J., et al. A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation. Nat. Chem. Biol. 10 (2014), 93–95.
    • (2014) Nat. Chem. Biol. , vol.10 , pp. 93-95
    • Liu, J.1
  • 45
    • 0036788427 scopus 로고    scopus 로고
    • Structure prediction and phylogenetic analysis of a functionally diverse family of proteins homologous to the MT-A70 subunit of the human mRNA:m(6)A methyltransferase
    • 45 Bujnicki, J.M., et al. Structure prediction and phylogenetic analysis of a functionally diverse family of proteins homologous to the MT-A70 subunit of the human mRNA:m(6)A methyltransferase. J. Mol. Evol. 55 (2002), 431–444.
    • (2002) J. Mol. Evol. , vol.55 , pp. 431-444
    • Bujnicki, J.M.1
  • 46
    • 84988476329 scopus 로고    scopus 로고
    • Structural insights into the molecular mechanism of the m(6)A writer complex
    • 46 Sledz, P., Jinek, M., Structural insights into the molecular mechanism of the m(6)A writer complex. eLife, 5, 2016, e18434.
    • (2016) eLife , vol.5 , pp. e18434
    • Sledz, P.1    Jinek, M.2
  • 47
    • 84978477054 scopus 로고    scopus 로고
    • Structural basis for cooperative function of Mettl3 and Mettl14 methyltransferases
    • 47 Wang, P., et al. Structural basis for cooperative function of Mettl3 and Mettl14 methyltransferases. Mol. Cell 63 (2016), 306–317.
    • (2016) Mol. Cell , vol.63 , pp. 306-317
    • Wang, P.1
  • 48
    • 84975700718 scopus 로고    scopus 로고
    • Structural basis of N-adenosine methylation by the METTL3–METTL14 complex
    • 48 Wang, X., et al. Structural basis of N-adenosine methylation by the METTL3–METTL14 complex. Nature 534 (2016), 575–578.
    • (2016) Nature , vol.534 , pp. 575-578
    • Wang, X.1
  • 49
    • 84864037029 scopus 로고    scopus 로고
    • RNA methylation by the MIS complex regulates a cell fate decision in yeast
    • 49 Agarwala, S.D., et al. RNA methylation by the MIS complex regulates a cell fate decision in yeast. PLoS Genet., 8, 2012, e1002732.
    • (2012) PLoS Genet. , vol.8 , pp. e1002732
    • Agarwala, S.D.1
  • 50
    • 84872274463 scopus 로고    scopus 로고
    • ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility
    • 50 Zheng, G., et al. ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Mol. Cell 49 (2013), 18–29.
    • (2013) Mol. Cell , vol.49 , pp. 18-29
    • Zheng, G.1
  • 51
    • 36749041363 scopus 로고    scopus 로고
    • The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase
    • 51 Gerken, T., et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 318 (2007), 1469–1472.
    • (2007) Science , vol.318 , pp. 1469-1472
    • Gerken, T.1
  • 52
    • 54849381000 scopus 로고    scopus 로고
    • Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO
    • 52 Jia, G., et al. Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO. FEBS Lett. 582 (2008), 3313–3319.
    • (2008) FEBS Lett. , vol.582 , pp. 3313-3319
    • Jia, G.1
  • 53
    • 84899425559 scopus 로고    scopus 로고
    • Crystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition
    • 53 Feng, C., et al. Crystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition. J. Biol. Chem. 289 (2014), 11571–11583.
    • (2014) J. Biol. Chem. , vol.289 , pp. 11571-11583
    • Feng, C.1
  • 54
    • 84896078447 scopus 로고    scopus 로고
    • Crystal structure of the RNA demethylase ALKBH5 from zebrafish
    • 54 Chen, W., et al. Crystal structure of the RNA demethylase ALKBH5 from zebrafish. FEBS Lett. 588 (2014), 892–898.
    • (2014) FEBS Lett. , vol.588 , pp. 892-898
    • Chen, W.1
  • 55
    • 77951623073 scopus 로고    scopus 로고
    • Crystal structure of the FTO protein reveals basis for its substrate specificity
    • 55 Han, Z., et al. Crystal structure of the FTO protein reveals basis for its substrate specificity. Nature 464 (2010), 1205–1209.
    • (2010) Nature , vol.464 , pp. 1205-1209
    • Han, Z.1
  • 56
    • 84868130511 scopus 로고    scopus 로고
    • Development of cell-active N6-methyladenosine RNA demethylase FTO inhibitor
    • 56 Chen, B., et al. Development of cell-active N6-methyladenosine RNA demethylase FTO inhibitor. J. Am. Chem. Soc. 134 (2012), 17963–17971.
    • (2012) J. Am. Chem. Soc. , vol.134 , pp. 17963-17971
    • Chen, B.1
  • 57
    • 84919342804 scopus 로고    scopus 로고
    • Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain
    • 57 Xu, C., et al. Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain. Nat. Chem. Biol. 10 (2014), 927–929.
    • (2014) Nat. Chem. Biol. , vol.10 , pp. 927-929
    • Xu, C.1
  • 58
    • 84930621650 scopus 로고    scopus 로고
    • N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency
    • 58 Wang, X., et al. N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency. Cell 161 (2015), 1388–1399.
    • (2015) Cell , vol.161 , pp. 1388-1399
    • Wang, X.1
  • 59
    • 84958624251 scopus 로고    scopus 로고
    • Nuclear m(6)A reader YTHDC1 regulates mRNA splicing
    • 59 Xiao, W., et al. Nuclear m(6)A reader YTHDC1 regulates mRNA splicing. Mol. Cell 61 (2016), 507–519.
    • (2016) Mol. Cell , vol.61 , pp. 507-519
    • Xiao, W.1
  • 60
    • 77952002827 scopus 로고    scopus 로고
    • The YTH domain is a novel RNA binding domain
    • 60 Zhang, Z., et al. The YTH domain is a novel RNA binding domain. J. Biol. Chem. 285 (2010), 14701–14710.
    • (2010) J. Biol. Chem. , vol.285 , pp. 14701-14710
    • Zhang, Z.1
  • 61
    • 84927593761 scopus 로고    scopus 로고
    • Solution structure of the YTH domain in complex with N6-methyladenosine RNA: a reader of methylated RNA
    • 61 Theler, D., et al. Solution structure of the YTH domain in complex with N6-methyladenosine RNA: a reader of methylated RNA. Nucleic Acids Res. 42 (2014), 13911–13919.
    • (2014) Nucleic Acids Res. , vol.42 , pp. 13911-13919
    • Theler, D.1
  • 62
    • 84927578754 scopus 로고    scopus 로고
    • Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine
    • 62 Zhu, T., et al. Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine. Cell Res 24 (2014), 1493–1496.
    • (2014) Cell Res , vol.24 , pp. 1493-1496
    • Zhu, T.1
  • 63
    • 84860221291 scopus 로고    scopus 로고
    • Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation
    • 63 Hashimoto, H., et al. Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation. Nucleic Acids Res. 40 (2012), 4841–4849.
    • (2012) Nucleic Acids Res. , vol.40 , pp. 4841-4849
    • Hashimoto, H.1
  • 64
    • 84941424170 scopus 로고    scopus 로고
    • HNRNPA2B1 is a mediator of m(6)A-dependent nuclear RNA processing Events
    • 64 Alarcon, C.R., et al. HNRNPA2B1 is a mediator of m(6)A-dependent nuclear RNA processing Events. Cell 162 (2015), 1299–1308.
    • (2015) Cell , vol.162 , pp. 1299-1308
    • Alarcon, C.R.1
  • 65
    • 0018115856 scopus 로고
    • Biosynthesis and utilization of extensively undermethylated poly(A)+ RNA in CHO cells during a cycloleucine treatment
    • 65 Bachellerie, J.P., et al. Biosynthesis and utilization of extensively undermethylated poly(A)+ RNA in CHO cells during a cycloleucine treatment. Nucleic Acids Res. 5 (1978), 2927–2943.
    • (1978) Nucleic Acids Res. , vol.5 , pp. 2927-2943
    • Bachellerie, J.P.1
  • 66
    • 84922342926 scopus 로고    scopus 로고
    • Stem cells. m6A mRNA methylation facilitates resolution of naive pluripotency toward differentiation
    • 66 Geula, S., et al. Stem cells. m6A mRNA methylation facilitates resolution of naive pluripotency toward differentiation. Science 347 (2015), 1002–1006.
    • (2015) Science , vol.347 , pp. 1002-1006
    • Geula, S.1
  • 67
    • 84983728274 scopus 로고    scopus 로고
    • YTHDF2 destabilizes m(6)A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex
    • 67 Du, H., et al. YTHDF2 destabilizes m(6)A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex. Nat. Commun., 7, 2016, 12626.
    • (2016) Nat. Commun. , vol.7 , pp. 12626
    • Du, H.1
  • 68
    • 84963960245 scopus 로고    scopus 로고
    • Posttranscriptional m(6)A editing of HIV-1 mRNAs enhances viral gene expression
    • 68 Kennedy, E.M., et al. Posttranscriptional m(6)A editing of HIV-1 mRNAs enhances viral gene expression. Cell Host Microbe 19 (2016), 675–685.
    • (2016) Cell Host Microbe , vol.19 , pp. 675-685
    • Kennedy, E.M.1
  • 69
    • 84979556508 scopus 로고    scopus 로고
    • N6-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression
    • 69 Tirumuru, N., et al. N6-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression. eLife, 5, 2016, e15528.
    • (2016) eLife , vol.5 , pp. e15528
    • Tirumuru, N.1
  • 70
    • 84893351549 scopus 로고    scopus 로고
    • Genome-wide probing of RNA structure reveals active unfolding of mRNA structures in vivo
    • 70 Rouskin, S., et al. Genome-wide probing of RNA structure reveals active unfolding of mRNA structures in vivo. Nature 505 (2014), 701–705.
    • (2014) Nature , vol.505 , pp. 701-705
    • Rouskin, S.1
  • 71
    • 84893427735 scopus 로고    scopus 로고
    • In vivo genome-wide profiling of RNA secondary structure reveals novel regulatory features
    • 71 Ding, Y., et al. In vivo genome-wide profiling of RNA secondary structure reveals novel regulatory features. Nature 505 (2014), 696–700.
    • (2014) Nature , vol.505 , pp. 696-700
    • Ding, Y.1
  • 72
    • 84925777836 scopus 로고    scopus 로고
    • Structural imprints in vivo decode RNA regulatory mechanisms
    • 72 Spitale, R.C., et al. Structural imprints in vivo decode RNA regulatory mechanisms. Nature 519 (2015), 486–490.
    • (2015) Nature , vol.519 , pp. 486-490
    • Spitale, R.C.1
  • 73
    • 84924072927 scopus 로고    scopus 로고
    • N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions
    • 73 Liu, N., et al. N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions. Nature 518 (2015), 560–564.
    • (2015) Nature , vol.518 , pp. 560-564
    • Liu, N.1
  • 74
    • 84945288814 scopus 로고    scopus 로고
    • Dynamic m(6)A mRNA methylation directs translational control of heat shock response
    • 74 Zhou, J., et al. Dynamic m(6)A mRNA methylation directs translational control of heat shock response. Nature 526 (2015), 591–594.
    • (2015) Nature , vol.526 , pp. 591-594
    • Zhou, J.1
  • 75
    • 84969822475 scopus 로고    scopus 로고
    • N(6)-Methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5
    • 75 Zou, S., et al. N(6)-Methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5. Sci. Rep., 6, 2016, 25677.
    • (2016) Sci. Rep. , vol.6 , pp. 25677
    • Zou, S.1
  • 76
    • 84963983880 scopus 로고    scopus 로고
    • The m(6)A methyltransferase METTL3 promotes translation in human cancer cells
    • 76 Lin, S., et al. The m(6)A methyltransferase METTL3 promotes translation in human cancer cells. Mol. Cell 62 (2016), 335–345.
    • (2016) Mol. Cell , vol.62 , pp. 335-345
    • Lin, S.1
  • 77
    • 84956714047 scopus 로고    scopus 로고
    • N(6)-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics
    • 77 Choi, J., et al. N(6)-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics. Nat. Struct. Mol. Biol. 23 (2016), 110–115.
    • (2016) Nat. Struct. Mol. Biol. , vol.23 , pp. 110-115
    • Choi, J.1
  • 78
    • 84920283621 scopus 로고    scopus 로고
    • FTO: linking m6A demethylation to adipogenesis
    • 78 Ben-Haim, M.S., et al. FTO: linking m6A demethylation to adipogenesis. Cell Res. 25 (2015), 3–4.
    • (2015) Cell Res. , vol.25 , pp. 3-4
    • Ben-Haim, M.S.1
  • 79
    • 3042836378 scopus 로고    scopus 로고
    • A molecular link between SR protein dephosphorylation and mRNA export
    • 79 Huang, Y., et al. A molecular link between SR protein dephosphorylation and mRNA export. Proc. Natl. Acad. Sci. U.S.A. 101 (2004), 9666–9670.
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 9666-9670
    • Huang, Y.1
  • 80
    • 3843075319 scopus 로고    scopus 로고
    • Hypophosphorylated ASF/SF2 binds TAP and is present in messenger ribonucleoproteins
    • 80 Lai, M.C., Tarn, W.Y., Hypophosphorylated ASF/SF2 binds TAP and is present in messenger ribonucleoproteins. J. Biol. Chem. 279 (2004), 31745–31749.
    • (2004) J. Biol. Chem. , vol.279 , pp. 31745-31749
    • Lai, M.C.1    Tarn, W.Y.2
  • 81
    • 84925796024 scopus 로고    scopus 로고
    • N6-methyladenosine marks primary microRNAs for processing
    • 81 Alarcon, C.R., et al. N6-methyladenosine marks primary microRNAs for processing. Nature 519 (2015), 482–485.
    • (2015) Nature , vol.519 , pp. 482-485
    • Alarcon, C.R.1
  • 82
    • 84924283323 scopus 로고    scopus 로고
    • m(6)A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency
    • 82 Chen, T., et al. m(6)A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency. Cell Stem Cell 16 (2015), 289–301.
    • (2015) Cell Stem Cell , vol.16 , pp. 289-301
    • Chen, T.1
  • 83
    • 78651335915 scopus 로고    scopus 로고
    • The RNA Modification Database, RNAMDB: 2011 update
    • 83 Cantara, W.A., et al. The RNA Modification Database, RNAMDB: 2011 update. Nucleic Acids Res. 39 (2011), D195–D201.
    • (2011) Nucleic Acids Res. , vol.39 , pp. D195-D201
    • Cantara, W.A.1


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