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Volumn 119, Issue 1, 2016, Pages 87-97

Pathogenesis of amyotrophic lateral sclerosis

Author keywords

amyotrophic lateral sclerosis; genetics; pathogenesis; treatment

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; GROWTH FACTOR; MYOGENIC FACTOR; TAR DNA BINDING PROTEIN; ANTICONVULSIVE AGENT; C9ORF72 PROTEIN, HUMAN; DNA BINDING PROTEIN; FUS PROTEIN, HUMAN; PROTEIN; RILUZOLE; RNA BINDING PROTEIN FUS; SOD1 PROTEIN, HUMAN; TDP-43 PROTEIN, HUMAN;

EID: 84994137659     PISSN: 00071420     EISSN: 14718391     Source Type: Journal    
DOI: 10.1093/bmb/ldw026     Document Type: Review
Times cited : (127)

References (58)
  • 1
    • 84908012653 scopus 로고    scopus 로고
    • Analysis of amyotrophic lateral sclerosis as a multistep process: A population-based modelling study
    • Al-Chalabi A, Calvo A, Chio A, et al. Analysis of amyotrophic lateral sclerosis as a multistep process: a population-based modelling study. Lancet Neurol 2014;13:1108-13.
    • (2014) Lancet Neurol , vol.13 , pp. 1108-1113
    • Al-Chalabi, A.1    Calvo, A.2    Chio, A.3
  • 2
    • 84887233527 scopus 로고    scopus 로고
    • The epidemiology of ALS: A conspiracy of genes, environment and time
    • Al-Chalabi A and Hardiman O. The epidemiology of ALS: a conspiracy of genes, environment and time. Nat Rev Neurol 2013;9:617-28.
    • (2013) Nat Rev Neurol , vol.9 , pp. 617-628
    • Al-Chalabi, A.1    Hardiman, O.2
  • 3
    • 78649632679 scopus 로고    scopus 로고
    • An estimate of amyotrophic lateral sclerosis heritability using twin data
    • Al-Chalabi A, Fang F, Hanby MF, et al. An estimate of amyotrophic lateral sclerosis heritability using twin data. J Neurol Neurosurg Psychiatry 2010;81:1324-6.
    • (2010) J Neurol Neurosurg Psychiatry , vol.81 , pp. 1324-1326
    • Al-Chalabi, A.1    Fang, F.2    Hanby, M.F.3
  • 4
    • 84907562357 scopus 로고    scopus 로고
    • Genomewide analysis of the heritability of amyotrophic lateral sclerosis
    • Keller MF, Ferrucci L, Singleton AB, et al. Genomewide analysis of the heritability of amyotrophic lateral sclerosis. JAMA Neurol 2014;71:1123-34.
    • (2014) JAMA Neurol , vol.71 , pp. 1123-1134
    • Keller, M.F.1    Ferrucci, L.2    Singleton, A.B.3
  • 5
    • 84900832142 scopus 로고    scopus 로고
    • Genetic heterogeneity of amyotrophic lateral sclerosis: Implications for clinical practice and research
    • Su XW, Broach JR, Connor JR, et al. Genetic heterogeneity of amyotrophic lateral sclerosis: implications for clinical practice and research. Muscle Nerve 2014;49:786-803.
    • (2014) Muscle Nerve , vol.49 , pp. 786-803
    • Su, X.W.1    Broach, J.R.2    Connor, J.R.3
  • 6
    • 84893649256 scopus 로고    scopus 로고
    • State of play in amyotrophic lateral sclerosis genetics
    • Renton AE, Chio A and Traynor BJ. State of play in amyotrophic lateral sclerosis genetics. Nat Neurosci 2014;17:17-23.
    • (2014) Nat Neurosci , vol.17 , pp. 17-23
    • Renton, A.E.1    Chio, A.2    Traynor, B.J.3
  • 7
    • 84858622829 scopus 로고    scopus 로고
    • Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: A cross-sectional study
    • Majounie E, Renton AE, Mok K, et al. Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study. Lancet Neurol 2012;11:323-30.
    • (2012) Lancet Neurol , vol.11 , pp. 323-330
    • Majounie, E.1    Renton, A.E.2    Mok, K.3
  • 8
    • 84864383816 scopus 로고    scopus 로고
    • Analysis of C9orf72 repeat expansions in 563 Japanese patients with amyotrophic lateral sclerosis
    • Ogaki K, Li Y, Atsuta N, et al. Analysis of C9orf72 repeat expansions in 563 Japanese patients with amyotrophic lateral sclerosis. Neurobiol Aging 2012;33:2527. e11-16.
    • (2012) Neurobiol Aging , vol.33 , pp. 2527e11-252716
    • Ogaki, K.1    Li, Y.2    Atsuta, N.3
  • 9
    • 85017066057 scopus 로고    scopus 로고
    • Large C9orf72 repeat expansions are seen in Chinese patients with sporadic amyotrophic lateral sclerosis
    • Chen Y, Lin Z, Chen Z, et al. Large C9orf72 repeat expansions are seen in Chinese patients with sporadic amyotrophic lateral sclerosis. Neurobiol Aging 2016;38:217.e15-22.
    • (2016) Neurobiol Aging , vol.38 , pp. 217e15-21722
    • Chen, Y.1    Lin, Z.2    Chen, Z.3
  • 10
    • 84923288410 scopus 로고    scopus 로고
    • C9orf72 expansions in frontotemporal dementia and amyotrophic lateral sclerosis
    • Rohrer JD, Isaacs AM, Mizielinska S, et al. C9orf72 expansions in frontotemporal dementia and amyotrophic lateral sclerosis. Lancet Neurol 2015;14:291-301.
    • (2015) Lancet Neurol , vol.14 , pp. 291-301
    • Rohrer, J.D.1    Isaacs, A.M.2    Mizielinska, S.3
  • 11
    • 84979253514 scopus 로고    scopus 로고
    • The C9orf72 repeat size correlates with onset age of disease, DNA methylation and transcriptional downregulation of the promoter
    • epub
    • Gijselinck I, Van Mossevelde S, van der Zee J, et al. The C9orf72 repeat size correlates with onset age of disease, DNA methylation and transcriptional downregulation of the promoter. Mol Psychiatry 2015 epub.
    • (2015) Mol Psychiatry
    • Gijselinck, I.1    Van Mossevelde, S.2    Van Der Zee, J.3
  • 12
    • 84908161213 scopus 로고    scopus 로고
    • Pathogenesis/genetics of frontotemporal dementia and how it relates to ALS
    • 2104
    • Bennion Callister J and Pickering-Brown SM. Pathogenesis/genetics of frontotemporal dementia and how it relates to ALS. Exp Neurol 2104;262:84-90.
    • Exp Neurol , vol.262 , pp. 84-90
    • Bennion Callister, J.1    Pickering-Brown, S.M.2
  • 14
    • 0027401203 scopus 로고
    • Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
    • Rosen DR, Siddique T, Patterson D, et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 1993; 362:59-62.
    • (1993) Nature , vol.362 , pp. 59-62
    • Rosen, D.R.1    Siddique, T.2    Patterson, D.3
  • 15
    • 40349102131 scopus 로고    scopus 로고
    • Prevalence of SOD1 mutations in the Italian ALS population
    • Chio A, Traynor BF, Lombardo F, et al. Prevalence of SOD1 mutations in the Italian ALS population. Neurology 2008;70:533-7.
    • (2008) Neurology , vol.70 , pp. 533-537
    • Chio, A.1    Traynor, B.F.2    Lombardo, F.3
  • 16
    • 84878131682 scopus 로고    scopus 로고
    • TARDBP and FUS mutations associated with amyotrophic lateral sclerosis: Summary and update
    • Lattante S, Rouleau GA and Kabashi E. TARDBP and FUS mutations associated with amyotrophic lateral sclerosis: summary and update. Hum Mutat 2013;34:812-26.
    • (2013) Hum Mutat , vol.34 , pp. 812-826
    • Lattante, S.1    Rouleau, G.A.2    Kabashi, E.3
  • 17
    • 84902291718 scopus 로고    scopus 로고
    • The role of FUS gene variants in neurodegenerative diseases
    • Deng H, Gao K and Jankovic J. The role of FUS gene variants in neurodegenerative diseases. Na Rev Neurol 2014;10:337-48.
    • (2014) Na Rev Neurol , vol.10 , pp. 337-348
    • Deng, H.1    Gao, K.2    Jankovic, J.3
  • 18
    • 84922481787 scopus 로고    scopus 로고
    • Dissection of genetic factors associated with amyotrophic lateral sclerosis
    • Leblond CS, Kaneb HM, Dion PA, et al. Dissection of genetic factors associated with amyotrophic lateral sclerosis. Exp Neurol 2014;262:91-101.
    • (2014) Exp Neurol , vol.262 , pp. 91-101
    • Leblond, C.S.1    Kaneb, H.M.2    Dion, P.A.3
  • 19
    • 84920848931 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis onset is influenced by the burden of rare variants in known amyotrophic lateral sclerosis genes
    • Cady J, Allred P, Bali T, et al. Amyotrophic lateral sclerosis onset is influenced by the burden of rare variants in known amyotrophic lateral sclerosis genes. Ann Neurol 2015;77:11-113.
    • (2015) Ann Neurol , vol.77 , pp. 11-113
    • Cady, J.1    Allred, P.2    Bali, T.3
  • 20
    • 84923602414 scopus 로고    scopus 로고
    • Investigation of next-generation sequencing technologies as a diagnostic tool for amyotrophic lateral sclerosis
    • Morgan S, Shoai M, Fratta P, et al. Investigation of next-generation sequencing technologies as a diagnostic tool for amyotrophic lateral sclerosis. Neurobiol Aging 2015;36:1600.e5-8.
    • (2015) Neurobiol Aging , vol.36 , pp. 1600e5-1600e8
    • Morgan, S.1    Shoai, M.2    Fratta, P.3
  • 21
    • 84929264163 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis: Mechanisms and therapeutics in the epigenomic era
    • Paez-Colasante X, Figueroa-Romero C, Sakowski SA, et al. Amyotrophic lateral sclerosis: mechanisms and therapeutics in the epigenomic era. Nat Rev Neurol 2015;11:266-79.
    • (2015) Nat Rev Neurol , vol.11 , pp. 266-279
    • Paez-Colasante, X.1    Figueroa-Romero, C.2    Sakowski, S.A.3
  • 22
    • 84908154846 scopus 로고    scopus 로고
    • Focality, stochasticity and neuroanatomic propagation in ALS pathogenesis
    • Ravits J. Focality, stochasticity and neuroanatomic propagation in ALS pathogenesis. Exp Neurol 2014;262:121-26.
    • (2014) Exp Neurol , vol.262 , pp. 121-126
    • Ravits, J.1
  • 23
    • 84890121734 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis-a model of corticofugal axonal spread
    • Braak H, Brettschneider J, Ludolph AC, et al. Amyotrophic lateral sclerosis-a model of corticofugal axonal spread. Nat Rev Neurol 2013;9:708-14.
    • (2013) Nat Rev Neurol , vol.9 , pp. 708-714
    • Braak, H.1    Brettschneider, J.2    Ludolph, A.C.3
  • 24
    • 84891825503 scopus 로고    scopus 로고
    • Spreading of amyotrophic lateral sclerosis lesions-multifocal hits and local propagation?
    • Sekiguchi T, Kanouchi T, Shibuya K, et al. Spreading of amyotrophic lateral sclerosis lesions-multifocal hits and local propagation? J Neurol Neurosurg Psychiatry 2014;85:85-91.
    • (2014) J Neurol Neurosurg Psychiatry , vol.85 , pp. 85-91
    • Sekiguchi, T.1    Kanouchi, T.2    Shibuya, K.3
  • 25
    • 84906666492 scopus 로고    scopus 로고
    • Widespread grey matter pathology dominates the longitudinal cerebral MRI and clinical landscape of amyotrophic lateral sclerosis
    • Menke RA, Korner S, Filippini N, et al. Widespread grey matter pathology dominates the longitudinal cerebral MRI and clinical landscape of amyotrophic lateral sclerosis. Brain 2014;137:2546-55.
    • (2014) Brain , vol.137 , pp. 2546-2555
    • Menke, R.A.1    Korner, S.2    Filippini, N.3
  • 26
    • 84902275577 scopus 로고    scopus 로고
    • Physical activity and amyotrophic lateral sclerosis: A European population-based case-control study
    • Pupillo E, Messina P, Giussani G, et al. Physical activity and amyotrophic lateral sclerosis: a European population-based case-control study. Ann Neurol 2014;75:708-16.
    • (2014) Ann Neurol , vol.75 , pp. 708-716
    • Pupillo, E.1    Messina, P.2    Giussani, G.3
  • 27
    • 77957285745 scopus 로고    scopus 로고
    • TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy
    • McKee AC, Gavett BE, Stern RA, et al. TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy. J Neuropathol Exp Neurol 2010; 69:918-29.
    • (2010) J Neuropathol Exp Neurol , vol.69 , pp. 918-929
    • McKee, A.C.1    Gavett, B.E.2    Stern, R.A.3
  • 28
    • 84923111823 scopus 로고    scopus 로고
    • Risk factors for amyotrophic lateral sclerosis
    • Ingre C, Roos PM, Piehl F, et al. Risk factors for amyotrophic lateral sclerosis. Clin Epidemiol 2015;7:181-93.
    • (2015) Clin Epidemiol , vol.7 , pp. 181-193
    • Ingre, C.1    Roos, P.M.2    Piehl, F.3
  • 29
    • 84896412275 scopus 로고    scopus 로고
    • Pathway analysis of two amyotrophic lateral sclerosis GWAS highlights shared genetic signals with Alzheimers Disease and Parkinsons disease
    • Shang H, Liu G, Jiang Y, et al. Pathway analysis of two amyotrophic lateral sclerosis GWAS highlights shared genetic signals with Alzheimers Disease and Parkinsons disease. Mol Neurobiol 2015;51:361-9.
    • (2015) Mol Neurobiol , vol.51 , pp. 361-369
    • Shang, H.1    Liu, G.2    Jiang, Y.3
  • 30
    • 84876411369 scopus 로고    scopus 로고
    • Large C9orf72 hexanucleotide repeat expansions are seen in multiple neurodegenerative syndromes and are more frequent than expected in the UK population
    • Beck J, Poulter M, Hensman D, et al. Large C9orf72 hexanucleotide repeat expansions are seen in multiple neurodegenerative syndromes and are more frequent than expected in the UK population. Am J Hum Genet 2013;92:345-53.
    • (2013) Am J Hum Genet , vol.92 , pp. 345-353
    • Beck, J.1    Poulter, M.2    Hensman, D.3
  • 31
    • 84929000939 scopus 로고    scopus 로고
    • Emerging mechanism of molecular pathology in ALS
    • Peters OM, Ghasemi M and Brown RH Jr.. Emerging mechanism of molecular pathology in ALS. J Clin Invest 2015;125:1767-79.
    • (2015) J Clin Invest , vol.125 , pp. 1767-1779
    • Peters, O.M.1    Ghasemi, M.2    Brown, R.H.3
  • 32
    • 84901412961 scopus 로고    scopus 로고
    • The emerging roles of microRNAs in the pathogenesis of frontotemporal dementia-amyotrophic lateral sclerosis (FTD-ALS) spectrum disorders
    • Gascon E and Gao FB. The emerging roles of microRNAs in the pathogenesis of frontotemporal dementia-amyotrophic lateral sclerosis (FTD-ALS) spectrum disorders. J Neurogenet 2014;28:30-40.
    • (2014) J Neurogenet , vol.28 , pp. 30-40
    • Gascon, E.1    Gao, F.B.2
  • 33
    • 84925748556 scopus 로고    scopus 로고
    • Genotype-property patient-phenotype relations suggest that proteome exhaustion can cause amyotrophic lateral sclerosis
    • Kepp KP. Genotype-property patient-phenotype relations suggest that proteome exhaustion can cause amyotrophic lateral sclerosis. PLoS One 2015;10:e0118649, doi:10.1371.
    • (2015) PLoS One , vol.10 , pp. e0118649
    • Kepp, K.P.1
  • 34
    • 84926019373 scopus 로고    scopus 로고
    • Exploring new pathways of neurodegeneration in ALS: The role of mitochondria quality control
    • Palomo GM and Manfredi G. Exploring new pathways of neurodegeneration in ALS: the role of mitochondria quality control. Brain Res 2015;1607:36-46.
    • (2015) Brain Res , vol.1607 , pp. 36-46
    • Palomo, G.M.1    Manfredi, G.2
  • 35
    • 84901826643 scopus 로고    scopus 로고
    • The ER mitochondria calcium cycle and ER stress response as therapeutic targets in amyotrophic lateral sclerosis
    • Tadic V, Prell T, Lautenschlaeger J, et al. The ER mitochondria calcium cycle and ER stress response as therapeutic targets in amyotrophic lateral sclerosis. Front Cell Neurosci 2014;8:147, doi:10.3389/fncel.2014.00147.
    • (2014) Front Cell Neurosci , vol.8 , pp. 147
    • Tadic, V.1    Prell, T.2    Lautenschlaeger, J.3
  • 36
    • 84941007556 scopus 로고    scopus 로고
    • SOD1 misplacing and mitochondrial dysfunction in amyotrophic lateral sclerosis pathogenesis
    • Tafuri F, Ronchi D, Magri F, et al. SOD1 misplacing and mitochondrial dysfunction in amyotrophic lateral sclerosis pathogenesis. Front Cell Neurosci 2015;9:336, doi:10.3389/fncel.2015.00336.
    • (2015) Front Cell Neurosci , vol.9 , pp. 336
    • Tafuri, F.1    Ronchi, D.2    Magri, F.3
  • 37
    • 84907351846 scopus 로고    scopus 로고
    • A computational model of motor neuron degeneration
    • Le Masson G, Przedborksi S and Abbott LF. A computational model of motor neuron degeneration. Neuron 2014;83:975-88.
    • (2014) Neuron , vol.83 , pp. 975-988
    • Le Masson, G.1    Przedborksi, S.2    Abbott, L.F.3
  • 38
    • 84905041572 scopus 로고    scopus 로고
    • A mitochondrial origin for frontotemporal dementia and amyotrophic lateral sclerosis through CHCHD10 involvement
    • Bannwarth S, Ait-El-Mikadem S, Chaussenot A, et al. A mitochondrial origin for frontotemporal dementia and amyotrophic lateral sclerosis through CHCHD10 involvement. Brain 2014;137:2329-45.
    • (2014) Brain , vol.137 , pp. 2329-2345
    • Bannwarth, S.1    Ait-El-Mikadem, S.2    Chaussenot, A.3
  • 39
    • 84876005922 scopus 로고    scopus 로고
    • The neuroprotective drug riluzole acts via small conductance Ca2+-activated K+ channels to ameliorate defects in spinal muscular atrophy models
    • Dimitriadi M, Kye MJ, Kalloo G, et al. The neuroprotective drug riluzole acts via small conductance Ca2+-activated K+ channels to ameliorate defects in spinal muscular atrophy models. J Neurosci 2013;33:6557-62.
    • (2013) J Neurosci , vol.33 , pp. 6557-6562
    • Dimitriadi, M.1    Kye, M.J.2    Kalloo, G.3
  • 40
    • 84901297430 scopus 로고    scopus 로고
    • Safety, pharmacokinetic, and functional effects of the nogo-a monoclonal antibody in amyotrophic lateral sclerosis: A randomized, first-in-human trail
    • Meininger V, Pradat PF, Corse A, et al. Safety, pharmacokinetic, and functional effects of the nogo-a monoclonal antibody in amyotrophic lateral sclerosis: a randomized, first-in-human trail. PLoS One 2014;9: e97803.
    • (2014) PLoS One , vol.9 , pp. e97803
    • Meininger, V.1    Pradat, P.F.2    Corse, A.3
  • 41
    • 84930452093 scopus 로고    scopus 로고
    • From molecule to molecule and cell to cell: Prion-like mechanisms in amyotrophic lateral sclerosis
    • Grad LI, Fernando SM and Cashman NR. From molecule to molecule and cell to cell: prion-like mechanisms in amyotrophic lateral sclerosis. Neuroubiol Dis 2015;77:257-65.
    • (2015) Neuroubiol Dis , vol.77 , pp. 257-265
    • Grad, L.I.1    Fernando, S.M.2    Cashman, N.R.3
  • 42
    • 84896970296 scopus 로고    scopus 로고
    • Prion-like activity of Cu/Zn superoxide dismutase: Implications for amyotrophic lateral sclerosis
    • Grad LI and Cashman NR. Prion-like activity of Cu/Zn superoxide dismutase: implications for amyotrophic lateral sclerosis. Prion 2014;8:33-41.
    • (2014) Prion , vol.8 , pp. 33-41
    • Grad, L.I.1    Cashman, N.R.2
  • 43
    • 84901445351 scopus 로고    scopus 로고
    • Microglia centered pathogenesis in ALS: Insights in cell interconnectivity
    • Brites D and Vaz AR. Microglia centered pathogenesis in ALS: insights in cell interconnectivity. Front Cell Neurosci 2014;8:117.
    • (2014) Front Cell Neurosci , vol.8 , pp. 117
    • Brites, D.1    Vaz, A.R.2
  • 44
    • 84892802245 scopus 로고    scopus 로고
    • The multifaceted role of glial cells in amyotrophic lateral sclerosis
    • Valori CF, Brambilla L, Martorana F, et al. The multifaceted role of glial cells in amyotrophic lateral sclerosis. Cell Mol Life Sci 2014;71:287-97.
    • (2014) Cell Mol Life Sci , vol.71 , pp. 287-297
    • Valori, C.F.1    Brambilla, L.2    Martorana, F.3
  • 45
    • 84891668636 scopus 로고    scopus 로고
    • More than a bystander: The contributions of intrinsic skeletal muscle defects in motor neuron diseases
    • Boyer JG, Ferrier A and Kothray R. More than a bystander: the contributions of intrinsic skeletal muscle defects in motor neuron diseases. Front Physiol 2013;4:356.
    • (2013) Front Physiol , vol.4 , pp. 356
    • Boyer, J.G.1    Ferrier, A.2    Kothray, R.3
  • 46
    • 84896543905 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis and skeletal muscle: An update
    • Pansarasa O, Rossi D, Berardenilli A, et al. Amyotrophic lateral sclerosis and skeletal muscle: an update. Mol Neurobiol 2014;49:984-90.
    • (2014) Mol Neurobiol , vol.49 , pp. 984-990
    • Pansarasa, O.1    Rossi, D.2    Berardenilli, A.3
  • 47
    • 78649941297 scopus 로고    scopus 로고
    • Exome sequencing reveals VCP mutations as a cause of familial ALS
    • Johnson JO, Mandrioli J, Benatar M, et al. Exome sequencing reveals VCP mutations as a cause of familial ALS. Neuron 2010;68:857-64.
    • (2010) Neuron , vol.68 , pp. 857-864
    • Johnson, J.O.1    Mandrioli, J.2    Benatar, M.3
  • 48
    • 84912130817 scopus 로고    scopus 로고
    • Phenotype of matrin-3-related distal myopathy in 16 German patients
    • Muller TJ, Kraya T, Stoltenburg-Didinger G, et al. Phenotype of matrin-3-related distal myopathy in 16 German patients. Ann Neurol 2014;76:669-80.
    • (2014) Ann Neurol , vol.76 , pp. 669-680
    • Muller, T.J.1    Kraya, T.2    Stoltenburg-Didinger, G.3
  • 49
    • 84908481936 scopus 로고    scopus 로고
    • The phenotypic variability of amyotrophic lateral sclerosis
    • Swinnen B and Robberecht W. The phenotypic variability of amyotrophic lateral sclerosis. Nat Rev Neurol 2014;10:661-70.
    • (2014) Nat Rev Neurol , vol.10 , pp. 661-670
    • Swinnen, B.1    Robberecht, W.2
  • 50
    • 77955396350 scopus 로고    scopus 로고
    • SOD1, ANG, VAPB, TARDBP, and FUS mutations in familial amyotrophic lateral sclerosis: Genotype-phenotype correlations
    • Millecamps S, Salachas F, Cazeneuve C, et al. SOD1, ANG, VAPB, TARDBP, and FUS mutations in familial amyotrophic lateral sclerosis: genotype-phenotype correlations. J Med Genet 2010;47:554-60.
    • (2010) J Med Genet , vol.47 , pp. 554-560
    • Millecamps, S.1    Salachas, F.2    Cazeneuve, C.3
  • 51
    • 84911394418 scopus 로고    scopus 로고
    • Experimental trials in amyotrophic lateral sclerosis: A review of recently completed, ongoing and planned trials using existing and novel drugs
    • Goyal NA and Mozaffar T. Experimental trials in amyotrophic lateral sclerosis: a review of recently completed, ongoing and planned trials using existing and novel drugs. Expert Opin Investig Drugs 2014;23: 1541-51.
    • (2014) Expert Opin Investig Drugs , vol.23 , pp. 1541-1551
    • Goyal, N.A.1    Mozaffar, T.2
  • 53
    • 84908390975 scopus 로고    scopus 로고
    • Translating biological findings into new treatment strategies for amyotrophic lateral sclerosis (ALS)
    • Poppe L, Rue L, Robberecht W, et al. Translating biological findings into new treatment strategies for amyotrophic lateral sclerosis (ALS). Exp Neurol 2014;262: 138-51.
    • (2014) Exp Neurol , vol.262 , pp. 138-151
    • Poppe, L.1    Rue, L.2    Robberecht, W.3
  • 54
    • 84876466100 scopus 로고    scopus 로고
    • An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: A phase 1, randomized, first-in-man study
    • Miller TM, Pestronk A, David W, et al. An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomized, first-in-man study. Lancet Neurol 2013;12:435-42.
    • (2013) Lancet Neurol , vol.12 , pp. 435-442
    • Miller, T.M.1    Pestronk, A.2    David, W.3
  • 55
    • 84931050764 scopus 로고    scopus 로고
    • Current developments in gene therapy for amyotrophic lateral sclerosis
    • Scarrott JM, Herranz-Martin S, Alrafiah AR, et al. Current developments in gene therapy for amyotrophic lateral sclerosis. Expert Opin Biol Ther 2015;15: 935-47.
    • (2015) Expert Opin Biol Ther , vol.15 , pp. 935-947
    • Scarrott, J.M.1    Herranz-Martin, S.2    Alrafiah, A.R.3
  • 56
    • 84891371641 scopus 로고    scopus 로고
    • Taking a risk: A therapeutic focus on ataxin-2 in amyotrophic lateral sclerosis?
    • Van den Heuvel DM, Harshnitz O, van den Berg LH, et al. Taking a risk: a therapeutic focus on ataxin-2 in amyotrophic lateral sclerosis? Trends Mol Med 2014;20:25-35.
    • (2014) Trends Mol Med , vol.20 , pp. 25-35
    • Van Den Heuvel, D.M.1    Harshnitz, O.2    Van Den Berg, L.H.3
  • 57
    • 84898847400 scopus 로고    scopus 로고
    • Genetic counseling in ALS: Facts, uncertainties and clinical suggestions
    • Chio A, Battistini S, Calvo A, et al. Genetic counseling in ALS: facts, uncertainties and clinical suggestions. J Neurol Neurosurg Psychiatry 2014;85:478-85.
    • (2014) J Neurol Neurosurg Psychiatry , vol.85 , pp. 478-485
    • Chio, A.1    Battistini, S.2    Calvo, A.3


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