메뉴 건너뛰기




Volumn 130, Issue , 2016, Pages 41-72

From the Blood to the Central Nervous System: A Nanoparticle's Journey Through the Blood–Brain Barrier by Transcytosis

Author keywords

Blood brain barrier; Central nervous system; Drug delivery; Intracellular trafficking; Nanoparticles; Receptor binding; Receptor recycling; Transcytosis

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; APOLIPOPROTEIN E; APOLIPOPROTEIN E RECEPTOR 2; FC RECEPTOR; GOLD NANOPARTICLE; INSULIN RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; MACROGOL; MEGALIN; MELANOTRANSFERRIN RECEPTOR; TRANSFERRIN RECEPTOR; UNCLASSIFIED DRUG; NANOPARTICLE;

EID: 84994076422     PISSN: 00747742     EISSN: 21625514     Source Type: Book Series    
DOI: 10.1016/bs.irn.2016.06.001     Document Type: Chapter
Times cited : (31)

References (97)
  • 1
    • 51049092308 scopus 로고    scopus 로고
    • Factors affecting the clearance and biodistribution of polymeric nanoparticles
    • Alexis, F., Pridgen, E., Molnar, L.K., Farokhzad, O.C., Factors affecting the clearance and biodistribution of polymeric nanoparticles. Molecular Pharmaceutics 5:4 (2008), 505–515, 10.1021/mp800051m.
    • (2008) Molecular Pharmaceutics , vol.5 , Issue.4 , pp. 505-515
    • Alexis, F.1    Pridgen, E.2    Molnar, L.K.3    Farokhzad, O.C.4
  • 2
    • 0030993566 scopus 로고    scopus 로고
    • Delivery of loperamide across the blood-brain barrier with polysorbate 80-coated polybutylcyanoacrylate nanoparticles
    • Alyautdin, R., Petrov, V., Langer, K., Berthold, A., Kharkevich, D., Kreuter, J., Delivery of loperamide across the blood-brain barrier with polysorbate 80-coated polybutylcyanoacrylate nanoparticles. Pharmaceutical Research 14:3 (1997), 325–328, 10.1023/a:1012098005098.
    • (1997) Pharmaceutical Research , vol.14 , Issue.3 , pp. 325-328
    • Alyautdin, R.1    Petrov, V.2    Langer, K.3    Berthold, A.4    Kharkevich, D.5    Kreuter, J.6
  • 3
    • 84922789726 scopus 로고    scopus 로고
    • Clathrin-dependent entry and vesicle-mediated exocytosis define insulin transcytosis across microvascular endothelial cells
    • Azizi, P.M., Zyla, R.E., Guan, S., Wang, C., Liu, J., Bolz, S.-S.,.. Lee, W.L., Clathrin-dependent entry and vesicle-mediated exocytosis define insulin transcytosis across microvascular endothelial cells. Molecular Biology of the Cell 26:4 (2015), 740–750, 10.1091/mbc.E14-08-1307.
    • (2015) Molecular Biology of the Cell , vol.26 , Issue.4 , pp. 740-750
    • Azizi, P.M.1    Zyla, R.E.2    Guan, S.3    Wang, C.4    Liu, J.5    Bolz, S.-S.6    Lee, W.L.7
  • 4
    • 1842734659 scopus 로고    scopus 로고
    • The source of cerebral insulin
    • Banks, W.A., The source of cerebral insulin. European Journal of Pharmacology 490:1–3 (2004), 5–12 http://dx.doi.org/10.1016/j.ejphar.2004.02.040.
    • (2004) European Journal of Pharmacology , vol.490 , Issue.1-3 , pp. 5-12
    • Banks, W.A.1
  • 6
    • 76249087751 scopus 로고    scopus 로고
    • Pharmacokinetics and brain uptake of a genetically engineered bi-functional fusion antibody targeting the mouse transferrin receptor
    • Boado, R.J., Zhou, Q.-H., Lu, J.Z., Hui, E.K.-W., Pardridge, W.M., Pharmacokinetics and brain uptake of a genetically engineered bi-functional fusion antibody targeting the mouse transferrin receptor. Molecular Pharmaceutics 7:1 (2010), 237–244, 10.1021/mp900235k.
    • (2010) Molecular Pharmaceutics , vol.7 , Issue.1 , pp. 237-244
    • Boado, R.J.1    Zhou, Q.-H.2    Lu, J.Z.3    Hui, E.K.-W.4    Pardridge, W.M.5
  • 7
    • 0014481056 scopus 로고
    • Junctions between intimately apposed cell membranes in the vertebrate brain
    • Brightman, M.W., Reese, T.S., Junctions between intimately apposed cell membranes in the vertebrate brain. The Journal of Cell Biology 40:3 (1969), 648–677, 10.1083/jcb.40.3.648.
    • (1969) The Journal of Cell Biology , vol.40 , Issue.3 , pp. 648-677
    • Brightman, M.W.1    Reese, T.S.2
  • 10
    • 0028150689 scopus 로고
    • Subcellular localization and endocytic function of low density lipoprotein receptor-related protein in human glioblastoma cells
    • Bu, G., Maksymovitch, E.A., Geuze, H., Schwartz, A.L., Subcellular localization and endocytic function of low density lipoprotein receptor-related protein in human glioblastoma cells. Journal of Biological Chemistry 269:47 (1994), 29874–29882.
    • (1994) Journal of Biological Chemistry , vol.269 , Issue.47 , pp. 29874-29882
    • Bu, G.1    Maksymovitch, E.A.2    Geuze, H.3    Schwartz, A.L.4
  • 12
    • 84946408279 scopus 로고    scopus 로고
    • Trafficking of gold nanoparticles coated with the 8D3 anti-transferrin receptor antibody at the mouse blood–brain barrier
    • Cabezón, I., Manich, G., Martín-Venegas, R., Camins, A., Pelegrí, C., Vilaplana, J., Trafficking of gold nanoparticles coated with the 8D3 anti-transferrin receptor antibody at the mouse blood–brain barrier. Molecular Pharmaceutics 12:11 (2015), 4137–4145, 10.1021/acs.molpharmaceut.5b00597.
    • (2015) Molecular Pharmaceutics , vol.12 , Issue.11 , pp. 4137-4145
    • Cabezón, I.1    Manich, G.2    Martín-Venegas, R.3    Camins, A.4    Pelegrí, C.5    Vilaplana, J.6
  • 13
    • 84858665557 scopus 로고    scopus 로고
    • Endocytosis at the nanoscale
    • Canton, I., Battaglia, G., Endocytosis at the nanoscale. Chemical Society Reviews 41:7 (2012), 2718–2739, 10.1039/c2cs15309b.
    • (2012) Chemical Society Reviews , vol.41 , Issue.7 , pp. 2718-2739
    • Canton, I.1    Battaglia, G.2
  • 14
    • 0022332365 scopus 로고
    • Morphometric analysis of CNS microvascular endothelium
    • Coomber, B.L., Stewart, P.A., Morphometric analysis of CNS microvascular endothelium. Microvascular Research 30:1 (1985), 99–115 http://dx.doi.org/10.1016/0026-2862(85)90042-1.
    • (1985) Microvascular Research , vol.30 , Issue.1 , pp. 99-115
    • Coomber, B.L.1    Stewart, P.A.2
  • 15
    • 7644225312 scopus 로고    scopus 로고
    • RAGE (Yin) versus LRP (Yang) balance regulates Alzheimer amyloid β-peptide clearance through transport across the blood–brain barrier
    • Deane, R., Wu, Z., Zlokovic, B.V., RAGE (Yin) versus LRP (Yang) balance regulates Alzheimer amyloid β-peptide clearance through transport across the blood–brain barrier. Stroke 35:11 Suppl. 1 (2004), 2628–2631, 10.1161/01.STR.0000143452.85382.d1.
    • (2004) Stroke , vol.35 , Issue.11 Suppl. 1 , pp. 2628-2631
    • Deane, R.1    Wu, Z.2    Zlokovic, B.V.3
  • 16
    • 33746092084 scopus 로고    scopus 로고
    • The adhesive strength of non-spherical particles mediated by specific interactions
    • Decuzzi, P., Ferrari, M., The adhesive strength of non-spherical particles mediated by specific interactions. Biomaterials 27:30 (2006), 5307–5314, 10.1016/j.biomaterials.2006.05.024.
    • (2006) Biomaterials , vol.27 , Issue.30 , pp. 5307-5314
    • Decuzzi, P.1    Ferrari, M.2
  • 17
    • 43849112187 scopus 로고    scopus 로고
    • The receptor-mediated endocytosis of nonspherical particles
    • Decuzzi, P., Ferrari, M., The receptor-mediated endocytosis of nonspherical particles. Biophysical Journal 94:10 (2008), 3790–3797 http://dx.doi.org/10.1529/biophysj.107.120238.
    • (2008) Biophysical Journal , vol.94 , Issue.10 , pp. 3790-3797
    • Decuzzi, P.1    Ferrari, M.2
  • 18
    • 48749095941 scopus 로고    scopus 로고
    • Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector angiopep-2
    • Demeule, M., Currie, J.-C., Bertrand, Y., Ché, C., Nguyen, T., Régina, A.,.. Béliveau, R., Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector angiopep-2. Journal of Neurochemistry 106:4 (2008), 1534–1544, 10.1111/j.1471-4159.2008.05492.x.
    • (2008) Journal of Neurochemistry , vol.106 , Issue.4 , pp. 1534-1544
    • Demeule, M.1    Currie, J.-C.2    Bertrand, Y.3    Ché, C.4    Nguyen, T.5    Régina, A.6    Béliveau, R.7
  • 21
    • 0035964954 scopus 로고    scopus 로고
    • Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice
    • Drab, M., Verkade, P., Elger, M., Kasper, M., Lohn, M., Lauterbach, B.,.. Kurzchalia, T.V., Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice. Science 293:5539 (2001), 2449–2452, 10.1126/science.1062688.
    • (2001) Science , vol.293 , Issue.5539 , pp. 2449-2452
    • Drab, M.1    Verkade, P.2    Elger, M.3    Kasper, M.4    Lohn, M.5    Lauterbach, B.6    Kurzchalia, T.V.7
  • 23
    • 4444224966 scopus 로고    scopus 로고
    • Endocytosis by random initiation and stabilization of clathrin-coated pits
    • Ehrlich, M., Boll, W., van Oijen, A., Hariharan, R., Chandran, K., Nibert, M.L., Kirchhausen, T., Endocytosis by random initiation and stabilization of clathrin-coated pits. Cell 118:5 (2004), 591–605, 10.1016/j.cell.2004.08.017.
    • (2004) Cell , vol.118 , Issue.5 , pp. 591-605
    • Ehrlich, M.1    Boll, W.2    van Oijen, A.3    Hariharan, R.4    Chandran, K.5    Nibert, M.L.6    Kirchhausen, T.7
  • 24
    • 84963966190 scopus 로고    scopus 로고
    • Interactions of PLGA nanoparticles with blood components: Protein adsorption, coagulation, activation of the complement system and hemolysis studies
    • Fornaguera, C., Caldero, G., Mitjans, M., Vinardell, M.P., Solans, C., Vauthier, C., Interactions of PLGA nanoparticles with blood components: Protein adsorption, coagulation, activation of the complement system and hemolysis studies. Nanoscale 7:14 (2015), 6045–6058, 10.1039/c5nr00733j.
    • (2015) Nanoscale , vol.7 , Issue.14 , pp. 6045-6058
    • Fornaguera, C.1    Caldero, G.2    Mitjans, M.3    Vinardell, M.P.4    Solans, C.5    Vauthier, C.6
  • 25
    • 84931273562 scopus 로고    scopus 로고
    • PLGA nanoparticles prepared by nano-emulsion templating using low-energy methods as efficient nanocarriers for drug delivery across the blood–brain barrier
    • Fornaguera, C., Dols-Perez, A., Calderó, G., García-Celma, M.J., Camarasa, J., Solans, C., PLGA nanoparticles prepared by nano-emulsion templating using low-energy methods as efficient nanocarriers for drug delivery across the blood–brain barrier. Journal of Controlled Release 211 (2015), 134–143 http://dx.doi.org/10.1016/j.jconrel.2015.06.002.
    • (2015) Journal of Controlled Release , vol.211 , pp. 134-143
    • Fornaguera, C.1    Dols-Perez, A.2    Calderó, G.3    García-Celma, M.J.4    Camarasa, J.5    Solans, C.6
  • 28
    • 13544273188 scopus 로고    scopus 로고
    • Protease-activated receptor-1 activation of endothelial cells induces protein kinase Cα-dependent phosphorylation of syntaxin 4 and Munc18c: Role in signaling P-selectin expression
    • Fu, J., Naren, A.P., Gao, X., Ahmmed, G.U., Malik, A.B., Protease-activated receptor-1 activation of endothelial cells induces protein kinase Cα-dependent phosphorylation of syntaxin 4 and Munc18c: Role in signaling P-selectin expression. Journal of Biological Chemistry 280:5 (2005), 3178–3184, 10.1074/jbc.M410044200.
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.5 , pp. 3178-3184
    • Fu, J.1    Naren, A.P.2    Gao, X.3    Ahmmed, G.U.4    Malik, A.B.5
  • 29
    • 84931275692 scopus 로고    scopus 로고
    • Modelling the transport of nanoparticles under blood flow using an agent-based approach
    • supplementary-information
    • Fullstone, G., Wood, J., Holcombe, M., Battaglia, G., Modelling the transport of nanoparticles under blood flow using an agent-based approach. Scientific Reports, 5, 2015, 10649, 10.1038/srep10649 http://www.nature.com/srep/2015/150610/srep10649/abs/srep10649.html supplementary-information.
    • (2015) Scientific Reports , vol.5 , pp. 10649
    • Fullstone, G.1    Wood, J.2    Holcombe, M.3    Battaglia, G.4
  • 30
    • 0029884848 scopus 로고    scopus 로고
    • Chemotherapeutic drugs released from polymers: Distribution of 1,3-bis(2-chloroethyl)-l-nitrosourea in the rat brain
    • Fung, L.K., Shin, M., Tyler, B., Brem, H., Saltzman, W.M., Chemotherapeutic drugs released from polymers: Distribution of 1,3-bis(2-chloroethyl)-l-nitrosourea in the rat brain. Pharmaceutical Research 13 (1996), 671–682.
    • (1996) Pharmaceutical Research , vol.13 , pp. 671-682
    • Fung, L.K.1    Shin, M.2    Tyler, B.3    Brem, H.4    Saltzman, W.M.5
  • 33
    • 33344460518 scopus 로고    scopus 로고
    • Influence of particle size on transport of methotrexate across blood brain barrier by polysorbate 80-coated polybutylcyanoacrylate nanoparticles
    • Gao, K., Jiang, X., Influence of particle size on transport of methotrexate across blood brain barrier by polysorbate 80-coated polybutylcyanoacrylate nanoparticles. International Journal of Pharmaceutics 310:1–2 (2006), 213–219 http://dx.doi.org/10.1016/j.ijpharm.2005.11.040.
    • (2006) International Journal of Pharmaceutics , vol.310 , Issue.1-2 , pp. 213-219
    • Gao, K.1    Jiang, X.2
  • 34
    • 84905494071 scopus 로고    scopus 로고
    • Angiopep-2 and activatable cell-penetrating peptide dual-functionalized nanoparticles for systemic glioma-targeting delivery
    • Gao, H., Zhang, S., Cao, S., Yang, Z., Pang, Z., Jiang, X., Angiopep-2 and activatable cell-penetrating peptide dual-functionalized nanoparticles for systemic glioma-targeting delivery. Molecular Pharmaceutics 11:8 (2014), 2755–2763, 10.1021/mp500113p.
    • (2014) Molecular Pharmaceutics , vol.11 , Issue.8 , pp. 2755-2763
    • Gao, H.1    Zhang, S.2    Cao, S.3    Yang, Z.4    Pang, Z.5    Jiang, X.6
  • 35
    • 34248402413 scopus 로고    scopus 로고
    • Shape effects of filaments versus spherical particles in flow and drug delivery
    • Geng, Y.A.N., Dalhaimer, P., Cai, S., Tsai, R., Tewari, M., Minko, T., Discher, D.E., Shape effects of filaments versus spherical particles in flow and drug delivery. Nature Nanotechnology 2:4 (2007), 249–255, 10.1038/nnano.2007.70.
    • (2007) Nature Nanotechnology , vol.2 , Issue.4 , pp. 249-255
    • Geng, Y.A.N.1    Dalhaimer, P.2    Cai, S.3    Tsai, R.4    Tewari, M.5    Minko, T.6    Discher, D.E.7
  • 36
    • 8344282653 scopus 로고    scopus 로고
    • Targeting anti-transferrin receptor antibody (OX26) and OX26-conjugated liposomes to brain capillary endothelial cells using in situ perfusion
    • Gosk, S., Vermehren, C., Storm, G., Moos, T., Targeting anti-transferrin receptor antibody (OX26) and OX26-conjugated liposomes to brain capillary endothelial cells using in situ perfusion. Journal of Cerebral Blood Flow and Metabolism 24:11 (2004), 1193–1204.
    • (2004) Journal of Cerebral Blood Flow and Metabolism , vol.24 , Issue.11 , pp. 1193-1204
    • Gosk, S.1    Vermehren, C.2    Storm, G.3    Moos, T.4
  • 37
    • 0343191443 scopus 로고    scopus 로고
    • ‘Stealth’ corona-core nanoparticles surface modified by polyethylene glycol (PEG): Influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption
    • Gref, R., Lück, M., Quellec, P., Marchand, M., Dellacherie, E., Harnisch, S.,.. Müller, R.H., ‘Stealth’ corona-core nanoparticles surface modified by polyethylene glycol (PEG): Influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption. Colloids and Surfaces. B, Biointerfaces 18:3–4 (2000), 301–313 http://dx.doi.org/10.1016/S0927-7765(99)00156-3.
    • (2000) Colloids and Surfaces. B, Biointerfaces , vol.18 , Issue.3-4 , pp. 301-313
    • Gref, R.1    Lück, M.2    Quellec, P.3    Marchand, M.4    Dellacherie, E.5    Harnisch, S.6    Müller, R.H.7
  • 38
    • 1042291304 scopus 로고    scopus 로고
    • Recent advances in brain tumor therapy: Local intracerebral drug delivery by polymers
    • Guerin, C., Olivi, A., Weingart, J.D., Lawson, H.C., Brem, H., Recent advances in brain tumor therapy: Local intracerebral drug delivery by polymers. Investigational New Drugs 22 (2004), 27–37.
    • (2004) Investigational New Drugs , vol.22 , pp. 27-37
    • Guerin, C.1    Olivi, A.2    Weingart, J.D.3    Lawson, H.C.4    Brem, H.5
  • 40
    • 0037423387 scopus 로고    scopus 로고
    • Coaxing the LDL receptor family into the fold
    • Herz, J., Marschang, P., Coaxing the LDL receptor family into the fold. Cell 112:3 (2003), 289–292 http://dx.doi.org/10.1016/S0092-8674(03)00073-4.
    • (2003) Cell , vol.112 , Issue.3 , pp. 289-292
    • Herz, J.1    Marschang, P.2
  • 41
    • 0034836428 scopus 로고    scopus 로고
    • LRP: A multifunctional scavenger and signaling receptor
    • Herz, J., Strickland, D.K., LRP: A multifunctional scavenger and signaling receptor. Journal of Clinical Investigation 108:6 (2001), 779–784.
    • (2001) Journal of Clinical Investigation , vol.108 , Issue.6 , pp. 779-784
    • Herz, J.1    Strickland, D.K.2
  • 42
    • 20444407298 scopus 로고    scopus 로고
    • SNAREs and traffic
    • Hong, W., SNAREs and traffic. Biochimica et Biophysica Acta 1744:2 (2005), 120–144 http://dx.doi.org/10.1016/j.bbamcr.2005.03.014.
    • (2005) Biochimica et Biophysica Acta , vol.1744 , Issue.2 , pp. 120-144
    • Hong, W.1
  • 45
    • 0025126177 scopus 로고
    • A morphometric study on the development of the lateral ventricle choroid plexus, choroid plexus capillaries and ventricular ependyma in the rat
    • Keep, R., Jones, H., A morphometric study on the development of the lateral ventricle choroid plexus, choroid plexus capillaries and ventricular ependyma in the rat. Developmental Brain Research 56:1 (1990), 47–53.
    • (1990) Developmental Brain Research , vol.56 , Issue.1 , pp. 47-53
    • Keep, R.1    Jones, H.2
  • 46
    • 0031778715 scopus 로고    scopus 로고
    • Immunohistochemical localization of the murine transferrin receptor (TfR) on blood–tissue barriers using a novel anti-TfR monoclonal antibody
    • Kissel, K., Hamm, S., Schulz, M., Vecchi, A., Garlanda, C., Engelhardt, B., Immunohistochemical localization of the murine transferrin receptor (TfR) on blood–tissue barriers using a novel anti-TfR monoclonal antibody. Histochemistry and Cell Biology 110 (1998), 63–72.
    • (1998) Histochemistry and Cell Biology , vol.110 , pp. 63-72
    • Kissel, K.1    Hamm, S.2    Schulz, M.3    Vecchi, A.4    Garlanda, C.5    Engelhardt, B.6
  • 47
    • 0032850453 scopus 로고    scopus 로고
    • Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease
    • Kordower, J.H., Palfi, S., Chen, E.-Y., Ma, S.Y., Sendera, T., Cochran, E.J.,.. Comella, C.D., Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease. Annals of Neurology 46:3 (1999), 419–424, 10.1002/1531-8249(199909)46:3<419::aid-ana21>3.0.co;2-q.
    • (1999) Annals of Neurology , vol.46 , Issue.3 , pp. 419-424
    • Kordower, J.H.1    Palfi, S.2    Chen, E.-Y.3    Ma, S.Y.4    Sendera, T.5    Cochran, E.J.6    Comella, C.D.7
  • 48
    • 0028911362 scopus 로고
    • Passage of peptides through the blood-brain barrier with colloidal polymer particles (nanoparticles)
    • Kreuter, J., Alyautdin, R.N., Kharkevich, D.A., Ivanov, A.A., Passage of peptides through the blood-brain barrier with colloidal polymer particles (nanoparticles). Brain Research 674:1 (1995), 171–174 http://dx.doi.org/10.1016/0006-8993(95)00023-J.
    • (1995) Brain Research , vol.674 , Issue.1 , pp. 171-174
    • Kreuter, J.1    Alyautdin, R.N.2    Kharkevich, D.A.3    Ivanov, A.A.4
  • 51
    • 0029752791 scopus 로고    scopus 로고
    • Endocytosis and molecular sorting
    • Mellman, I., Endocytosis and molecular sorting. Annual Review of Cell and Developmental Biology 12:1 (1996), 575–625, 10.1146/annurev.cellbio.12.1.575.
    • (1996) Annual Review of Cell and Developmental Biology , vol.12 , Issue.1 , pp. 575-625
    • Mellman, I.1
  • 52
    • 0034093531 scopus 로고    scopus 로고
    • Intracerebral implantation of NGF-releasing biodegradable microspheres protects striatum against excitotoxic damage
    • Menei, P., Pean, J.M., Nerrière-Daguin, V., Jollivet, C., Brachet, P., Benoit, J.P., Intracerebral implantation of NGF-releasing biodegradable microspheres protects striatum against excitotoxic damage. Experimental Neurology 161:1 (2000), 259–272 http://dx.doi.org/10.1006/exnr.1999.7253.
    • (2000) Experimental Neurology , vol.161 , Issue.1 , pp. 259-272
    • Menei, P.1    Pean, J.M.2    Nerrière-Daguin, V.3    Jollivet, C.4    Brachet, P.5    Benoit, J.P.6
  • 53
    • 0033961913 scopus 로고    scopus 로고
    • Transferrin and transferrin receptor function in brain barrier systems
    • Moos, T., Morgan, E.H., Transferrin and transferrin receptor function in brain barrier systems. Cellular and Molecular Neurobiology 20 (2000), 77–95.
    • (2000) Cellular and Molecular Neurobiology , vol.20 , pp. 77-95
    • Moos, T.1    Morgan, E.H.2
  • 54
    • 0034794883 scopus 로고    scopus 로고
    • Restricted transport of anti-transferrin receptor antibody (OX26) through the blood–brain barrier in the rat
    • Moos, T., Morgan, E.H., Restricted transport of anti-transferrin receptor antibody (OX26) through the blood–brain barrier in the rat. Journal of Neurochemistry 79:1 (2001), 119–129, 10.1046/j.1471-4159.2001.00541.x.
    • (2001) Journal of Neurochemistry , vol.79 , Issue.1 , pp. 119-129
    • Moos, T.1    Morgan, E.H.2
  • 55
    • 84891804917 scopus 로고    scopus 로고
    • Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle
    • Niewoehner, J., Bohrmann, B., Collin, L., Urich, E., Sade, H., Maier, P.,.. Freskgård, P.-O., Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle. Neuron 81:1 (2014), 49–60 http://dx.doi.org/10.1016/j.neuron.2013.10.061.
    • (2014) Neuron , vol.81 , Issue.1 , pp. 49-60
    • Niewoehner, J.1    Bohrmann, B.2    Collin, L.3    Urich, E.4    Sade, H.5    Maier, P.6    Freskgård, P.-O.7
  • 56
    • 33947146207 scopus 로고    scopus 로고
    • Live dynamic imaging of caveolae pumping targeted antibody rapidly and specifically across endothelium in the lung
    • Oh, P., Borgstrom, P., Witkiewicz, H., Li, Y., Borgstrom, B.J., Chrastina, A.,.. Schnitzer, J.E., Live dynamic imaging of caveolae pumping targeted antibody rapidly and specifically across endothelium in the lung. Nature Biotechnology 25:3 (2007), 327–337 http://www.nature.com/nbt/journal/v25/n3/suppinfo/nbt1292_S1.html.
    • (2007) Nature Biotechnology , vol.25 , Issue.3 , pp. 327-337
    • Oh, P.1    Borgstrom, P.2    Witkiewicz, H.3    Li, Y.4    Borgstrom, B.J.5    Chrastina, A.6    Schnitzer, J.E.7
  • 57
    • 0032489880 scopus 로고    scopus 로고
    • Dynamin at the neck of caveolae mediates their budding to form transport vesicles by GTP-driven fission from the plasma membrane of endothelium
    • Oh, P., McIntosh, D.P., Schnitzer, J.E., Dynamin at the neck of caveolae mediates their budding to form transport vesicles by GTP-driven fission from the plasma membrane of endothelium. The Journal of Cell Biology 141:1 (1998), 101–114, 10.1083/jcb.141.1.101.
    • (1998) The Journal of Cell Biology , vol.141 , Issue.1 , pp. 101-114
    • Oh, P.1    McIntosh, D.P.2    Schnitzer, J.E.3
  • 59
    • 28844488494 scopus 로고    scopus 로고
    • Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
    • Owens, D.E., Peppas, N.A., Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. International Journal of Pharmaceutics 307:1 (2006), 93–102, 10.1016/j.ijpharm.2005.10.010.
    • (2006) International Journal of Pharmaceutics , vol.307 , Issue.1 , pp. 93-102
    • Owens, D.E.1    Peppas, N.A.2
  • 60
    • 43449094024 scopus 로고    scopus 로고
    • Preparation and brain delivery property of biodegradable polymersomes conjugated with OX26
    • Pang, Z., Lu, W., Gao, H., Hu, K., Chen, J., Zhang, C.,.. Zhu, C., Preparation and brain delivery property of biodegradable polymersomes conjugated with OX26. Journal of Controlled Release 128:2 (2008), 120–127 http://dx.doi.org/10.1016/j.jconrel.2008.03.007.
    • (2008) Journal of Controlled Release , vol.128 , Issue.2 , pp. 120-127
    • Pang, Z.1    Lu, W.2    Gao, H.3    Hu, K.4    Chen, J.5    Zhang, C.6    Zhu, C.7
  • 62
    • 0025836586 scopus 로고
    • Selective transport of an anti-transferrin receptor antibody through the blood-brain barrier in vivo
    • Pardridge, W.M., Buciak, J.L., Friden, P.M., Selective transport of an anti-transferrin receptor antibody through the blood-brain barrier in vivo. Journal of Pharmacology and Experimental Therapeutics 259:1 (1991), 66–70.
    • (1991) Journal of Pharmacology and Experimental Therapeutics , vol.259 , Issue.1 , pp. 66-70
    • Pardridge, W.M.1    Buciak, J.L.2    Friden, P.M.3
  • 63
    • 0029009048 scopus 로고
    • Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood–brain barrier in vivo in the primate
    • Pardridge, W.M., Kang, Y.-S., Buciak, J.L., Yang, J., Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood–brain barrier in vivo in the primate. Pharmaceutical Research 12 (1995), 807–816.
    • (1995) Pharmaceutical Research , vol.12 , pp. 807-816
    • Pardridge, W.M.1    Kang, Y.-S.2    Buciak, J.L.3    Yang, J.4
  • 65
    • 0035017308 scopus 로고    scopus 로고
    • Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER
    • Pelkmans, L., Kartenbeck, J., Helenius, A., Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER. Nature Cell Biology 3:5 (2001), 473–483 http://www.nature.com/ncb/journal/v3/n5/suppinfo/ncb0501_473_S1.html.
    • (2001) Nature Cell Biology , vol.3 , Issue.5 , pp. 473-483
    • Pelkmans, L.1    Kartenbeck, J.2    Helenius, A.3
  • 66
    • 0035575616 scopus 로고    scopus 로고
    • Rab GTPases: Specifying and deciphering organelle identity and function
    • Pfeffer, S.R., Rab GTPases: Specifying and deciphering organelle identity and function. Trends in Cell Biology 11:12 (2001), 487–491, 10.1016/s0962-8924(01)02147-x.
    • (2001) Trends in Cell Biology , vol.11 , Issue.12 , pp. 487-491
    • Pfeffer, S.R.1
  • 67
    • 0028372277 scopus 로고
    • The motion of particles in the Hele-Shaw cell
    • Pozrikidis, C., The motion of particles in the Hele-Shaw cell. Journal of Fluid Mechanics 261 (1994), 199–222.
    • (1994) Journal of Fluid Mechanics , vol.261 , pp. 199-222
    • Pozrikidis, C.1
  • 70
    • 0035158570 scopus 로고    scopus 로고
    • Endothelial transcytotic machinery involves supramolecular protein–lipid complexes
    • Predescu, S.A., Predescu, D.N., Palade, G.E., Endothelial transcytotic machinery involves supramolecular protein–lipid complexes. Molecular Biology of the Cell 12:4 (2001), 1019–1033.
    • (2001) Molecular Biology of the Cell , vol.12 , Issue.4 , pp. 1019-1033
    • Predescu, S.A.1    Predescu, D.N.2    Palade, G.E.3
  • 71
    • 1642575957 scopus 로고    scopus 로고
    • Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis
    • Rejman, J., Oberle, V., Zuhorn, I.S., Hoekstra, D., Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis. Biochemical Journal 377:Pt. 1 (2004), 159–169, 10.1042/bj20031253.
    • (2004) Biochemical Journal , vol.377 , pp. 159-169
    • Rejman, J.1    Oberle, V.2    Zuhorn, I.S.3    Hoekstra, D.4
  • 72
    • 84862777853 scopus 로고    scopus 로고
    • The targeted delivery of anticancer drugs to brain glioma by PEGylated oxidized multi-walled carbon nanotubes modified with angiopep-2
    • Ren, J., Shen, S., Wang, D., Xi, Z., Guo, L., Pang, Z.,.. Jiang, X., The targeted delivery of anticancer drugs to brain glioma by PEGylated oxidized multi-walled carbon nanotubes modified with angiopep-2. Biomaterials 33:11 (2012), 3324–3333 http://dx.doi.org/10.1016/j.biomaterials.2012.01.025.
    • (2012) Biomaterials , vol.33 , Issue.11 , pp. 3324-3333
    • Ren, J.1    Shen, S.2    Wang, D.3    Xi, Z.4    Guo, L.5    Pang, Z.6    Jiang, X.7
  • 73
    • 0026724792 scopus 로고
    • Studies of the mechanism of iron transport across the blood-brain barrier
    • Roberts, R., Sandra, A., Siek, G.C., Lucas, J.J., Fine, R.E., Studies of the mechanism of iron transport across the blood-brain barrier. Annals of Neurology 32:S1 (1992), S43–S50, 10.1002/ana.410320709.
    • (1992) Annals of Neurology , vol.32 , Issue.S1 , pp. S43-S50
    • Roberts, R.1    Sandra, A.2    Siek, G.C.3    Lucas, J.J.4    Fine, R.E.5
  • 74
    • 0023019234 scopus 로고
    • Transferrin receptor number, synthesis, and endocytosis during erythropoietin-induced maturation of Friend virus-infected erythroid cells
    • Sawyer, S.T., Krantz, S.B., Transferrin receptor number, synthesis, and endocytosis during erythropoietin-induced maturation of Friend virus-infected erythroid cells. Journal of Biological Chemistry 261:20 (1986), 9187–9195.
    • (1986) Journal of Biological Chemistry , vol.261 , Issue.20 , pp. 9187-9195
    • Sawyer, S.T.1    Krantz, S.B.2
  • 75
    • 0027997787 scopus 로고
    • Filipin-sensitive caveolae-mediated transport in endothelium: Reduced transcytosis, scavenger endocytosis, and capillary permeability of select macromolecules
    • Schnitzer, J.E., Oh, P., Pinney, E., Allard, J., Filipin-sensitive caveolae-mediated transport in endothelium: Reduced transcytosis, scavenger endocytosis, and capillary permeability of select macromolecules. The Journal of Cell Biology 127:5 (1994), 1217–1232, 10.1083/jcb.127.5.1217.
    • (1994) The Journal of Cell Biology , vol.127 , Issue.5 , pp. 1217-1232
    • Schnitzer, J.E.1    Oh, P.2    Pinney, E.3    Allard, J.4
  • 77
    • 0343267787 scopus 로고    scopus 로고
    • Nanoparticles, a drug carrier system to pass the blood-brain barrier, permit central analgesic effects of i.v. dalargin injections
    • Schröder, U., Sabel, B.A., Nanoparticles, a drug carrier system to pass the blood-brain barrier, permit central analgesic effects of i.v. dalargin injections. Brain Research 710:1–2 (1996), 121–124 http://dx.doi.org/10.1016/0006-8993(95)01375-X.
    • (1996) Brain Research , vol.710 , Issue.1-2 , pp. 121-124
    • Schröder, U.1    Sabel, B.A.2
  • 78
    • 0034521392 scopus 로고    scopus 로고
    • Clearance of Alzheimer's amyloid-β(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier
    • Shibata, M., Yamada, S., Kumar, S.R., Calero, M., Bading, J., Frangione, B.,.. Zlokovic, B.V., Clearance of Alzheimer's amyloid-β(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. Journal of Clinical Investigation 106:12 (2000), 1489–1499.
    • (2000) Journal of Clinical Investigation , vol.106 , Issue.12 , pp. 1489-1499
    • Shibata, M.1    Yamada, S.2    Kumar, S.R.3    Calero, M.4    Bading, J.5    Frangione, B.6    Zlokovic, B.V.7
  • 79
  • 81
    • 0037038819 scopus 로고    scopus 로고
    • Receptor for advanced glycation endproducts: A multiligand receptor magnifying cell stress in diverse pathologic settings
    • Stern, D., Du Yan, S., Fang Yan, S., Marie Schmidt, A., Receptor for advanced glycation endproducts: A multiligand receptor magnifying cell stress in diverse pathologic settings. Advanced Drug Delivery Reviews 54:12 (2002), 1615–1625 http://dx.doi.org/10.1016/S0169-409X(02)00160-6.
    • (2002) Advanced Drug Delivery Reviews , vol.54 , Issue.12 , pp. 1615-1625
    • Stern, D.1    Du Yan, S.2    Fang Yan, S.3    Marie Schmidt, A.4
  • 83
    • 58849092285 scopus 로고    scopus 로고
    • Membrane fusion: Grappling with SNARE and SM proteins
    • Südhof, T.C., Rothman, J.E., Membrane fusion: Grappling with SNARE and SM proteins. Science (New York, N.Y.) 323:5913 (2009), 474–477, 10.1126/science.1161748.
    • (2009) Science (New York, N.Y.) , vol.323 , Issue.5913 , pp. 474-477
    • Südhof, T.C.1    Rothman, J.E.2
  • 84
    • 0027463890 scopus 로고
    • Control of protein traffic between distinct plasma membrane domains. Requirement for a novel 108,000 protein in the fusion of transcytotic vesicles with the apical plasma membrane
    • Sztul, E., Colombo, M., Stahl, P., Samanta, R., Control of protein traffic between distinct plasma membrane domains. Requirement for a novel 108,000 protein in the fusion of transcytotic vesicles with the apical plasma membrane. Journal of Biological Chemistry 268:3 (1993), 1876–1885.
    • (1993) Journal of Biological Chemistry , vol.268 , Issue.3 , pp. 1876-1885
    • Sztul, E.1    Colombo, M.2    Stahl, P.3    Samanta, R.4
  • 85
    • 84937710410 scopus 로고    scopus 로고
    • LRP-1-mediated intracellular antibody delivery to the central nervous system
    • supplementary-information
    • Tian, X., Nyberg, S., Sharp, P.S., Madsen, J., Daneshpour, N., Armes, S.P.,.. Battaglia, G., LRP-1-mediated intracellular antibody delivery to the central nervous system. Scientific Reports, 5, 2015, 11990, 10.1038/srep11990 http://www.nature.com/articles/srep11990 supplementary-information.
    • (2015) Scientific Reports , vol.5 , pp. 11990
    • Tian, X.1    Nyberg, S.2    Sharp, P.S.3    Madsen, J.4    Daneshpour, N.5    Armes, S.P.6    Battaglia, G.7
  • 87
    • 0037817352 scopus 로고    scopus 로고
    • Transcytosis: Crossing cellular barriers
    • Tuma, P.L., Hubbard, A.L., Transcytosis: Crossing cellular barriers. Physiological Reviews 83:3 (2003), 871–932, 10.1152/physrev.00001.2003.
    • (2003) Physiological Reviews , vol.83 , Issue.3 , pp. 871-932
    • Tuma, P.L.1    Hubbard, A.L.2
  • 88
    • 59649102668 scopus 로고    scopus 로고
    • Transferrin- and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood–brain barrier (BBB)
    • Ulbrich, K., Hekmatara, T., Herbert, E., Kreuter, J., Transferrin- and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood–brain barrier (BBB). European Journal of Pharmaceutics and Biopharmaceutics 71:2 (2009), 251–256 http://dx.doi.org/10.1016/j.ejpb.2008.08.021.
    • (2009) European Journal of Pharmaceutics and Biopharmaceutics , vol.71 , Issue.2 , pp. 251-256
    • Ulbrich, K.1    Hekmatara, T.2    Herbert, E.3    Kreuter, J.4
  • 89
    • 3042836954 scopus 로고    scopus 로고
    • Characterization and modulation of the transferrin receptor on brain capillary endothelial cells
    • Visser, C.C., Voorwinden, L.H., Crommelin, D.J.A., Danhof, M., de Boer, A.G., Characterization and modulation of the transferrin receptor on brain capillary endothelial cells. Pharmaceutical Research 21:5 (2004), 761–769, 10.1023/B:PHAM.0000026425.69874.8e.
    • (2004) Pharmaceutical Research , vol.21 , Issue.5 , pp. 761-769
    • Visser, C.C.1    Voorwinden, L.H.2    Crommelin, D.J.A.3    Danhof, M.4    de Boer, A.G.5
  • 91
    • 0031037424 scopus 로고    scopus 로고
    • Reversible Schwann cell hyperplasia and sprouting of sensory and sympathetic neurites after intraventricular administration of nerve growth factor
    • Winkler, J., Ramirez, G.A., Kuhn, H.G., Peterson, D.A., Day-Lollini, P.A., Stewart, G.R.,.. Thal, L.J., Reversible Schwann cell hyperplasia and sprouting of sensory and sympathetic neurites after intraventricular administration of nerve growth factor. Annals of Neurology 41:1 (1997), 82–93, 10.1002/ana.410410114.
    • (1997) Annals of Neurology , vol.41 , Issue.1 , pp. 82-93
    • Winkler, J.1    Ramirez, G.A.2    Kuhn, H.G.3    Peterson, D.A.4    Day-Lollini, P.A.5    Stewart, G.R.6    Thal, L.J.7
  • 92
    • 33644681150 scopus 로고    scopus 로고
    • Multiple kinetic components of exocytosis distinguished by neurotoxin sensitivity
    • Xu, T., Binz, T., Niemann, H., Neher, E., Multiple kinetic components of exocytosis distinguished by neurotoxin sensitivity. Nature Neuroscience 1:3 (1998), 192–200, 10.1038/642.
    • (1998) Nature Neuroscience , vol.1 , Issue.3 , pp. 192-200
    • Xu, T.1    Binz, T.2    Niemann, H.3    Neher, E.4
  • 94
    • 84908884134 scopus 로고    scopus 로고
    • Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates
    • Yu, Y.J., Atwal, J.K., Zhang, Y., Tong, R.K., Wildsmith, K.R., Tan, C.,.. Watts, R.J., Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates. Science Translational Medicine, 6(261), 2014, 261ra154, 10.1126/scitranslmed.3009835.
    • (2014) Science Translational Medicine , vol.6 , Issue.261 , pp. 261ra154
    • Yu, Y.J.1    Atwal, J.K.2    Zhang, Y.3    Tong, R.K.4    Wildsmith, K.R.5    Tan, C.6    Watts, R.J.7
  • 95
    • 79957439772 scopus 로고    scopus 로고
    • Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target
    • Yu, Y.J., Zhang, Y., Kenrick, M., Hoyte, K., Luk, W., Lu, Y.,.. Dennis, M.S., Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target. Science Translational Medicine, 3(84), 2011, 84ra44, 10.1126/scitranslmed.3002230.
    • (2011) Science Translational Medicine , vol.3 , Issue.84 , pp. 84ra44
    • Yu, Y.J.1    Zhang, Y.2    Kenrick, M.3    Hoyte, K.4    Luk, W.5    Lu, Y.6    Dennis, M.S.7
  • 97
    • 0025213058 scopus 로고
    • A saturable mechanism for transport of immunoglobulin G across the blood-brain barrier of the guinea pig
    • Zlokovic, B.V., Skundric, D.S., Segal, M.B., Lipovac, M.N., Mackic, J.B., Davson, H., A saturable mechanism for transport of immunoglobulin G across the blood-brain barrier of the guinea pig. Experimental Neurology 107:3 (1990), 263–270 http://dx.doi.org/10.1016/0014-4886(90)90144-H.
    • (1990) Experimental Neurology , vol.107 , Issue.3 , pp. 263-270
    • Zlokovic, B.V.1    Skundric, D.S.2    Segal, M.B.3    Lipovac, M.N.4    Mackic, J.B.5    Davson, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.