Structural basis for regulation of human calcium-sensing receptor by magnesium ions and an unexpected tryptophan derivative co-agonist

Science Advances

Volumn 2, Issue 5, 2016, Pages

  Zhang, Chen ^a   Zhang, Tuo ^b   Zou, Juan ^a   Miller, Cassandra Lynn ^a   Gorkhali, Rakshya ^a   Yang, Jeong Yeh ^c   Schilmiller, Anthony ^b   Wang, Shuo ^c   Huang, Kenneth ^a   Brown, Edward M ^d   Moremen, Kelley W ^c   Hu, Jian ^b,e   Yang, Jenny J ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

^b Michigan State University   (United States)

^c UNIVERSITY OF GEORGIA   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CALCIUM; MAGNESIUM; MEDICAL PROBLEMS; METAL IONS; METALS; PHYSIOLOGY; POSITIVE IONS; PROTEINS;

AROMATIC AMINO ACID; CALCIUM AND MAGNESIUMS; CALCIUM SENSING RECEPTORS; EXTRACELLULAR DOMAINS; EXTRACELLULAR STIMULI; GUANINE NUCLEOTIDE-BINDING PROTEINS; PHYSIOLOGICAL PROCESS; STRUCTURE-FUNCTION RELATION;

CRYSTAL STRUCTURE;

CALCIUM SENSING RECEPTOR; ION; LIGAND; MAGNESIUM; PROTEIN BINDING; TRYPTOPHAN;

AGONISTS; ANALOGS AND DERIVATIVES; CELL LINE; CHEMISTRY; CONFORMATION; GENETICS; HUMAN; METABOLISM; MOLECULAR MODEL; MUTATION; STRUCTURE ACTIVITY RELATION;

CELL LINE; HUMANS; IONS; LIGANDS; MAGNESIUM; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MUTATION; PROTEIN BINDING; RECEPTORS, CALCIUM-SENSING; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPTOPHAN;

EID: 84994039793     PISSN: None     EISSN: 23752548     Source Type: Journal    
DOI: 10.1126/sciadv.1600241     Document Type: Article

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