Enzymatic basis for N-glycan sialylation: Structure of rat α2,6-sialyltransferase (ST6GAL1) reveals conserved and unique features for glycan sialylation

Journal of Biological Chemistry

Volumn 288, Issue 48, 2013, Pages 34680-34698

  Meng, Lu ^a   Forouhar, Farhad ^b   Thieker, David ^a   Gao, Zhongwei ^a   Ramiah, Annapoorani ^a   Moniz, Heather ^a   Xiang, Yong ^a   Seetharaman, Jayaraman ^b   Milaninia, Sahand ^b   Su, Min ^b   Bridger, Robert ^a   Veillon, Lucas ^a   Azadi, Parastoo ^a   Kornhaber, Gregory ^c,d   Wells, Lance ^a   Montelione, Gaetano T ^c,d   Woods, Robert J ^a,e   Tong, Liang ^b   Moremen, Kelley W ^a  

^a UNIVERSITY OF GEORGIA   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c Center for Biotechnology and Medicine   (United States)

^d RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^e NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

2 ,6-SIALYLTRANSFERASE; ACCEPTOR SPECIFICITIES; BIOLOGICAL FUNCTIONS; BIOLOGICAL RECOGNITION; DISULFIDE BONDING PATTERNS; ENZYME PREPARATION; MOLECULAR DYNAMICS SIMULATIONS; STRUCTURAL FRAMEWORKS;

CARBOXYLIC ACIDS; CELL MEMBRANES; ENZYMES; GLYCOSYLATION; MOLECULAR DYNAMICS; RATS;

POLYSACCHARIDES;

ALPHA 2,6 SIALYLTRANSFERASE; CYTIDINE PHOSPHATE; GLYCAN; SELENOMETHIONINE; SIALIC ACID; SIALYLTRANSFERASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DISULFIDE BOND; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN PURIFICATION; PROTEIN STRUCTURE; RAT; SIALYLATION;

EID: 84889053976     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.519041     Document Type: Article

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