Role of Antioxidants and Natural Products in Inflammation

Oxidative Medicine and Cellular Longevity

Volumn 2016, Issue , 2016, Pages

  Arulselvan, Palanisamy ^a   Fard, Masoumeh Tangestani ^a   Tan, Woan Sean ^a   Gothai, Sivapragasam ^a   Fakurazi, Sharida ^a   Norhaizan, Mohd Esa ^a   Kumar, S Suresh ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANTS; FREE RADICALS; PATHOLOGY; PHYSIOLOGICAL MODELS; VIRUSES;

CARDIO-VASCULAR DISEASE; CHRONIC INFLAMMATION; CHRONIC INFLAMMATORY DISEASE; FREE RADICAL PRODUCTIONS; INFLAMMATORY BOWEL DISEASE; INFLAMMATORY PROCESS; NATURAL ANTIOXIDANTS; PHYSIOLOGICAL RESPONSE;

DISEASES;

ACTINIDIA ARGUTA EXTRACT; AINSLIAEA FRAGRANS EXTRACT; AMPELOPSIS GROSSEDENTATA EXTRACT; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; ARTEMISIAE ANNUAE EXTRACT; CASSIA OCCIDENTALIS EXTRACT; CHEILANTHES ALBOMARGINATA EXTRACT; CLERODENDRUM INERME EXTRACT; CRATAEVA NURVALA EXTRACT; CYPERUS ROTUNDUS EXTRACT; DATURA METEL EXTRACT; ELEUTHEROCOCCUS SENTICOSUS EXTRACT; FREE RADICAL; GRATELOUPIA LANCEOLATA EXTRACT; HIBISCUS SABDARIFFA EXTRACT; HOUTTUYNIA CORDATA EXTRACT; INULA JAPONICA EXTRACT; LIGNOSUS RHINOCEROTIS EXTRACT; LYCIUM BARBARUM EXTRACT; MATRICARIA FLOWER EXTRACT; MORINGA OLEIFERA EXTRACT; NATURAL PRODUCT; PORPHYRA YEZOENSIS EXTRACT; SCHISANDRA CHINENSIS EXTRACT; SMILAX GLABRA EXTRACT; UNCLASSIFIED DRUG; BIOLOGICAL PRODUCT;

ACTINIDIA ARGUTA; AINSLIAEA FRAGRANS; AMPELOPSIS; AMPELOPSIS GROSSEDENTATA; ANGELICA; ANGELICA KEISKEI; ARTEMISIAE ANNUAE; CHEILANTHES ALBOMARGINATA; CHRONIC INFLAMMATION; CLERODENDRUM; CLERODENDRUM INERME; CRATAEVA NURVALA; CYPERUS ROTUNDUS; DATURA METEL; ELEUTHEROCOCCUS SENTICOSUS; GRATELOUPIA LANCEOLATA; HIBISCUS SABDARIFFA; HOUTTUYNIA CORDATA; HUMAN; INFLAMMATION; INFLAMMATORY DISEASE; INULA; INULA JAPONICA; LIGNOSUS RHINOCEROTIS; LYCIUM BARBARUM; MATRICARIA RECUTITA; MEDICINAL PLANT; MORINGA OLEIFERA; NONHUMAN; NUPHAR; NUPHAR LUTEA; ORYEONGSAN; PERSICARIA; PERSICARIA CHINENSIS; PHYSALIS; PHYSALIS ALKEKENGI; PORPHYRA YEZOENSIS; REVIEW; SARSAPARILLA; SCHISANDRA CHINENSIS; SENNA OCCIDENTALIS; SMILAX GLABRA; TISSUE INJURY; ANIMAL; CHEMISTRY; CHRONIC DISEASE; CLASSIFICATION; DRUG EFFECTS; SIGNAL TRANSDUCTION;

ANIMALS; ANTIOXIDANTS; BIOLOGICAL PRODUCTS; CHRONIC DISEASE; HUMANS; INFLAMMATION; SIGNAL TRANSDUCTION;

EID: 84994037380     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2016/5276130     Document Type: Review

References (96)

1. G. W. Schmid-Schönbein, "Analysis of inflammation, " Annual Review of Biomedical Engineering, vol. 8, pp. 93-151, 2006.
2. P. Henson, G. Larsen, J. Henson, S. Newman, R. Musson, C. Leslie, "Resolution of pulmonary inflammation, " Federation Proceedings, vol. 43, no. 13, pp. 2799-2806, 1984.
3. M. M. Markiewski and J. D. Lambris, "The role of complement in inflammatory diseases from behind the scenes into the spotlight, "AmericanJournal of Pathology, vol. 171, no. 3, pp. 715-727, 2007.
4. H. Kobayashi, Y. Higashiura, H. Shigetomi, H. Kajihara, "Pathogenesis of endometriosis: the role of initial infection and subsequent sterile inflammation (Review), "MolecularMedicine Reports, vol. 9, no. 1, pp. 9-15, 2014.
5. R. Medzhitov, "Inflammation 2010: new adventures of an old flame, " Cell, vol. 140, no. 6, pp. 771-776, 2010.
6. E. Pecchi, M. Dallaporta, A. Jean, S. Thirion, J.-D. Troadec, "Prostaglandins and sickness behavior: old story, new insights, " Physiology and Behavior, vol. 97, no. 3-4, pp. 279-292, 2009.
7. C. Nathan, "Points of control in inflammation, " Nature, vol. 420, no. 6917, pp. 846-852, 2002.
8. R. Medzhitov, "Origin and physiological roles of inflammation, " Nature, vol. 454, no. 7203, pp. 428-435, 2008.
9. C. N. Serhan and J. Savill, "Resolution of inflammation: the beginning programs the end, " Nature Immunology, vol. 6, no. 12, pp. 1191-1197, 2005.
10. C. N. Serhan, "Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways, " Annual Review of Immunology, vol. 25, pp. 101-137, 2007.
11. T. Eaves-Pyles, C. A. Allen, J. Taormina et al., "Escherichia coli isolated from a Crohn's disease patient adheres, invades, induces inflammatory responses in polarized intestinal epithelial cells, " International Journal of Medical Microbiology, vol. 298, no. 5-6, pp. 397-409, 2008.
12. L. R. Ferguson, "Chronic inflammation and mutagenesis, " Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, vol. 690, no. 1-2, pp. 3-11, 2010.
13. A. Weber, Y. Boege, F. Reisinger, M. Heikenwalder, "Chronic liver inflammation and hepatocellular carcinoma: persistencematters, " SwissMedicalWeekly, vol. 141, no. 4, Article ID 13197, 2011.
14. A. J. Czaja and M. P. Manns, "Advances in the diagnosis, pathogenesis, management of autoimmune hepatitis, " Gastroenterology, vol. 139, no. 1, pp. 58-72, e4, 2010.
15. C. Berasain, J. Castillo, M. J. Perugorria, M. U. Latasa, J. Prieto, M. A. Avila, "Inflammationandliver cancer: newmolecular links, " Annals of the New York Academy of Sciences, vol. 1155, pp. 206-221, 2009.
16. E. Liaskou, D. V. Wilson, Y. H. Oo, "Innate immune cells in liver inflammation, " Mediators of Inflammation, vol. 2012, Article ID 949157, 21 pages, 2012.
17. J. M. Schattenberg, M. Schuchmann, P. R. Galle, "Cell death and hepatocarcinogenesis: dysregulation of apoptosis signaling pathways, " Journal of Gastroenterology and Hepatology, vol. 26, no. 1, pp. 213-219, 2011.
18. J. M. Schattenberg, P. R. Galle, M. Schuchmann, "Apoptosis in liver disease, " Liver International, vol. 26, no. 8, pp. 904-911, 2006.
19. K. Iwaisako, D. A. Brenner, T. Kisseleva, "What's newinliver fibrosisTheorigin ofmyofibroblasts in liver fibrosis, " Journal of Gastroenterology and Hepatology, vol. 27, supplement 2, pp. 65-68, 2012.
20. R. Engler, G. Schmid-Schönbein, R. Pavelec, "Leukocyte capillary plugging in myocardial ischemia and reperfusion in the dog, " The American Journal of Pathology, vol. 111, no. 1, pp. 98-111, 1983.
21. G. W. Schmid-Schönbein, S. Takase, J. J. Bergan, "New advances in the understanding of the pathophysiology of chronic venous insufficiency, " Angiology, vol. 52, no. 1, supplement, pp. S27-S34, 2001.
22. G. W. Schmid-Schönbein and T. E. Hugli, "A new hypothesis for microvascular inflammation in shock and multiorgan failure: self-digestion by pancreatic enzymes, " Microcirculation, vol. 12, no. 1, pp. 71-82, 2005.
23. M. L. Entman, L. Michael, R. D. Rossen et al., "Inflammation in the course of earlymyocardial ischemia, " The FASEB Journal, vol. 5, no. 11, pp. 2529-2537, 1991.
24. A. Anselmi, A. Abbate, F. Girola et al., "Myocardial ischemia, stunning, inflammation, apoptosis during cardiac surgery: a review of evidence, " European Journal of Cardio-Thoracic Surgery, vol. 25, no. 3, pp. 304-311, 2004.
25. M. Suematsu, H. Suzuki, F. A. Delano, G. W. Schmid-Schönbein, "The inflammatory aspect of the microcirculation in hypertension: oxidative stress, leukocytes/endothelial interaction, apoptosis, " Microcirculation, vol. 9, no. 4, pp. 259-276, 2002.
26. T. Stürmer, H. Brenner, W. Koenig, K.-P. Günther, "Severity and extent of osteoarthritis and low grade systemic inflammation as assessed by high sensitivity C reactive protein, " Annals of the Rheumatic Diseases, vol. 63, no. 2, pp. 200-205, 2004.
27. M. J. Benito, D. J. Veale, O. FitzGerald, W. B. van den Berg, B. Bresnihan, "Synovial tissue inflammation in early and late osteoarthritis, " Annals of the Rheumatic Diseases, vol. 64, no. 9, pp. 1263-1267, 2005.
28. S. Toker, A. Shirom, I. Shapira, S. Berliner, S. Melamed, "The association between burnout, depression, anxiety, inflammation biomarkers: C-reactive protein and fibrinogen in men and women, " Journal of Occupational Health Psychology, vol. 10, no. 4, pp. 344-362, 2005.
29. B. J. Nicklas, W. Ambrosius, S. P. Messier et al., "Diet-induced weight loss, exercise, chronic inflammation in older, obese adults: a randomized controlled clinical trial, " The American Journal of Clinical Nutrition, vol. 79, no. 4, pp. 544-551, 2004.
30. P. Calabro, D. W. Chang, J. T. Willerson, E. T. H. Yeh, "Release of C-reactive protein in response to inflammatory cytokines by human adipocytes: linking obesity to vascular inflammation, " Journal of the American College of Cardiology, vol. 46, no. 6, pp. 1112-1113, 2005.
31. L. H. Colbert, M. Visser, E. M. Simonsick et al., "Physical activity, exercise, inflammatory markers in older adults: findings from the health, aging and body composition study, " Journal of the American Geriatrics Society, vol. 52, no. 7, pp. 1098-1104, 2004.
32. R. O. Poyton, K. A. Ball, P. R. Castello, "Mitochondrial generation of free radicals and hypoxic signaling, " Trends in Endocrinology andMetabolism, vol. 20, no. 7, pp. 332-340, 2009.
33. S. Reuter, S. C. Gupta, M. M. Chaturvedi, B. B. Aggarwal, "Oxidative stress, inflammation, cancer: how are they linked" Free Radical Biology and Medicine, vol. 49, no. 11, pp. 1603-1616, 2010.
34. L. M. Coussens and Z. Werb, "Inflammation and cancer, " Nature, vol. 420, no. 6917, pp. 860-867, 2002.
35. S. P. Hussain, L. J. Hofseth, C. C. Harris, "Radical causes of cancer, " Nature Reviews Cancer, vol. 3, no. 4, pp. 276-285, 2003.
36. A. Federico, F. Morgillo, C. Tuccillo, F. Ciardiello, C. Loguercio, "Chronic inflammation and oxidative stress in human carcinogenesis, " International Journal of Cancer, vol. 121, no. 11, pp. 2381-2386, 2007.
37. S. P. Hussain and C. C. Harris, "Inflammation and cancer: an ancient link with novel potentials, " International Journal of Cancer, vol. 121, no. 11, pp. 2373-2380, 2007.
38. V. R. Tandon, S. Verma, J. Singh, A. Mahajan, "Antioxidants and cardiovascular health, " Journal of Medical Education & Research, vol. 7, no. 2, pp. 115-118, 2005.
39. A. S. Ravipati, L. Zhang, S. R. Koyyalamudi et al., "Antioxidant and anti-inflammatory activities of selected Chinese medicinal plants and their relation with antioxidant content, " BMC Complementary and Alternative Medicine, vol. 12, article 173, 2012.
40. S. Subramanian, S. Kumar, A. Arulselvan, S. Senthilkumar, "In vitro antibacterial and antifungal activities of ethanolic extract of aloe vera leaf gel, " Journal of Plant Sciences, vol. 1, no. 4, pp. 348-355, 2006.
41. S. Rajasekaran, N. Sriram, P. Arulselvan, S. Subramanian, "Effect of Aloe vera leaf gel extract on membrane bound phosphatases and lysosomal hydrolases in rats with streptozotocin diabetes, " Pharmazie, vol. 62, no. 3, pp. 221-225, 2007.
42. W.-C. Wei, S.-Y. Lin, Y.-J. Chen et al., "Topical application of marine briarane-type diterpenes effectively inhibits 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and dermatitis inmurine skin, " Journal of Biomedical Science, vol. 18, no. 1, article 94, 13 pages, 2011.
43. C.-C. Wen, L.-F. Shyur, J.-T. Jan et al., "Traditional Chinese medicine herbal extracts of Cibotium barometz, Gentiana scabra, Dioscorea batatas, Cassia tora, Taxillus chinensis inhibit SARS-CoV replication, " Journal of Traditional andComplementary Medicine, vol. 1, no. 1, pp. 41-50, 2011.
44. P. Arulselvan, C.-C. Wen, C.-W. Lan, Y.-H. Chen, W.-C. Wei, N.-S. Yang, "Dietary administration of scallion extract effectively inhibits colorectal tumor growth: cellular andmolecular mechanisms in mice, " PLoS ONE, vol. 7, no. 9, Article ID e44658, 2012.
45. Y.-T. Huang, C.-C. Wen, Y.-H. Chen et al., "Dietary uptake of wedelia chinensis extract attenuates dextran sulfate sodiuminduced colitis in mice, " PLoS ONE, vol. 8, no. 5, Article ID e64152, 2013.
46. P. Arulselvan, H. A. A. Ghofar, G. Karthivashan, M. F. A. Halim, M. S. A. Ghafar, S. Fakurazi, "Antidiabetic therapeutics from natural source: a systematic review, " Biomedicine & Preventive Nutrition, vol. 4, no. 4, pp. 607-617, 2014.
47. P. S. Sellamuthu, P. Arulselvan, S. Fakurazi, M. Kandasamy, "Beneficial effects of mangiferin isolated fromSalacia chinensis on biochemical and hematological parameters in rats with streptozotocininduced diabetes, " Pakistan Journal of Pharmaceutical Sciences, vol. 27, no. 1, pp. 161-167, 2014.
48. W. S. Tan, P. Arulselvan, G. Karthivashan, S. Fakurazi, "Moringa oleifera flower extract suppresses the activation of inflammatory mediators in lipopolysaccharide-stimulated RAW 264. 7 macrophages via NF-B pathway, " Mediators of Inflammation, vol. 2015, Article ID 720171, 11 pages, 2015.
49. S. Gothai, P. Arulselvan, W. S. Tan, S. Fakurazi, "Wound healing properties of ethyl acetate fraction of Moringa oleifera in normal human dermal fibroblasts, " Journal of Intercultural Ethnopharmacology, vol. 5, no. 1, pp. 1-6, 2016.
50. D. Krishnaiah, R. Sarbatly, R. Nithyanandam, "A review of the antioxidant potential of medicinal plant species, " Food and Bioproducts Processing, vol. 89, no. 3, pp. 217-233, 2011.
51. M. Gerber, M.-C. Boutron-Ruault, S. Hercberg, E. Riboli, A. Scalbert, M.-H. Siess, "Food and cancer: state of the art about the protective effect of fruits and vegetables, " Bulletin du Cancer, vol. 89, no. 3, pp. 293-312, 2002.
52. S. Bhatia, R. Shukla, S. V. Madhu, J. K. Gambhir, K. M. Prabhu, "Antioxidant status, lipid peroxidation and nitric oxide end products in patients of type 2 diabetes mellitus with nephropathy, " Clinical Biochemistry, vol. 36, no. 7, pp. 557-562, 2003.
53. P. Steer, J. Millgard, D. M. Sarabi et al., "Cardiac and vascular structure and function are related to lipid peroxidation and metabolism, " Lipids, vol. 37, no. 3, pp. 231-236, 2002.
54. V. Di Matteo and E. Esposito, "Biochemical and therapeutic effects of antioxidants in the treatment of Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, " Current Drug Targets-CNS&Neurological Disorders, vol. 2, no. 2, pp. 95-107, 2003.
55. Y. Jiang and M.-H. Wang, "Different solvent fractions of acanthopanax senticosus harms exert antioxidant and antiinflammatory activities and inhibit the human Kv1. 3 channel, " Journal of Medicinal Food, vol. 18, no. 4, pp. 468-475, 2015.
56. H.-Y. Kim, K. W. Hwang, S.-Y. Park, "Extracts of Actinidia arguta stems inhibited LPS-induced inflammatory responses through nuclear factor-B pathway in Raw 264. 7 cells, " Nutrition Research, vol. 34, no. 11, pp. 1008-1016, 2014.
57. X. Chen, J. Miao, H. Wang et al., "The anti-inflammatory activities of Ainsliaea fragrans Champ. extract and its components in lipopolysaccharide-stimulated RAW264. 7 macrophages through inhibition of NF-B pathway, " Journal of Ethnopharmacology, vol. 170, pp. 72-80, 2015.
58. X. L. Hou, Q. Tong, W. Q. Wang et al., "Suppression of inflammatory responses by dihydromyricetin, a flavonoid from ampelopsis grossedentata, via inhibiting the activation of NF-B and MAPK signaling pathways, " Journal of Natural Products, vol. 78, no. 7, pp. 1689-1696, 2015.
59. S. Qi, Y. Xin, Y. Guo et al., "Ampelopsin reduces endotoxic inflammation via repressing ROS-mediated activation of PI3K/Akt/NF-B signaling pathways, " International Immunopharmacology, vol. 12, no. 1, pp. 278-287, 2012.
60. H. R. Chang, H. J. Lee, J.-H. Ryu, "Chalcones fromangelica keiskei attenuate the inflammatory responses by suppressing nuclear translocation of NF-B, " Journal ofMedicinal Food, vol. 17, no. 12, pp. 1306-1313, 2014.
61. Y.-C. Oh, Y. H. Jeong, T. Kim, W.-K. Cho, J. Y. Ma, "Anti-inflammatory effect of Artemisiae annuae herba in lipopolysaccharide-stimulated RAW 264. 7 Cells, " Pharmacognosy Magazine, vol. 10, no. 39, pp. S588-S595, 2014.
62. N. K. Patel, S. Pulipaka, S. P. Dubey, K. K. Bhutani, "Proinflammatory cytokines and nitric oxide inhibitory constituents from Cassia occidentalis roots, " Natural Product Communications, vol. 9, no. 5, pp. 661-664, 2014.
63. R. Lamichhane, S.-G. Kim, A. Poudel, D. Sharma, K.-H. Lee, H.-J. Jung, "Evaluation of in vitro and in vivo biological activities of cheilanthes albomarginata clarke, " BMC Complementary and Alternative Medicine, vol. 14, article 342, 2014.
64. K. Srisook, E. Srisook, W. Nachaiyo et al., "Bioassay-guided isolation andmechanistic action of anti-inflammatory agents from Clerodendrum inerme leaves, " Journal of Ethnopharmacology, vol. 165, pp. 94-102, 2015.
65. T. Akihisa, S. G. Franzblau, M. Ukiya et al., "Antitubercular activity of triterpenoids fromAsteraceae flowers, " Biological and Pharmaceutical Bulletin, vol. 28, no. 1, pp. 158-160, 2005.
66. Y.-C. Cho, A. Ju, B. R. Kim, S. Cho, "Anti-inflammatory effects of Crataeva nurvala Buch. Ham. are mediated via inactivation of ERK but not NF-B, " Journal of Ethnopharmacology, vol. 162, pp. 140-147, 2015.
67. J.-S. Shin, Y. Hong, H.-H. Lee et al., "Fulgidic acid isolated from the rhizomes of Cyperus rotundus suppresses LPS-induced iNOS, COX-2, TNF-, IL-6 expression by AP-1 inactivation in RAW264. 7 macrophages, " Biological and Pharmaceutical Bulletin, vol. 38, no. 7, pp. 1081-1086, 2015.
68. B.-Y. Yang, R. Guo, T. Li et al., "New anti-inflammatory withanolides from the leaves of Datura metel L., " Steroids, vol. 87, pp. 26-34, 2014.
69. R. G. de Oliveira, C. P. A. N. Mahon, P. G. M. Ascêncio, S. D. Ascêncio, S. O. Balogun, D. T. D. O. Martins, "Evaluation of anti-inflammatory activity of hydroethanolic extract of Dilodendron bipinnatumRadlk, " Journal of Ethnopharmacology, vol. 155, no. 1, pp. 387-395, 2014.
70. D. H. Kim, M. E. Kim, J. S. Lee, "Inhibitory effects of extract from G. lanceolata on LPS-induced production of nitric oxide and IL-1 via down-regulation of MAPK in macrophages, " Applied Biochemistry and Biotechnology, vol. 175, no. 2, pp. 657-665, 2015.
71. T. Sogo, N. Terahara, A. Hisanaga et al., "Anti-inflammatory activity and molecular mechanism of delphinidin 3-sambubioside, a hibiscus anthocyanin, " BioFactors, vol. 41, no. 1, pp. 58-65, 2015.
72. J. M. Chun, K. J. Nho, H. S. Kim, A. Y. Lee, B. C. Moon, H. K. Kim, "An ethyl acetate fraction derived from Houttuynia cordata extract inhibits the production of inflammatory markers by suppressing NF-B and MAPK activation in lipopolysaccharide-stimulated RAW264. 7 macrophages, " BMC Complementary and Alternative Medicine, vol. 14, article 234, 2014.
73. X. Chen, S. Tang, E. Lee et al., "IVSE, isolated from Inula japonica, suppresses LPS-induced NO production via NF-B and MAPK inactivation in RAW264. 7 cells, " Life Sciences, vol. 124, pp. 8-15, 2015.
74. H.-H. Park, M. J. Kim, Y. Li et al., "Britanin suppresses LPSinduced nitric oxide, PGE2 and cytokine production via NF-B and MAPK inactivation in RAW 264. 7 cells, " International Immunopharmacology, vol. 15, no. 2, pp. 296-302, 2013.
75. X. Wang, S.-A. Tang, R. Wang, Y. Qiu, M. Jin, D. Kong, "Inhibitory effects of JEUD-38, a new sesquiterpene lactone from inula japonica thunb, on LPS-induced iNOS expression in RAW264. 7 cells, " Inflammation, vol. 38, no. 3, pp. 941-948, 2015.
76. S. S. Lee, N. H. Tan, S. Y. Fung, S. M. Sim, C. S. Tan, S. T. Ng, "Anti-inflammatory effect of the sclerotium of Lignosus rhinocerotis (Cooke) Ryvarden, the Tiger Milk mushroom, " BMC Complementary and Alternative Medicine, vol. 14, no. 1, article 359, 2014.
77. M. Y. Song, H. W. Jung, S. Y. Kang, K.-H. Kim, Y.-K. Park, "Anti-inflammatory effect of Lycii radicis in LPS-stimulated RAW 264. 7 macrophages, " The American Journal of Chinese Medicine, vol. 42, no. 4, pp. 891-904, 2014.
78. M. Flemming, B. Kraus, A. Rascle et al., "Revisited antiinflammatory activity of matricine in vitro: comparison with chamazulene, " Fitoterapia, vol. 106, pp. 122-128, 2015.
79. M. E. Gerritsen, W. W. Carley, G. E. Ranges et al., "Flavonoids inhibit cytokine-induced endothelial cell adhesion protein gene expression, " The American Journal of Pathology, vol. 147, no. 2, pp. 278-292, 1995.
80. C. Muangnoi, P. Chingsuwanrote, P. Praengamthanachoti, S. Svasti, S. Tuntipopipat, "Moringa oleifera pod inhibits inflammatory mediator production by lipopolysaccharidestimulated RAW 264. 7 murine macrophage cell lines, " Inflammation, vol. 35, no. 2, pp. 445-455, 2012.
81. H.-J. Lee, Y.-J. Jeong, T.-S. Lee et al., "Moringa fruit inhibits LPSinduced NO/iNOS expression through suppressing the NF-B activation in RAW264. 7 cells, " The American Journal of Chinese Medicine, vol. 41, no. 5, pp. 1109-1123, 2013.
82. A. A. Adedapo, O. O. Falayi, A. A. Oyagbemi, "Evaluation of the analgesic, anti-inflammatory, anti-oxidant, phytochemical and toxicological properties of the methanolic leaf extract of commercially processed Moringa oleifera in some laboratory animals, " Journal of Basic and Clinical Physiology and Pharmacology, vol. 26, no. 5, pp. 491-499, 2015.
83. M. T. Fard, P. Arulselvan, G. Karthivashan, S. K. Adam, S. Fakurazi, "Bioactive extract from Moringa oleifera inhibits the pro-inflammatory mediators in Lipopolysaccharide stimulated macrophages, " PharmacognosyMagazine, vol. 11, supplement 4, pp. S556-S563, 2015.
84. L. Ozer, J. El-On, A. Golan-Goldhirsh, J. Gopas, "Leishmania major: anti-leishmanial activity of Nuphar lutea extract mediated by the activation of transcription factor NF-B, " Experimental Parasitology, vol. 126, no. 4, pp. 510-516, 2010.
85. H. Turker, A. B. Yldrm, F. P. Karakaş, "Sensitivity of bacteria isolated from fish to some medicinal plants, " Turkish Journal of Fisheries and Aquatic Sciences, vol. 9, no. 2, pp. 181-186, 2009.
86. A. B. Yildirim, F. P. Karakas, A. U. Turker, "In vitro antibacterial and antitumor activities of some medicinal plant extracts, growing in Turkey, " Asian Pacific Journal of Tropical Medicine, vol. 6, no. 8, pp. 616-624, 2013.
87. J. Ozer, T. Levi, A. Golan-Goldhirsh, J. Gopas, "Antiinflammatory effect of a Nuphar lutea partially purified leaf extract inmurinemodels of septic shock, " Journal of Ethnopharmacology, vol. 161, pp. 86-91, 2015.
88. Y.-C. Oh, Y. H. Jeong, J.-H. Ha, W.-K. Cho, J. Y. Ma, "Oryeongsan inhibits LPS-induced production of inflammatory mediators via blockade of the NF-kappaB, MAPK pathways and leads to HO-1 induction in macrophage cells, " BMC Complementary and Alternative Medicine, vol. 14, article 242, 2014.
89. D. R. Luitel, M. B. Rokaya, B. Timsina, Z. Münzbergová, "Medicinal plants used by the Tamang community in the Makawanpur district of central Nepal, " Journal of Ethnobiology and Ethnomedicine, vol. 10, no. 1, article 5, 2014.
90. M. J. Hossen, K.-S. Baek, E. Kim et al., "In vivo and in vitro anti-inflammatory activities of Persicaria chinensis methanolic extract targeting Src/Syk/NF-B, " Journal of Ethnopharmacology, vol. 159, pp. 9-16, 2015.
91. J.-M. Hong, O.-K. Kwon, I.-S. Shin et al., "Anti-inflammatory activities of Physalis alkekengi var. franchetii extract through the inhibition of MMP-9 and AP-1 activation, " Immunobiology, vol. 220, no. 1, pp. 1-9, 2015.
92. S. Isaka, K. Cho, S. Nakazono et al., "Antioxidant and antiinflammatory activities of porphyran isolated from discolored nori (Porphyra yezoensis), " International Journal of Biological Macromolecules, vol. 74, pp. 68-75, 2015.
93. S.-Y. Cheon, K.-S. Chung, E. Jeon, A. Nugroho, H.-J. Park, H.-J. An, "Anti-inflammatory activity of saxifragin via inhibition of NF-B involves caspase-1 activation, " Journal of Natural Products, vol. 78, no. 7, pp. 1579-1585, 2015.
94. Z. Chen, Y.-M. Liu, S. Yang et al., "Studies on the chemical constituents and anticancer activity of Saxifraga stolonifera (L) Meeb, " Bioorganic & Medicinal Chemistry, vol. 16, no. 3, pp. 1337-1344, 2008.
95. J.-S. Shin, S. Ryu, Y.-W. Cho, H. J. Kim, D. S. Jang, K.-T. Lee, "Inhibitory effects of-chamigrenal, isolated from the fruits of schisandra chinensis, on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 2647 macrophages, " PlantaMedica, vol. 80, no. 8-9, pp. 655-661, 2014.
96. L. Chuan-li, Z. Wei, W. Min et al., "Polysaccharides fromSmilax glabra inhibit the pro-inflammatory mediators via ERK1/2 and JNK pathways in LPS-induced RAW264. 7 cells, " Carbohydrate Polymers, vol. 122, pp. 428-436, 2015.