Ethanol Exposure Suppresses Bone Marrow-Derived Dendritic Cell Inflammatory Responses Independent of TLR4 Expression

Journal of Interferon and Cytokine Research

Volumn 32, Issue 9, 2012, Pages 416-425

  Rendon, Juan L ^a,b   Janda, Brian A ^a   Bianco, Monica E ^a   Choudhry, Mashkoor A ^a,b  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b Department of Neurology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84993937514     PISSN: 10799907     EISSN: 15577465     Source Type: Journal    
DOI: 10.1089/jir.2012.0005     Document Type: Article

References (50)

1. Aggarwal S, Ghilardi N, Xie M.H., de Sauvage F.J., Gurney AL. 2003. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem 278(3):1910-1914
2. Banchereau J, Steinman RM. 1998. Dendritic cells and the control of immunity. Nature 392(6673):245-252
3. Celluzzi C.M., Mayordomo J.I., Storkus W.J., Lotze M.T., Falo L.D., Jr. 1996. Peptide-pulsed dendritic cells induce antigen-specific CTL-mediated protective tumor immunity. J Exp Med 183(1):283-287
4. Cook RT. 1998. Alcohol abuse, alcoholism, and damage to the immune systemâa review. Alcohol Clin Exp Res 22(9):1927-1942
5. Dai Q, Pruett SB. 2006a. Different effects of acute and chronic ethanol on LPS-induced cytokine production and TLR4 receptor behavior in mouse peritoneal macrophages. J Immunotoxicol 3(4):217-225
6. Dai Q, Pruett SB. 2006b. Ethanol suppresses LPS-induced toll-like receptor 4 clustering, reorganization of the actin cytoskeleton, and associated TNF-alpha production. Alcohol Clin Exp Res 30(8):1436-1444
7. Dai Q, Zhang J, Pruett SB. 2005. Ethanol alters cellular activation and CD14 partitioning in lipid rafts. Biochem Biophys Res Commun 332(1):37-42
8. Dumitru C.D., Ceci J.D., Tsatsanis C, Kontoyiannis D, Stamatakis K, Lin J.H., Patriotis C, Jenkins N.A., Copeland N.G., Kollias G, et al. 2000. TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway. Cell 103(7):1071-1083
9. Eken A, Ortiz V, Wands JR. 2011. Ethanol inhibits antigen presentation by dendritic cells. Clin Vaccine Immunol 18(7):1157-1166
10. Fan J, Edsen-Moore M.R., Turner L.E., Cook R.T., Legge K.L., Waldschmidt T.J., Schlueter AJ. 2011. Mechanisms by which chronic ethanol feeding limits the ability of dendritic cells to stimulate T-cell proliferation. Alcohol Clin Exp Res 35(1):47-59
11. Fan J, Frey R.S., Malik AB. 2003. TLR4 signaling induces TLR2 expression in endothelial cells via neutrophil NADPH oxidase. J Clin Invest 112(8):1234-1243
12. Faure E, Thomas L, Xu H, Medvedev A, Equils O, Arditi M. 2001. Bacterial lipopolysaccharide and IFN-gamma induce toll-like receptor 2 and toll-like receptor 4 expression in human endothelial cells: Role of NF-kappa B activation. J Immunol 166(3):2018-2024
13. Feng G.J., Goodridge H.S., Harnett M.M., Wei X.Q., Nikolaev A.V., Higson A.P., Liew FY. 1999. Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase. J Immunol 163(12):6403-6412
14. Gately M.K., Renzetti L.M., Magram J, Stern A.S., Adorini L, Gubler U, Presky DH. 1998. The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses. Annu Rev Immunol 16:495-521
15. Germann G, Barthold U, Lefering R, Raff T, Hartmann B. 1997. The impact of risk factors and pre-existing conditions on the mortality of burn patients and the precision of predictive admission-scoring systems. Burns 23(3):195-203
16. Goral J, Choudhry M.A., Kovacs EJ. 2004. Acute ethanol exposure inhibits macrophage IL-6 production: role of p38 and ERK1/2 MAPK. J Leukoc Biol 75(3):553-559
17. Goral J, Kovacs EJ. 2005. In vivo ethanol exposure down-regulates TLR2-, TLR4-, and TLR9-mediated macrophage inflammatory response by limiting p38 and ERK1/2 activation. J Immunol 174(1):456-463
18. Guha M, Mackman N. 2001. LPS induction of gene expression in human monocytes. Cell Signal 13(2):85-94
19. Guha M, O'Connell M.A., Pawlinski R, Hollis A, McGovern P, Yan S.F., Stern D, Mackman N. 2001. Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor alpha expression by inducing elk-1 phosphorylation and egr-1 expression. Blood 98(5):1429-1439
20. Hart DN. 1997. Dendritic cells: unique leukocyte populations which control the primary immune response. Blood 90(9):3245-3287
21. Karavitis J, Murdoch E.L., Gomez C.R., Ramirez L, Kovacs EJ. 2008. Acute ethanol exposure attenuates pattern recognition receptor activated macrophage functions. J Interferon Cytokine Res 28(7):413-422
22. Khader S.A., Partida-Sanchez S, Bell G, Jelley-Gibbs D.M., Swain S, Pearl J.E., Ghilardi N, Desauvage F.J., Lund F.E., Cooper AM. 2006. Interleukin 12p40 is required for dendritic cell migration and T cell priming after mycobacterium tuberculosis infection. J Exp Med 203(7):1805-1815
23. Khayrullina T, Yen J.H., Jing H, Ganea D. 2008. In vitro differentiation of dendritic cells in the presence of prostaglandin E2 alters the IL-12/IL-23 balance and promotes differentiation of Th17 cells. J Immunol 181(1):721-735
24. Langrish C.L., Chen Y, Blumenschein W.M., Mattson J, Basham B, Sedgwick J.D., McClanahan T, Kastelein R.A., Cua DJ. 2005. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 201(2):233-240
25. Lau A.H., Abe M, Thomson AW. 2006. Ethanol affects the generation, cosignaling molecule expression, and function of plasmacytoid and myeloid dendritic cell subsets in vitro and in vivo. J Leukoc Biol 79(5):941-953
26. Liang S.C., Tan X.Y., Luxenberg D.P., Karim R, Dunussi-Joannopoulos K, Collins M, Fouser LA. 2006. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med 203(10):2271-2279
27. Liu W, Ouyang X, Yang J, Liu J, Li Q, Gu Y, Fukata M, Lin T, He J.C., Abreu M, et al. 2009. AP-1 activated by toll-like receptors regulates expression of IL-23 p19. J Biol Chem 284(36):24006-24016
28. Liu YJ. 2001. Dendritic cell subsets and lineages, and their functions in innate and adaptive immunity. Cell 106(3):259-262
29. Lorne E, Dupont H, Abraham E. 2010. Toll-like receptors 2 and 4: initiators of non-septic inflammation in critical care medicine? Intensive Care Med 36(11):1826-1835
30. Lu H.T., Yang D.D., Wysk M, Gatti E, Mellman I, Davis R.J., Flavell RA. 1999. Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice. EMBO J 18(7):1845-1857
31. Mandrekar P, Catalano D, Dolganiuc A, Kodys K, Szabo G. 2004. Inhibition of myeloid dendritic cell accessory cell function and induction of T cell anergy by alcohol correlates with decreased IL-12 production. J Immunol 173(5):3398-3407
32. Mandrekar P, Catalano D, Girouard L, Szabo G. 1996. Human monocyte IL-10 production is increased by acute ethanol treatment. Cytokine 8(7):567-577
33. Mayordomo J.I., Zorina T, Storkus W.J., Zitvogel L, Celluzzi C, Falo L.D., Melief C.J., Ildstad S.T., Kast W.M., Deleo AB. 1995. Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity. Nat Med 1(12):1297-1302
34. Mazzoni A, Segal DM. 2004. Controlling the toll road to dendritic cell polarization. J Leukoc Biol 75(5):721-730
35. McGill V, Kowal-Vern A, Fisher S.G., Kahn S, Gamelli RL. 1995. The impact of substance use on mortality and morbidity from thermal injury. J Trauma 38(6):931-934
36. Messingham K.A., Faunce D.E., Kovacs EJ. 2002. Alcohol, injury, and cellular immunity. Alcohol 28(3):137-149
37. Murphy C.A., Langrish C.L., Chen Y, Blumenschein W, McClanahan T, Kastelein R.A., Sedgwick J.D., Cua DJ. 2003. Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med 198(12):1951-1957
38. Nagai Y, Akashi S, Nagafuku M, Ogata M, Iwakura Y, Akira S, Kitamura T, Kosugi A, Kimoto M, Miyake K. 2002. Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat Immunol 3(7):667-672
39. Nelson S, Bagby G.J., Bainton B.G., Summer WR. 1989. The effects of acute and chronic alcoholism on tumor necrosis factor and the inflammatory response. J Infect Dis 160(3):422-429
40. Nelson S, Kolls JK. 2002. Alcohol, host defence and society. Nat Rev Immunol 2(3):205-209
41. Oppmann B, Lesley R, Blom B, Timans J.C., Xu Y, Hunte B, Vega F, Yu N, Wang J, Singh K, et al. 2000. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13(5):715-725
42. Shortman K, Liu YJ. 2002. Mouse and human dendritic cell subtypes. Nat Rev Immunol 2(3):151-161
43. Steinman RM. 2007. Dendritic cells: understanding immunogenicity. Eur J Immunol 37 Suppl 1:S53-S60
44. Sweet M.J., Hume DA. 1996. Endotoxin signal transduction in macrophages. J Leukoc Biol 60(1):8-26
45. Szabo G, Catalano D, White B, Mandrekar P. 2004. Acute alcohol consumption inhibits accessory cell function of monocytes and dendritic cells. Alcohol Clin Exp Res 28(5):824-828
46. Szabo G, Mandrekar P, Girouard L, Catalano D. 1996. Regulation of human monocyte functions by acute ethanol treatment: decreased tumor necrosis factor-alpha, interleukin-1 beta and elevated interleukin-10, and transforming growth factor-beta production. Alcohol Clin Exp Res 20(5):900-907
47. Takeda K, Kaisho T, Akira S. 2003. Toll-like receptors. Annu Rev Immunol 21:335-376
48. Traver D, Akashi K, Manz M, Merad M, Miyamoto T, Engleman E.G., Weissman IL. 2000. Development of CD8alpha-positive dendritic cells from a common myeloid progenitor. Science 290(5499):2152-2154
49. Verma B.K., Fogarasi M, Szabo G. 1993. Down-regulation of tumor necrosis factor alpha activity by acute ethanol treatment in human peripheral blood monocytes. J Clin Immunol 13(1):8-22
50. Wu T.T., Chen T.L., Loon W.S., Tai Y.T., Cherng Y.G., Chen RM. 2011. Lipopolysaccharide stimulates syntheses of toll-like receptor 2 and surfactant protein-A in human alveolar epithelial A549 cells through upregulating phosphorylation of MEK1 and ERK1/2 and sequential activation of NF-kappaB. Cytokine 55:40-47