Alcohol, injury, and cellular immunity

Alcohol

Volumn 28, Issue 3, 2002, Pages 137-149

  Messingham, Kelly A Nordyke ^a,b   Faunce, Douglas E ^a   Kovacs, Elizabeth J ^a,c  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

Burn injury; Cytokines; Ethanol; Immune responses; Interleukins; Trauma

Indexed keywords

ALCOHOL; CYTOKINE;

ALCOHOL CONSUMPTION; BURN; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; DEPRESSION; DISEASE SEVERITY; HUMAN; IMMUNE FUNCTION TEST; IMMUNOSUPPRESSIVE TREATMENT; INJURY; MEDICAL RESEARCH; NONHUMAN; REVIEW; RISK FACTOR;

ALCOHOL DRINKING; ANIMALS; HUMANS; IMMUNITY, CELLULAR; RISK FACTORS; WOUNDS AND INJURIES;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 0036873765     PISSN: 07418329     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0741-8329(02)00278-1     Document Type: Review

References (192)

1. Alexander J.W. Mechanism of immunologic suppression in burn injury. J Trauma. 30:1990;S70-S75.
2. Annoni G., Weiner F.R., Zern M.A. Increased transforming growth factor-β 1 gene expression in human liver disease. J Hepatol. 14:1992;259-264.
3. Ayala A., Lehman D.L., Herdon C.D., Chaudry I.H. Mechanism of enhanced susceptibility to sepsis following hemorrhage. Interleukin-10 suppression of T-cell response is mediated by eicosanoid-induced interleukin-4 release. Arch Surg. 129:1994;1172-1178.
4. Baker C.C., Oppenheimer L., Stephens B., Lewis F.R., Trunkey D.D. Epidemiology of trauma deaths. Am J Surg. 140:1980;144-150.
5. Bankey P.E., Williams J.G., Guice K.S., Taylor S.N. Interleukin-6 production after thermal injury. evidence for nonmacrophage sources in the lung and liver Surgery. 118:1995;431-438.
6. Bautista A.P. The role of Kupffer cells and reactive oxygen species in hepatic injury during acute and chronic alcohol intoxication. Alcohol Clin Exp Res. 22:1998;255S-259S.
7. Bautista A.P., D'Souza N.B., Lang C.H., Bagwell J., Spitzer J.J. Alcohol-induced downregulation of superoxide anion release by hepatic phagocytes in endotoxemic rats. Am J Physiol. 260:1991;R969-R976.
8. Bautista A.P., D'Souza N.B., Lang C.H., Spitzer J.J. Modulation of f-met-leu-phe induced chemotactic activity and superoxide production by neutrophils during chronic ethanol intoxication. Alcohol Clin Exp Res. 16:1992;788-794.
9. Biffl W.L., Moore E.E., Moore F.A., Peterson V.M. Interleukin-6 in the injured patient. Marker of injury or mediator of inflammation? Ann Surg. 224:1996;647-664.
10. Blomquist S., Elmer O., Thorne J. Central hemodynamics and pulmonary ventilation after trauma. effect of portacaval transposition Circ Shock. 23:1987;151-156.
11. 2 biosynthesis in rat stomach. Dig Dis Sci. 33:1988;814-818.
12. Bone R.C. Toward an epidemiology and natural history of SIRS (systemic inflammatory response syndrome). JAMA. 268:1992;3452-3455.
13. Bone R.C. Toward a theory regarding the pathogenesis of the systemic inflammatory response syndrome. what we do and do not know about cytokine regulation Crit Care Med. 24:1996;163-172.
14. Branch C.D., Wilkins C.F., Ross F.P. The coagulum contact method of skin grafting in the treatment of burns and wounds. Surgery. 19:1945;460-467.
15. Brezel B.S., Kassenbrock J.M., Stein J.M. Burns in substance abusers and in neurologically and mentally impaired patients. J Burn Care Rehabil. 9:1988;169-171.
16. Brodner R.A., Van Gilder J.C., Collins W.F. Jr. Experimental spinal cord trauma. potentiation by alcohol J Trauma. 21:1981;124-129.
17. Cannon J.G., Friedberg J.S., Gelfand J.A., Tompkins R.G., Burke J.F., Dinarello C.A. Circulating interleukin-1 beta and tumor necrosis factor-alpha concentrations after burn injury in humans. Crit Care Med. 20:1992;1414-1419.
18. Carrigan T.D., Field H., Illingworth R.N., Gaffney P., Hamer D.W. Toxicological screening in trauma. J Accid Emerg Med. 17:2000;33-37.
19. Choudhry M.A., Messingham K.A.N., Namak S., Colantoni A., Fontanilla C.V., Duffner L.A., Sayeed M.M., Kovacs E.J. Ethanol exacerbates T cell dysfunction after thermal injury. Alcohol. 21:2000;239-243.
20. Christou N.V. The delayed hypersensitivity skin test response, granulocyte function and sepsis in surgical patients. J Burn Care Rehabil. 6:1985;157-166.
21. Colantoni A., Duffner L.A., De Maria N., Fontanilla C.V., Messingham K.A.N., Van Thiel D.H., Kovacs E.J. Dose-dependent effect of ethanol on hepatic oxidative stress and interleukin-6 production after burn injury in the mouse. Alcohol Clin Exp Res. 24:2000;1443-1448.
22. Conboy K., Welage L.S., Walawander C.A., Duffy L.C., Welliver R.C., Zielezny M.A., DiPiro J.T., Raebel M.A., Grasela T.H. Sepsis syndrome and associated sequelae in patients at high risk for gram-negative sepsis. Pharmacotherapy. 15:1995;66-77.
23. Cook R.T. Alcohol abuse, alcoholism, and damage to the immune system - a review. Alcohol Clin Exp Res. 22:1998;1927-1942.
24. Cortese M.M., Wolff M., Almeido-Hill J., Reid R., Ketcham J., Santosham M. High incidence rates of invasive pneumococcal disease in the White Mountain Apache population. Arch Intern Med. 152:1992;2277-2282.
25. Davis J.M., Dineen P., Gallin J.I. Neutrophil degranulation and abnormal chemotaxis after thermal injury. J Immunol. 124:1980;1467-1471.
26. Dawson D.A. Heavy drinking and the risk of occupational injury. Accid Anal Prev. 26:1994;655-665.
27. Deaciuc I.V., Alappat J.M., McDonough K.H., D'Souza N.B. Effect of chronic alcohol consumption by rats on tumor necrosis factor-alpha and interleukin-6 clearance in vivo and by the isolated, perfused liver. Biochem Pharmacol. 52:1996;891-899.
28. Decker D., Schondorf M., Bidlingmaier F., Hirner A., von Ruecker A.A. Surgical stress induces a shift in the type-1/type-2 T-helper cell balance, suggesting down-regulation of cell-mediated and up-regulation of antibody-mediated immunity commensurate to the trauma. Surgery. 119:1996;316-325.
29. Dehne N.E., Mendenhall C.L., Roselle G.A., Grossman C.J. Cell-mediated immune responses associated with short term alcohol intake. time course and dose dependency Alcohol Clin Exp Res. 13:1989;201-205.
30. Deitch E.A. Bacterial translocation. is it of clinical significance? Gastroenterology. 98:1990;243-244.
31. Demling R.H. Burns. N Engl J Med. 313:1985;1389-1398.
32. Demling R.H., LaLonde C., Ikegami K. Pulmonary edema. pathophysiology, methods of measurement, and clinical importance in acute respiratory failure New Horiz. 1:1993;371-380.
33. Dinkel R.H., Lebok U. A survey of nosocomial infections and their influence on hospital mortality rates. J Hosp Infect. 28:1994;297-304.
34. Donnelly R.P., Crofford L.J., Freeman S.L., Buras J., Remmers E., Wilder R.L., Fenton M.J. Tissue-specific regulation of IL-6 production by IL-4. Differential effects of IL-4 on nuclear factor-κB activity in monocytes and fibroblasts. J Immunol. 151:1993;5603-5612.
35. Drost A.C., Burleson D.G., Cioffi W.G. Jr., Jordan B.S., Mason A.D. Jr., Pruitt B.A. Jr. Plasma cytokines following thermal injury and their relationship with patient mortality, burn size, and time postburn. J Trauma. 35:1993;335-339. a.
36. Drost A.C., Burleson D.G., Cioffi W.G. Jr., Mason A.D. Jr., Pruitt B.A. Jr. Plasma cytokines after thermal injury and their relationship to infection. Ann Surg. 218:1993;74-78. b.
37. Durbin E.A., Gregory M.S., Messingham K.A.N., Fontanilla C.V., Duffner L.A., Kovacs E.J. The role of interleukin 6 in interferon-gamma production in thermally injured mice. Cytokine. 12:2000;1669-1675.
38. Earnest D.L., Abril E.R., Jolley C.S., Martinez F. Ethanol and diet-induced alterations in Kupffer cell function. Alcohol Alcohol. 28:1993;73-83.
39. Espevik T., Figari I.S., Shalaby M.R., Lackides G.A., Lewis G.D., Shepard H.M., Palladino M.A. Jr. Inhibition of cytokine production by cyclosporin A and transforming growth factor β J Exp Med. 166:1987;571-576.
40. Esposito A.L. Community-acquired bacteremic pneumococcal pneumonia. Effect of age on manifestations and outcome. Arch Intern Med. 144:1984;945-948.
41. Faist E. The mechanisms of host defense dysfunction following shock and trauma. Curr Top Microbiol Immunol. 216:1996;259-274.
42. Faist E., Mewes A., Strasser T., Walz A., Alkan S., Baker C., Ertel W., Heberer G. Alteration of monocyte function following major injury. Arch Surg. 123:1988;287-292.
43. Faist E., Schinkel C., Zimmer S. Update on the mechanisms of immune suppression of injury and immune modulation. World J Surg. 20:1996;454-459.
44. Faunce D.E., Gregory M.S., Kovacs E.J. Effects of acute ethanol exposure on cellular immune responses in a murine model of thermal injury. J Leukoc Biol. 62:1997;733-740.
45. Faunce D.E., Gregory M.S., Kovacs E.J. Acute ethanol exposure prior to thermal injury results in decreased T-cell responses mediated in part by increased production of IL-6. Shock. 10:1998;135-140. a.
46. Faunce D.E., Gregory M.S., Kovacs E.J. Glucocorticoids protect against suppression of T cell responses in a murine model of acute ethanol exposure and thermal injury by regulating IL-6. J Leukoc Biol. 64:1998;724-732. b.
47. Flamm E.S., Demopoulos H.B., Seligman M.L., Tomasula J.J., De Crescito V., Ransohoff J. Ethanol potentiation of central nervous system trauma. J Neurosurg. 46:1977;328-335.
48. Fontanilla C.V., Faunce D.E., Gregory M.S., Messingham K.A.N., Durbin E.A., Duffner L.A., Kovacs E.J. Anti-interleukin-6 antibody treatment restores cell-mediated immune function in mice with acute ethanol exposure before burn trauma. Alcohol Clin Exp Res. 24:2000;1392-1399.
49. Friedman H. Alcohol effects on cytokine responses by immunocytes. Alcohol Clin Exp Res. 22:1998;184S-187S.
50. Friedman L.N., Sullivan G.M., Bevilaqua R.P., Loscos R. Tuberculosis screening in alcoholics and drug addicts. Am Rev Respir Dis. 136:1987;1188-1192.
51. 2 by macrophages isolated after thermal injury and bacterial translocation. Circ Shock. 42:1994;154-162.
52. Gennari R., Alexander J.W., Pyles T., Hartmann S., Ogle C.K. Effects of anti-murine interleukin-. 6(on bacterial translocation during gut-derived sepsis. Arch Surg 129):1994;1191-1197.
53. Gentilello L.M., Cobean R.A., Walker A.P., Moore E.E., Wertz M.J., Dellinger E.P. Acute ethanol intoxication increases the risk of infection following penetrating abdominal trauma. J Trauma. 34:1993;669-674.
54. Germann G., Barthold U., Lefering R., Raff T., Hartmann B. The impact of risk factors and pre-existing conditions on the mortality of burn patients and the precision of predictive admission scoring systems. Burns. 23:1997;195-203.
55. Girouard L., Mandrekar P., Catalano D., Szabo G. Regulation of monocyte interleukin-12 production by acute alcohol. a role for inhibition by interleukin-10 Alcohol Clin Exp Res. 22:1998;211-216.
56. Goldstein D.B. Ethanol-induced adaptation in biological membranes. Ann N Y Acad Sci. 492:1987;103-111.
57. 2 in immune suppression following injury. Ann Surg. 214:1991;253-263.
58. Gregory M.S., Duffner L.A., Faunce D.E., Kovacs E.J. Estrogen mediates the sex difference in post-burn immunosuppression. J Endocrinol. 164:2000;129-138. a.
59. 2 in male and female mice subjected to thermal injury contributes to the gender difference in immune function. possible role for 15-hydroxyprostaglandin dehydrogenase Cell Immunol. 205:2000;94-102. b.
60. Gregory M.S., Faunce D.E., Duffner L.A., Kovacs E.J. Gender difference in cell-mediated immunity after thermal injury is mediated, in part, by elevated levels of interleukin-6. J Leukoc Biol. 67:2000;319-326. c.
61. Grobmyer S.R., Maniscalco S.P., Purdue G.F., Hunt J.L. Alcohol, drug intoxication, or both at the time of burn injury as a predictor of complications and mortality in hospitalized patients with burns. J Burn Care Rehabil. 17:1996;532-539.
62. Grossman C.J., Mendenhall C.L., Roselle G.A. Alcohol and immune regulation. I. In vivo effects of ethanol on concanavalin A sensitive thymic lymphocyte function. Int J Immunopharmacol. 10:1988;187-195.
63. Guo Y., Dickerson C., Chrest F.J., Adler W.H., Munster A.M., Winchurch R.A. Increased levels of circulating interleukin 6 in burn patients. Clin Immunol Immunopathol. 54:1990;361-371.
64. Gurney J.G., Rivara F.P., Mueller B.A., Newell D.W., Copass M.K., Jurkovich G.J. The effects of alcohol intoxication on the initial treatment and hospital course of patients with acute brain injury. J Trauma. 33:1992;709-713.
65. Hansbrough J., Peterson V., Zapata-Sirvent R., Claman H.N. Postburn immunosuppression in an animal model. II. Restoration of cell-mediated immunity by immunomodulating drugs. Surgery. 95:1984;290-296.
66. Haum A., Perbix W., Hack H.J., Stark G.B., Spilker G., Doehn M. Alcohol and drug abuse in burn injuries. Burns. 21:1995;194-199.
67. Hensler T., Hecker H., Heeg K., Heidecke C.D., Bartels H., Barthlen W., Wagner H., Siewert J.R., Holzmann B. Distinct mechanisms of immunosuppression as a consequence of major surgery. Infect Immun. 65:1997;2283-2291.
68. Hoek J.B., Rubin E. Alcohol and membrane-associated signal transduction. Alcohol Alcohol. 25:1990;143-156.
69. Honkanen R., Ertama L., Kuosmanen P., Linnoila M., Alha A., Visuri T. The role of alcohol in accidental falls. J Stud Alcohol. 44:1983;231-245.
70. Honkanen R., Visuri T., Kilpio J. Blood alcohol levels in accident victims. Ann Chir Gynaecol Fenn. 64:1975;365-368.
71. Horgan A.F., Mendez M.V., O'Riordain D.S., Holzheimer R.G., Mannick J.A., Rodrick M.L. Altered gene transcription after burn injury results in depressed T-lymphocyte activation. Ann Surg. 220:1994;342-352. a.
72. Horgan A.F., O'Riordain D.S., Chin D.H., Mannick J.A., Rodrick M.L. The role of cyclic adenosine monophosphate in the suppression of cellular immunity after thermal injury. Arch Surg. 129:1994;1284-1289. b.
73. Howland J., Hingson R. Alcohol as a risk factor for injuries or death due to fires and burns. review of the literature Public Health Rep. 102:1987;475-483.
74. Hsiung L., Wang J., Waltenbaugh C. Flow cytometric analysis of lymphocyte subsets of mice maintained on an ethanol-containing liquid diet. Alcohol Clin Exp Res. 18:1994;12-20.
75. Huth J.F., Maier R.V., Simonowitz D.A., Herman C.M. Effect of acute ethanolism on the hospital course and outcome of injured automobile drivers. J Trauma. 23:1983;494-498.
76. Imhoff M., Gahr R.H., Hoffmann P. Delayed cutaneous hypersensitivity after multiple injury and severe burn. Ann Ital Chir. 61:1990;525-528.
77. Jagger J., Fife D., Vernberg K., Jane J.A. Effect of alcohol intoxication on the diagnosis and apparent severity of brain injury. Neurosurgery. 15:1984;303-306.
78. Jareo P.W., Preheim L.C., Gentry M.J. Ethanol ingestion impairs neutrophil bactericidal mechanisms against Streptococcus pneumoniae. Alcohol Clin Exp Res. 20:1996;1646-1652.
79. Jareo P.W., Preheim L.C., Lister P.D., Gentry M.J. The effect of ethanol ingestion on killing of Streptococcus pneumoniae, Staphylococcus aureus and Staphylococcus epidermidis by rat neutrophils. Alcohol Alcohol. 30:1995;311-318.
80. Jayasinghe R., Gianutsos G., Hubbard A.K. Ethanol-induced suppression of cell-mediated immunity in the mouse. Alcohol Clin Exp Res. 16:1992;331-335.
81. Jerrells T.R., Marietta C.A., Eckardt M.J., Majchrowicz E., Weight F.F. Effects of ethanol administration on parameters of immunocompetency in rats. J Leukoc Biol. 39:1986;499-510.
82. Jerrells T.R., Saad A.J., Domiati-Saad R. Effects of ethanol on parameters of cellular immunity and host defense mechanisms to infectious agents. Alcohol. 9:1992;459-463.
83. Jerrells T.R., Saad A.J., Kruger T.E. Ethanol-induced suppression of in vivo host defense mechanisms to bacterial infection. Adv Exp Med Biol. 335:1993;153-157.
84. Jones J.D., Barber B., Engrav L., Heimbach D. Alcohol use and burn injury. J Burn Care Rehabil. 12:1991;148-152.
85. Jurkovich G.J., Rivara F.P., Gurney J.G., Flinger C., Ries R., Mueller B.A., Copass M. The effect of acute alcohol intoxication and chronic alcohol abuse on outcome from trauma. JAMA. 270:1993;51-56.
86. Jurkovich G.J., Rivara F.P., Gurney J.G., Seguin D., Fligner C.L., Copass M. Effects of alcohol intoxication on the initial assessment of trauma patients. Ann Emerg Med. 21:1992;704-708.
87. Kahlke V., Dohm C., Brotzmann K., Schreiber S., Schroder J. Gender-related therapy. early IL-10 administration after hemorrhage restores immune function in males but not in females Shock. 14:2000;354-359.
88. Kawakami M., Meyer A.A., Johnson M.C., deSerres S., Peterson H.D. Chronic ethanol exposure before injury produces greater immune dysfunction after thermal injury in rats. J Trauma. 30:1990;27-31.
89. Kawakami M., Switzer B.R., Herzog S.R., Meyer A.A. Immune suppression after acute ethanol ingestion and thermal injury. J Surg Res. 51:1991;210-215.
90. Kelley D., Lynch J.B. Burns in alcohol and drug users result in longer treatment times with more complications. J Burn Care Rehabil. 13:1992;218-220.
91. Kelly J.L., Lyons A., Soberg C.C., Mannick J.A., Lederer J.A. Anti-interleukin-10 antibody restores burn-induced defects in T-cell dysfunction. Surgery. 122:1997;146-152.
92. Kimchi A. Cytokine triggered molecular pathways that control cell cycle arrest. J Cell Biochem. 50:1992;1-9.
93. Knott D.H., Beard J.D. The effect of chronic ethanol administration on the response of the dog to repeated acute hemorrhages. Am J Med Sci. 254:1967;178-188.
94. Koelega H.S. Alcohol and vigilance performance. a review Psychopharmacology. 118:1995;233-249.
95. Kowal-Vern A., Walenga J.M., Hoppensteadt D., Sharp-Pucci M., Gamelli R.L. Interleukin-2 and interleukin-6 in relation to burn wound size in the acute phase of thermal injury. J Am Coll Surg. 178:1994;357-362.
96. Laskin C.A., Vidins E., Blendis L.M., Soloninka C.A. Autoantibodies in alcoholic liver disease. Am J Med. 89:1990;129-133.
97. Lazaron V., Barke R.A. Gram-negative bacterial sepsis and the sepsis syndrome. Urol Clin North Am. 26:1999;687-699.
98. Li G., Keyl P.M., Smith G.S., Baker S.P. Alcohol and injury severity. reappraisal of the continuing controversy J Trauma. 42:1997;562-569.
99. Loose L.D., Megirian R., Turinsky J. Biochemical and functional alterations in macrophages after thermal injury. Infect Immun. 44:1984;554-558.
100. MacGregor R.R. Alcohol and immune defense. JAMA. 256:1986;1474-1479.
101. Mandrekar P., Catalano D., Girouard L., Szabo G. Human monocyte IL-10 production is increased by acute ethanol treatment. Cytokine. 8:1996;567-577.
102. Maull K.I., Clapp A.R., Ellis L.M. Driver behaviour of ethanol-impaired non-vehicular trauma victims. Arch Emerg Med. 3:1986;16-19.
103. McCarter M.D., Mack V.E., Daly J.M., Naama H.A., Calvano S.E. Trauma-induced alterations in macrophage function. Surgery. 123:1998;96-101.
104. McClain C., Hill D., Schmidt J., Diehl A.M. Cytokines and alcoholic liver disease. Semin Liver Dis. 13:1993;170-182.
105. McGill V., Kowal-Vern A., Fisher S.G., Kahn S., Gamelli R.L. The impact of substance use on mortality and morbidity from thermal injury. J Trauma. 38:1995;931-934.
106. Mendenhall C.L., Theus S.A., Roselle G.A., Grossman C.J., Rouster S.D. Biphasic in vivo immune function after low-versus high-dose alcohol consumption. Alcohol. 14:1997;255-260.
107. Messingham K.A.N., Fontanilla C.V., Colantoni A., Duffner L.A., Kovacs E.J. Cellular immunity after ethanol exposure and burn injury. dose and time dependence Alcohol. 22:2000;35-44.
108. Messingham K.A.N., Heinrich S.A., Kovacs E.J. Estrogen restores cellular immunity in injured male mice via suppression of interleukin-6 production. J Leukoc Biol. 70:2001;887-895.
109. Messingham K.A.N., Heinrich S.A., Schilling E.M., Kovacs E.J. Interleukin-4 treatment restores cellular immunity after ethanol exposure and burn injury. Alcohol Clin Exp Res. 26:2002;519-526.
110. Mikszta J.A., Waltenbaugh C., Kim B.S. Impaired antigen presentation by splenocytes of ethanol-consuming C57BL/6 mice. Alcohol. 12:1995;265-271.
111. Miller C.L., Baker C.C. Changes in lymphocyte activity after thermal injury. The role of suppressor cells. J Clin Invest. 63:1979;202-210.
112. 2 production in severely injured patients. Arch Surg. 123:1988;293-299.
113. Miller-Graziano C.L., Szabo G., Griffey K., Mehta B., Kodys K., Catalano D. Role of elevated monocyte transforming growth factor beta (TGF β) production in posttrauma immunosuppression. J Clin Immunol. 11:1991;95-102.
114. Mills C.D., Caldwell M.D., Gann D.S. Evidence of a plasma-mediated "window" of immunodeficiency in rats following trauma. J Clin Immunol. 9:1989;139-150.
115. Moss N.M., Gough D.B., Jordan A.L., Grbic J.T., Wood J.J., Rodrick M.L., Mannick J.A. Temporal correlation of impaired immune response after thermal injury with susceptibility to infection in a murine model. Surgery. 104:1988;882-887.
116. Munster A.M. Alterations of the host defense mechanism in burns. Surg Clin North Am. 50:1970;1217-1225.
117. Munster A.M. Burns of the world. J Burn Care Rehabil. 17:1996;477-484.
118. Munster A.M., Eurenius K., Katz R.M., Canales L., Foley F.D., Mortensen R.F. Cell-mediated immunity after thermal injury. Ann Surg. 177:1973;139-143.
119. Nakanishi T., Nishi Y., Sato E.F., Ishii M., Hamada T., Inoue M. Thermal injury induces thymocyte apoptosis in the rat. J Trauma. 44:1998;143-148.
120. Napolitano L.M., Koruda M.J., Zimmerman K., McCowan K., Chang J., Meyer A.A. Chronic ethanol intake and burn injury. evidence for synergistic alteration in gut and immune integrity J Trauma. 38:1995;198-207.
121. Ninnemann J.L., Fisher J.C., Frank H.A. Prolonged survival of human skin allografts following thermal injury. Transplantation. 25:1978;69-72.
122. Nishimura T., Nishiura T., deSerres S., Nakagawa T., Meyer A.A. Transforming growth factor-beta1 and splenocyte apoptotic cell death after burn injuries. J Burn Care Rehabil. 21:2000;128-134.
123. Oberholzer A., Keel M., Zellweger R., Steckholzer U., Trentz O., Ertel W. Incidence of septic complications and multiple organ failure in severely injured patients is sex specific. J Trauma. 48:2000;932-937.
124. 2 by LPS-stimulated rat bone marrow macrophages after thermal injury. effect of indomethacin Inflammation. 18:1994;175-185. a.
125. 2 by isolated enterocytes and gut macrophages. effect of lipopolysaccharide and thermal injury J Burn Care Rehabil. 15:1994;470-477. b.
126. O'Riordain D.S., Mendez M.V., Holzheimer R.G., Collins K., Mannick J.A., Rodrick M.L. Interleukin-2 receptor expression and function following thermal injury. Arch Surg. 130:1995;165-170.
127. O'Riordain M.G., Collins K.H., Pilz M., Saporoschetz I.B., Mannick J.A., Rodrick M.L. Modulation of macrophage hyperactivity improves survival in a burn-sepsis model. Arch Surg. 127:1992;152-157.
128. O'Sullivan S.T., Lederer J.A., Horgan A.F., Chin D.H., Mannick J.A., Rodrick M.L. Major injury leads to predominance of the T helper-2 lymphocyte phenotype and diminished interleukin-12 production associated with decreased resistance to infection. Ann Surg. 222:1995;482-490.
129. O'Sullivan S.T., O'Connor T.P. Immunosuppression following thermal injury. the pathogenesis of immunodysfunction Br J Plast Surg. 50:1997;615-623.
130. Paronetto F. Immunologic reactions in alcoholic liver disease. Semin Liver Dis. 13:1993;183-195.
131. Patel M., Keshavarzian A., Kottapalli V., Badie B., Winship D., Fields J.Z. Human neutrophil functions are inhibited in vitro by clinically relevant ethanol concentrations. Alcohol Clin Exp Res. 20:1996;275-283.
132. Patel P.J., Faunce D.E., Gregory M.S., Duffner L.A., Kovacs E.J. Elevation in pulmonary neutrophils and prolonged production of pulmonary macrophage inflammatory protein-2 after burn injury with prior alcohol exposure. Am J Respir Cell Mol Biol. 20:1999;1229-1237.
133. Pennington H.L., Hall P.M., Wilce P.A., Worrall S. Ethanol feeding enhances inflammatory cytokine expression in lipopolysaccharide-induced hepatitis. J Gastroenterol Hepatol. 12:1997;305-313.
134. Peterson J.D., Vasquez K., Waltenbaugh C. Interleukin-12 therapy restores cell-mediated immunity in ethanol-consuming mice. Alcohol Clin Exp Res. 22:1998;245-251.
135. Peterson V., Hansbrough J., Buerk C., Rundus C., Wallner S., Smith H., Robinson W.A. Regulation of granulopoiesis following severe thermal injury. J Trauma. 23:1983;19-24.
136. Polk H.C. Jr. Prolongation of xenograft survival in patients with pseudomonas sepsis. a clarification Surg Forum. 19:1968;514-515.
137. Pories S.E., Gamelli R.L., Vacek P., Goodwin G., Shinozaki T., Harris F. Intoxication and injury. J Trauma. 32:1992;60-64.
138. Pruitt B.A. Jr. Infection and the burn patient. Br J Surg. 77:1990;1081-1082.
139. Puyana J.C., Pellegrini J.D., De A.K., Kodys K., Silva W.E., Miller C.L. Both T-helper-1- and T-helper-2-type lymphokines are depressed in posttrauma anergy. J Trauma. 44:1998;1037-1046.
140. Raff T., Germann G., Barthold U. Factors influencing the early prediction of outcome from burns. Acta Chir Plast. 38:1996;122-127.
141. Ramzy P.I., Barret J.P., Herndon D.N. Thermal injury. Crit Care Clin. 15:1999;333-352.
142. Rangel-Frausto M.S., Pittet D., Costigan M., Hwang T., Davis C.S., Wenzel R.P. The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study. JAMA. 273:1995;117-123.
143. Rivara F.P., Gurney J.G., Ries R.K., Seguin D.A., Copass M.K., Jurkovich G.J. A descriptive study of trauma, alcohol, and alcoholism in young adults. J Adolesc Health. 13:1992;663-667.
144. Rivier C. Effect of pretreatment with alcohol on subsequent endocrine and immune responses in the adult male rat. Alcohol Clin Exp Res. 21:1997;1690-1694.
145. Runyan C.W., Bangdiwala S.I., Linzer M.A., Sacks J.J., Butts J. Risk factors for fatal residential fires. N Engl J Med. 327:1992;859-863.
146. Saad A.J., Jerrells T.R. Flow cytometric and immunohistochemical evaluation of ethanol-induced changes in splenic and thymic lymphoid cell populations. Alcohol Clin Exp Res. 15:1991;796-803.
147. Sakai H., Daniels J.C., Beathard G.A., Lewis S.R., Lynch J.B., Ritzmann S.E. Mixed lymphocyte culture reaction in patients with acute thermal burns. J Trauma. 14:1974;53-57.
148. Sartorelli K.H., Silver G.M., Gamelli R.L. The effect of granulocyte colony-stimulating factor (G-CSF) upon burn-induced defective neutrophil chemotaxis. J Trauma. 31:1991;523-530.
149. Schafer C., Schips I., Landig J., Bode J.C., Bode C. Tumor-necrosis-factor and interleukin-6 response of peripheral blood monocytes to low concentrations of lipopolysaccharide in patients with alcoholic liver disease. Z Gastroenterol. 33:1995;503-508.
150. Schluter B., Konig B., Bergmann U., Muller F.E., Konig W. Interleukin 6 - a potential mediator of lethal sepsis after major thermal trauma. evidence for increased IL-6 production by peripheral blood mononuclear cells J Trauma. 31:1991;1663-1670.
151. Schodde H., Hurst S., Munroe M., Barrett T., Waltenbaugh C. Ethanol ingestion inhibits cell-mediated immune responses of unprimed T-cell receptor transgenic mice. Alcohol Clin Exp Res. 20:1996;890-899.
152. Schroder J., Kahlke V., Staubach K.-H., Zabel P., Stuber F. Gender differences in human sepsis. Arch Surg. 133:1998;1200-1205.
153. Schwacha M.G., Somers S.D. Thermal injury-induced immunosuppression in mice. the role of macrophage-derived reactive nitrogen intermediates J Leukoc Biol. 63:1998;51-58.
154. Shirani K.Z., Vaughan G.M., Mason A.D. Jr., Pruitt B.A. Jr. Update on current therapeutic approaches in burns. Shock. 5:1996;4-16.
155. Shoup M., Weisenberger J.M., Wang J.L., Pyle J.M., Gamelli R.L., Shankar R. Mechanisms of neutropenia involving myeloid maturation arrest in burn sepsis. Ann Surg. 228:1998;112-122.
156. Slukvin I.I., Jerrells T.R. Different pathways of in vitro ethanol-induced apoptosis in thymocytes and splenic T and B lymphocytes. Immunopharmacology. 31:1995;43-57.
157. Smith G.S., Kraus J.F. Alcohol and residential, recreational, and occupational injuries. a review of the epidemiologic evidence Ann Rev Pub Health. 9:1988;99-121.
158. Soderstrom C.A., Smith G.S., Kufera J.A., Dischinger P.C., Hebel J.R., McDuff D.R., Gorelick D.A., Ho S.M., Kerns T.J., Read K.M. The accuracy of the CAGE, the Brief Michigan Alcoholism Screening Test, and the Alcohol Use Disorders Identification Test in screening trauma center patients for alcoholism. J Trauma. 43:1997;962-969.
159. Solomkin J.S., Nelson R.D., Chenoweth D.E., Solem L.D., Simmons R.L. Regulation of neutrophil migratory function in burn injury by complement activation products. Ann Surg. 200:1984;742-746.
160. Spaite D.W., Criss E.A., Weist D.J., Valenzuela T.D., Judkins D., Meislin H.W. A prospective investigation of the impact of alcohol consumption on helmet use, injury severity, medical resource utilization, and health care costs in bicycle-related trauma. J Trauma. 38:1995;287-290.
161. Sparkes B.G. Mechanisms of immune failure in burn injury. Vaccine. 11:1993;504-510.
162. Starkenburg S., Munroe M.E., Waltenbaugh C. Early alteration in leukocyte populations and Th1/Th2 function in ethanol-consuming mice. Alcohol Clin Exp Res. 25:2001;1221-1230.
163. Szabo G. Monocytes, alcohol use, and altered immunity. Alcohol Clin Exp Res. 22:1998;216S-219S.
164. Szabo G., Mandrekar P., Girouard L., Catalano D. Regulation of human monocyte functions by acute ethanol treatment. decreased tumor necrosis factor-alpha, interleukin-1 beta and elevated interleukin-10, and transforming growth factor-beta production Alcohol Clin Exp Res. 20:1996;900-907.
165. Szabo G., Verma B., Catalano D. Selective inhibition of antigen-specific T lymphocyte proliferation by acute ethanol exposure. the role of impaired monocyte antigen presentation capacity and mediator production J Leukoc Biol. 54:1993;534-544.
166. 2 production by ethanol in human monocytes. J Leukoc Biol. 52:1992;602-610.
167. Tamura D.Y., Moore E.E., Partrick D.A., Johnson J.L., Offner P.J., Harbeck R.J., Silliman C.C. Clinically relevant concentrations of ethanol attenuate primed neutrophil bactericidal activity. J Trauma. 44:1998;320-324.
168. Teodorczyk-Injeyan J.A., Sparkes B.G., Mills G.B., Peters W.J., Falk R.E. Impairment of T cell activation in burn patients. a possible mechanism of thermal injury-induced immunosuppression Clin Exp Immunol. 65:1986;570-581.
169. Thal E.R., Bost R.O., Anderson R.J. Effects of alcohol and other drugs on traumatized patients. Arch Surg. 120:1985;708-712.
170. Tilg H., Wilmer A., Vogel W., Herold M., Nolchen B., Judmaier G., Huber C. Serum levels of cytokines in chronic liver diseases. Gastroenterology. 103:1992;264-274.
171. Tonnesen H., Kehlet H. Preoperative alcoholism and postoperative morbidity. Br J Surg. 86:1999;869-874.
172. Tonnesen H., Petersen K.R., Hojgaard L., Stokholm K.H., Nielsen H.J., Knigge U., Kehlet H. Postoperative morbidity among symptom-free alcohol misusers. Lancet. 340:1992;334-337.
173. Tulloh B.R., Collopy B.T. Positive correlation between blood alcohol level and ISS in road trauma. Injury. 25:1994;539-543.
174. Ueyama M., Maruyama I., Osame M., Sawada Y. Marked increase in plasma interleukin-6 in burn patients. J Lab Clin Med. 120:1992;693-698.
175. Vinson D.C., Mabe N., Leonard L.L., Alexander J., Becker J., Boyer J., Moll J. Alcohol and injury. A case-crossover study. Arch Fam Med. 4:1995;505-511.
176. Wahl S.M. Transforming growth factor beta (TGF-beta) in inflammation. a cause and a cure J Clin Immunol. 12:1992;61-74.
177. Waller P.F., Stewart J.R., Hansen A.R., Stutts J.C., Popkin C.L., Rodgman E.A. The potentiating effects of alcohol on driver injury. JAMA. 256:1986;1461-1466.
178. Waltenbaugh C., Peterson J.D. Ethanol impairs the induction of delayed hypersensitivity in C57BL/6 mice. Alcohol. 14:1997;149-153.
179. Waltenbaugh C., Vasquez K., Peterson J.D. Alcohol consumption alters antigen-specific Th1 responses. mechanisms of deficit and repair Alcohol Clin Exp Res. 22:1998;220S-223S.
180. Ward R.E., Flynn T.C., Miller P.W., Blaisdell W.F. Effects of ethanol ingestion on the severity and outcome of trauma. Am J Surg. 144:1982;153-157.
181. Warda L., Tenenbein M., Moffatt M.E. House fire injury prevention update. Part I. A review of risk factors for fatal and non-fatal house fire injury. Inj Prev. 5:1999;145-150.
182. Watson J.S. Illegal blood alcohol levels and traffic death rates. Percept Mot Skills. 79:1994;82.
183. Winkelstein A. What are the immunological alterations induced by burn injury? J Trauma. 24:1984;S72-S83.
184. Wolfe J.H., Wu A.V., O'Connor N.E., Saporoschetz I., Mannick J.A. Anergy, immunosuppressive serum, and impaired lymphocyte blastogenesis in burn patients. Arch Surg. 117:1982;1266-1271.
185. Wu J.Z., Ogle C.K., Mao J.X., Szczur K., Fischer J.E., Ogle J.D. The increased potential for the production of inflammatory cytokines by Kupffer cells and splenic macrophages eight days after thermal injury. Inflammation. 19:1995;529-541.
186. Yamagishi Y., Horie Y., Kato S., Kajihara M., Tamai H., Granger D.N., Ishii H. Ethanol modulates gut ischemia/reperfusion-induced liver injury in rats. Am J Physiol Gastrointest Liver Physiol. 282:2002;G640-G646.
187. Yang L., Hsu B. The roles of macrophage (M phi) and PGE-2 in postburn immunosuppression. Burns. 18:1992;132-136.
188. Zedler S., Bone R.C., Baue A.E., von Donnersmarck G.H., Faist E. T-cell reactivity and its predictive role in immunosuppression after burns. Crit Care Med. 27:1999;66-72.
189. Zeldin G., Yang S.Q., Yin M., Lin H.Z., Rai R., Diehl A.M. Alcohol and cytokine-inducible transcription factors. Alcohol Clin Exp Res. 20:1996;1639-1645.
190. Zhou D., Munster A., Winchurch R.A. Pathologic concentrations of interleukin 6 inhibit T cell responses via induction of activation of TGF-β FASEB J. 5:1991;2582-2585.
191. Zhou D.H., Munster A.M., Winchurch R.A. Inhibitory effects of interleukin 6 on immunity. Possible implications in burn patients. Arch Surg. 127:1992;65-68.
192. Zink B.J., Feustel P.J. Effects of ethanol on respiratory function in traumatic brain injury. J Neurosurg. 82:1995;822-828.