Psychological profiles in the prediction of leukocyte telomere length in healthy individuals

PLoS ONE

Volumn 11, Issue 10, 2016, Pages

  Starnino, Louisia ^a,b   Busque, Lambert ^c   Tardif, Jean Claude ^a   D'Antono, Bianca ^a,b,d  

^a MONTREAL HEART INSTITUTE   (Canada)

^b UNIVERSITÉ DU QUÉBEC À MONTRÉAL   (Canada)

^c MAISONNEUVE ROSEMONT HOSPITAL   (Canada)

^d UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGE DISTRIBUTION; AGED; ALCOHOL CONSUMPTION; ANXIETY; ARTICLE; DEFENSIVENESS; DEPRESSION; EXERCISE; FEMALE; HOSTILITY; HUMAN; INFLAMMATION; LEUKOCYTE; MALE; MEAN ARTERIAL PRESSURE; NORMAL HUMAN; PSYCHOLOGICAL ASPECT; RISK FACTOR; SEX DIFFERENCE; TELOMERE LENGTH; GENETICS; METABOLISM; PSYCHOLOGY; TELOMERE; TELOMERE SHORTENING;

ADULT; ANXIETY; DEPRESSION; FEMALE; HEALTHY VOLUNTEERS; HUMANS; LEUKOCYTES; MALE; RISK FACTORS; TELOMERE; TELOMERE SHORTENING;

EID: 84992754523     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0165482     Document Type: Article

References (117)

1. Everson-Rose SA, Roetker NS, Lutsey PL, Kershaw KN, Longstreth WT Jr., Sacco RL, et al. Chronic stress, depressive symptoms, anger, hostility, and risk of stroke and transient ischemic attack in the multi-ethnic study of atherosclerosis. Stroke. 2014; 45(8):2318-23. doi: 10.1161/STROKEAHA.114. 004815 PMID: 25013018
2. Pragodpol P, Ryan C. Critical review of factors predicting health-related quality of life in newly diagnosed coronary artery disease patients. The Journal of cardiovascular nursing. 2013; 28(3):277-84. doi: 10.1097/JCN.0b013e31824af56e PMID: 22495801
3. Chida Y, Steptoe A. The association of anger and hostility with future coronary heart disease: a metaanalytic review of prospective evidence. Journal of the American College of Cardiology. 2009; 53 (11):936-46. doi: 10.1016/j.jacc.2008.11.044 PMID: 19281923
4. Stafford M, Soljak M, Pledge V, Mindell J. Socio-economic differences in the health-related quality of life impact of cardiovascular conditions. European journal of public health. 2012; 22(3):301-5. doi: 10.1093/eurpub/ckr007 PMID: 21398378
5. Spaderna H, Vogele C, Barten MJ, Smits JM, Bunyamin V, Weidner G. Physical activity and depression predict event-free survival in heart transplant candidates. Health psychology: official journal of the Division of Health Psychology, American Psychological Association. 2014; 33(11):1328-36. doi: 10.1037/hea0000033 PMID: 24512323
6. Mann SJ, James GD. Defensiveness and essential hypertension. Journal of psychosomatic research. 1998; 45(2):139-48. PMID: 9753386
7. Khan FM, Kulaksizoglu B, Cilingiroglu M. Depression and coronary heart disease. Current atherosclerosis reports. 2010; 12(2):105-9. doi: 10.1007/s11883-010-0096-5 PMID: 20425245
8. Khayyam-Nekouei Z, Neshatdoost H, Yousefy A, Sadeghi M, Manshaee G. Psychological factors and coronary heart disease. ARYA atherosclerosis. 2013; 9(1):102-11. PMID: 23690809
9. Rafanelli C, Gostoli S, Tully PJ, Roncuzzi R. Hostility and the clinical course of outpatients with congestive heart failure. Psychology & health. 2015:1-11.
10. Compare A, Zarbo C, Manzoni GM, Castelnuovo G, Baldassari E, Bonardi A, et al. Social support, depression, and heart disease: a ten year literature review. Frontiers in psychology. 2013; 4:384. doi: 10.3389/fpsyg.2013.00384 PMID: 23847561
11. Carty CL, Kooperberg C, Liu J, Herndon M, Assimes T, Hou L, et al. Leukocyte Telomere Length and Risks of Incident Coronary Heart Disease and Mortality in a Racially Diverse Population of Postmenopausal Women. Arteriosclerosis, thrombosis, and vascular biology. 2015; 35(10):2225-31. doi: 10.1161/ATVBAHA.115.305838 PMID: 26249011
12. Haycock PC, Heydon EE, Kaptoge S, Butterworth AS, Thompson A, Willeit P. Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis. BMJ. 2014; 349: g4227. doi: 10.1136/bmj.g4227 PMID: 25006006
13. Blackburn EH. Telomere states and cell fates. Nature. 2000; 408(6808):53-6. doi: 10.1038/35040500 PMID: 11081503
14. Raschenberger J, Kollerits B, Titze S, Kottgen A, Barthlein B, Ekici AB, et al. Association of relative telomere length with cardiovascular disease in a large chronic kidney disease cohort: the GCKD study. Atherosclerosis. 2015; 242(2):529-34. doi: 10.1016/j.atherosclerosis.2015.08.020 PMID: 26302167
15. Olovnikov AM. Telomeres, telomerase, and aging: origin of the theory. Experimental gerontology. 1996; 31(4):443-8. PMID: 9415101
16. Farzaneh-Far R, Cawthon RM, Na B, Browner WS, Schiller NB, Whooley MA. Prognostic value of leukocyte telomere length in patients with stable coronary artery disease: data from the Heart and Soul Study. Arteriosclerosis, thrombosis, and vascular biology. 2008; 28(7):1379-84. doi: 10.1161/ATVBAHA.108.167049 PMID: 18467646
17. Willeit P, Willeit J, Brandstatter A, Ehrlenbach S, Mayr A, Gasperi A, et al. Cellular ging reflected by leukocyte telomere length predicts advanced atherosclerosis and cardiovascular disease risk. Arteriosclerosis, thrombosis, and vascular biology. 2010; 30(8):1649-56. doi: 10.1161/ATVBAHA.110.205492 PMID: 20508208
18. Codd V, Nelson CP, Albrecht E, Mangino M, Deelen J, Buxton JL, et al. Identification of seven loci affecting mean telomere length and their association with disease. Nature genetics. 2013; 45(4):422-7, 7e1-2. doi: 10.1038/ng.2528 PMID: 23535734
19. Wu X, Amos CI, Zhu Y, Zhao H, Grossman BH, Shay JW, et al. Telomere dysfunction: a potential cancer predisposition factor. Journal of the National Cancer Institute. 2003; 95(16):1211-8. PMID: 12928346
20. Okereke OI, Prescott J, Wong JY, Han J, Rexrode KM, De Vivo I. High phobic anxiety is related to lower leukocyte telomere length in women. PloS one. 2012; 7(7):e40516. doi: 10.1371/journal.pone. 0040516 PMID: 22808180
21. Ladwig KH, Brockhaus AC, Baumert J, Lukaschek K, Emeny RT, Kruse J, et al. Posttraumatic stress disorder and not depression is associated with shorter leukocyte telomere length: findings from 3,000 participants in the population-based KORA F4 study. PloS one. 2013; 8(7):e64762. doi: 10.1371/journal.pone.0064762 PMID: 23843935
22. Wolkowitz OM, Mellon SH, Epel ES, Lin J, Dhabhar FS, Su Y, et al. Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress-preliminary findings. PloS one. 2011; 6(3):e17837. doi: 10.1371/journal.pone.0017837 PMID: 21448457
23. Hartmann N, Boehner M, Groenen F, Kalb R. Telomere length of patients with major depression is shortened but independent from therapy and severity of the disease. Depression and anxiety. 2010; 27(12):1111-6. doi: 10.1002/da.20749 PMID: 21053332
24. Needham BL, Mezuk B, Bareis N, Lin J, Blackburn EH, Epel ES. Depression, anxiety and telomere length in young adults: evidence from the National Health and Nutrition Examination Survey. Molecular psychiatry. 2015; 20(4):520-8. doi: 10.1038/mp.2014.89 PMID: 25178165
25. Wikgren M, Maripuu M, Karlsson T, Nordfjall K, Bergdahl J, Hultdin J, et al. Short telomeres in depression and the general population are associated with a hypocortisolemic state. Biological psychiatry. 2012; 71(4):294-300. doi: 10.1016/j.biopsych.2011.09.015 PMID: 22055018
26. Needham BL, Adler N, Gregorich S, Rehkopf D, Lin J, Blackburn EH, et al. Socioeconomic status, health behavior, and leukocyte telomere length in the National Health and Nutrition Examination Survey, 1999-2002. Social science & medicine. 2013; 85:1-8.
27. Simon NM, Smoller JW, McNamara KL, Maser RS, Zalta AK, Pollack MH, et al. Telomere shortening and mood disorders: preliminary support for a chronic stress model of accelerated aging. Biological psychiatry. 2006; 60(5):432-5. doi: 10.1016/j.biopsych.2006.02.004 PMID: 16581033
28. Verhoeven JE, Revesz D, Epel ES, Lin J, Wolkowitz OM, Penninx BW. Major depressive disorder and accelerated cellular aging: results from a large psychiatric cohort study. Molecular psychiatry. 2014; 19(8):895-901. doi: 10.1038/mp.2013.151 PMID: 24217256
29. Huzen J, van der Harst P, de Boer RA, Lesman-Leegte I, Voors AA, van Gilst WH, et al. Telomere length and psychological well-being in patients with chronic heart failure. Age and ageing. 2010; 39 (2):223-7. doi: 10.1093/ageing/afp256 PMID: 20085922
30. Teyssier JR, Chauvet-Gelinier JC, Ragot S, Bonin B. Up-regulation of leucocytes genes implicated in telomere dysfunction and cellular senescence correlates with depression and anxiety severity scores. PloS one. 2012; 7(11):e49677. doi: 10.1371/journal.pone.0049677 PMID: 23185405
31. Hoen PW, de Jonge P, Na BY, Farzaneh-Far R, Epel E, Lin J, et al. Depression and leukocyte telomere length in patients with coronary heart disease: data from the Heart and Soul Study. Psychosomatic medicine. 2011; 73(7):541-7. doi: 10.1097/PSY.0b013e31821b1f6e PMID: 21597035
32. Shaffer JA, Epel E, Kang MS, Ye S, Schwartz JE, Davidson KW, et al. Depressive symptoms are not associated with leukocyte telomere length: findings from the Nova Scotia Health Survey (NSHS95), a population-based study. PloS one. 2012; 7(10):e48318. doi: 10.1371/journal.pone.0048318 PMID: 23133583
33. Hoen PW, Rosmalen JG, Schoevers RA, Huzen J, van der Harst P, de Jonge P. Association between anxiety but not depressive disorders and leukocyte telomere length after 2 years of follow-up in a population-based sample. Psychological medicine. 2013; 43(4):689-97. doi: 10.1017/S0033291712001766 PMID: 22877856
34. Brydon L, Lin J, Butcher L, Hamer M, Erusalimsky JD, Blackburn EH, et al. Hostility and cellular aging in men from the Whitehall II cohort. Biological psychiatry. 2012; 71(9):767-73. doi: 10.1016/j. biopsych.2011.08.020 PMID: 21974787
35. Starkweather AR, Sherwood P, Lyon DE, Bovbjerg DH, Broaddus WC, Elswick RK Jr., et al. Depressive symptoms and cytokine levels in Serum and Tumor Tissue in patients with an Astrocytoma: a pilot study. BMC research notes. 2014; 7:423. doi: 10.1186/1756-0500-7-423 PMID: 24997057
36. Muezzinler A, Zaineddin AK, Brenner H. A systematic review of leukocyte telomere length and age in adults. Ageing research reviews. 2013; 12(2):509-19. doi: 10.1016/j.arr.2013.01.003 PMID: 23333817
37. Somers JM, Goldner EM, Waraich P, Hsu L. Prevalence and incidence studies of anxiety disorders: a systematic review of the literature. Canadian journal of psychiatry Revue canadienne de psychiatrie. 2006; 51(2):100-13. PMID: 16989109
38. Gardner M, Bann D, Wiley L, Cooper R, Hardy R, Nitsch D, et al. Gender and telomere length: systematic review and meta-analysis. Experimental gerontology. 2014; 51:15-27. doi: 10.1016/j.exger. 2013.12.004 PMID: 24365661
39. Okuda K, Bardeguez A, Gardner JP, Rodriguez P, Ganesh V, Kimura M, et al. Telomere length in the newborn. Pediatric research. 2002; 52(3):377-81. doi: 10.1203/00006450-200209000-00012 PMID: 12193671
40. Hunt SC, Chen W, Gardner JP, Kimura M, Srinivasan SR, Eckfeldt JH, et al. Leukocyte telomeres are longer in African Americans than in whites: the National Heart, Lung, and Blood Institute Family Heart Study and the Bogalusa Heart Study. Aging cell. 2008; 7(4):451-8. doi: 10.1111/j.1474-9726. 2008.00397.x PMID: 18462274
41. Piccinelli M, Wilkinson G. Gender differences in depression. Critical review. The British journal of psychiatry: the journal of mental science. 2000; 177:486-92.
42. Eaton WW, Kramer M, Anthony JC, Dryman A, Shapiro S, Locke BZ. The incidence of specific DIS/DSM-III mental disorders: data from the NIMH Epidemiologic Catchment Area Program. Acta psychiatrica Scandinavica. 1989; 79(2):163-78. PMID: 2784251
43. Weisberg YJ, Deyoung CG, Hirsh JB. Gender Differences in Personality across the Ten Aspects of the Big Five. Frontiers in psychology. 2011; 2:178. doi: 10.3389/fpsyg.2011.00178 PMID: 21866227
44. Kananen L, Surakka I, Pirkola S, Suvisaari J, Lonnqvist J, Peltonen L, et al. Childhood adversities are associated with shorter telomere length at adult age both in individuals with an anxiety disorder and controls. PloS one. 2010; 5(5):e10826. doi: 10.1371/journal.pone.0010826 PMID: 20520834
45. Crowne DP, Marlowe D. A new scale of social desirability independent of psychopathology. J Consult Psychol. 1960; 24:349-54. PMID: 13813058
46. Paulhus DL. Two-component models of socially desirable responding. Journal of personality and social psychology. 1984; 46(3):598.
47. Helmers KF, Krantz DS, Merz CN, Klein J, Kop WJ, Gottdiener JS, et al. Defensive hostility: relationship to multiple markers of cardiac ischemia in patients with coronary disease. Health psychology: official journal of the Division of Health Psychology, American Psychological Association. 1995; 14 (3):202-9.
48. Jorgensen RS, Frankowski JJ, Lantinga LJ, Phadke K, Sprafkin RP, Abdul-Karim KW. Defensive hostility and coronary heart disease: a preliminary investigation of male veterans. Psychosomatic medicine. 2001; 63(3):463-9. PMID: 11382274
49. Denollet J. Negative affectivity and repressive coping: pervasive influence on self-reported mood, health, and coronary-prone behavior. Psychosomatic medicine. 1991; 53(5):538-56. PMID: 1758940
50. Rutledge T, Linden W. Defensiveness and 3-year blood pressure levels among young adults: the mediating effect of stress-reactivity. Annals of behavioral medicine: a publication of the Society of Behavioral Medicine. 2003; 25(1):34-40.
51. Nyklíček I, Vingerhoets A, Van Heck G, Van Limpt M. Defensive coping in relation to casual blood pressure and self-reported daily hassles and life events. Journal of behavioral medicine. 1998; 21 (2):145-61. PMID: 9591167
52. Rutledge T, Hogan BE. A quantitative review of prospective evidence linking psychological factors with hypertension development. Psychosomatic medicine. 2002; 64(5):758-66. PMID: 12271106
53. Levesque K, Moskowitz DS, Tardif JC, Dupuis G, D'Antono B. Physiological stress responses in defensive individuals: age and sex matter. Psychophysiology. 2010; 47(2):332-41. doi: 10.1111/j. 1469-8986.2009.00943.x PMID: 20070571
54. Lévesque K, Bureau S, Moskowitz DS, Tardif JC, Lavoie J, Dupuis G, et al. Defensiveness and metabolic syndrome: impact of sex and age. Biol Psychol. 2009; 80(3):354-60. doi: 10.1016/j.biopsycho. 2008.12.003 PMID: 19150480
55. Gentile C, Dragomir AI, Solomon C, Nigam A, D'Antono B. Sex differences in the prediction of metabolic burden from physiological responses to stress. Annals of behavioral medicine: a publication of the Society of Behavioral Medicine. 2015; 49(1):112-27.
56. Gordon JL, Ditto B, D'Antono B. Cognitive depressive symptoms associated with delayed heart rate recovery following interpersonal stress in healthy men and women. Psychophysiology. 2012; 49 (8):1082-9. doi: 10.1111/j.1469-8986.2012.01397.x PMID: 22725718
57. Juster RP, Moskowitz DS, Lavoie J, D'Antono B. Sex-specific interaction effects of age, occupational status, and workplace stress on psychiatric symptoms and allostatic load among healthy Montreal workers. Stress. 2013; 16(6):616-29. doi: 10.3109/10253890.2013.835395 PMID: 23952366
58. Boisclair Demarble J, Moskowitz DS, Tardif JC, D'Antono B. The relation between hostility and concurrent levels of inflammation is sex, age, and measure dependent. Journal of psychosomatic research. 2014; 76(5):384-93. doi: 10.1016/j.jpsychores.2014.02.010 PMID: 24745780
59. Dragomir AI, Gentile C, Nolan RP, D'Antono B. Three-year stability of cardiovascular and autonomic nervous system responses to psychological stress. Psychophysiology. 2014; 51(9):921-31. doi: 10.1111/psyp.12231 PMID: 24853995
60. Rappaport LM, Moskowitz DS, D'Antono B. Naturalistic interpersonal behavior patterns differentiate depression and anxiety symptoms in the community. Journal of counseling psychology. 2014; 61 (2):253-63. doi: 10.1037/a0035625 PMID: 24660689
61. Beck AT, Epstein N, Brown G, Steer RA. An inventory for measuring clinical anxiety: psychometric properties. J Consult Clin Psychol. 1988; 56(6):893-7. PMID: 3204199
62. Beck AT, Steer RA, Brown GK. Beck depression inventory-II. San Antonio, TX: Psychological Corporation. 1996:b9.
63. Arnau RC, Meagher MW, Norris MP, Bramson R. Psychometric evaluation of the Beck Depression Inventory-II with primary care medical patients. Health Psychology. 2001; 20(2):112. PMID: 11315728
64. Cook WW, Medley DM. Proposed hostility and pharisaic-virtue scales for the MMPI. Journal of Applied Psychology. 1954; 38(6):414.
65. Smith TW, Frohm KD. What's so unhealthy about hostility? Construct validity and psychosocial correlates of the Cook and Medley Ho scale. Health Psychol. 1985; 4(6):503-20. PMID: 3830702
66. Barefoot JC, Dahlstrom WG, Williams RB Jr. Hostility, CHD incidence, and total mortality: a 25-year follow-up study of 255 physicians. Psychosomatic medicine. 1983; 45(1):59-63. PMID: 6844529
67. Crowne DP, Marlowe D. A new scale of social desirability independent of psychopathology. Journal of consulting psychology. 1960; 24(4):349.
68. Crino MD, Svoboda M, Rubenfeld S, White MC. Data on the Marlowe-Crowne and Edwards social desirability scales. Psychological Reports. 1983; 53(3):963-8.
69. Cawthon RM. Telomere measurement by quantitative PCR. Nucleic acids research. 2002; 30(10): e47. PMID: 12000852
70. Mollica L, Fleury I, Belisle C, Provost S, Roy DC, Busque L. No association between telomere length and blood cell counts in elderly individuals. J Gerontol A Biol Sci Med Sci. 2009; 64(9):965-7. doi: 10.1093/gerona/glp065 PMID: 19435952
71. Llabre MM, Spitzer SB, Saab PG, Ironson GH, Schneiderman N. The reliability and specificity of delta versus residualized change as measures of cardiovascular reactivity to behavioral challenges. Psychophysiology. 1991; 28(6):701-11. PMID: 1816598
72. Ludlow AT, Ludlow LW, Roth SM. Do telomeres adapt to physiological stress? Exploring the effect of exercise on telomere length and telomere-related proteins. Bio Med research international. 2013;2013.
73. Soares-Miranda L, Imamura F, Siscovick D, Jenny NS, Fitzpatrick AL, Mozaffarian D. Physical Activity, Physical Fitness, and Leukocyte Telomere Length: The Cardiovascular Health Study. Medicine and science in sports and exercise. 2015; 47(12):2525-34. doi: 10.1249/MSS.0000000000000720 PMID: 26083773
74. Shin C, Baik I. Associations Between Alcohol Consumption and Leukocyte Telomere Length Modified by a Common Polymorphism of ALDH2. Alcoholism: Clinical and Experimental Research. 2016; 40 (4):765-71.
75. Pavanello S, Hoxha M, Dioni L, Bertazzi PA, Snenghi R, Nalesso A, et al. Shortened telomeres in individuals with abuse in alcohol consumption. International Journal of Cancer. 2011; 129(4):983-92. doi: 10.1002/ijc.25999 PMID: 21351086
76. Prasad K. C-reactive protein increases oxygen radical generation by neutrophils. Journal of cardiovascular pharmacology and therapeutics. 2004; 9(3):203-9. PMID: 15378141
77. von Zglinicki T. Oxidative stress shortens telomeres. Trends in biochemical sciences. 2002; 27 (7):339-44. PMID: 12114022
78. Pedroso DCC, Miranda-Furtado CL, Kogure GS, Meola J, Okuka M, Silva C, et al. Inflammatory biomarkers and telomere length in women with polycystic ovary syndrome. Fertility and sterility. 2015; 103(2):542-7. e2. doi: 10.1016/j.fertnstert.2014.10.035 PMID: 25467041
79. Rode L, Nordestgaard BG, Weischer M, Bojesen SE. Increased body mass index, elevated C-reactive protein, and short telomere length. The Journal of Clinical Endocrinology & Metabolism. 2014; 99 (9):E1671-E5.
80. Smith TW, Allred KD. Blood-pressure responses during social interaction in high-and low-cynically hostile males. Journal of Behavioral Medicine. 1989; 12(2):135-43. PMID: 2760919
81. Jorgensen RS, Frankowski JJ, Lantinga LJ, Phadke K, Sprafkin RP, Abdul-Karim KW. Defensive hostility and coronary heart disease: a preliminary investigation of male veterans. Psychosomatic Medicine. 2001; 63(3):463-9. PMID: 11382274
82. Markovitz JH, Matthews KA, Wing RR, Kuller LH, Meilahn EN. Psychological, biological and health behavior predictors of blood pressure changes in middle-aged women. Journal of Hypertension. 1991; 9(5):399-406. PMID: 1649859
83. Koh DJ, Kim NY, Kim YW. Predictors of Depressive Mood in Patients With Isolated Cerebellar Stroke: A Retrospective Study. Annals of Rehabilitation Medicine. 2016; 40(3):412-9. doi: 10.5535/arm.2016.40.3.412 PMID: 27446777
84. Kim J-H, Kim HK, Ko J-H, Bang H, Lee D-C. The relationship between leukocyte mitochondrial DNA copy number and telomere length in community-dwelling elderly women. PLoS One. 2013; 8(6): e67227. doi: 10.1371/journal.pone.0067227 PMID: 23785520
85. Preacher KJ, Hayes AF. SPSS and SAS procedures for estimating indirect effects in simple mediation models. Behavior research methods, instruments, & computers: a journal of the Psychonomic Society, Inc. 2004; 36(4):717-31.
86. Lin J, Blalock JA, Chen M, Ye Y, Gu J, Cohen L, et al. Depressive symptoms and short telomere length are associated with increased mortality in bladder cancer patients. Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2015; 24(2):336-43.
87. Kinser PA, Lyon DE. Major depressive disorder and measures of cellular aging: an integrative review. Nursing research and practice. 2013; 2013:469070. doi: 10.1155/2013/469070 PMID: 23691300
88. Pasupathi M. Age differences in response to conformity pressure for emotional and nonemotional material. Psychology and aging. 1999; 14(1):170-4. PMID: 10224640
89. Jorgensen RS, Johnson BT, Kolodziej ME, Schreer GE. Elevated blood pressure and personality: a meta-analytic review. Psychological bulletin. 1996; 120(2):293-320. PMID: 8831299
90. Zalli A, Carvalho LA, Lin J, Hamer M, Erusalimsky JD, Blackburn EH, et al. Shorter telomeres with high telomerase activity are associated with raised allostatic load and impoverished psychosocial resources. Proceedings of the National Academy of Sciences of the United States of America. 2014; 111(12):4519-24. doi: 10.1073/pnas.1322145111 PMID: 24616496
91. D'Antono B, Moskowitz DS, Nigam A. The metabolic costs of hostility in healthy adult men and women: cross-sectional and prospective analyses. J Psychosom Res. 2013; 75(3):262-9. doi: 10.1016/j.jpsychores.2013.05.010 PMID: 23972416
92. Everson-Rose SA, Lewis TT, Karavolos K, Matthews KA, Sutton-Tyrrell K, Powell LH. Cynical hostility and carotid atherosclerosis in African American and white women: the Study of Women's Health Across the Nation (SWAN) Heart Study. American Heart Journal. 2006; 152(5):982. e7-. e13.
93. Mwendwa DT, Ali MK, Sims RC, Madhere S, Levy S-A, Callender CO, et al. Psychometric properties of the Cook Medley Hostility Scale and its association with inflammatory markers in African Americans. Psychology, health & medicine. 2013; 18(4):431-44.
94. Lemogne C, Schuster J-P, Levenstein S, Melchior M, Nabi H, Ducimetière P, et al. Hostility and the risk of peptic ulcer in the GAZEL cohort. Health Psychology. 2015; 34(2):181. doi: 10.1037/hea0000129 PMID: 25110845
95. Sykes D, Arveiler D, Salters C, Ferrieres J, McCrum E, Amouyel P, et al. Psychosocial risk factors for heart disease in France and Northern Ireland: the Prospective Epidemiological Study of Myocardial Infarction (PRIME). International journal of epidemiology. 2002; 31(6):1227-34. PMID: 12540727
96. Bermúdez J, Sánchez-Elvira A, Fernández E, editors. Contenido del Inventario de Hostilidad de Cook y Medley (ICM): implicaciones pronocoronarias. Comunicación presentada al IV Congreso de Evaluación Psicoló gica, Santiago de Compostela; 1994.
97. Miller SB, Dolgoy L, Friese M, Sita A. Parental history of hypertension and hostility moderate cardiovascular responses to interpersonal conflict. International Journal of Psychophysiology. 1998; 28 (2):193-206. PMID: 9545656
98. Boks MP, van Mierlo HC, Rutten BP, Radstake TR, De Witte L, Geuze E, et al. Longitudinal changes of telomere length and epigenetic age related to traumatic stress and post-traumatic stress disorder. Psychoneuroendocrinology. 2015; 51:506-12. doi: 10.1016/j.psyneuen.2014.07.011 PMID: 25129579
99. Verhoeven JE, Revesz D, van Oppen P, Epel ES, Wolkowitz OM, Penninx BW. Anxiety disorders and accelerated cellular ageing. The British journal of psychiatry: the journal of mental science. 2015; 206(5):371-8.
100. Shalev I, Moffitt TE, Braithwaite AW, Danese A, Fleming NI, Goldman-Mellor S, et al. Internalizing disorders and leukocyte telomere erosion: a prospective study of depression, generalized anxiety disorder and post-traumatic stress disorder. Molecular psychiatry. 2014; 19(11):1163-70. doi: 10.1038/mp.2013.183 PMID: 24419039
101. Nordfjall K, Svenson U, Norrback KF, Adolfsson R, Lenner P, Roos G. The individual blood cell telomere attrition rate is telomere length dependent. PLoS Genet. 2009; 5(2):e1000375. doi: 10.1371/journal.pgen.1000375 PMID: 19214207
102. Epel ES, Merkin SS, Cawthon R, Blackburn EH, Adler NE, Pletcher MJ, et al. The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men. Aging (Albany NY). 2009; 1(1):81-8.
103. Blackburn EH, Collins K. Telomerase: an RNP enzyme synthesizes DNA. Cold Spring Harbor perspectives in biology. 2011; 3(5).
104. Epel ES, Lin J, Dhabhar FS, Wolkowitz OM, Puterman E, Karan L, et al. Dynamics of telomerase activity in response to acute psychological stress. Brain, behavior, and immunity. 2010; 24(4):531-9. doi: 10.1016/j.bbi.2009.11.018 PMID: 20018236
105. Robles TF, Carroll JE. Restorative biological processes and health. Social and personality psychology compass. 2011; 5(8):518-37. doi: 10.1111/j.1751-9004.2011.00368.x PMID: 21927619
106. Chida Y, Hamer M. Chronic psychosocial factors and acute physiological responses to laboratoryinduced stress in healthy populations: a quantitative review of 30 years of investigations. Psychol Bull. 2008; 134(6):829-85. doi: 10.1037/a0013342 PMID: 18954159
107. Skilton MR, Moulin P, Terra JL, Bonnet F. Associations between anxiety, depression, and the metabolic syndrome. Biological psychiatry. 2007; 62(11):1251-7. doi: 10.1016/j.biopsych.2007.01.012 PMID: 17553465
108. Frasure-Smith N, Lesperance F. Recent evidence linking coronary heart disease and depression. Canadian journal of psychiatry Revue canadienne de psychiatrie. 2006; 51(12):730-7. PMID: 17168247
109. Vasan RS, Demissie S, Kimura M, Cupples LA, White C, Gardner JP, et al. Association of leukocyte telomere length with echocardiographic left ventricular mass: the Framingham heart study. Circulation. 2009; 120(13):1195-202. doi: 10.1161/CIRCULATIONAHA.109.853895 PMID: 19752323
110. Kuznetsova T, Codd V, Brouilette S, Thijs L, Gonzalez A, Jin Y, et al. Association between left ventricular mass and telomere length in a population study. American journal of epidemiology. 2010; 172 (4):440-50. doi: 10.1093/aje/kwq142 PMID: 20660518
111. Sun Y, Zhang L, Zhao L, Wu X, Gu J. Association of leukocyte telomere length in peripheral blood leukocytes with endometrial cancer risk in Caucasian Americans. Carcinogenesis. 2015; 36(11):1327-32. doi: 10.1093/carcin/bgv133 PMID: 26385889
112. Degerman S, Domellof M, Landfors M, Linder J, Lundin M, Haraldsson S, et al. Long leukocyte telomere length at diagnosis is a risk factor for dementia progression in idiopathic parkinsonism. PloS one. 2014; 9(12):e113387. doi: 10.1371/journal.pone.0113387 PMID: 25501556
113. Gonda X, Fountoulakis KN, Juhasz G, Rihmer Z, Lazary J, Laszik A, et al. Association of the s allele of the 5-HTTLPR with neuroticism-related traits and temperaments in a psychiatrically healthy population. Eur Arch Psychiatry Clin Neurosci. 2009; 259(2):106-13. doi: 10.1007/s00406-008-0842-7 PMID: 18806915
114. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science. 1996; 274 (5292):1527-31. PMID: 8929413
115. Li P, Liu T, Liu J, Zhang Q, Lou F, Kong F, et al. Promoter polymorphism in the serotonin transporter (5-HTT) gene is significantly associated with leukocyte telomere length in Han Chinese. PloS one. 2014; 9(4):e94442. doi: 10.1371/journal.pone.0094442 PMID: 24710073
116. Geronimus AT, Pearson JA, Linnenbringer E, Schulz AJ, Reyes AG, Epel ES, et al. Race-Ethnicity, Poverty, Urban Stressors, and Telomere Length in a Detroit Community-based Sample. Journal of health and social behavior. 2015; 56(2):199-224. doi: 10.1177/0022146515582100 PMID: 25930147
117. Lynch SM, Peek MK, Mitra N, Ravichandran K, Branas C, Spangler E, et al. Race, Ethnicity, Psychosocial Factors, and Telomere Length in a Multicenter Setting. PloS one. 2016; 11(1):e0146723. doi: 10.1371/journal.pone.0146723 PMID: 26752285