The individual blood cell telomere attrition rate is telomere length dependent

PLoS Genetics

Volumn 5, Issue 2, 2009, Pages

  Nordfjäll, Katarina ^a   Svenson, Ulrika ^a   Norrback, Karl Fredrik ^a,b   Adolfsson, Rolf ^a,b   Lenner, Per ^a   Roos, Göran ^a  

^a UMEÅ UNIVERSITY   (Sweden)

^b SUNDERBY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; BLOOD CELL; BLOOD DISEASE; BRAIN TUMOR; BREAST CANCER; CHILD; COLORECTAL CANCER; CONTROLLED STUDY; ENDOMETRIUM CANCER; FEMALE; FOLLOW UP; HUMAN; IN VIVO STUDY; INFANT; KIDNEY CANCER; LIVER CANCER; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; MELANOMA; NEWBORN; OVARY CANCER; PRESCHOOL CHILD; PROSTATE CANCER; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHOOL CHILD; TELOMERE; TELOMERE LENGTH; AGE; CHEMISTRY; COHORT ANALYSIS; GENETICS; METABOLISM;

ADOLESCENT; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; BLOOD CELLS; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; FEMALE; HUMANS; INFANT; MALE; TELOMERE; YOUNG ADULT;

EID: 61449242820     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1000375     Document Type: Article

References (36)

1. Graakjaer J, Londono-Vallejo JA, Christensen K, Kolvraa S (2003) The pattern of chromosome-specific variations in telomere length in humans is determined by inherited, telomere-near factors and is maintained throughout life. Mech Ageing Dev 124: 629-640.
2. Graakjaer J, Londono-Vallejo JA, Christensen K, Kolvraa S (2006) The pattern of chromosome-specific variations in telomere length in humans shows signs of heritability and is maintained through life. Ann N Y Acad Sci 1067: 311-316.
3. Jeanclos E, Schork NJ, Kyvik KO, Kimura M, Skurnick JH, et al. (2000) Telomere length inversely correlates with pulse pressure and is highly familial. Hypertension 36: 195-200.
4. Slagboom PE, Droog S, Boomsma DI (1994) Genetic determination of telomere size in humans: a twin study of three age groups. Am J Hum Genet 55: 876-882.
5. Graakjaer J, Der-Sarkissian H, Schmitz A, Bayer J, Thomas G, et al. (2006) Allele-specific relative telomere lengths are inherited. Hum Genet 119: 344-350.
6. Vasa-Nicotera M, Brouilette S, Mangino M, Thompson JR, Braund P, et al. (2005) Mapping of a major locus that determines telomere length in humans. Am J Human Genetics 76: 147-151.
7. Bekaert S, De Meyer T, Rietzschel ER, De Buyzere ML, De Bacquer D, et al. (2007) Telomere length and cardiovascular risk factors in a middle-aged population free of overt cardiovascular disease. Aging Cell 6: 639-647.
8. Richter T, von Zglinicki T (2007) A continuous correlation between oxidative stress and telomere shortening in fibroblasts. Exp Gerontol 42: 1039-1042.
9. Blasco MA (2007) The epigenetic regulation of mammalian telomeres. Nat Rev Genet 8: 299-309.
10. Huda N, Tanaka H, Herbert BS, Reed T, Gilley D (2007) Shared environmental factors associated with telomere length maintenance in elderly male twins. Aging Cell 6: 709-713.
11. Nordfjäll K, Eliasson M, Stegmayr B, Melander O, Nilsson P, et al. (2008) Telomere length is associated to obesity parameters but with a gender difference. Obesity, In press.
12. Wu X, Amos CI, Zhu Y, Zhao H, Grossman BH, et al. (2003) Telomere dysfunction: a potential cancer predisposition factor. J Natl Cancer Inst 95: 1211-1218.
13. Shao L, Wood CG, Zhang D, Tannir NM, Matin S, et al. (2007) Telomere dysfunction in peripheral lymphocytes as a potential predisposition factor for renal cancer. J Urol 178: 1492-1496.
14. Barwell J, Pangon L, Georgiou A, Docherty Z, Kesterton I, et al. (2007) Is telomere length in peripheral blood lymphocytes correlated with cancer susceptibility or radiosensitivity? Br J Cancer 97: 1696-1700.
15. Svenson U, Nordfjäll K, Stegmayr B, Manjer J, Nilsson P, et al. (2008) Breast cancer survival is associated with telomere length in peripheral blood cells. Cancer Res 68: 3618-3623.
16. Iwama H, Ohyashiki K, Ohyashiki JH, Hayashi S, Yahata N, et al. (1998) Telomeric length and telomerase activity vary with age in peripheral blood cells obtained from normal individuals. Hum Genet 102: 397-402.
17. Frenck RW, Blackburn EH, Shannon KM (1998) The rate of telomere sequence loss in human leukocytes varies with age. Proc Natl Acad Sci U S A 95: 5607-5610.
18. Nordfjäll K, Larefalk A, Lindgren P, Holmberg D, Roos G (2005) Telomere length and heredity: Indications of paternal inheritance. Proc Natl Acad Sci U S A 102: 16374-16378.
19. Martin-Ruiz CM, Gussekloo J, van Heemst D, von Zglinicki T, Westendorp RG (2005) Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population-based study. Aging Cell 4: 287-290.
20. Gardner JP, Li S, Srinivasan SR, Chen W, Kimura M, et al. (2005) Rise in insulin resistance is associated with escalated telomere attrition. Circulation 111: 2171-2177.
21. Aviv A, Chen W, Gardner JP, Kimura M, Brimacombe M (2008) Leukocyte telomere dynamics: longitudinal findings among young adults in the Bogalusa Heart Study. Am J Epidemiol, In press.
22. Teixeira MT, Arneric M, Sperisen P, Lingner J (2004) Telomere length homeostasis is achieved via a switch between telomerase- extendible and -nonextendible states. Cell 117: 323-335.
23. Ouellette MM, Liao M, Herbert BS, Johnson M, Holt SE (2000) Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase. J Biol Chem 275: 10072-10076.
24. Zhu L, Hathcock KS, Hande P, Lansdorp PM, Seldin MF, et al. (1998) Telomere length regulation in mice is linked to a novel chromosome locus. Proc Natl Acad Sci U S A 95: 8648-8653.
25. -/- mice with short telomeres. EMBO Rep 2: 800-807.
26. Hemann MT, Strong MA, Hao LY, Greider CW (2001) The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell 107: 67-77.
27. Han J, Qureshi AA, Prescott J, Guo Q, Ye L, et al. (2009) A prospective study of telomere length and the risk of skin cancer. J Invest Dermatol 129: 415-421.
28. Marcand S, Gilson E, Shore D (1997) A protein-counting mechanism for telomere length regulation in yeast. Science 275: 986-990.
29. Krauskopf A, Blackburn EH (1996) Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats. Nature 383: 354-357.
30. van Steensel B, de Lange T (1997) Control of telomere length by the human telomeric protein TRF1. Nature 385: 740-743.
31. Ancelin K, Brunori M, Bauwens S, Koering CE, Brun C, et al. (2002) Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2. Mol Cell Biol 22: 3474-3487.
32. Cherkas LF, Hunkin JL, Kato BS, Richards JB, Gardner JP, et al. (2008) The association between physical activity in leisure time and leukocyte telomere length. Arch Intern Med 168: 131-132.
33. Kaaks R, Lundin E, Rinaldi S, Manjer J, Biessy C, et al. (2002) Prospective study of IGF-I, IGF-binding proteins, and breast cancer risk, in northern and southern Sweden. Cancer Causes Control 13: 307-316.
34. Cawthon RM (2002) Telomere measurement by quantitative PCR. Nucleic Acids Res 30: e47.
35. Nordfjäll K, Osterman P, Melander O, Nilsson P, Roos G (2007) hTERT (-1327)T/C polymorphism is not associated with age-related telomere attrition in peripheral blood. Biochem Biophys Res Commun 358: 215-218.
36. Goldstein H, Browne W, Rasbash J (2002) Multilevel modelling of medical data. Stat Med 21: 3291-3315.