Effect of curcumin on systemic t helper 17 cell response; Gingival expressions of interleukin-17 and retinoic acid receptor-related orphan receptor gt; And alveolar bone loss in experimental periodontitis

Journal of Periodontology

Volumn 87, Issue 11, 2016, Pages e183-e191

  Bakr, Burcu ^a   Ay, Zuhal Yetkin ^a   Büyükbayram, H Ibrahim ^b   Dogucx, Duygu Kumbul ^b   Bayram, Dilek ^b   Candan, I Aydn ^b   Uskun, Ersin ^b  

^a SULEYMAN DEMIREL UNIVERSITY   (Turkey)

^b SULEYMAN DEMIREL UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

Author keywords

Alveolar bone loss; Curcumin; Interleukin 17; Interleukin 23; Periodontitis; Th17

Indexed keywords

CURCUMIN; IL17 PROTEIN, RAT; INTERLEUKIN 17; RETINOIC ACID RECEPTOR; RETINOID RELATED ORPHAN RECEPTOR GAMMA;

ALVEOLAR BONE LOSS; ANIMAL; MALE; METABOLISM; PERIODONTITIS; RAT; WISTAR RAT;

ALVEOLAR BONE LOSS; ANIMALS; CURCUMIN; INTERLEUKIN-17; MALE; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; PERIODONTITIS; RATS; RATS, WISTAR; RECEPTORS, RETINOIC ACID;

EID: 84992656328     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2016.150722     Document Type: Article

References (50)

1. Page RC, Kornman KS. The pathogenesis of human periodontitis: An introduction. Periodontol 2000 1997; 14:9-11.
2. Hernández M, Dutzan N, Garća-Sesnich J, et al. Hostpathogen interactions in progressive chronic periodontitis. J Dent Res 2011;90:1164-1170.
3. Aggarwal BB, Sung B. Pharmacological basis for the role of curcumin in chronic diseases: An age-old spice with modern targets. Trends Pharmacol Sci 2009;30: 85-94.
4. Aggarwal BB, Harikumar KB. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol 2009;41:40-59.
5. Zhang HJ, Xing YQ, Jin W, Li D, Wu K, Lu Y. Effects of curcumin on interleukin-23 and interleukin-17 expression in rat retina after retinal ischemia-reperfusion injury. Int J Clin Exp Pathol 2015;8:9223-9231.
6. Park M-J, Moon S-J, Lee S-H, et al. Curcumin attenuates acute graft-versus-host disease severity via in vivo regulations on Th1, Th17 and regulatory T cells. PLoS One 2013;8:e67171.
7. Gaedeke J, Noble NA, Border WA. Curcumin blocks multiple sites of the TGF-beta signaling cascade in renal cells. Kidney Int 2004;66:112-120.
8. Brouet I, Ohshima H. Curcumin, an anti-tumour promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages. Biochem Biophys Res Commun 1995;206:533-540.
9. Xie L, Li XK, Funeshima-Fuji N, et al. Amelioration of experimental autoimmune encephalomyelitis by curcumin treatment through inhibition of IL-17 production. Int Immunopharmacol 2009;9:575-581.
10. Zhang M, Deng CS, Zheng JJ, Xia J. Curcumin regulated shift from Th1 to Th2 in trinitrobenzene sulphonic acid-induced chronic colitis. Acta Pharmacol Sin 2006;27:1071-1077.
11. Korn T, Bettelli E, Oukka M, Kuchroo VK. IL-17 and Th17 Cells. Annu Rev Immunol 2009;27:485-517.
12. Cardoso CR, Garlet GP, Crippa GE, et al. Evidence of the presence of T helper type 17 cells in chronic lesions of human periodontal disease. Oral Microbiol Immunol 2009;24:1-6.
13. Dutzan N, Gamonal J, Silva A, Sanz M, Vernal R. Overexpression of forkhead box P3 and its association with receptor activator of nuclear factor-kappa B ligand, interleukin (IL)-17, IL-10 and transforming growth factor-beta during the progression of chronic periodontitis. J Clin Periodontol 2009;36:396-403.
14. Santos VR, Ribeiro FV, Lima JA, Napimoga MH, Bastos MF, Duarte PM. Cytokine levels in sites of chronic periodontitis of poorly controlled and well-controlled type 2 diabetic subjects. J Clin Periodontol 2010;37:1049-1058.
15. Chung Y, Yang X, Chang SH, Ma L, Tian Q, Dong C. Expression and regulation of IL-22 in the IL-17-producing CD4+ T lymphocytes. Cell Res 2006;16:902-907.
16. Liang SC, Tan XY, Luxenberg DP, et al. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med 2006;203:2271-2279.
17. Wilson NJ, Boniface K, Chan JR, et al. Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol 2007;8:950-957.
18. Luo Z, Wang H, Wu Y, Sun Z, Wu Y. Clinical significance of IL-23 regulating IL-17A and/or IL-17F positive Th17 cells in chronic periodontitis. Mediators Inflamm 2014; 2014:627959.
19. McGeachy MJ, Chen Y, Tato CM, et al. The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo. Nat Immunol 2009;10:314-324.
20. O'Garra A, Vieira P. T(H)1 cells control themselves by producing interleukin-10. Nat Rev Immunol 2007;7: 425-428.
21. Duhen R, Glatigny S, Arbelaez CA, Blair TC, Oukka M, Bettelli E. Cutting edge: The pathogenicity of IFNg-producing Th17 cells is independent of T-bet. J Immunol 2013;190:4478-4482.
22. Kleinewietfeld M, Hafler DA. The plasticity of human Treg and Th17 cells and its role in autoimmunity. Semin Immunol 2013;25:305-312.
23. Guimarães MR, de Aquino SG, Coimbra LS, Spolidorio LC, Kirkwood KL, Rossa C Jr. Curcumin modulates the immune response associated with LPS-induced periodontal disease in rats. Innate Immun 2012;18:155-163.
24. Björnsson MJ, Velschow S, Stoltze K, Havemose-Poulsen A, Schou S, Holmstrup P. The influence of diet consistence, drinking water and bedding on periodontal disease in Sprague-Dawley rats. J Periodontal Res 2003;38:543-550.
25. Zhang L, Meng S, Tu Q, et al. Adiponectin ameliorates experimental periodontitis in diet-induced obesity mice. PLoS One 2014;9:e97824.
26. Fernandes MI, Gaio EJ, Oppermann RV, Rados PV, Rosing CK. Comparison of histometric and morphometric analyses of bone height in ligature-induced periodontitis in rats. Braz Oral Res 2007;21:216-221.
27. Refaiy A, Muhammad E, ElGanainy EO. Semiquantitative smoothelin expression in detection of muscle invasion in transurethral resection and cystectomy specimens in cases of urinary bladder carcinoma. Afr J Urol 2011;17:6-10.
28. Garcia de Aquino S, Manzolli LeiteFR, Stach-MachadoDR, Francisco da Silva JA, Spolidorio LC,RossaCJr. Signaling pathways associated with the expression of inflammatory mediators activated during the course of two models of experimental periodontitis. Life Sci 2009;84:745-754.
29. Aggarwal BB, Sundaram C, Malani N, Ichikawa H. Curcumin: The Indian solid gold. Adv Exp Med Biol 2007;595:1-75.
30. Xie L, Li XK, Takahara S. Curcumin has bright prospects for the treatment of multiple sclerosis. Int Immunopharmacol 2011;11:323-330.
31. Ghoreschi K, Laurence A, Yang XP, et al. Generation of pathogenic T(H)17 cells in the absence of TGF-b signalling. Nature 2010;467:967-971.
32. Gulen MF, Kang Z, Bulek K, et al. The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation. Immunity 2010;32:54-66.
33. Taylor JJ. Cytokine regulation of immune responses to Porphyromonas gingivalis. Periodontol 2000 2010;54: 160-194.
34. Guimarães MR, Coimbra LS, de Aquino SG, Spolidorio LC, Kirkwood KL, Rossa C Jr. Potent anti-inflammatory effects of systemically administered curcumin modulate periodontal disease in vivo. J Periodontal Res 2011;46:269-279.
35. Zhou T, Chen D, Li Q, Sun X, Song Y, Wang C. Curcumin inhibits inflammatory response and bone loss during experimental periodontitis in rats. Acta Odontol Scand 2013;71:349-356.
36. Napimoga MH, Benatti BB, Lima FO, et al. Cannabidiol decreases bone resorption by inhibiting RANK/RANKL expression and pro-inflammatory cytokines during experimental periodontitis in rats. Int Immunopharmacol 2009;9:216-222.
37. Elburki MS, Rossa C, Guimaraes MR, et al. A novel chemically modified curcumin reduces severity of experimental periodontal disease in rats: Initial observations. Mediators Inflamm 2014;2014:959471.
38. AdibradM, Deyhimi P, Ganjalikhani Hakemi M, Behfarnia P, Shahabuei M, Rafiee L. Signs of the presence of Th17 cells in chronic periodontal disease. J Periodontal Res 2012;47:525-531.
39. Boniface K, Blom B, Liu YJ, de Waal Malefyt R. From interleukin-23 to T-helper 17 cells: Human T-helper cell differentiation revisited. Immunol Rev 2008;226: 132-146.
40. Lester SR, Bain JL, Johnson RB, Serio FG. Gingival concentrations of interleukin-23 and-17 at healthy sites and at sites of clinical attachment loss. J Periodontol 2007;78:1545-1550.
41. Kanakasabai S, Casalini E,Walline CC,Mo C, Chearwae W, Bright JJ. Differential regulation of CD4(+) T helper cell responses by curcumin in experimental autoimmune encephalomyelitis. J Nutr Biochem 2012;23: 1498-1507.
42. Bereswill S, Muñoz M, Fischer A, et al. Anti-inflammatory effects of resveratrol, curcumin and simvastatin in acute small intestinal inflammation. PLoS One 2010;5: e15099.
43. Silva JAF, Ferrucci DL, Peroni LA, et al. Sequential IL-23 and IL-17 and increased Mmp8 and Mmp14 expression characterize the progression of an experimental model of periodontal disease in type 1 diabetes. J Cell Physiol 2012;227:2441-2450.
44. Himani GS, Prabhuji ML, Karthikeyan BV. Gingival crevicular fluid and interleukin-23 concentration in systemically healthy subjects: Their relationship in periodontal health and disease. J Periodontal Res 2014;49:237-245.
45. Behfarnia P, Birang R, Pishva SS, Hakemi MG, Khorasani MM. Expression levels of th-2 and th-17 characteristic genes in healthy tissue versus periodontitis. J Dent (Tehran) 2013;10:23-31.
46. Bell NH. RANK ligand and the regulation of skeletal remodeling. J Clin Invest 2003;111:1120-1122.
47. Bharti AC, Takada Y, Aggarwal BB. Curcumin (diferuloylmethane) inhibits receptor activator of NF-kappa B ligand-induced NF-kappa B activation in osteoclast precursors and suppresses osteoclastogenesis. J Immunol 2004;172:5940-5947.
48. Hussan F, Ibraheem NG, Kamarudin TA, Shuid AN, Soelaiman IN, Othman F. Curcumin protects against ovariectomy-induced bone changes in rat model. Evid Based Complement Alternat Med 2012;2012: 174916.
49. Folwarczna J, Zych M, Trzeciak HI. Effects of curcumin on the skeletal system in rats. Pharmacol Rep 2010;62: 900-909.
50. Hosadurga RR, Rao SN, Jose J, Rompicharla NC, Shakil M, Shashidhara R. Evaluation of the efficacy of 2% curcumin gel in the treatment of experimental periodontitis. Pharmacognosy Res 2014;6:326-333.