메뉴 건너뛰기




Volumn 46, Issue 2, 2011, Pages 269-279

Potent anti-inflammatory effects of systemically administered curcumin modulate periodontal disease in vivo

Author keywords

Curcumin; Inflammation; Nuclear factor B; P38 mitogen activated protein kinase; Periodontal disease

Indexed keywords

COLLAGEN; CURCUMIN; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; ISOMERASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN E SYNTHASE; PTGS2 PROTEIN, RAT; TUMOR NECROSIS FACTOR ALPHA;

EID: 79951915925     PISSN: 00223484     EISSN: 16000765     Source Type: Journal    
DOI: 10.1111/j.1600-0765.2010.01342.x     Document Type: Article
Times cited : (121)

References (62)
  • 2
    • 6044276740 scopus 로고    scopus 로고
    • Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance
    • Sharma RA, Euden SA, Platton SL et al. Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance. Clin Cancer Res 2004;10:6847-6854.
    • (2004) Clin Cancer Res , vol.10 , pp. 6847-6854
    • Sharma, R.A.1    Euden, S.A.2    Platton, S.L.3
  • 3
    • 0033778209 scopus 로고    scopus 로고
    • Curcumin inhibition of bleomycin-induced pulmonary fibrosis in rats
    • Punithavathi D, Venkatesan N, Babu M. Curcumin inhibition of bleomycin-induced pulmonary fibrosis in rats. Br J Pharmacol 2000;131:169-172.
    • (2000) Br J Pharmacol , vol.131 , pp. 169-172
    • Punithavathi, D.1    Venkatesan, N.2    Babu, M.3
  • 4
    • 0345016388 scopus 로고    scopus 로고
    • Curcumin suppresses Janus kinase-STAT inflammatory signaling through activation of Src homology 2 domain-containing tyrosine phosphatase 2 in brain microglia
    • Kim HY, Park EJ, Joe EH, Jou I. Curcumin suppresses Janus kinase-STAT inflammatory signaling through activation of Src homology 2 domain-containing tyrosine phosphatase 2 in brain microglia. J Immunol 2003;171:6072-6079.
    • (2003) J Immunol , vol.171 , pp. 6072-6079
    • Kim, H.Y.1    Park, E.J.2    Joe, E.H.3    Jou, I.4
  • 5
    • 19344368071 scopus 로고    scopus 로고
    • Chemopreventive and therapeutic effects of curcumin
    • Duvoix A, Blasius R, Delhalle S et al. Chemopreventive and therapeutic effects of curcumin. Cancer Lett 2005;223:181-190.
    • (2005) Cancer Lett , vol.223 , pp. 181-190
    • Duvoix, A.1    Blasius, R.2    Delhalle, S.3
  • 6
    • 0028872989 scopus 로고
    • Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound
    • Rao CV, Rivenson A, Simi B, Reddy BS. Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound. Cancer Res 1995;55:259-266.
    • (1995) Cancer Res , vol.55 , pp. 259-266
    • Rao, C.V.1    Rivenson, A.2    Simi, B.3    Reddy, B.S.4
  • 7
    • 0030322880 scopus 로고    scopus 로고
    • Clinical development plan: curcumin
    • Anonymous.
    • Anonymous. Clinical development plan: curcumin. J Cell Biochem Suppl 1996;26:72-85.
    • (1996) J Cell Biochem Suppl , vol.26 , pp. 72-85
  • 8
    • 15744405822 scopus 로고    scopus 로고
    • Curcumin regulates expression and activity of matrix metalloproteinases 9 and 2 during prevention and healing of indomethacin-induced gastric ulcer
    • Swarnakar S, Ganguly K, Kundu P, Banerjee A, Maity P, Sharma AV. Curcumin regulates expression and activity of matrix metalloproteinases 9 and 2 during prevention and healing of indomethacin-induced gastric ulcer. J Biol Chem 2005;280:9409-9415.
    • (2005) J Biol Chem , vol.280 , pp. 9409-9415
    • Swarnakar, S.1    Ganguly, K.2    Kundu, P.3    Banerjee, A.4    Maity, P.5    Sharma, A.V.6
  • 9
    • 0031056998 scopus 로고    scopus 로고
    • Presence of an acidic glycoprotein in the serum of arthritic rats: modulation by capsaicin and curcumin
    • Joe B, Rao UJ, Lokesh BR. Presence of an acidic glycoprotein in the serum of arthritic rats: modulation by capsaicin and curcumin. Mol Cell Biochem 1997;169:125-134.
    • (1997) Mol Cell Biochem , vol.169 , pp. 125-134
    • Joe, B.1    Rao, U.J.2    Lokesh, B.R.3
  • 10
    • 20444402292 scopus 로고    scopus 로고
    • Curcumin inhibits immunostimulatory function of dendritic cells: MAPKs and translocation of NF-kappa B as potential targets
    • Kim GY, Kim KH, Lee SH et al. Curcumin inhibits immunostimulatory function of dendritic cells: MAPKs and translocation of NF-kappa B as potential targets. J Immunol 2005;174:8116-8124.
    • (2005) J Immunol , vol.174 , pp. 8116-8124
    • Kim, G.Y.1    Kim, K.H.2    Lee, S.H.3
  • 11
    • 33645331312 scopus 로고    scopus 로고
    • Effects of curcumin on tumour necrosis factor-alpha and interleukin-6 in the late phase of experimental acute pancreatitis
    • Gulcubuk A, Altunatmaz K, Sonmez K et al. Effects of curcumin on tumour necrosis factor-alpha and interleukin-6 in the late phase of experimental acute pancreatitis. J Vet Med 2006;53:49-54.
    • (2006) J Vet Med , vol.53 , pp. 49-54
    • Gulcubuk, A.1    Altunatmaz, K.2    Sonmez, K.3
  • 12
    • 77950516262 scopus 로고    scopus 로고
    • Curcumin attenuates inflammatory response in IL-1beta-induced human synovial fibroblasts and collagen-induced arthritis in mouse model
    • Moon DO, Kim MO, Choi YH, Park YM, Kim GY. Curcumin attenuates inflammatory response in IL-1beta-induced human synovial fibroblasts and collagen-induced arthritis in mouse model. Int Immunopharmacol 2010;10:605-610.
    • (2010) Int Immunopharmacol , vol.10 , pp. 605-610
    • Moon, D.O.1    Kim, M.O.2    Choi, Y.H.3    Park, Y.M.4    Kim, G.Y.5
  • 13
    • 70349501979 scopus 로고    scopus 로고
    • Oral administration of curcumin suppresses production of matrix metalloproteinase (MMP)-1 and MMP-3 to ameliorate collagen-induced arthritis: inhibition of the PKCdelta/JNK/c-Jun pathway
    • Mun SH, Kim HS, Kim JW et al. Oral administration of curcumin suppresses production of matrix metalloproteinase (MMP)-1 and MMP-3 to ameliorate collagen-induced arthritis: inhibition of the PKCdelta/JNK/c-Jun pathway. J Pharmacol Sci 2009;111:13-21.
    • (2009) J Pharmacol Sci , vol.111 , pp. 13-21
    • Mun, S.H.1    Kim, H.S.2    Kim, J.W.3
  • 14
    • 67650973761 scopus 로고    scopus 로고
    • Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research
    • Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern Med Rev 2009;14:141-153.
    • (2009) Altern Med Rev , vol.14 , pp. 141-153
    • Jurenka, J.S.1
  • 16
    • 77950363955 scopus 로고    scopus 로고
    • Curcumin suppresses p38 mitogen-activated protein kinase activation, reduces IL-1beta and matrix metalloproteinase-3 and enhances IL-10 in the mucosa of children and adults with inflammatory bowel disease
    • Epstein J, Docena G, MacDonald TT, Sanderson IR. Curcumin suppresses p38 mitogen-activated protein kinase activation, reduces IL-1beta and matrix metalloproteinase-3 and enhances IL-10 in the mucosa of children and adults with inflammatory bowel disease. Br J Nutr 2010;103:824-832.
    • (2010) Br J Nutr , vol.103 , pp. 824-832
    • Epstein, J.1    Docena, G.2    MacDonald, T.T.3    Sanderson, I.R.4
  • 17
    • 68449085126 scopus 로고    scopus 로고
    • Curcumin has bright prospects for the treatment of inflammatory bowel disease
    • Hanai H, Sugimoto K. Curcumin has bright prospects for the treatment of inflammatory bowel disease. Curr Pharm Des 2009;15:2087-2094.
    • (2009) Curr Pharm Des , vol.15 , pp. 2087-2094
    • Hanai, H.1    Sugimoto, K.2
  • 18
    • 27144456477 scopus 로고    scopus 로고
    • Curcumin therapy in inflammatory bowel disease: a pilot study
    • Holt PR, Katz S, Kirshoff R. Curcumin therapy in inflammatory bowel disease: a pilot study. Dig Dis Sci 2005;50:2191-2193.
    • (2005) Dig Dis Sci , vol.50 , pp. 2191-2193
    • Holt, P.R.1    Katz, S.2    Kirshoff, R.3
  • 20
    • 0034767683 scopus 로고    scopus 로고
    • Tumor necrosis factor modulates fibroblast apoptosis, PMN recruitment, and osteoclast formation in response to P. gingivalis infection
    • Graves DT, Oskoui M, Volejnikova S et al. Tumor necrosis factor modulates fibroblast apoptosis, PMN recruitment, and osteoclast formation in response to P. gingivalis infection. J Dent Res 2001;80:1875-1879.
    • (2001) J Dent Res , vol.80 , pp. 1875-1879
    • Graves, D.T.1    Oskoui, M.2    Volejnikova, S.3
  • 21
    • 4243636072 scopus 로고    scopus 로고
    • The expression of monocyte chemoattractant protein-1 and other chemokines by osteoblasts
    • Graves DT, Jiang Y, Valente AJ. The expression of monocyte chemoattractant protein-1 and other chemokines by osteoblasts. Front Biosci 1999;4:D571-D580.
    • (1999) Front Biosci , vol.4
    • Graves, D.T.1    Jiang, Y.2    Valente, A.J.3
  • 22
    • 14044250270 scopus 로고    scopus 로고
    • Curcumin treatment enhances the repair and regeneration of wounds in mice exposed to hemibody gamma-irradiation
    • Jagetia GC, Rajanikant GK. Curcumin treatment enhances the repair and regeneration of wounds in mice exposed to hemibody gamma-irradiation. Plast Reconstr Surg 2005;115:515-528.
    • (2005) Plast Reconstr Surg , vol.115 , pp. 515-528
    • Jagetia, G.C.1    Rajanikant, G.K.2
  • 23
    • 33644901007 scopus 로고    scopus 로고
    • Multiple biological activities of curcumin: a short review
    • Maheshwari RK, Singh AK, Gaddipati J, Srimal RC. Multiple biological activities of curcumin: a short review. Life Sci 2006;78:2081-2087.
    • (2006) Life Sci , vol.78 , pp. 2081-2087
    • Maheshwari, R.K.1    Singh, A.K.2    Gaddipati, J.3    Srimal, R.C.4
  • 24
    • 0032010057 scopus 로고    scopus 로고
    • Enhancement of wound healing by curcumin in animals
    • Sidhu GS, Singh AK, Thaloor D et al. Enhancement of wound healing by curcumin in animals. Wound Repair Regen 1998;6:167-177.
    • (1998) Wound Repair Regen , vol.6 , pp. 167-177
    • Sidhu, G.S.1    Singh, A.K.2    Thaloor, D.3
  • 25
    • 67349252776 scopus 로고    scopus 로고
    • Signaling pathways associated with the expression of inflammatory mediators activated during the course of two models of experimental periodontitis
    • Garcia de Aquino S, Manzolli Leite FR, Stach-Machado DR, Francisco da Silva JA, Spolidorio LC, Rossa C Jr. Signaling pathways associated with the expression of inflammatory mediators activated during the course of two models of experimental periodontitis. Life Sci 2009;84:745-754.
    • (2009) Life Sci , vol.84 , pp. 745-754
    • Garcia de Aquino, S.1    Manzolli Leite, F.R.2    Stach-Machado, D.R.3    Francisco da Silva, J.A.4    Spolidorio, L.C.5    Rossa Jr, C.6
  • 26
    • 38549153486 scopus 로고    scopus 로고
    • Curcumin protects the rat liver from CCl4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation
    • Fu Y, Zheng S, Lin J, Ryerse J, Chen A. Curcumin protects the rat liver from CCl4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation. Mol Pharmacol 2008;73:399-409.
    • (2008) Mol Pharmacol , vol.73 , pp. 399-409
    • Fu, Y.1    Zheng, S.2    Lin, J.3    Ryerse, J.4    Chen, A.5
  • 27
    • 0029398963 scopus 로고
    • The subgingival microflora and gingival crevicular fluid cytokines in refractory periodontitis
    • Lee HJ, Kang IK, Chung CP, Choi SM. The subgingival microflora and gingival crevicular fluid cytokines in refractory periodontitis. J Clin Periodontol 1995;22:885-890.
    • (1995) J Clin Periodontol , vol.22 , pp. 885-890
    • Lee, H.J.1    Kang, I.K.2    Chung, C.P.3    Choi, S.M.4
  • 28
    • 0027602936 scopus 로고
    • Modulation of host PGE2 secretion as a determinant of periodontal disease expression
    • Offenbacher S, Heasman PA, Collins JG. Modulation of host PGE2 secretion as a determinant of periodontal disease expression. J Periodontol 1993;64:432-444.
    • (1993) J Periodontol , vol.64 , pp. 432-444
    • Offenbacher, S.1    Heasman, P.A.2    Collins, J.G.3
  • 29
    • 0037295833 scopus 로고    scopus 로고
    • Are cytokines linked to collagen breakdown during periodontal disease progression?
    • Ejeil AL, Gaultier F, Igondjo-Tchen S et al. Are cytokines linked to collagen breakdown during periodontal disease progression? J Periodontol 2003;74:196-201.
    • (2003) J Periodontol , vol.74 , pp. 196-201
    • Ejeil, A.L.1    Gaultier, F.2    Igondjo-Tchen, S.3
  • 30
    • 0034305350 scopus 로고    scopus 로고
    • Levels of interleukin-1 beta, -8, and -10 and RANTES in gingival crevicular fluid and cell populations in adult periodontitis patients and the effect of periodontal treatment
    • Gamonal J, Acevedo A, Bascones A, Jorge O, Silva A. Levels of interleukin-1 beta, -8, and -10 and RANTES in gingival crevicular fluid and cell populations in adult periodontitis patients and the effect of periodontal treatment. J Periodontol 2000;71:1535-1545.
    • (2000) J Periodontol , vol.71 , pp. 1535-1545
    • Gamonal, J.1    Acevedo, A.2    Bascones, A.3    Jorge, O.4    Silva, A.5
  • 31
    • 0027673768 scopus 로고
    • Measurements of interleukin-6 in gingival crevicular fluid from adults with destructive periodontal disease
    • Geivelis M, Turner DW, Pederson ED, Lamberts BL. Measurements of interleukin-6 in gingival crevicular fluid from adults with destructive periodontal disease. J Periodontol 1993;64:980-983.
    • (1993) J Periodontol , vol.64 , pp. 980-983
    • Geivelis, M.1    Turner, D.W.2    Pederson, E.D.3    Lamberts, B.L.4
  • 32
    • 0346256617 scopus 로고    scopus 로고
    • Relationship between clinical parameters and cytokine profiles in inflamed gingival tissue and serum samples from patients with chronic periodontitis
    • Gorska R, Gregorek H, Kowalski J, Laskus-Perendyk A, Syczewska M, Madalinski K. Relationship between clinical parameters and cytokine profiles in inflamed gingival tissue and serum samples from patients with chronic periodontitis. J Clin Periodontol 2003;30:1046-1052.
    • (2003) J Clin Periodontol , vol.30 , pp. 1046-1052
    • Gorska, R.1    Gregorek, H.2    Kowalski, J.3    Laskus-Perendyk, A.4    Syczewska, M.5    Madalinski, K.6
  • 35
    • 0033613436 scopus 로고    scopus 로고
    • Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK/IKK signalling complex
    • Plummer SM, Holloway KA, Manson MM et al. Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK/IKK signalling complex. Oncogene 1999;18:6013-6020.
    • (1999) Oncogene , vol.18 , pp. 6013-6020
    • Plummer, S.M.1    Holloway, K.A.2    Manson, M.M.3
  • 36
    • 0042309594 scopus 로고    scopus 로고
    • Differential regulation of cytokines and transcription factors in liver by curcumin following hemorrhage/resuscitation
    • Gaddipati JP, Sundar SV, Calemine J, Seth P, Sidhu GS, Maheshwari RK. Differential regulation of cytokines and transcription factors in liver by curcumin following hemorrhage/resuscitation. Shock 2003;19:150-156.
    • (2003) Shock , vol.19 , pp. 150-156
    • Gaddipati, J.P.1    Sundar, S.V.2    Calemine, J.3    Seth, P.4    Sidhu, G.S.5    Maheshwari, R.K.6
  • 38
    • 0037908832 scopus 로고    scopus 로고
    • Modulation of inflammatory mediators by ibuprofen and curcumin treatment during chronic inflammation in rat
    • Banerjee M, Tripathi LM, Srivastava VM, Puri A, Shukla R. Modulation of inflammatory mediators by ibuprofen and curcumin treatment during chronic inflammation in rat. Immunopharmacol Immunotoxicol 2003;25:213-224.
    • (2003) Immunopharmacol Immunotoxicol , vol.25 , pp. 213-224
    • Banerjee, M.1    Tripathi, L.M.2    Srivastava, V.M.3    Puri, A.4    Shukla, R.5
  • 39
    • 0026093041 scopus 로고
    • Pharmacology of Curcuma longa
    • Ammon HP, Wahl MA. Pharmacology of Curcuma longa. Planta Med 1991;57:1-7.
    • (1991) Planta Med , vol.57 , pp. 1-7
    • Ammon, H.P.1    Wahl, M.A.2
  • 40
    • 84934444244 scopus 로고    scopus 로고
    • Clinical studies with curcumin
    • Hsu CH, Cheng AL. Clinical studies with curcumin. Adv Exp Med Biol 2007;595:471-480.
    • (2007) Adv Exp Med Biol , vol.595 , pp. 471-480
    • Hsu, C.H.1    Cheng, A.L.2
  • 42
    • 53449091077 scopus 로고    scopus 로고
    • Anti-inflammatory activity of curcumin in macrophages stimulated by lipopolysaccharides from Porphyromonas gingivalis
    • Chen D, Nie M, Fan MW, Bian Z. Anti-inflammatory activity of curcumin in macrophages stimulated by lipopolysaccharides from Porphyromonas gingivalis. Pharmacology 2008;82:264-269.
    • (2008) Pharmacology , vol.82 , pp. 264-269
    • Chen, D.1    Nie, M.2    Fan, M.W.3    Bian, Z.4
  • 43
    • 34250370973 scopus 로고    scopus 로고
    • Curcumin suppresses AP1 transcription factor-dependent differentiation and activates apoptosis in human epidermal keratinocytes
    • Balasubramanian S, Eckert RL. Curcumin suppresses AP1 transcription factor-dependent differentiation and activates apoptosis in human epidermal keratinocytes. J Biol Chem 2007;282:6707-6715.
    • (2007) J Biol Chem , vol.282 , pp. 6707-6715
    • Balasubramanian, S.1    Eckert, R.L.2
  • 44
    • 34247281580 scopus 로고    scopus 로고
    • Curcumin attenuates glutamate-induced HT22 cell death by suppressing MAP kinase signaling
    • Suh HW, Kang S, Kwon KS. Curcumin attenuates glutamate-induced HT22 cell death by suppressing MAP kinase signaling. Mol Cell Biochem 2007;298:187-194.
    • (2007) Mol Cell Biochem , vol.298 , pp. 187-194
    • Suh, H.W.1    Kang, S.2    Kwon, K.S.3
  • 45
    • 35348853689 scopus 로고    scopus 로고
    • Pharmacological doses of dietary curcumin increase colon epithelial cell proliferation in vivo in rats
    • Kim SJ, Hellerstein MK. Pharmacological doses of dietary curcumin increase colon epithelial cell proliferation in vivo in rats. Phytother Res 2007;21:995-998.
    • (2007) Phytother Res , vol.21 , pp. 995-998
    • Kim, S.J.1    Hellerstein, M.K.2
  • 46
    • 22244486007 scopus 로고    scopus 로고
    • Curcumin inhibits the expression of COX-2 in UVB-irradiated human keratinocytes (HaCaT) by inhibiting activation of AP-1: p38 MAP kinase and JNK as potential upstream targets
    • Cho JW, Park K, Kweon GR et al. Curcumin inhibits the expression of COX-2 in UVB-irradiated human keratinocytes (HaCaT) by inhibiting activation of AP-1: p38 MAP kinase and JNK as potential upstream targets. Exp Mol Med 2005;37:186-192.
    • (2005) Exp Mol Med , vol.37 , pp. 186-192
    • Cho, J.W.1    Park, K.2    Kweon, G.R.3
  • 47
    • 34547601772 scopus 로고    scopus 로고
    • Transcriptional activation of MMP-13 by periodontal pathogenic LPS requires p38 MAP kinase
    • Rossa C Jr, Liu M, Bronson P, Kirkwood KL. Transcriptional activation of MMP-13 by periodontal pathogenic LPS requires p38 MAP kinase. J Endotoxin Res 2007;13:85-93.
    • (2007) J Endotoxin Res , vol.13 , pp. 85-93
    • Rossa Jr, C.1    Liu, M.2    Bronson, P.3    Kirkwood, K.L.4
  • 48
    • 70450167549 scopus 로고    scopus 로고
    • MAP kinase phosphatase-1 protects against inflammatory bone loss
    • Sartori R, Li F, Kirkwood KL. MAP kinase phosphatase-1 protects against inflammatory bone loss. J Dent Res 2009;88:1125-1130.
    • (2009) J Dent Res , vol.88 , pp. 1125-1130
    • Sartori, R.1    Li, F.2    Kirkwood, K.L.3
  • 49
    • 26644468372 scopus 로고    scopus 로고
    • MKK3/6-p38 MAPK negatively regulates murine MMP-13 gene expression induced by IL-1beta and TNF-alpha in immortalized periodontal ligament fibroblasts
    • Rossa C Jr., Liu M, Patil C, Kirkwood KL. MKK3/6-p38 MAPK negatively regulates murine MMP-13 gene expression induced by IL-1beta and TNF-alpha in immortalized periodontal ligament fibroblasts. Matrix Biol 2005;24:478-488.
    • (2005) Matrix Biol , vol.24 , pp. 478-488
    • Rossa Jr, C.1    Liu, M.2    Patil, C.3    Kirkwood, K.L.4
  • 50
    • 33750600353 scopus 로고    scopus 로고
    • MKK3/6-p38 MAPK signaling is required for IL-1beta and TNF-alpha-induced RANKL expression in bone marrow stromal cells
    • Rossa C, Ehmann K, Liu M, Patil C, Kirkwood KL. MKK3/6-p38 MAPK signaling is required for IL-1beta and TNF-alpha-induced RANKL expression in bone marrow stromal cells. J Interferon Cytokine Res 2006;26:719-729.
    • (2006) J Interferon Cytokine Res , vol.26 , pp. 719-729
    • Rossa, C.1    Ehmann, K.2    Liu, M.3    Patil, C.4    Kirkwood, K.L.5
  • 51
    • 2542469918 scopus 로고    scopus 로고
    • p38 MAPK regulates IL-1beta induced IL-6 expression through mRNA stability in osteoblasts
    • Patil C, Zhu X, Rossa C Jr., Kim YJ, Kirkwood KL. p38 MAPK regulates IL-1beta induced IL-6 expression through mRNA stability in osteoblasts. Immunol Invest 2004;33:213-233.
    • (2004) Immunol Invest , vol.33 , pp. 213-233
    • Patil, C.1    Zhu, X.2    Rossa Jr, C.3    Kim, Y.J.4    Kirkwood, K.L.5
  • 52
    • 33750328512 scopus 로고    scopus 로고
    • Actinobacillus actinomycetemcomitans lipopolysaccharide induces interleukin-6 expression through multiple mitogen-activated protein kinase pathways in periodontal ligament fibroblasts
    • Patil C, Rossa C Jr, Kirkwood KL. Actinobacillus actinomycetemcomitans lipopolysaccharide induces interleukin-6 expression through multiple mitogen-activated protein kinase pathways in periodontal ligament fibroblasts. Oral Microbiol Immunol 2006;21:392-398.
    • (2006) Oral Microbiol Immunol , vol.21 , pp. 392-398
    • Patil, C.1    Rossa Jr, C.2    Kirkwood, K.L.3
  • 53
    • 33646808648 scopus 로고    scopus 로고
    • Inhibition of p38 mitogen-activated protein kinase prevents inflammatory bone destruction
    • Mbalaviele G, Anderson G, Jones A et al. Inhibition of p38 mitogen-activated protein kinase prevents inflammatory bone destruction. J Pharmacol Exp Ther 2006;317:1044-1053.
    • (2006) J Pharmacol Exp Ther , vol.317 , pp. 1044-1053
    • Mbalaviele, G.1    Anderson, G.2    Jones, A.3
  • 54
    • 77649181941 scopus 로고    scopus 로고
    • Curcumin protects against hyperosmoticity-induced IL-1beta elevation in human corneal epithelial cell via MAPK pathways
    • Chen M, Hu DN, Pan Z, Lu CW, Xue CY, Aass I. Curcumin protects against hyperosmoticity-induced IL-1beta elevation in human corneal epithelial cell via MAPK pathways. Exp Eye Res 2010;90:437-443.
    • (2010) Exp Eye Res , vol.90 , pp. 437-443
    • Chen, M.1    Hu, D.N.2    Pan, Z.3    Lu, C.W.4    Xue, C.Y.5    Aass, I.6
  • 57
    • 77954844483 scopus 로고    scopus 로고
    • The temporal expression and localization of extracellular matrix metalloproteinase inducer (EMMPRIN) during the development of periodontitis in an animal model
    • Liu L, Li C, Cai X, Xiang J, Cao Z, Dong W. The temporal expression and localization of extracellular matrix metalloproteinase inducer (EMMPRIN) during the development of periodontitis in an animal model. J Periodontal Res 2010;45:541-549.
    • (2010) J Periodontal Res , vol.45 , pp. 541-549
    • Liu, L.1    Li, C.2    Cai, X.3    Xiang, J.4    Cao, Z.5    Dong, W.6
  • 58
    • 2442607612 scopus 로고    scopus 로고
    • Curcumin (diferuloylmethane) inhibits receptor activator of NF-kappa B ligand-induced NF-kappa B activation in osteoclast precursors and suppresses osteoclastogenesis
    • Bharti AC, Takada Y, Aggarwal BB. Curcumin (diferuloylmethane) inhibits receptor activator of NF-kappa B ligand-induced NF-kappa B activation in osteoclast precursors and suppresses osteoclastogenesis. J Immunol 2004;172:5940-5947.
    • (2004) J Immunol , vol.172 , pp. 5940-5947
    • Bharti, A.C.1    Takada, Y.2    Aggarwal, B.B.3
  • 59
    • 58049107780 scopus 로고    scopus 로고
    • Curcumin inhibits osteoclastogenesis by decreasing receptor activator of nuclear factor-kappaB ligand (RANKL) in bone marrow stromal cells
    • Oh S, Kyung TW, Choi HS. Curcumin inhibits osteoclastogenesis by decreasing receptor activator of nuclear factor-kappaB ligand (RANKL) in bone marrow stromal cells. Mol Cells 2008;26:486-489.
    • (2008) Mol Cells , vol.26 , pp. 486-489
    • Oh, S.1    Kyung, T.W.2    Choi, H.S.3
  • 60
    • 70349515164 scopus 로고    scopus 로고
    • Curcumin suppresses increased bone resorption by inhibiting osteoclastogenesis in rats with streptozotocin-induced diabetes
    • Hie M, Yamazaki M, Tsukamoto I. Curcumin suppresses increased bone resorption by inhibiting osteoclastogenesis in rats with streptozotocin-induced diabetes. Eur J Pharmacol 2009;621:1-9.
    • (2009) Eur J Pharmacol , vol.621 , pp. 1-9
    • Hie, M.1    Yamazaki, M.2    Tsukamoto, I.3
  • 61
    • 0028928877 scopus 로고
    • Curcumin, an anti-tumour promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages
    • Brouet I, Ohshima H. Curcumin, an anti-tumour promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages. Biochem Biophys Res Commun 1995;206:533-540.
    • (1995) Biochem Biophys Res Commun , vol.206 , pp. 533-540
    • Brouet, I.1    Ohshima, H.2
  • 62
    • 0036027805 scopus 로고    scopus 로고
    • The curcuma antioxidants: pharmacological effects and prospects for future clinical use. A review
    • Miquel J, Bernd A, Sempere JM, Diaz-Alperi J, Ramirez A. The curcuma antioxidants: pharmacological effects and prospects for future clinical use. A review. Arch Gerontol Geriatr 2002;34:37-46.
    • (2002) Arch Gerontol Geriatr , vol.34 , pp. 37-46
    • Miquel, J.1    Bernd, A.2    Sempere, J.M.3    Diaz-Alperi, J.4    Ramirez, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.