Identification and optimization of a new series of anti-tubercular quinazolinones

Bioorganic and Medicinal Chemistry Letters

Volumn 26, Issue 21, 2016, Pages 5290-5299

  Couturier, Cédric ^a   Lair, Christine ^a   Pellet, Alain ^a   Upton, Anna ^b   Kaneko, Takushi ^b   Perron, Corinne ^a   Cogo, Eric ^a   Menegotto, Jérome ^a   Bauer, Armin ^a   Scheiper, Bodo ^a   Lagrange, Sophie ^a   Bacqué, Eric ^a  

^a SANOFI   (France)

^b GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT   (United States)

Author keywords

Antitubercular drugs; High throughput screening; Lead optimization; Tuberculosis

Indexed keywords

ETHAMBUTOL; QUINAZOLINONE DERIVATIVE; RIFAMPICIN; TUBERCULOSTATIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC THERAPY; AREA UNDER THE CURVE; ARTICLE; BACTERIOSTASIS; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG EXCRETION; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG PENETRATION; DRUG POTENCY; DRUG PROTEIN BINDING; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOUSE; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; STRUCTURE ACTIVITY RELATION; TUBERCULOSIS; ANIMAL; CELL LINE; CHEMISTRY; DRUG EFFECTS; MICROBIAL SENSITIVITY TEST;

ANIMALS; ANTITUBERCULAR AGENTS; CELL LINE; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MICE; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; QUINAZOLINONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84992598434     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2016.09.043     Document Type: Article

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