Clinical variants of the native class D β-lactamase of Acinetobacter baumannii pose an emerging threat through increased hydrolytic activity against carbapenems

Antimicrobial Agents and Chemotherapy

Volumn 60, Issue 10, 2016, Pages 6155-6164

  Schroder, Emma C ^a   Klamer, Zachary L ^a   Saral, Aysegul ^b   Sugg, Kyle A ^a   June, Cynthia M ^a   Wymore, Troy ^c   Szarecka, Agnieszka ^a   Leonard, David A ^a  

^a GRAND VALLEY STATE UNIVERSITY   (United States)

^b ARTVIN CORUH UNIVERSITY   (Turkey)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; AZTREONAM; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE; CARBAPENEM; CARBAPENEM DERIVATIVE; CEFOTAXIME; CEFTAZIDIME; CEFTRIAXONE; CEPHALOSPORIN DERIVATIVE; DORIPENEM; ENZYME VARIANT; IMIPENEM; PENICILLIN DERIVATIVE; TRYPTOPHAN; BETA-LACTAMASE OXA-51, ACINETOBACTER BAUMANNII;

ACINETOBACTER BAUMANNII; AMINO ACID SUBSTITUTION; ARTICLE; DRUG EFFICACY; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME SPECIFICITY; HYDROLYSIS; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; SIMULATION; STEREOSPECIFICITY; ANTIBIOTIC RESISTANCE; CHEMISTRY; DRUG EFFECTS; GENETICS; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; PROTEIN CONFORMATION;

ACINETOBACTER BAUMANNII; AMINO ACID SUBSTITUTION; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; CARBAPENEMS; CATALYTIC DOMAIN; HUMANS; HYDROLYSIS; MOLECULAR DYNAMICS SIMULATION; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

EID: 84992584835     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01277-16     Document Type: Article

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