Hypnotic effects and GABAergic mechanism of licorice (Glycyrrhiza glabra) ethanol extract and its major flavonoid constituent glabrol

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 11, 2012, Pages 3493-3501

  Cho, Suengmok ^a,b   Park, Ji Hae ^c   Pae, Ae Nim ^d   Han, Daeseok ^a   Kim, Dongsoo ^a   Cho, Nam Chul ^d,e   No, Kyoung Tai ^e   Yang, Hyejin ^a   Yoon, Minseok ^a   Lee, Changho ^a   Shimizu, Makoto ^b   Baek, Nam In ^c  

^a Korea Food Research Institute   (South Korea)

^b UNIVERSITY OF TOKYO   (Japan)

^c Kyung Hee University   (South Korea)

^d Korea Institute of Science and Technology   (South Korea)

^e Yonsei University   (South Korea)

Author keywords

Flavonoid; GABA type A benzodiazepine receptor; Glabrol; Glycyrrhiza glabra; Hypnotic effect; Pharmacophore modeling

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALCOHOL; BENZODIAZEPINE RECEPTOR; DIAZEPAM; FLAVONOID; FLUMAZENIL; GLABROL; GLYCYRRHIZA GLABRA EXTRACT; LIQUIRITIGENIN; PENTOBARBITAL; UNCLASSIFIED DRUG; ZOLPIDEM;

ALLOSTERISM; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BRAIN MEMBRANE; CONTROLLED STUDY; DELTA RHYTHM; DOSE RESPONSE; DRUG MECHANISM; DRUG STRUCTURE; GABAERGIC SYSTEM; HYPNOTIC EFFECT; MALE; MOUSE; NONHUMAN; NONREM SLEEP; PHARMACOPHORE; RECEPTOR BINDING; SLEEP TIME;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; EYE MOVEMENTS; FLAVANONES; FLAVONOIDS; FLUMAZENIL; GABA-A RECEPTOR ANTAGONISTS; GLYCYRRHIZA; HYPNOTICS AND SEDATIVES; LIGANDS; MICE; MICE, INBRED C57BL; MOLECULAR STRUCTURE; PENTOBARBITAL; PLANT EXTRACTS; PLANT PREPARATIONS; RECEPTORS, GABA-A; SLEEP;

GLYCYRRHIZA; GLYCYRRHIZA GLABRA; MUS; RATTUS;

EID: 84861196041     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.04.011     Document Type: Article

References (43)

1. Ody, P. Dorling Kindersley: London, UK, 2000.
2. M.N. Asl, and H. Hosseinzadeh Phytother. Res. 22 2008 709
3. S. Shibata Yakugaku Zasshi 120 2000 849
4. F. Aoki, K. Nakagawa, M. Kitano, H. Ikematsu, K. Nakamura, S. Yokota, Y. Tominaga, N. Arai, and T. Mae J. Am. Coll. Nutr. 26 2007 209
5. R.A. Isbrucker, and G.A. Burdock Regul. Toxicol. Pharm. 46 2006 167
6. K. Nakagawa, M. Kitano, H. Kishida, T. Hidaka, K. Nabae, M. Kawabe, and K. Hosoe Food Chem. Toxicol. 46 2008 2349
7. T. Hatano, Y. Aga, Y. Shintani, H. Ito, T. Okuda, and T. Yoshida Phytochemistry 55 2000 959
8. D. Dhingra, and A. Sharma Prog. Neuropsychopharmacol. Biol. Psychiatry 30 2006 449
9. D. Dhingra, M. Parle, and S.K. Kulkarni J. Ethnopharmacol. 91 2004 361
10. Y.O. Fedotova, V.A. Krauz, and A.A. Papkovskaya Pharm. Chem. J. 39 2005 422
11. S.D. Ambawade, V.S. Kasture, and S.B. Kasture J. Nat. Remedies 2 2001 130
12. S.D. Ambawade, V.S. Kasture, and S.B. Kasture Ind. J. Pharmacol. 34 2002 251
13. P.L. Yi, C.P. Lin, C.H. Tsai, J.G. Lin, and F.C. Chang J. Biomed. Sci. 14 2007 829
14. M.H. Qiu, W.M. Qu, X.H. Xu, M.M. Yan, Y. Urade, and Z.L. Huang Pharmacol. Biochem. Behav. 94 2009 16
15. I. Tobler, C. Kopp, T. Deboer, and U. Rudolph Proc. Natl. Acad. Sci. U.S.A. 98 2001 6464
16. M. Masaki, K. Aritake, H. Tanaka, Y. Shoyama, Z.L. Huang, and Y. Urade Mol. Nutr. Food Res. 2011 10.1002/mnfr.201100181
17. C.H. Bastien, M. LeBlanc, J. Carrier, and C.M. Morin Sleep 26 2003 313
18. R. Winsky-Sommerer Eur. J. Neurosci. 29 2009 1779
19. H. van Lier, W.H. Drinkenburg, Y.J. van Eeten, and A.M. Coenen Neuropharmacology 47 2004 163
20. B. Ebert, K.A. Wafford, and S. Deacon Pharmacol. Ther. 112 2006 612
21. A.N. Bateson Sleep Med. 7 2006 3
22. A.J. Trevor, and W.L. Way Sedative-hypnotic Drugs B.G. Katzung, Basic and Clinical Pharmacology 2007 McGraw-Hill Medical New York, USA
23. M.K. Erman J. Clin. Psychiatry 66 2005 18
24. F.A. Stephenson Biochem. J. 310 1995 1
25. G.A.R. Johnston Curr. Pharm. Des. 2005 1867 11
26. C. Gottesmann Neuroscience 111 2002 231
27. E. Sigel, and A. Buhr Trends Pharmacol. Sci. 18 1997 425
28. J.D. Goutman, M.D. Waxemberg, F. Doñate-Oliver, P.E. Pomata, and D.J. Calvo Eur. J. Pharmacol. 461 2003 79
29. A.K. Jäger, and L. Saaby Molecules 16 2011 1471
30. Y. Cao, Y. Wang, C. Ji, and J. Ye J. Chromatogr., A. 1042 2004 203
31. D. Kavvadias, P. Sand, K.A. Youdim, M.Z. Qaiser, C. Rice-Evans, R. Baur, E. Sigel, W.D. Rausch, P. Riederer, and P. Schreier Br. J. Pharmacol. 71 2000 811
32. S. Cho, S. Kim, Z. Jin, H. Yang, D. Han, N.I. Baek, J. Jo, C.W. Cho, J.H. Park, M. Shimizu, and Y.H. Jin Biochem. Biophys. Res. Commun. 413 2011 637
33. A.K. Jäger, J.P. Almquist, S.A.K. Vangsoe, G.I. Stafford, A. Adsersen, and J. Van Staden S. Afr. J. Bot. 73 2007 518
34. Q. Wang, Y. Han, and H. Xue CNS Drug Rev. 5 1999 125
35. W. Zhang, K.F. Koehler, P. Zhang, and J.M. Cook Drug Des. Dis. 12 1995 193
36. J.H. Choi, J.N. Choi, S.Y. Lee, K. Kim, and Y.K. Kim Arch. Pharmacol. Res. 33 2010 237
37. J.H. Choi, M.C. Rho, S.W. Lee, O.E. Kwon, H.R. Park, J.Y. Kang, S.H. Lee, H.S. Lee, K.H. Bae, and Y.K. Kim J. Ethnopharmacol. 110 2007 563
38. M. Kuroda, Y. Mimaki, S. Honda, H. Tanaka, S. Yokota, and T. Mae Bioorg. Med. Chem. 18 2010 962
39. M.I. Moreno, M.I. Isla, A.R. Sampietro, and M.A. Vattuone J. Ethnopharmacol. 71 2000 109
40. W.L. Lo, F.R. Chang, T.J. Hsieh, and W.C. Wu J. Chin. Chem. Soc. 49 2002 421
41. J. Risa, A. Risa, A. Adsersen, B. Gauguin, G.I. Stafford, J. van Staden, and A.K. Jäger J. Ethnopharmacol. 93 2004 177
42. P. Kahnberg, E. Lager, C. Rosenberg, J. Schougaard, L. Camet, O. Sterner, N.E. Ostergaard, M. Nielsen, and T. Liljefors J. Med. Chem. 45 2002 4188
43. S. Kohtoh, Y. Taguchi, N. Matsumoto, and M. Wada Sleep Biol. Rhythms. 6 2008 163