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Volumn 29, Issue 6, 2016, Pages 783-789

Metformin associated lactic acidosis (MALA): clinical profiling and management

Author keywords

Acute renal failure; Bicarbonate; Hemodialysis; Lactic acidosis; Metformin; Type 2 diabetes

Indexed keywords

ALKALI; ANTIDIABETIC AGENT; BICARBONATE; LACTIC ACID; METFORMIN;

EID: 84992446867     PISSN: 11218428     EISSN: 17246059     Source Type: Journal    
DOI: 10.1007/s40620-016-0267-8     Document Type: Article
Times cited : (42)

References (52)
  • 1
    • 84861675892 scopus 로고    scopus 로고
    • Diabetes management issues for patients with chronic kidney disease
    • PID: 22015216, (Epub 2011 Oct 20)
    • Oulahiane A, Anaddam S, Ouleghzal H et al (2012) Diabetes management issues for patients with chronic kidney disease. Nephrol Ther 8:135–140. doi:10.1016/j.nephro.2011.07.410 (Epub 2011 Oct 20)
    • (2012) Nephrol Ther , vol.8 , pp. 135-140
    • Oulahiane, A.1    Anaddam, S.2    Ouleghzal, H.3
  • 2
    • 48749096999 scopus 로고    scopus 로고
    • Type 2 diabetes: the management of type 2 diabetes
    • NICE (2009) Type 2 diabetes: the management of type 2 diabetes. NICE guideline CG87. http://www.nice.org.uk/guidance/cg87/chapter/guidance
    • (2009) NICE guideline CG87
  • 3
    • 84866268783 scopus 로고    scopus 로고
    • Management of hyperglycemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
    • COI: 1:CAS:528:DC%2BC38Xps1Kitb4%3D, PID: 22517736, (Epub 2012 Apr 19)
    • Inzucchi SE, Bergenstal RM, Buse JB et al (2012) Management of hyperglycemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care 35:1364–1379. doi:10.2337/dc12-0413 (Epub 2012 Apr 19)
    • (2012) Diabetes Care , vol.35 , pp. 1364-1379
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3
  • 4
    • 80051978747 scopus 로고    scopus 로고
    • Use of metformin in the setting of mild-to-moderate renal insufficiency
    • COI: 1:CAS:528:DC%2BC3MXos1Kmt70%3D, PID: 21617112
    • Lipska KJ, Bailey CJ, Inzucchi SE (2011) Use of metformin in the setting of mild-to-moderate renal insufficiency. Diabetes Care 34:1431–1437. doi:10.2337/dc10-2361
    • (2011) Diabetes Care , vol.34 , pp. 1431-1437
    • Lipska, K.J.1    Bailey, C.J.2    Inzucchi, S.E.3
  • 5
    • 33745780301 scopus 로고    scopus 로고
    • Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. A Consensus Statement from the American Diabetes Association and the European Association for the Study of Diabetes
    • COI: 1:STN:280:DC%2BD28vgslygtw%3D%3D, PID: 16802130
    • Nathan DM, Buse JB, Davidson MB (2006) Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. A Consensus Statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 49:1711–1721
    • (2006) Diabetologia , vol.49 , pp. 1711-1721
    • Nathan, D.M.1    Buse, J.B.2    Davidson, M.B.3
  • 6
    • 84892649479 scopus 로고    scopus 로고
    • Diabetes Care 37 Suppl 1:S14–S80
    • (2014) Standards of medical care in diabetes. Diabetes Care 37 Suppl 1:S14–S80. doi:10.2337/dc14-S014
    • (2014) Standards of medical care in diabetes.
  • 7
    • 84855603512 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of metformin: an overview
    • COI: 1:CAS:528:DC%2BC3MXhsFaitLfP
    • Viollet B, Guigas B, Sanz Garcia N et al (2012) Cellular and molecular mechanisms of metformin: an overview. Clin Sci (Lond) 122:253–270. doi:10.1042/CS20110386
    • (2012) Clin Sci (Lond) , vol.122 , pp. 253-270
    • Viollet, B.1    Guigas, B.2    Sanz Garcia, N.3
  • 8
    • 0030605388 scopus 로고    scopus 로고
    • Metformin
    • COI: 1:CAS:528:DyaK28XhvVCjs74%3D, PID: 8569826
    • Bailey CJ, Turner RC (1996) Metformin. N Engl J Med 334:574–579
    • (1996) N Engl J Med , vol.334 , pp. 574-579
    • Bailey, C.J.1    Turner, R.C.2
  • 9
    • 84886992019 scopus 로고    scopus 로고
    • Population pharmacokinetics of metformin in healthy subjects and patients with type 2 diabetes mellitus: simulation of doses according to renal function
    • COI: 1:CAS:528:DC%2BC3sXhvVSnu7rL, PID: 23475568
    • Duong JK, Kumar SS, Kirkpatrick CM et al (2013) Population pharmacokinetics of metformin in healthy subjects and patients with type 2 diabetes mellitus: simulation of doses according to renal function. Clin Pharmacokinet 52:373–384. doi:10.1007/s40262-013-0046-9
    • (2013) Clin Pharmacokinet , vol.52 , pp. 373-384
    • Duong, J.K.1    Kumar, S.S.2    Kirkpatrick, C.M.3
  • 10
    • 84893467321 scopus 로고    scopus 로고
    • Metformin accumulation: lactic acidosis and high plasmatic metformin levels in a retrospective case series of 66 patients on chronic therapy
    • COI: 1:CAS:528:DC%2BC2cXitVOqtbc%3D, (Epub 2013 Nov 28)
    • Vecchio S, Giampreti A, Petrolini VM et al (2014) Metformin accumulation: lactic acidosis and high plasmatic metformin levels in a retrospective case series of 66 patients on chronic therapy. Clin Toxicol (Phila) 52:129–135. doi:10.3109/15563650.2013.860985 (Epub 2013 Nov 28)
    • (2014) Clin Toxicol (Phila) , vol.52 , pp. 129-135
    • Vecchio, S.1    Giampreti, A.2    Petrolini, V.M.3
  • 11
    • 84920450301 scopus 로고    scopus 로고
    • Mortality rate in so-called “metformin-associated lactic acidosis”: a review of the data since the 1960s
    • COI: 1:CAS:528:DC%2BC2cXhvFShsr7F, PID: 25079826, (Epub 2014 Jul 31)
    • Kajbaf F, Lalau JD (2014) Mortality rate in so-called “metformin-associated lactic acidosis”: a review of the data since the 1960s. Pharmacoepidemiol Drug Saf 23:1123–1127. doi:10.1002/pds.3689 (Epub 2014 Jul 31)
    • (2014) Pharmacoepidemiol Drug Saf , vol.23 , pp. 1123-1127
    • Kajbaf, F.1    Lalau, J.D.2
  • 12
    • 84925622469 scopus 로고    scopus 로고
    • Metformin-associated lactic acidosis
    • Pasquel FJ, Klein R, Adigweme A (2015) Metformin-associated lactic acidosis. Am J Me Sci 349:263–267. doi:10.1097/MAJ.0b013e3182a562b7
    • (2015) Am J Me Sci , vol.349 , pp. 263-267
    • Pasquel, F.J.1    Klein, R.2    Adigweme, A.3
  • 13
    • 77950868733 scopus 로고    scopus 로고
    • Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus
    • Salpeter SR, Greyber E, Pasternak GA et al (2010) Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. Cochrane Database Syst Rev. doi:10.1002/14651858.CD002967.pub3
    • (2010) Cochrane Database Syst Rev
    • Salpeter, S.R.1    Greyber, E.2    Pasternak, G.A.3
  • 14
    • 34548791255 scopus 로고    scopus 로고
    • Establishing pragmatic estimated GFR thresholds to guide metformin prescribing
    • COI: 1:STN:280:DC%2BD2srmslSksQ%3D%3D, PID: 17672860
    • Shaw JS, Wilmot RL, Kilpatrick ES (2007) Establishing pragmatic estimated GFR thresholds to guide metformin prescribing. Diabet Med 24:1160–1163
    • (2007) Diabet Med , vol.24 , pp. 1160-1163
    • Shaw, J.S.1    Wilmot, R.L.2    Kilpatrick, E.S.3
  • 15
    • 84919615360 scopus 로고    scopus 로고
    • Metformin: from mechanisms of action to therapies
    • COI: 1:CAS:528:DC%2BC2cXhvVGks7fM, PID: 25456737, (Epub 2014 Oct 30)
    • Foretz M, Guigas B, Bertrand L et al (2014) Metformin: from mechanisms of action to therapies. Cell Metab 20:953–966. doi:10.1016/j.cmet.2014.09.018 (Epub 2014 Oct 30)
    • (2014) Cell Metab , vol.20 , pp. 953-966
    • Foretz, M.1    Guigas, B.2    Bertrand, L.3
  • 16
    • 84931836592 scopus 로고    scopus 로고
    • Molecular action of metformin in hepatocytes: an updated insight
    • COI: 1:CAS:528:DC%2BC2MXhtFWlsb7M, PID: 25808533
    • Sliwinska A, Drzewoski J (2015) Molecular action of metformin in hepatocytes: an updated insight. Curr Diabetes Rev 11:175–181
    • (2015) Curr Diabetes Rev , vol.11 , pp. 175-181
    • Sliwinska, A.1    Drzewoski, J.2
  • 17
    • 84905757105 scopus 로고    scopus 로고
    • Metformin—mode of action and clinicla implications for diabetes and cancer
    • COI: 1:CAS:528:DC%2BC2cXmtVSitA%3D%3D, PID: 24393785, (Epub 2014 Jan 7)
    • Pernicova I, Korbonits M (2014) Metformin—mode of action and clinicla implications for diabetes and cancer. Nat Rev Endocrinol 10:143–156. doi:10.1038/nrendo.2013.256 (Epub 2014 Jan 7)
    • (2014) Nat Rev Endocrinol , vol.10 , pp. 143-156
    • Pernicova, I.1    Korbonits, M.2
  • 18
    • 0031007415 scopus 로고    scopus 로고
    • Contraindications to metformin therapy in patients with NIDDM
    • COI: 1:STN:280:DyaK2szgvFKrtA%3D%3D, PID: 9167101
    • Sulkin TV, Bosman D, Krentz AJ (1997) Contraindications to metformin therapy in patients with NIDDM. Diabetes Care 20:925–928
    • (1997) Diabetes Care , vol.20 , pp. 925-928
    • Sulkin, T.V.1    Bosman, D.2    Krentz, A.J.3
  • 19
    • 84920025605 scopus 로고    scopus 로고
    • Metformin in patients with type 2 diabetes and kidney disease: a systematic review
    • PID: 25536258
    • Inzucchi SE, Lipska KJ, Mayo H et al (2014) Metformin in patients with type 2 diabetes and kidney disease: a systematic review. JAMA 312:2668–2675. doi:10.1001/jama.2014.15298
    • (2014) JAMA , vol.312 , pp. 2668-2675
    • Inzucchi, S.E.1    Lipska, K.J.2    Mayo, H.3
  • 20
    • 84938208500 scopus 로고    scopus 로고
    • Metformin use and mortality in patients with advanced chronic kidney disease: national, retrospective, observational, cohort study
    • COI: 1:CAS:528:DC%2BC2MXhvVSksrfM, PID: 26094107, (Epub 2015 Jun 17)
    • Hung SC, Chang YK, Liu JS et al (2015) Metformin use and mortality in patients with advanced chronic kidney disease: national, retrospective, observational, cohort study. Lancet Diabetes Endocrinol 3:605–614. doi:10.1016/S2213-8587(15)00123-0 (Epub 2015 Jun 17)
    • (2015) Lancet Diabetes Endocrinol , vol.3 , pp. 605-614
    • Hung, S.C.1    Chang, Y.K.2    Liu, J.S.3
  • 21
    • 84951907344 scopus 로고    scopus 로고
    • Does lactate account for all of the increase in anion gap in cases of metformin-induced lactic acidosis?
    • PID: 25982073, (Epub 2015 May 16)
    • Makehei S, Sam R (2015) Does lactate account for all of the increase in anion gap in cases of metformin-induced lactic acidosis? Clin Exp Nephrol 19:1210–1211. doi:10.1007/s10157-015-1124-0 (Epub 2015 May 16)
    • (2015) Clin Exp Nephrol , vol.19 , pp. 1210-1211
    • Makehei, S.1    Sam, R.2
  • 22
    • 84955479349 scopus 로고    scopus 로고
    • Metformin-associated lactic acidosis
    • Suh S (2015) Metformin-associated lactic acidosis. Endocrinol Metab (Seoul) 30:45–46. doi:10.3803/EnM.2015.30.1.45
    • (2015) Endocrinol Metab (Seoul) , vol.30 , pp. 45-46
    • Suh, S.1
  • 23
    • 84906093541 scopus 로고    scopus 로고
    • A justification for less restrictive guidelines on the use of metformin in stable chronic renal failure
    • COI: 1:CAS:528:DC%2BC2cXhsVSrurrL, PID: 24909998
    • Adam WR, O’Brien RC (2014) A justification for less restrictive guidelines on the use of metformin in stable chronic renal failure. Diabet Med 31:1032–1038. doi:10.1111/dme.12515
    • (2014) Diabet Med , vol.31 , pp. 1032-1038
    • Adam, W.R.1    O’Brien, R.C.2
  • 24
    • 84904999202 scopus 로고    scopus 로고
    • Risk of lactic acidosis or elevated lactate concentrations in metformin users with renal impairment: a population-based cohort study
    • COI: 1:CAS:528:DC%2BC2cXhsFertrfJ, PID: 24842984, (Epub 2014 May 19)
    • Eppenga WL, Lalmohamed A, Geerts AF et al (2014) Risk of lactic acidosis or elevated lactate concentrations in metformin users with renal impairment: a population-based cohort study. Diabetes Care 37:2218–2224. doi:10.2337/dc13-3023 (Epub 2014 May 19)
    • (2014) Diabetes Care , vol.37 , pp. 2218-2224
    • Eppenga, W.L.1    Lalmohamed, A.2    Geerts, A.F.3
  • 25
    • 84925883671 scopus 로고    scopus 로고
    • Metformin in chronic kidney disease: time for a rethink
    • PID: 24711640, (Epub 2014 Apr 7)
    • Heaf J (2014) Metformin in chronic kidney disease: time for a rethink. Perit Dial Int 34:353–357. doi:10.3747/pdi.2013.00344 (Epub 2014 Apr 7)
    • (2014) Perit Dial Int , vol.34 , pp. 353-357
    • Heaf, J.1
  • 26
    • 84922253642 scopus 로고    scopus 로고
    • Metformin and other antidiabetic agents in renal failure patients
    • COI: 1:CAS:528:DC%2BC2cXjsFGks7w%3D, PID: 24599253, (Epub 2014 Mar 5)
    • Lalau JD, Arnouts P, Sharif A (2015) Metformin and other antidiabetic agents in renal failure patients. Kidney Int 87:308–322. doi:10.1038/ki.2014.19 (Epub 2014 Mar 5)
    • (2015) Kidney Int , vol.87 , pp. 308-322
    • Lalau, J.D.1    Arnouts, P.2    Sharif, A.3
  • 27
    • 84896837578 scopus 로고    scopus 로고
    • Metformin usage in type 2 diabetes mellitus: Are safety guidelines adhered to?
    • COI: 1:CAS:528:DC%2BC2cXktlKrtL0%3D, PID: 24405767
    • Huang W, Castelino RL, Peterson GM (2014) Metformin usage in type 2 diabetes mellitus: Are safety guidelines adhered to? Intern Med J 44:266–272. doi:10.1111/imj.12369
    • (2014) Intern Med J , vol.44 , pp. 266-272
    • Huang, W.1    Castelino, R.L.2    Peterson, G.M.3
  • 28
    • 84889038435 scopus 로고    scopus 로고
    • Unleash metformin: reconsideration of the contraindication in patients with renal impairment
    • PID: 24259604, (Epub 2013 Oct 10)
    • Lu WR, Defilippi J, Braun A (2013) Unleash metformin: reconsideration of the contraindication in patients with renal impairment. Ann Pharmacother 47:1488–1497. doi:10.1177/1060028013505428 (Epub 2013 Oct 10)
    • (2013) Ann Pharmacother , vol.47 , pp. 1488-1497
    • Lu, W.R.1    Defilippi, J.2    Braun, A.3
  • 29
    • 0028856712 scopus 로고
    • Kidney function and age are both predictors of pharmacokinetics of metformin
    • COI: 1:CAS:528:DyaK28XkslWguw%3D%3D, PID: 8626883
    • Sambol NC, Chiang J, Lin ET, Goodman AM et al (1995) Kidney function and age are both predictors of pharmacokinetics of metformin. J Clin Pharmacol 35:1094–1102
    • (1995) J Clin Pharmacol , vol.35 , pp. 1094-1102
    • Sambol, N.C.1    Chiang, J.2    Lin, E.T.3    Goodman, A.M.4
  • 30
    • 0034901899 scopus 로고    scopus 로고
    • Contraindications to metformin therapy in patients with type 2 diabetes—a population-based study of adherence to prescribing guidelines
    • COI: 1:CAS:528:DC%2BD3MXmsFOgsL4%3D, PID: 11472468
    • Emslie-Smith AM, Boyle DIR, Evans JMM et al (2001) Contraindications to metformin therapy in patients with type 2 diabetes—a population-based study of adherence to prescribing guidelines. Diabet Med 18:483–488
    • (2001) Diabet Med , vol.18 , pp. 483-488
    • Emslie-Smith, A.M.1    Boyle, D.I.R.2    Evans, J.M.M.3
  • 31
    • 84929845274 scopus 로고    scopus 로고
    • Metformin should not be contraindicated in patients with type 2 diabetes and mild to moderate renal impairment
    • PID: 25827139, (Epub 2015 Mar 31)
    • Scheen AJ (2015) Metformin should not be contraindicated in patients with type 2 diabetes and mild to moderate renal impairment. Evid Based Med 20:115. doi:10.1136/ebmed-2015-110184 (Epub 2015 Mar 31)
    • (2015) Evid Based Med , vol.20 , pp. 115
    • Scheen, A.J.1
  • 32
    • 84942295218 scopus 로고    scopus 로고
    • Metformin-associated lactic acidosis: predisposing factors and outcome
    • (Epub 2014 Jul 18)
    • Kim MJ, Han JY, Shin JY et al (2015) Metformin-associated lactic acidosis: predisposing factors and outcome. Endocrinol Metab (Seoul) 30:78–83. doi:10.3803/EnM.2015.30.1.78 (Epub 2014 Jul 18)
    • (2015) Endocrinol Metab (Seoul) , vol.30 , pp. 78-83
    • Kim, M.J.1    Han, J.Y.2    Shin, J.Y.3
  • 33
    • 0029044687 scopus 로고
    • Role of metformin accumulation in metformin-associated lactic acidosis
    • COI: 1:STN:280:DyaK28%2Fgt1KrtA%3D%3D, PID: 7555503
    • Lalau JD, Lacroix C, Compagnon P et al (1995) Role of metformin accumulation in metformin-associated lactic acidosis. Diabetes Care 18:779–784
    • (1995) Diabetes Care , vol.18 , pp. 779-784
    • Lalau, J.D.1    Lacroix, C.2    Compagnon, P.3
  • 34
    • 84955749139 scopus 로고    scopus 로고
    • Unexpectedly long half-life of metformin elimination in cases of metformin accumulation
    • PID: 26337524, (Epub ahead of print)
    • Kajbaf F, Bennis Y, Hurtel-Lemaire AS, Andréjak M, Lalau JD (2015) Unexpectedly long half-life of metformin elimination in cases of metformin accumulation. Diabet Med. doi:10.1111/dme.12959 (Epub ahead of print)
    • (2015) Diabet Med
    • Kajbaf, F.1    Bennis, Y.2    Hurtel-Lemaire, A.S.3    Andréjak, M.4    Lalau, J.D.5
  • 35
    • 84893437463 scopus 로고    scopus 로고
    • The enigma of metformin-associated lactic acidosis
    • COI: 1:STN:280:DC%2BC2cvht1egsw%3D%3D
    • Juurlink DN, Roberts DM (2014) The enigma of metformin-associated lactic acidosis. Clin Toxicol (Phila) 52:85–87. doi:10.3109/15563650.2014.880174
    • (2014) Clin Toxicol (Phila) , vol.52 , pp. 85-87
    • Juurlink, D.N.1    Roberts, D.M.2
  • 36
    • 46849098978 scopus 로고    scopus 로고
    • Metformin-associated lactic acidosis in type 2 diabetes mellitus: incidence and presentation in common clinical practice
    • COI: 1:CAS:528:DC%2BD1cXnvFShurk%3D, PID: 18388117, (Epub 2008 Apr 3)
    • Almirall J, Briculle M et al (2008) Metformin-associated lactic acidosis in type 2 diabetes mellitus: incidence and presentation in common clinical practice. Nephrol Dial Transplant 23:2436–2438. doi:10.1093/ndt/gfn152 (Epub 2008 Apr 3)
    • (2008) Nephrol Dial Transplant , vol.23 , pp. 2436-2438
    • Almirall, J.1    Briculle, M.2
  • 37
    • 84964285862 scopus 로고    scopus 로고
    • Hyperlactataemia and clinical severity of acute metformin overdose
    • COI: 1:CAS:528:DC%2BC2MXlsFaktrc%3D, PID: 25659252
    • McNamara K, Isbister GK (2015) Hyperlactataemia and clinical severity of acute metformin overdose. Intern Med J 45:402–408. doi:10.1111/imj.12713
    • (2015) Intern Med J , vol.45 , pp. 402-408
    • McNamara, K.1    Isbister, G.K.2
  • 38
    • 84905020679 scopus 로고    scopus 로고
    • Incidence of lactic acidosis in patients with type 2 diabetes with and without renal impairment treated with metformin: a retrospective cohort study
    • COI: 1:CAS:528:DC%2BC2cXhsFertrfF, PID: 24879835, (Epub 2014 May 30)
    • Richy FF, Sabidó-Espin M, Guedes S, Corvino FA, Gottwald-Hostalek U (2014) Incidence of lactic acidosis in patients with type 2 diabetes with and without renal impairment treated with metformin: a retrospective cohort study. Diabetes Care 37:2291–2295. doi:10.2337/dc14-0464 (Epub 2014 May 30)
    • (2014) Diabetes Care , vol.37 , pp. 2291-2295
    • Richy, F.F.1    Sabidó-Espin, M.2    Guedes, S.3    Corvino, F.A.4    Gottwald-Hostalek, U.5
  • 39
    • 84955750791 scopus 로고    scopus 로고
    • Interpreting the consequences of metformin accumulation in an emergency context: impact of the time frame on the blood metformin levels
    • PID: 25587274, (Epub 2014 Dec 17)
    • Lalau JD, Kajbaf F (2014) Interpreting the consequences of metformin accumulation in an emergency context: impact of the time frame on the blood metformin levels. Int J Endocrinol 2014:717198. doi:10.1155/2014/717198 (Epub 2014 Dec 17)
    • (2014) Int J Endocrinol , vol.2014 , pp. 717198
    • Lalau, J.D.1    Kajbaf, F.2
  • 40
    • 0344420380 scopus 로고    scopus 로고
    • Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus: systematic review and meta-analysis
    • PID: 14638559
    • Salpeter SR, Greyber E, Pasternak GA, Salpeter EE (2003) Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus: systematic review and meta-analysis. Arch Intern Med 163:2594–2602
    • (2003) Arch Intern Med , vol.163 , pp. 2594-2602
    • Salpeter, S.R.1    Greyber, E.2    Pasternak, G.A.3    Salpeter, E.E.4
  • 41
    • 84884946402 scopus 로고    scopus 로고
    • Metformin therapy and kidney disease: a review of guidelines and proposals for metformin withdrawal around the world
    • COI: 1:CAS:528:DC%2BC3sXhsF2gs7bM, PID: 23960029, (Epub 2013 Aug 19)
    • Kajbaf F, Arnouts P, de Broe M (2013) Metformin therapy and kidney disease: a review of guidelines and proposals for metformin withdrawal around the world. Pharmacoepidemiol Drug Saf 22:1027–1035. doi:10.1002/pds.3501 (Epub 2013 Aug 19)
    • (2013) Pharmacoepidemiol Drug Saf , vol.22 , pp. 1027-1035
    • Kajbaf, F.1    Arnouts, P.2    de Broe, M.3
  • 42
    • 84878753448 scopus 로고    scopus 로고
    • Metformin revisited: a critical review of the benefit-risk balance in at-risk patients with type 2 diabetes
    • COI: 1:CAS:528:DC%2BC3sXksFeqsbo%3D, PID: 23528671, (Epub 2013 Mar 23)
    • Scheen AJ, Paquot N (2013) Metformin revisited: a critical review of the benefit-risk balance in at-risk patients with type 2 diabetes. Diabetes Metab 39:179–190. doi:10.1016/j.diabet.2013.02.006 (Epub 2013 Mar 23)
    • (2013) Diabetes Metab , vol.39 , pp. 179-190
    • Scheen, A.J.1    Paquot, N.2
  • 43
    • 84936972128 scopus 로고    scopus 로고
    • Use of metformin in chronic kidney disease should continue to be based on common sense in the absence of an evidence base
    • COI: 1:STN:280:DC%2BC2MrhvFKgsA%3D%3D, PID: 25645049
    • Petrie MC, Boyle JG, McKay GA (2015) Use of metformin in chronic kidney disease should continue to be based on common sense in the absence of an evidence base. Diabet Med 32:981–982. doi:10.1111/dme.12709
    • (2015) Diabet Med , vol.32 , pp. 981-982
    • Petrie, M.C.1    Boyle, J.G.2    McKay, G.A.3
  • 44
    • 84948716194 scopus 로고    scopus 로고
    • Metformin-associated lactic acidosis: time to let it go?
    • PID: 26297215, (Epub ahead of print)
    • Mathieu C (2015) Metformin-associated lactic acidosis: time to let it go? J Diabetes Complications. doi:10.1016/j.jdiacomp.2015.07.022 (Epub ahead of print)
    • (2015) J Diabetes Complications
    • Mathieu, C.1
  • 45
    • 84937966491 scopus 로고    scopus 로고
    • Metformin use in type 2 diabetes mellitus with CKD: Is it time to liberalize dosing recommendations?
    • COI: 1:CAS:528:DC%2BC2MXotVWgsLY%3D, PID: 25960301, (Epub 2015 May 8)
    • Stanton RC (2015) Metformin use in type 2 diabetes mellitus with CKD: Is it time to liberalize dosing recommendations? Am J Kidney Dis 66:193–195. doi:10.1053/j.ajkd.2015.04.001 (Epub 2015 May 8)
    • (2015) Am J Kidney Dis , vol.66 , pp. 193-195
    • Stanton, R.C.1
  • 46
    • 84880630562 scopus 로고    scopus 로고
    • The prognostic value of blood pH and lactate and metformin concentrations in severe metformin-associated lactic acidosis
    • COI: 1:CAS:528:DC%2BC3sXotVKgs74%3D, PID: 23587368
    • Kajbaf F, Lalau JD (2013) The prognostic value of blood pH and lactate and metformin concentrations in severe metformin-associated lactic acidosis. BMC Pharmacol Toxicol 14:22. doi:10.1186/2050-6511-14-22
    • (2013) BMC Pharmacol Toxicol , vol.14 , pp. 22
    • Kajbaf, F.1    Lalau, J.D.2
  • 47
    • 84918545715 scopus 로고    scopus 로고
    • Lactic acidosis
    • PID: 25494270
    • Kraut JA, Madias NE (2014) Lactic acidosis. N Engl J Med 371:2309–2319. doi:10.1056/NEJMra1309483
    • (2014) N Engl J Med , vol.371 , pp. 2309-2319
    • Kraut, J.A.1    Madias, N.E.2
  • 48
    • 84939148989 scopus 로고    scopus 로고
    • The use of sodium bicarbonate in the treatment of acidosis in sepsis: a literature update on a long term debate
    • PID: 26294968, (Epub 2015 Jul 30)
    • Velissaris D, Karamouzos V, Ktenopoulos N et al (2015) The use of sodium bicarbonate in the treatment of acidosis in sepsis: a literature update on a long term debate. Crit Care Res Pract 2015:605830. doi:10.1155/2015/605830 (Epub 2015 Jul 30)
    • (2015) Crit Care Res Pract , vol.2015 , pp. 605830
    • Velissaris, D.1    Karamouzos, V.2    Ktenopoulos, N.3
  • 49
    • 84903149605 scopus 로고    scopus 로고
    • Comprehensive review on lactate metabolism in human health
    • COI: 1:CAS:528:DC%2BC2cXht1Kqtb7K, PID: 24929216, (Epub 2014 Jun 12)
    • Adeva-Andany M, López-Ojén M, Funcasta-Calderón R et al (2014) Comprehensive review on lactate metabolism in human health. Mitochondrion 17:76–100. doi:10.1016/j.mito.2014.05.007 (Epub 2014 Jun 12)
    • (2014) Mitochondrion , vol.17 , pp. 76-100
    • Adeva-Andany, M.1    López-Ojén, M.2    Funcasta-Calderón, R.3
  • 50
    • 84942524266 scopus 로고    scopus 로고
    • Extracorporeal treatment for metformin poisoning: systematic review and recommendations from the Extracorporeal Treatments in Poisoning Workgroup
    • PID: 25860205
    • Calello DP, Liu KD, Wiegand TJ et al (2015) Extracorporeal treatment for metformin poisoning: systematic review and recommendations from the Extracorporeal Treatments in Poisoning Workgroup. Crit Care Med 43:1716–1730. doi:10.1097/CCM.0000000000001002
    • (2015) Crit Care Med , vol.43 , pp. 1716-1730
    • Calello, D.P.1    Liu, K.D.2    Wiegand, T.J.3
  • 51
    • 84901036356 scopus 로고    scopus 로고
    • Impact of preexisting chronic kidney disease on acute and long-term outcome of critically ill patients on a medical intensive care unit
    • COI: 1:CAS:528:DC%2BC28Xhs1yktb0%3D, PID: 24519865, (Epub 2013 Dec 7)
    • Lebiedz P, Knickel L, Engelbertz C et al (2014) Impact of preexisting chronic kidney disease on acute and long-term outcome of critically ill patients on a medical intensive care unit. J Nephrol 27(1):73–80. doi:10.1007/s40620-013-0016-1 (Epub 2013 Dec 7)
    • (2014) J Nephrol , vol.27 , Issue.1 , pp. 73-80
    • Lebiedz, P.1    Knickel, L.2    Engelbertz, C.3
  • 52
    • 84944156051 scopus 로고    scopus 로고
    • The impact of fluid balance on diagnosis, staging and prediction of mortality in critically ill patients with acute kidney injury
    • Thongprayoon C, Cheungpasitporn W, Srivali N et al (2015) The impact of fluid balance on diagnosis, staging and prediction of mortality in critically ill patients with acute kidney injury. J Nephrol (Epub ahead of print) PMID: 26012379
    • (2015) J Nephrol (Epub ahead of print) PMID
    • Thongprayoon, C.1    Cheungpasitporn, W.2    Srivali, N.3


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