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Volumn 349, Issue 3, 2015, Pages 263-267

Metformin-associated lactic acidosis

Author keywords

Acidosis; Diabetes; Inpatient diabetes; Lactate; Metformin

Indexed keywords

ACTIVATED CARBON; DIURETIC AGENT; ISOPHANE INSULIN; LISINOPRIL; METFORMIN; PIG INSULIN; ANTIDIABETIC AGENT;

EID: 84925622469     PISSN: 00029629     EISSN: 15382990     Source Type: Journal    
DOI: 10.1097/MAJ.0b013e3182a562b7     Document Type: Article
Times cited : (35)

References (53)
  • 1
    • 84862289404 scopus 로고    scopus 로고
    • Choosing a blood-glucose-lowering agent after metformin
    • Diamant M. Choosing a blood-glucose-lowering agent after metformin. Lancet 2012;379:2220-1
    • (2012) Lancet , vol.379 , pp. 2220-2221
    • Diamant, M.1
  • 2
    • 0034773404 scopus 로고    scopus 로고
    • Role of AMP-activated protein kinase in mechanism of metformin action
    • Zhou G, Myers R, Li Y, et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 2001;108:1167-74
    • (2001) J Clin Invest , vol.108 , pp. 1167-1174
    • Zhou, G.1    Myers, R.2    Li, Y.3
  • 3
    • 78649957959 scopus 로고    scopus 로고
    • Management of type 2 diabetes: Evolving strategies for the treatment of patients with type 2 diabetes
    • Nyenwe EA, Jerkins TW, Umpierrez GE, et al. Management of type 2 diabetes: evolving strategies for the treatment of patients with type 2 diabetes. Metabolism 2011;60:1-23
    • (2011) Metabolism , vol.60 , pp. 1-23
    • Nyenwe, E.A.1    Jerkins, T.W.2    Umpierrez, G.E.3
  • 4
    • 78951476273 scopus 로고    scopus 로고
    • Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-alpha in mice
    • Maida A, Lamont BJ, Cao X, et al. Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-alpha in mice. Diabetologia 2011;54:339-49
    • (2011) Diabetologia , vol.54 , pp. 339-349
    • Maida, A.1    Lamont, B.J.2    Cao, X.3
  • 5
    • 78951479936 scopus 로고    scopus 로고
    • New aspects of an old drug: Metformin as a glucagon-like peptide 1 (GLP-1) enhancer and sensitiser
    • Cho YM, Kieffer TJ. New aspects of an old drug: metformin as a glucagon-like peptide 1 (GLP-1) enhancer and sensitiser. Diabetologia 2011;54:219-22
    • (2011) Diabetologia , vol.54 , pp. 219-222
    • Cho, Y.M.1    Kieffer, T.J.2
  • 7
    • 80051978747 scopus 로고    scopus 로고
    • Use of metformin in the setting of mild-to-moderate renal insufficiency
    • Lipska KJ, Bailey CJ, Inzucchi SE. Use of metformin in the setting of mild-to-moderate renal insufficiency. Diabetes Care 2011;34:1431-7
    • (2011) Diabetes Care , vol.34 , pp. 1431-1437
    • Lipska, K.J.1    Bailey, C.J.2    Inzucchi, S.E.3
  • 8
    • 77950868733 scopus 로고    scopus 로고
    • Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus
    • Salpeter SR, Greyber E, Pasternak GA, et al. Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. Cochrane Database Syst Rev 2010;CD002967
    • (2010) Cochrane Database Syst Rev , pp. CD002967
    • Salpeter, S.R.1    Greyber, E.2    Pasternak, G.A.3
  • 9
    • 3042798575 scopus 로고    scopus 로고
    • The phantom of lactic acidosis due to metformin in patients with diabetes
    • Misbin RI. The phantom of lactic acidosis due to metformin in patients with diabetes. Diabetes Care 2004;27:1791-3
    • (2004) Diabetes Care , vol.27 , pp. 1791-1793
    • Misbin, R.I.1
  • 10
    • 1242340408 scopus 로고    scopus 로고
    • Metformin and lactic acidosis: Cause or coincidence?. A review of case reports
    • Stades AM, Heikens JT, Erkelens DW, et al. Metformin and lactic acidosis: cause or coincidence?. A review of case reports. J Intern Med 2004;255:179-87
    • (2004) J Intern Med , vol.255 , pp. 179-187
    • Stades, A.M.1    Heikens, J.T.2    Erkelens, D.W.3
  • 11
    • 0344420380 scopus 로고    scopus 로고
    • Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus: Systematic review and meta-analysis
    • Salpeter SR, Greyber E, Pasternak GA, et al. Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus: systematic review and meta-analysis. Arch Intern Med 2003;163:2594-602
    • (2003) Arch Intern Med , vol.163 , pp. 2594-2602
    • Salpeter, S.R.1    Greyber, E.2    Pasternak, G.A.3
  • 12
    • 28444452977 scopus 로고    scopus 로고
    • Contraindications can damage your health-is metformin a case in point?
    • Holstein A, Stumvoll M. Contraindications can damage your health-is metformin a case in point?. Diabetologia 2005;48:2454-9
    • (2005) Diabetologia , vol.48 , pp. 2454-2459
    • Holstein, A.1    Stumvoll, M.2
  • 13
    • 0031685819 scopus 로고    scopus 로고
    • Lactic acidosis rates in type 2 diabetes
    • Brown JB, Pedula K, Barzilay J, et al. Lactic acidosis rates in type 2 diabetes. Diabetes Care 1998;21:1659-63
    • (1998) Diabetes Care , vol.21 , pp. 1659-1663
    • Brown, J.B.1    Pedula, K.2    Barzilay, J.3
  • 14
    • 0032556946 scopus 로고    scopus 로고
    • Lactic acidosis in patients with diabetes treated with metformin
    • Misbin RI, Green L, Stadel BV, et al. Lactic acidosis in patients with diabetes treated with metformin. N Engl J Med 1998;338:265-6
    • (1998) N Engl J Med , vol.338 , pp. 265-266
    • Misbin, R.I.1    Green, L.2    Stadel, B.V.3
  • 15
    • 0027276027 scopus 로고
    • Metformin-associated lactic acidosis in Sweden 1977-1991
    • Wiholm BE, Myrhed M. Metformin-associated lactic acidosis in Sweden 1977-1991. Eur J Clin Pharmacol 1993;44:589-91
    • (1993) Eur J Clin Pharmacol , vol.44 , pp. 589-591
    • Wiholm, B.E.1    Myrhed, M.2
  • 16
    • 84864285795 scopus 로고    scopus 로고
    • Management of hyperglycaemia in type 2 diabetes: A patient-centered approach position statement of the american diabetes association ada and the european association for the study of diabetes (easd
    • Inzucchi SE, Bergenstal RM, Buse JB, et al. Management of hyperglycaemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia 2012; 55:1577-96
    • (2012) Diabetologia , vol.55 , pp. 1577-1596
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3
  • 17
    • 61349138261 scopus 로고    scopus 로고
    • Metformin treatment in diabetes and heart failure: When academic equipoise meets clinical reality
    • Eurich DT, Tsuyuki RT, Majumdar SR, et al. Metformin treatment in diabetes and heart failure: when academic equipoise meets clinical reality. Trials 2009;10:12
    • (2009) Trials , vol.10 , pp. 12
    • Eurich, D.T.1    Tsuyuki, R.T.2    Majumdar, S.R.3
  • 18
    • 25644459350 scopus 로고    scopus 로고
    • Improved clinical outcomes associated with metformin in patients with diabetes and heart failure
    • Eurich DT, Majumdar SR, McAlister FA, et al. Improved clinical outcomes associated with metformin in patients with diabetes and heart failure. Diabetes Care 2005;28:2345-51
    • (2005) Diabetes Care , vol.28 , pp. 2345-2351
    • Eurich, D.T.1    Majumdar, S.R.2    McAlister, F.A.3
  • 19
    • 13444272949 scopus 로고    scopus 로고
    • Thiazolidinediones, metformin, and outcomes in older patients with diabetes and heart failure: An observational study
    • Masoudi FA, Inzucchi SE, Wang Y, et al. Thiazolidinediones, metformin, and outcomes in older patients with diabetes and heart failure: an observational study. Circulation 2005;111:583-90
    • (2005) Circulation , vol.111 , pp. 583-590
    • Masoudi, F.A.1    Inzucchi, S.E.2    Wang, Y.3
  • 20
    • 77956971910 scopus 로고    scopus 로고
    • Effect of metformin on mortality in patients with heart failure and type 2 diabetes mellitus
    • Evans JM, Doney AS, AlZadjali MA, et al. Effect of metformin on mortality in patients with heart failure and type 2 diabetes mellitus. Am J Cardiol 2010;106:1006-10
    • (2010) Am J Cardiol , vol.106 , pp. 1006-1010
    • Evans, J.M.1    Doney, A.S.2    Alzadjali, M.A.3
  • 21
    • 79952260043 scopus 로고    scopus 로고
    • Metformin use and mortality in ambulatory patients with diabetes and heart failure
    • Aguilar D, Chan W, Bozkurt B, et al. Metformin use and mortality in ambulatory patients with diabetes and heart failure. Circ Heart Fail 2011;4:53-8
    • (2011) Circ Heart Fail , vol.4 , pp. 53-58
    • Aguilar, D.1    Chan, W.2    Bozkurt, B.3
  • 22
    • 84865172032 scopus 로고    scopus 로고
    • Inappropriate metformin prescribing in elderly type 2 diabetes mellitus (T2DM) patients
    • Kosmalski M, Drozdowska A, Sliwinska A, et al. Inappropriate metformin prescribing in elderly type 2 diabetes mellitus (T2DM) patients. Adv Med Sci 2012;57:65-70
    • (2012) Adv Med Sci , vol.57 , pp. 65-70
    • Kosmalski, M.1    Drozdowska, A.2    Sliwinska, A.3
  • 23
    • 0037169941 scopus 로고    scopus 로고
    • Evaluation of prescribing practices: Risk of lactic acidosis with metformin therapy
    • Calabrese AT, Coley KC, DaPos SV, et al. Evaluation of prescribing practices: risk of lactic acidosis with metformin therapy. Arch Intern Med 2002;162:434-7
    • (2002) Arch Intern Med , vol.162 , pp. 434-437
    • Calabrese, A.T.1    Coley, K.C.2    Dapos, S.V.3
  • 24
    • 0032724997 scopus 로고    scopus 로고
    • Contra-indications to metformin therapy are largely disregarded
    • Holstein A, Nahrwold D, Hinze S, et al. Contra-indications to metformin therapy are largely disregarded. Diabet Med 1999;16:692-6
    • (1999) Diabet Med , vol.16 , pp. 692-696
    • Holstein, A.1    Nahrwold, D.2    Hinze, S.3
  • 25
    • 0031007415 scopus 로고    scopus 로고
    • Contraindications to metformin therapy in patients with niddm
    • Sulkin TV, Bosman D, Krentz AJ. Contraindications to metformin therapy in patients with NIDDM. Diabetes Care 1997;20:925-8
    • (1997) Diabetes Care , vol.20 , pp. 925-928
    • Sulkin, T.V.1    Bosman, D.2    Krentz, A.J.3
  • 26
    • 57649166566 scopus 로고    scopus 로고
    • Metformin-associated lactic acidosis in an intensive care unit
    • Peters N, Jay N, Barraud D, et al. Metformin-associated lactic acidosis in an intensive care unit. Crit Care 2008;12:R149
    • (2008) Crit Care , vol.12 , pp. R149
    • Peters, N.1    Jay, N.2    Barraud, D.3
  • 27
    • 79955785504 scopus 로고    scopus 로고
    • Metformin associated lactic acidosis: Incidence and clinical correlation with metformin serum concentration measurements
    • van Berlo-van de Laar IR, Vermeij CG, Doorenbos CJ. Metformin associated lactic acidosis: incidence and clinical correlation with metformin serum concentration measurements. J Clin Pharm Ther 2011;36: 376-82
    • (2011) J Clin Pharm Ther , vol.36 , pp. 376-382
    • Van Berlo-Van De Laar, I.R.1    Vermeij, C.G.2    Doorenbos, C.J.3
  • 28
    • 79954475809 scopus 로고    scopus 로고
    • Metformin-associated lactic acidosis (mala): Clinical profile and outcomes in patients admitted to the intensive care unit
    • Biradar V, Moran JL, Peake SL, et al. Metformin-associated lactic acidosis (MALA): clinical profile and outcomes in patients admitted to the intensive care unit. Crit Care Resusc 2010;12:191-5
    • (2010) Crit Care Resusc , vol.12 , pp. 191-195
    • Biradar, V.1    Moran, J.L.2    Peake, S.L.3
  • 29
    • 33645342741 scopus 로고    scopus 로고
    • Severe acidosis in patients taking metformin-rapid reversal and survival despite high apache score
    • Nyirenda MJ, Sandeep T, Grant I, et al. Severe acidosis in patients taking metformin-rapid reversal and survival despite high APACHE score. Diabet Med 2006;23:432-5
    • (2006) Diabet Med , vol.23 , pp. 432-435
    • Nyirenda, M.J.1    Sandeep, T.2    Grant, I.3
  • 30
    • 66449095741 scopus 로고    scopus 로고
    • Alarming increase of the number of metformin intoxications ten times doubled number of inquiries to the swedish poison information center since 2000 [in swedish
    • Personne M. Alarming increase of the number of metformin intoxications. Ten times doubled number of inquiries to the Swedish Poison Information Center since 2000 [in Swedish]. Lakartidningen 2009;106: 994
    • (2009) Lakartidningen , vol.106 , pp. 994
    • Personne, M.1
  • 31
    • 14644390253 scopus 로고    scopus 로고
    • Comparative outcomes study of metformin intervention versus conventional approach the cosmic approach study
    • Cryer DR, Nicholas SP, Henry DH, et al. Comparative outcomes study of metformin intervention versus conventional approach the COSMIC Approach Study. Diabetes Care 2005;28:539-43
    • (2005) Diabetes Care , vol.28 , pp. 539-543
    • Cryer, D.R.1    Nicholas, S.P.2    Henry, D.H.3
  • 32
    • 84555167878 scopus 로고    scopus 로고
    • Metformin-induced lactic acidosis: No one left behind
    • Vecchio S, Protti A. Metformin-induced lactic acidosis: no one left behind. Crit Care 2011;15:107
    • (2011) Crit Care , vol.15 , pp. 107
    • Vecchio, S.1    Protti, A.2
  • 33
    • 0017853392 scopus 로고
    • Blood lactate and pyruvate levels in diabetic patients treated with biguanides with and without sulphonylureas
    • Waters AK, Morgan DB, Wales JK. Blood lactate and pyruvate levels in diabetic patients treated with biguanides with and without sulphonylureas. Diabetologia 1978;14:95-8
    • (1978) Diabetologia , vol.14 , pp. 95-98
    • Waters, A.K.1    Morgan, D.B.2    Wales, J.K.3
  • 34
    • 0017838931 scopus 로고
    • The effect of short-term administration of antidiabetic biguanide derivatives on the blood lactate levels in healthy subjects
    • Czyzyk A, Lao B, Bartosiewicz W, et al. The effect of short-term administration of antidiabetic biguanide derivatives on the blood lactate levels in healthy subjects. Diabetologia 1978;14:89-94
    • (1978) Diabetologia , vol.14 , pp. 89-94
    • Czyzyk, A.1    Lao, B.2    Bartosiewicz, W.3
  • 35
    • 0018642945 scopus 로고
    • Metabolic effects of glucocorticoid and ethanol administration in phenformin- and metformin-treated obese diabetics
    • Schaffalitzky de Muckadell OB, Mortensen H, Lyngsoe J. Metabolic effects of glucocorticoid and ethanol administration in phenformin- and metformin-treated obese diabetics. Acta Med Scand 1979;206:269-73
    • (1979) Acta Med Scand , vol.206 , pp. 269-273
    • Schaffalitzky De Muckadell, O.B.1    Mortensen, H.2    Lyngsoe, J.3
  • 36
    • 0018147397 scopus 로고
    • The risk of lacticate acidosis: A comparison of the 3 biguanides in treatment of diabetics (authors' transl) [in german
    • Irsigler K, Kritz H, Regal H, et al. The risk of lacticate acidosis: a comparison of the 3 biguanides in treatment of diabetics (authors' transl) [in German]. Wien Klin Wochenschr 1978;90:332-7
    • (1978) Wien Klin Wochenschr , vol.90 , pp. 332-337
    • Irsigler, K.1    Kritz, H.2    Regal, H.3
  • 37
    • 0034332118 scopus 로고    scopus 로고
    • Metformin-induced lacticacidemia in patients with type 2 diabetes mellitus
    • Abbasi AA, Kasmikha R, Sotingeanu DG. Metformin-induced lacticacidemia in patients with type 2 diabetes mellitus. Endocr Pract 2000; 6:442-6
    • (2000) Endocr Pract , vol.6 , pp. 442-446
    • Abbasi, A.A.1    Kasmikha, R.2    Sotingeanu, D.G.3
  • 39
    • 44049086017 scopus 로고    scopus 로고
    • Population exposureresponse modeling of metformin in patients with type 2 diabetes mellitus
    • Hong Y, Rohatagi S, Habtemariam B, et al. Population exposureresponse modeling of metformin in patients with type 2 diabetes mellitus. J Clin Pharmacol 2008;48:696-707
    • (2008) J Clin Pharmacol , vol.48 , pp. 696-707
    • Hong, Y.1    Rohatagi, S.2    Habtemariam, B.3
  • 40
    • 80051635036 scopus 로고    scopus 로고
    • Management of metformin-associated lactic acidosis by continuous renal replacement therapy
    • Keller G, Cour M, Hernu R, et al. Management of metformin-associated lactic acidosis by continuous renal replacement therapy. PLoS One 2011; 6:e23200
    • (2011) Plos One , vol.6 , pp. e23200
    • Keller, G.1    Cour, M.2    Hernu, R.3
  • 41
    • 0034659785 scopus 로고    scopus 로고
    • Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
    • Owen MR, Doran E, Halestrap AP. Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem J 2000;348:607-14
    • (2000) Biochem J , vol.348 , pp. 607-614
    • Owen, M.R.1    Doran, E.2    Halestrap, A.P.3
  • 42
    • 78149272522 scopus 로고    scopus 로고
    • Where does the lactate come from?. A rare cause of reversible inhibition of mitochondrial respiration
    • Levy B, Perez P, Perny J.Where does the lactate come from?. A rare cause of reversible inhibition of mitochondrial respiration. Crit Care 2010;14:136
    • (2010) Crit Care , vol.14 , pp. 136
    • Levy, B.1    Perez, P.2    Perny, J.3
  • 43
    • 34548155042 scopus 로고    scopus 로고
    • Mitochondrial function and substrate availability
    • Leverve XM. Mitochondrial function and substrate availability. Crit Care Med 2007;35(suppl 9):S454-60
    • (2007) Crit Care Med , vol.35 , pp. S454-S460
    • Leverve, X.M.1
  • 44
    • 0141649391 scopus 로고    scopus 로고
    • Estimating the contribution of genes and environment to variation in renal drug clearance
    • Leabman MK, Giacomini KM. Estimating the contribution of genes and environment to variation in renal drug clearance. Pharmacogenetics 2003;13:581-4
    • (2003) Pharmacogenetics , vol.13 , pp. 581-584
    • Leabman, M.K.1    Giacomini, K.M.2
  • 45
    • 69449098951 scopus 로고    scopus 로고
    • The effects of genetic polymorphisms in the organic cation transporters oct1 oct2, and oct3 on the renal clearance of metformin
    • Tzvetkov MV, Vormfelde SV, Balen D, et al. The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin. Clin Pharmacol Ther 2009;86:299-306
    • (2009) Clin Pharmacol Ther , vol.86 , pp. 299-306
    • Tzvetkov, M.V.1    Vormfelde, S.V.2    Balen, D.3
  • 46
  • 47
    • 84864062799 scopus 로고    scopus 로고
    • Overview of metformin: Special focus on metformin extended release
    • Ali S, Fonseca V. Overview of metformin: special focus on metformin extended release. Expert Opin Pharmacother 2012;13:1797-805
    • (2012) Expert Opin Pharmacother , vol.13 , pp. 1797-1805
    • Ali, S.1    Fonseca, V.2
  • 48
    • 79956333806 scopus 로고    scopus 로고
    • Effects of a mate protein inhibitor, pyrimethamine, on the renal elimination of metformin at oral microdose and at therapeutic dose in healthy subjects
    • Kusuhara H, Ito S, Kumagai Y, et al. Effects of a MATE protein inhibitor, pyrimethamine, on the renal elimination of metformin at oral microdose and at therapeutic dose in healthy subjects. Clin Pharmacol Ther 2011;89:837-44
    • (2011) Clin Pharmacol Ther , vol.89 , pp. 837-844
    • Kusuhara, H.1    Ito, S.2    Kumagai, Y.3
  • 49
    • 0037347482 scopus 로고    scopus 로고
    • Measurement of metformin concentration in erythrocytes: Clinical implications
    • Lalau JD, Lacroix C. Measurement of metformin concentration in erythrocytes: clinical implications. Diabetes Obes Metab 2003;5:93-8
    • (2003) Diabetes Obes Metab , vol.5 , pp. 93-98
    • Lalau, J.D.1    Lacroix, C.2
  • 50
    • 0017843124 scopus 로고
    • Lactic acidosis in biguanidetreated diabetics: A review of 330 cases
    • Luft D, Schmulling RM, Eggstein M. Lactic acidosis in biguanidetreated diabetics: a review of 330 cases. Diabetologia 1978;14:75-87
    • (1978) Diabetologia , vol.14 , pp. 75-87
    • Luft, D.1    Schmulling, R.M.2    Eggstein, M.3
  • 51
    • 78651265104 scopus 로고    scopus 로고
    • Diabetes, metformin and lactic acidosis
    • Scale T, Harvey JN. Diabetes, metformin and lactic acidosis. Clin Endocrinol (Oxf) 2011;74:191-6
    • (2011) Clin Endocrinol (Oxf , vol.74 , pp. 191-196
    • Scale, T.1    Harvey, J.N.2
  • 52
    • 78650271675 scopus 로고    scopus 로고
    • Outcome of severe lactic acidosis associated with metformin accumulation
    • Friesecke S, Abel P, Roser M, et al. Outcome of severe lactic acidosis associated with metformin accumulation. Crit Care 2010;14:R226
    • (2010) Crit Care , vol.14 , pp. R226
    • Friesecke, S.1    Abel, P.2    Roser, M.3
  • 53
    • 0029044687 scopus 로고
    • Role of metformin accumulation in metformin-associated lactic acidosis
    • Lalau JD, Lacroix C, Compagnon P, et al. Role of metformin accumulation in metformin-associated lactic acidosis. Diabetes Care 1995; 18:779-84
    • (1995) Diabetes Care , vol.18 , pp. 779-784
    • Lalau, J.D.1    Lacroix, C.2    Compagnon, P.3


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