Heritability and genome-wide association analyses of sleep duration in children: The EAGLE consortium

Sleep

Volumn 39, Issue 10, 2016, Pages 1859-1869

  Marinelli, Marcella ^a,b,c   Pappa, Irene ^d,e   Bustamante, Mariona ^b,c,f,g   Bonilla, Carolina ^u,v   Suarez, Anna ^h   Tiesler, Carla M ^i,j   Vilor Tejedor, Natalia ^b,c,g   Zafarmand, Mohammad Hadi ^k   Alvarez Pedrerol, Mar ^b,c,g   Andersson, Sture ^h   Bakermans Kranenburg, Marian J ^l   Estivill, Xavier ^b,f,g,m   Evans, David M ^u,v,w   Flexeder, Claudia ⁱ   Forns, Joan ^b,g   Gonzalez, Juan R ^b,c,g   Guxens, Monica ^b,c,g,n   Huss, Anke ^o   Van Ijzendoorn, Marinus H ^d,e,l   Jaddoe, Vincent W V ^e,n   Julvez, Jordi ^b,c,g   Lahti, Jari ^h,p   López Vicente, Mónica ^b,c,g   Lopez Espinosa, Maria Jose ^b,q   Manz, Judith ⁱ   Mileva Seitz, Viara R ^l   Perola, Markus ^h,r   Pesonen, Anu Katriina ^h   Rivadeneira, Fernando ^e,n   Salo, Perttu P ^h,r   Shahand, Shayan ^k   Schulz, Holger ⁱ   Standl, Marie ⁱ   Thiering, Elisabeth ^i,j   Timpson, Nicholas J ^u,v   Torrent, Maties ^s   Uitterlinden, André G ^e,n,t   Smith, George Davey ^u,v   Estarlich, Marisa ^b,q   Heinrich, Joachim ⁱ   Räikkönen, Katri ^h   Vrijkotte, Tanja G M ^k   Tiemeier, Henning ^e,n   Sunyer, Jordi ^b,c,g,m   more..

^a Agency for Health Quality and Assessment of Catalonia (AQuAS)   (Spain)

^b CIBER EPIDEMIOLOGÍA Y SALUD PÚBLICA CIBERESP   (Spain)

^c CENTRE FOR RESEARCH IN ENVIRONMENTAL EPIDEMIOLOGY CREAL   (Spain)

^d ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^e ERASMUS MEDICAL CENTER   (Netherlands)

^f BARCELONA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Spain)

^g UNIVERSITAT POMPEU FABRA   (Spain)

^h UNIVERSITY OF HELSINKI   (Finland)

ⁱ INSTITUTE OF EPIDEMIOLOGY   (Germany)

^j LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^k UNIVERSITY OF AMSTERDAM   (Netherlands)

^l LEIDEN UNIVERSITY   (Netherlands)

^m HOSPITAL DEL MAR   (Spain)

ⁿ SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^o UTRECHT UNIVERSITY   (Netherlands)

^p FOLKHÄLSAN RESEARCH CENTER   (Finland)

^q UNIVERSITAT JAUME I   (Spain)

^r NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^s Area de Salut de Menorca ib salut   (Spain)

^t Netherlands Genomics Initiative   (Netherlands)

^u UNIVERSITY OF BRISTOL   (United Kingdom)

^v UNIVERSITY OF BRISTOL   (United Kingdom)

^w UNIVERSITY OF QUEENSLAND   (Australia)

more..

Author keywords

Childhood sleep duration; Genome wide association study (GWAS); Meta analysis; Pathway analysis; SNP heritability

Indexed keywords

ARTICLE; CHROMOSOME 11Q; EUROPEAN; GENETIC ASSOCIATION; GENETIC CORRELATION; GENETIC VARIABILITY; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HERITABILITY; HUMAN; MAJOR CLINICAL STUDY; META ANALYSIS (TOPIC); MOLECULAR GENETICS; NON INSULIN DEPENDENT DIABETES MELLITUS; PHENOTYPE; POPULATION RESEARCH; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SLEEP TIME; ADOLESCENT; CAUCASIAN; CHILD; COHORT ANALYSIS; DIABETES MELLITUS, TYPE 2; FEMALE; GENETICS; LONGITUDINAL STUDY; MALE; META ANALYSIS; PRESCHOOL CHILD; PROCEDURES; QUANTITATIVE TRAIT; SLEEP; TIME FACTOR;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; DIABETES MELLITUS, TYPE 2; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; LONGITUDINAL STUDIES; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT, HERITABLE; SLEEP; TIME FACTORS;

EID: 84992436597     PISSN: 01618105     EISSN: 15509109     Source Type: Journal    
DOI: 10.5665/sleep.6170     Document Type: Article

References (76)

1. Allada R, Siegel JM. Unearthing the phylogenetic roots of sleep. Curr Biol 2008; 18:R670-R9.
2. Cappuccio FP, Taggart FM, Kandala NB, et al. Meta-analysis of short sleep duration and obesity in children and adults. Sleep 2008; 31:619-26.
3. Gangwisch JE, Heymsfield SB, Boden-Albala B, et al. Short sleep duration as a risk factor for hypertension - Analyses of the first national health and nutrition examination survey. Hypertension 2006; 47:833-9.
4. Ayas NT, White DP, Manson JE, et al. A prospective study of sleep duration and coronary heart disease in women. Arch Intern Med 2003; 163:205-9.
5. Leng Y, Cappuccio FP, Wainwright NWJ, et al. Sleep duration and risk of fatal and nonfatal stroke: a prospective study and meta-analysis. Neurology 2015; 84:1072-9.
6. Shan ZL, Ma HF, Xie ML, et al. Sleep duration and risk of type 2 diabetes: a meta-analysis of prospective studies. Diabetes Care 2015; 38:529-37.
7. Cappuccio FP, D'Elia L, Strazzullo P, Miller MA. Sleep duration and all-cause mortality: a systematic review and meta-analysis of prospective studies. Sleep 2010; 33:585-92.
8. Astill RG, Van der Heijden KB, Van IJzendoorn MH, Van Someren EJ. Sleep, Cognition, and behavioral problems in school-age children: a century of research meta-analyzed. Psychol Bull 2012; 138:1109-38.
9. Watson NF, Harden K P, Buchwald D, et al. Sleep duration and depressive symptoms: a gene-environment interaction. Sleep 2014; 37:351-8.
10. Perlman CA, Johnson SL, Mellman TA. The prospective impact of sleep duration on depression and mania. Bipolar Disord 2006; 8:271-4.
11. Barnes JC, Meldrum RC. The impact of sleep duration on adolescent development: a genetically informed analysis of identical twin pairs. J Youth Adolesc 2015; 44:489-506.
12. Liu XC Sleep and adolescent suicidal behavior. Sleep 2004; 27:1351-8.
13. Hvolby A. Associations of sleep disturbance with ADHD: implications for treatment. Atten Defic Hyperact Disord 2015; 7:1-18.
14. Anderson B, Storfer-Isser A, Taylor HG, Rosen CL, Redline S. Associations of executive function with sleepiness and sleep duration in adolescents. Pediatrics 2009; 123:E701-7.
15. Cohrs S, Rodenbeck A, Riemann D, et al. Impaired sleep quality and sleep duration in smokers-results from the German Multicenter Study on Nicotine Dependence. Addict Biol 2014; 19:486-96.
16. Calamaro CJ, Mason TBA, Ratcliffe SJ. Adolescents living the 24/7 lifestyle: effects of caffeine and technology on sleep duration and daytime functioning. Pediatrics 2009; 123:E1005-10.
17. Krueger PM, Friedman EM. Sleep duration in the United States: a cross-sectional population-based study. Am J Epidemiol 2009; 169:1052-63.
18. Blair PS, Humphreys JS, Gringras P, et al. Childhood sleep duration and associated demographic characteristics in an English cohort. Sleep 2012; 35:353-60.
19. de Castro JM. The influence of heredity on self-reported sleep patterns in free-living humans. Physiol Behav 2002; 76:479-86.
20. Heath AC, Kendler KS, Eaves LJ, Martin NG. Evidence for genetic influences on sleep disturbance and sleep pattern in twins. Sleep 1990; 13:318-35.
21. Watson NF, Buchwald D, Vitiello MV, Noonan C, Goldberg J. A twin study of sleep duration and body mass index. J Clin Sleep Med 2010; 6:11-7.
22. Partinen M, Kaprio J, Koskenvuo M, Putkonen P, Langinvainio H. Genetic and environmental determination of human sleep. Sleep 1983; 6:179-85.
23. Gottlieb DJ, O'Connor GT, Wilk JB. Genome-wide association of sleep and circadian phenotypes. BMC Med Genet 2007; 8 Suppl 1:S9.
24. Brescianini S, Volzone A, Fagnani C, et al. Genetic and environmental factors shape infant sleep patterns: a study of 18-month-old twins. Pediatrics 2011; 127:E1296-302.
25. Touchette E, Dionne G, Forget-Dubois N, et al. Genetic and environmental influences on daytime and nighttime sleep duration in early childhood. Pediatrics 2013; 131:E1874-80.
26. Fisher A, van Jaarsveld CH, Llewellyn CH, Wardle J. Genetic and environmental influences on infant sleep. Pediatrics 2012; 129:1091-6.
27. Yang JA, Lee SH, Goddard ME, Visscher PM. GCTA: a tool for genome-wide complex trait analysis. Am J Hum Genet 2011; 88:76-82.
28. Bulik-Sullivan BK, Loh PR, Finucane HK, et al. LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat Genet 2015; 47:291-5.
29. He Y, Jones CR, Fujiki N, et al. The transcriptional repressor DEC2 Regulates sleep length in mammals. Science 2009; 325:866-70.
30. Allebrandt KV, Teder-Laving M, Akyol M, et al. CLOCK gene variants associate with sleep duration in two independent populations. Biol Psychiat 2010; 67:1040-7.
31. Kripke DF, Kline LE, Nievergelt CM, et al. Genetic variants associated with sleep disorders. Sleep Med 2015; 16:217-24.
32. Scheinfeldt LB, Gharani N, Kasper RS, et al. Using the Coriell Personalized Medicine Collaborative Data to conduct a genome-wide association study of sleep duration. Am J Med Genet B Neuropsychiatr Genet. 2015; 168:697-705.
33. Ollila HM, Kettunen J, Pietilainen O, et al. Genome-wide association study of sleep duration in the Finnish population. J Sleep Res 2014; 23:609-18.
34. Allebrandt KV, Amin N, Muller-Myhsok B, et al. A K-ATP channel gene effect on sleep duration: from genome-wide association studies to function in Drosophila. Mol Psychiatr 2013; 18:122-32.
35. Parsons MJ, Lester KJ, Barclay NL, Nolan PM, Eley TC, Gregory AM. Replication of genome-wide association studies (GWAS) loci for sleep in the British G1219 cohort. Am J Med Genet B 2013; 162B:431-8.
36. Gottlieb DJ, Hek K, Chen TH, et al. Novel loci associated with usual sleep duration: the CHARGE consortium genome-wide association study. Mol Psychiatry 2015; 20:1232-9.
37. Akerstedt T. Shift work and disturbed sleep/wakefulness. Occup Med-Oxford 2003; 53:89-94.
38. Iglowstein I, Jenni OG, Molinari L, Largo RH. Sleep duration from infancy to adolescence: reference values and generational trends. Pediatrics 2003; 111:302-7.
39. Maslowsky J, Ozer EJ. Developmental trends in sleep duration in adolescence and young adulthood: evidence from a national United States sample. J Adolesc Health 2014; 54:691-7.
40. Watson NF, Harden K P, Buchwald D, et al. Sleep duration and body mass index in twins: a gene-environment interaction. Sleep 2012; 35:597-603.
41. Winkler TW, Day FR, Croteau-Chonka DC, et al. Quality control and conduct of genome-wide association meta-analyses. Nat Protoc 2014; 9:1192-212.
42. R Core Team. R: a language and environment for statistical computing. 2013. Accessed 2015. Available from: http://www.R-project.org/.
43. Willer CJ, Li Y, Abecasis GR. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics 2010; 26:2190-1.
44. Pruim RJ, Welch R P, Sanna S, et al. LocusZoom: regional visualization of genome-wide association scan results. Bioinformatics 2010; 26:2336-7.
45. Ward LD, Kellis M. HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants. Nucleic Acids Res 2012; 40:D930-4.
46. Ardlie KG, DeLuca DS, Segre AV, et al. The genotype-tissue expression (GTEx) pilot analysis: multitissue gene regulation in humans. Science 2015; 348:648-60.
47. Pers TH, Karjalainen JM, Chan Y, et al. Biological interpretation of genome-wide association studies using predicted gene functions. Nat Commun 2015; 6:5890.
48. Mi HY, Muruganujan A, Thomas PD. PANTHER in 2013: modeling the evolution of gene function, and other gene attributes, in the context of phylogenetic trees. Nucleic Acids Res 2013; 41:D377-86.
49. Finucane HK, Bulik-Sullivan B, Gusev A, et al. Partitioning heritability by functional annotation using genome-wide association summary statistics. Nat Genet 2015; 47:1228-35.
50. Bulik-Sullivan B, Finucane HK, Anttila V, et al. An atlas of genetic correlations across human diseases and traits. Nat Genet 2015; 47:1236-41.
51. Bradfield JP, Taal HR, Timpson NJ, et al. A genome-wide association meta-analysis identifies new childhood obesityloci. Nat Genet 2012; 44:526-31.
52. Morris AP, Voight BF, Teslovich TM, et al. Large-scale association analysis providesinsights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet 2012; 44:981-90.
53. Saxena R, Hivert MF, Langenberg C, et al. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet 2010; 42:142-U75.
54. Sklar P, Ripke S, Scott LJ, et al. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet 2011; 43:977-U162.
55. Sullivan PF, Daly MJ, Ripke S, et al. A mega-analysis of genomewide association studies for major depressive disorder. Mol Psychiatr 2013; 18:497-511.
56. Ripke S, Neale BM, Corvin A, et al. Biological insights from 108 schizophrenia-associated genetic loci. Nature 2014; 511:421-7.
57. Mick E, Todorov A, Smalley S, et al. Family-based genome-wide association scan of attention-deficit/hyperactivity disorder. J Am Acad Child Psy 2010; 49:898-905.
58. Byrne EM, Gehrman PR, Medland SE, et al. A genome-wide association study of sleep habits and insomnia. Am J Med Genet B 2013; 162B:439-51.
59. Comuzzie AG, Cole SA, Laston SL, et al. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. PLoS One 2012; 7:e51954.
60. Johnson AD, Handsaker RE, Pulit SL, Nizzari MM, O'Donnell CJ, de Bakker PIW. SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap. Bioinformatics 2008; 24:2938-9.
61. Mahajan A, Go MJ, Zhang WH, et al. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet 2014; 46:234-44.
62. Manning AK, Hivert MF, Scott RA, et al. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet 2012; 44:659-U81.
63. Strawbridge RJ, Dupuis J, Prokopenko I, et al. Genome-Wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes 2011; 60:2624-34.
64. Voight BF, Scott LJ, Steinthorsdottir V, et al. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet 2010; 42:579-89.
65. Kulzer JR, Stitzel ML, Morken MA, et al. A common functional regulatory variant at a type 2 diabetes locus upregulates ARAP1 expression in the pancreatic beta cell. Am J Hum Genet 2014; 94:186-97.
66. Okada Y, Terao C, Ikari K, et al. Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. Nat Genet 2012; 44:511-6.
67. Schmid SM, Hallschmid M, Schultes B. The metabolic burden of sleep loss. Lancet Diabetes Endo 2015; 3:52-62.
68. Felson J. What can we learn from twin studies? A comprehensive evaluation of the equal environments assumption. Soc Sci Res 2014; 43:184-99.
69. Visscher PM, Brown MA, McCarthy MI, Yang J. Five years of GWAS discovery. Am J Hum Genet 2012; 90:7-24.
70. Gottlieb DJ, Punjabi NM, Newman AB, et al. Association of sleep time with diabetes mellitus and impaired glucose tolerance. Arch Intern Med 2005; 165:863-8.
71. Furihata R, Uchiyama M, Suzuki M, et al. Association of short sleep duration and short time in bed with depression: a Japanese general population survey. Sleep Biol Rhythms 2015; 13:136-45.
72. Monti JM, Monti D. Sleep disturbance in schizophrenia. Int Rev Psychiatry 2005; 17:247-53.
73. Lauderdale DS, Knutson KL, Yan LL, Liu K, Rathouz PJ. Sleep duration: how well do self-reports reflect objective measures? The CARDIA Sleep Study. Epidemiology 2008; 19:838-45.
74. Van Den Berg JF, Van Rooij FJA, Vos H, et al. Disagreement between subjective and actigraphic measures of sleep duration in a population based study of elderly persons. J Sleep Res 2008; 17:295-302.
75. Ambrosius U, Lietzenmaier S, Wehrle R, et al. Heritability of sleep electroencephalogram. Biol Psychiat 2008; 64:344-8.
76. Chabris CF, Hebert BM, Benjamin DJ, et al. Most reported genetic associations with general intelligence are probably false positives. Psychol Sci 2012; 23:1314-23.