CLOCK Gene Variants Associate with Sleep Duration in Two Independent Populations

Biological Psychiatry

Volumn 67, Issue 11, 2010, Pages 1040-1047

  Allebrandt, Karla V ^a,c   Teder Laving, Maris ^b   Akyol, Mahmut ^c   Pichler, Irene ^d   Müller Myhsok, Bertram ^e   Pramstaller, Peter ^d,f,g   Merrow, Martha ^h   Meitinger, Thomas ^c,e   Metspalu, Andreas ^b   Roenneberg, Till ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF TARTU   (Estonia)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

^d Institute of Genetic Medicine   (Germany)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^f UNIVERSITY OF LÜBECK   (Germany)

^g General Central Hospital   (Italy)

^h UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

CLOCK; clock genes; long sleepers; MCTQ; short sleepers; sleep duration

Indexed keywords

TRANSCRIPTION FACTOR CLOCK;

ADOLESCENT; ADULT; AGED; ARTICLE; CONTROLLED STUDY; ESTONIA; EUROPE; FEMALE; FOLLOW UP; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; INTRON; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; QUESTIONNAIRE; SINGLE NUCLEOTIDE POLYMORPHISM; SLEEP;

ALLELES; BIOLOGICAL CLOCKS; CIRCADIAN RHYTHM; CLOCK PROTEINS; ESTONIA; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC VARIATION; GENOTYPE; HAPLOTYPES; HUMANS; ITALY; MALE; PHENOTYPE; SEX FACTORS; SLEEP; TIME FACTORS;

EID: 77951879348     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2009.12.026     Document Type: Article

References (52)

1. Cirelli C. Cellular consequences of sleep deprivation in the brain. Sleep Med Rev 10 (2006) 307-321
2. Cirelli C. Sleep disruption, oxidative stress, and aging: New insights from fruit flies. Proc Natl Acad Sci U S A 103 (2006) 13901-13902
3. Cirelli C., Faraguna U., and Tononi G. Changes in brain gene expression after long-term sleep deprivation. J Neurochem 98 (2006) 1632-1645
4. Gilestro G.F., Tononi G., and Cirelli C. Widespread changes in synaptic markers as a function of sleep and wakefulness in Drosophila. Science 324 (2009) 109-112
5. Borbely A.A. Processes underlying sleep regulation. Horm Res 49 (1998) 114-117
6. Daan S., Beersma D.G., and Borbely A.A. Timing of human sleep: Recovery process gated by a circadian pacemaker. Am J Physiol 246 (1984) R161-R183
7. Roenneberg T., and Merrow M. Entrainment of the human circadian clock. Cold Spring Harb Symp Quant Biol 72 (2007) 293-299
8. Youngstedt S.D., and Kripke D.F. Long sleep and mortality: Rationale for sleep restriction. Sleep Med Rev 8 (2004) 159-174
9. Terracciano A., Sanna S., Uda M., Deiana B., Usala G., Busonero F., et al. Genome-wide association scan for five major dimensions of personality. [published online ahead of print October 28]. Mol Psychiatry (2008)
10. Vincent N., Cox B., and Clara I. Are personality dimensions associated with sleep length in a large nationally representative sample?. Compr Psychiatry 50 (2009) 158-163
11. Stickgold R., Hobson J.A., Fosse R., and Fosse M. Sleep, learning, and dreams: Off-line memory reprocessing. Science 294 (2001) 1052-1057
12. Van Cauter E., Holmback U., Knutson K., Leproult R., Miller A., Nedeltcheva A., et al. Impact of sleep and sleep loss on neuroendocrine and metabolic function. Horm Res 67 suppl 1 (2007) 2-9
13. Aeschbach D., Postolache T.T., Sher L., Matthews J.R., Jackson M.A., and Wehr T.A. Evidence from the waking electroencephalogram that short sleepers live under higher homeostatic sleep pressure than long sleepers. Neuroscience 102 (2001) 493-502
14. Viola A.U., Archer S.N., James L.M., Groeger J.A., Lo J.C., Skene D.J., et al. PER3 polymorphism predicts sleep structure and waking performance. Curr Biol 17 (2007) 613-618
15. Franken P., Dudley C.A., Estill S.J., Barakat M., Thomason R., O'Hara B.F., et al. NPAS2 as a transcriptional regulator of non-rapid eye movement sleep: Genotype and sex interactions. Proc Natl Acad Sci U S A 103 (2006) 7118-7123
16. Franken P., Thomason R., Heller H.C., and O'Hara B.F. A non-circadian role for clock-genes in sleep homeostasis: A strain comparison. BMC Neurosci 8 (2007) 87
17. Partinen M., Kaprio J., Koskenvuo M., Putkonen P., and Langinvainio H. Genetic and environmental determination of human sleep. Sleep 6 (1983) 179-185
18. Tafti M., and Franken P. Invited review: Genetic dissection of sleep. J Appl Physiol 92 (2002) 1339-1347
19. Iwase T., Kajimura N., Uchiyama M., Ebisawa T., Yoshimura K., Kamei Y., et al. Mutation screening of the human clock gene in circadian rhythm sleep disorders. Psychiatry Res 109 (2002) 121-128
20. King V.M., Bentley G.E., and Follett B.K. A direct comparison of photoperiodic time measurement and the circadian system in European starlings and Japanese quail. J Biol Rhythms 12 (1997) 431-442
21. Naylor E., Bergmann B.M., Krauski K., Zee P.C., Takahashi J.S., Vitaterna M.H., et al. The circadian clock mutation alters sleep homeostasis in the mouse. J Neurosci 20 (2000) 8138-8143
22. Siepka S.M., Yoo S.H., Park J., Lee C., and Takahashi J.S. Genetics and neurobiology of circadian clocks in mammals. Cold Spring Harb Symp Quant Biol 72 (2007) 251-259
23. Allebrandt K.V., and Roenneberg T. The search for circadian clock components in humans: New perspectives for association studies. Braz J Med Biol Res 41 (2008) 716-721
24. von Schantz M. Phenotypic effects of genetic variability in human clock genes on circadian and sleep parameters. J Genet 87 (2008) 513-519
25. Gottlieb D.J., O'Connor G.T., and Wilk J.B. Genome-wide association of sleep and circadian phenotypes. BMC Med Genet 8 suppl 1 (2007) S9
26. Pattaro C., Marroni F., Riegler A., Mascalzoni D., Pichler I., Volpato C.B., et al. The genetic study of three population microisolates in South Tyrol (MICROS): Study design and epidemiological perspectives. BMC Med Genet 8 (2007) 29
27. Aulchenko Y.S., de Koning D.J., and Haley C. Genomewide rapid association using mixed model and regression: A fast and simple method for genomewide pedigree-based quantitative trait loci association analysis. Genetics 177 (2007) 577-585
28. Nelis M., Esko T., Magi R., Zimprich F., Zimprich A., Toncheva D., et al. Genetic structure of Europeans: A view from the North-East. PLoS ONE 4 (2009) e5472
29. Kantermann T., Juda M., Merrow M., and Roenneberg T. The human circadian clock's seasonal adjustment is disrupted by daylight saving time. Curr Biol 17 (2007) 1996-2000
30. Barrett J.C., Fry B., Maller J., and Daly M.J. Haploview: Analysis and visualization of LD and haplotype maps. Bioinformatics 21 (2005) 263-265
31. Miller S.A., Dykes D.D., and Polesky H.F. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16 (1988) 1215
32. Storm N., Darnhofer-Patel B., van den Boom D., and Rodi C.P. MALDI-TOF mass spectrometry-based SNP genotyping. Methods Mol Biol 212 (2003) 241-262
33. Heid C.A., Stevens J., Livak K.J., and Williams P.M. Real time quantitative PCR. Genome Res 6 (1996) 986-994
34. Purcell S., Neale B., Todd-Brown K., Thomas L., Ferreira M.A., Bender D., et al. PLINK: A tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81 (2007) 559-575
35. Roenneberg T., Kuehnle T., Pramstaller P.P., Ricken J., Havel M., Guth A., et al. A marker for the end of adolescence. Curr Biol 14 (2004) R1038-R1039
36. Arking D.E., Pfeufer A., Post W., Kao W.H., Newton-Cheh C., Ikeda M., et al. A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization. Nat Genet 38 (2006) 644-651
37. Tonetti L., Fabbri M., and Natale V. Sex difference in sleep-time preference and sleep need: A cross-sectional survey among Italian pre-adolescents, adolescents, and adults. Chronobiol Int 25 (2008) 745-759
38. Sowers M.F., Zheng H., Kravitz H.M., Matthews K., Bromberger J.T., Gold E.B., et al. Sex steroid hormone profiles are related to sleep measures from polysomnography and the Pittsburgh Sleep quality Index. Sleep 31 (2008) 1339-1349
39. Greer W., Sandridge A.L., and Chehabeddine R.S. The frequency distribution of age at natural menopause among Saudi Arabian women. Maturitas 46 (2003) 263-272
40. King D.P., Vitaterna M.H., Chang A.M., Dove W.F., Pinto L.H., Turek F.W., et al. The mouse clock mutation behaves as an antimorph and maps within the W19H deletion, distal of Kit. Genetics 146 (1997) 1049-1060
41. Iuvone P.M., Tosini G., Pozdeyev N., Haque R., Klein D.C., and Chaurasia S.S. Circadian clocks, clock networks, arylalkylamine N-acetyltransferase, and melatonin in the retina. Prog Retin Eye Res 24 (2005) 433-456
42. Panda S., Antoch M.P., Miller B.H., Su A.I., Schook A.B., Straume M., et al. Coordinated transcription of key pathways in the mouse by the circadian clock. Cell 109 (2002) 307-320
43. Jeffreys A.J., Kauppi L., and Neumann R. Intensely punctate meiotic recombination in the class II region of the major histocompatibility complex. Nat Genet 29 (2001) 217-222
44. Serretti A., Benedetti F., Mandelli L., Lorenzi C., Pirovano A., Colombo C., et al. Genetic dissection of psychopathological symptoms: Insomnia in mood disorders and CLOCK gene polymorphism. Am J Med Genet B Neuropsychiatr Genet 121B (2003) 35-38
45. Katzenberg D., Young T., Finn L., Lin L., King D.P., Takahashi J.S., et al. A CLOCK polymorphism associated with human diurnal preference. Sleep 21 (1998) 569-576
46. Mishima K., Tozawa T., Satoh K., Saitoh H., and Mishima Y. The 3111T/C polymorphism of hClock is associated with evening preference and delayed sleep timing in a Japanese population sample. Am J Med Genet B Neuropsychiatr Genet 133B (2005) 101-104
47. Sookoian S., Gemma C., Gianotti T.F., Burgueno A., Castano G., and Pirola C.J. Genetic variants of clock transcription factor are associated with individual susceptibility to obesity. Am J Clin Nutr 87 (2008) 1606-1615
48. Sookoian S., Castano G., Gemma C., Gianotti T.F., and Pirola C.J. Common genetic variations in CLOCK transcription factor are associated with nonalcoholic fatty liver disease. World J Gastroenterol 13 (2007) 4242-4248
49. Taheri S., and Thomas G.N. Is sleep duration associated with obesity-where do U stand?. Sleep Med Rev 12 (2008) 299-302
50. Shi J., Wittke-Thompson J.K., Badner J.A., Hattori E., Potash J.B., Willour V.L., et al. Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm. Am J Med Genet B Neuropsychiatr Genet 147B (2008) 1047-1055
51. Dahl R.E. Regulation of sleep and arousal: Comments on part VII. Ann N Y Acad Sci 1021 (2004) 292-293
52. Harvey A.G., Mullin B.C., and Hinshaw S.P. Sleep and circadian rhythms in children and adolescents with bipolar disorder. Dev Psychopathol 18 (2006) 1147-1168