Targeted disruption of the interaction between WD-40 repeat protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes

Journal of Biological Chemistry

Volumn 291, Issue 43, 2016, Pages 22357-22372

  Alicea Velázquez, Nilda L ^a   Shinsky, Stephen A ^a   Loh, Daniel M ^a   Lee, Jeong Heon ^b   Skalnik, David G ^b   Cosgrove, Michael S ^a  

^a State University of New York Upstate Medical University: College of Medicine   (United States)

^b INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; DISEASES; PROTEINS;

ACUTE LEUKEMIA; COMPLEX ASSEMBLY; DEVELOPMENTAL DISORDERS; ENZYMATIC ACTIVITIES; METHYLTRANSFERASES; PEPTIDOMIMETICS; REPEAT PROTEINS; TRANSCRIPTIONAL ACTIVATIONS;

COMPLEXATION;

BINDING PROTEIN; METHYLTRANSFERASE; MIXED LINEAGE LEUKEMIA PROTEIN; MIXED LINEAGE LEUKEMIA PROTEIN 1; MIXED LINEAGE LEUKEMIA PROTEIN 2; MIXED LINEAGE LEUKEMIA PROTEIN 4; SET1 PROTEIN; SETD1A PROTEIN; UNCLASSIFIED DRUG; WD 40 REPEAT PROTEIN 5; HISTONE LYSINE METHYLTRANSFERASE; MLL PROTEIN, HUMAN; MULTIENZYME COMPLEX; SETD1A PROTEIN, HUMAN; WDR5 PROTEIN, HUMAN;

ARTICLE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; IN VITRO STUDY; MUTATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN FAMILY; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM;

AMINO ACID MOTIFS; HEK293 CELLS; HISTONE-LYSINE N-METHYLTRANSFERASE; HUMANS; MULTIENZYME COMPLEXES; MUTATION; MYELOID-LYMPHOID LEUKEMIA PROTEIN;

EID: 84992391798     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.752626     Document Type: Article

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