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Volumn 317, Issue , 2017, Pages 332-339

Physical exercise induces hippocampal neurogenesis and prevents cognitive decline

Author keywords

Aging; Brain plasticity; Cognition; Exercise; Neurodegenerative disease; Neurogenesis

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; TRANSCRIPTION FACTOR SOX2;

EID: 84992146623     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2016.09.067     Document Type: Review
Times cited : (134)

References (105)
  • 1
    • 77649319831 scopus 로고    scopus 로고
    • Developmental cues and persistent neurogenic potential within an in vitro neural niche
    • (PubMed: 20074373)
    • [1] Pierret, C., Morrison, J.A., Rath, P., Zigler, R.E., Engel, L.A., Fairchild, C.L., et al. Developmental cues and persistent neurogenic potential within an in vitro neural niche. BMC Dev. Biol., 10, 2010, 5 (PubMed: 20074373).
    • (2010) BMC Dev. Biol. , vol.10 , pp. 5
    • Pierret, C.1    Morrison, J.A.2    Rath, P.3    Zigler, R.E.4    Engel, L.A.5    Fairchild, C.L.6
  • 2
    • 77951498581 scopus 로고    scopus 로고
    • New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?
    • (PubMed: 20354534)
    • [2] Deng, W., Aimone, J.B., Gage, F.H., New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?. Nat. Rev. Neurosci. 11 (2010), 339–350 (PubMed: 20354534).
    • (2010) Nat. Rev. Neurosci. , vol.11 , pp. 339-350
    • Deng, W.1    Aimone, J.B.2    Gage, F.H.3
  • 3
    • 0037186524 scopus 로고    scopus 로고
    • Gage FH: Functional neurogenesis in the adult hippocampus
    • (PubMed: 11875571)
    • [3] van Praag, H., Schinder, A.F., Christie, B.R., Toni, N., Palmer, T.D., Gage FH: Functional neurogenesis in the adult hippocampus. Nature 415 (2002), 1030–1034 (PubMed: 11875571).
    • (2002) Nature , vol.415 , pp. 1030-1034
    • van Praag, H.1    Schinder, A.F.2    Christie, B.R.3    Toni, N.4    Palmer, T.D.5
  • 4
    • 31844447757 scopus 로고    scopus 로고
    • GABA regulates synaptic integration of newly generated neurons in the adult brain
    • (PubMed: 16341203)
    • [4] Ge, S., Goh, E.L., Sailor, K.A., Kitabatake, Y., Ming, G.L., Song, H., GABA regulates synaptic integration of newly generated neurons in the adult brain. Nature 439 (2006), 589–593 (PubMed: 16341203).
    • (2006) Nature , vol.439 , pp. 589-593
    • Ge, S.1    Goh, E.L.2    Sailor, K.A.3    Kitabatake, Y.4    Ming, G.L.5    Song, H.6
  • 5
    • 33847163934 scopus 로고    scopus 로고
    • Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus
    • (PubMed: 17277773)
    • [5] Kee, N., Teixeira, C.M., Wang, A.H., Frankland, P.W., Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus. Nat. Neurosci. 10 (2007), 355–362 (PubMed: 17277773).
    • (2007) Nat. Neurosci. , vol.10 , pp. 355-362
    • Kee, N.1    Teixeira, C.M.2    Wang, A.H.3    Frankland, P.W.4
  • 6
    • 59649095732 scopus 로고    scopus 로고
    • Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats
    • (PubMed: 19181621)
    • [6] Jessberger, S., Clark, R.E., Broadbent, N.J., Clemenson, G.D. Jr., Consiglio, A., Lie, D.C., et al. Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. Learn. Mem. 16 (2009), 147–154 (PubMed: 19181621).
    • (2009) Learn. Mem. , vol.16 , pp. 147-154
    • Jessberger, S.1    Clark, R.E.2    Broadbent, N.J.3    Clemenson, G.D.4    Consiglio, A.5    Lie, D.C.6
  • 7
    • 79955526702 scopus 로고    scopus 로고
    • Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
    • (PubMed: 21460835)
    • [7] Sahay, A., Scobie, K.N., Hill, A.S., O'Carroll, C.M., Kheirbek, M.A., Burghardt, N.S., et al. Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation. Nature 472 (2011), 466–470 (PubMed: 21460835).
    • (2011) Nature , vol.472 , pp. 466-470
    • Sahay, A.1    Scobie, K.N.2    Hill, A.S.3    O'Carroll, C.M.4    Kheirbek, M.A.5    Burghardt, N.S.6
  • 8
    • 79956221127 scopus 로고    scopus 로고
    • Pattern separation: a common function for new neurons in hippocampus and olfactory bulb
    • (PubMed: 21609817)
    • [8] Sahay, A., Wilson, D.A., Hen, R., Pattern separation: a common function for new neurons in hippocampus and olfactory bulb. Neuron 70 (2011), 582–588 (PubMed: 21609817).
    • (2011) Neuron , vol.70 , pp. 582-588
    • Sahay, A.1    Wilson, D.A.2    Hen, R.3
  • 9
    • 34548348778 scopus 로고    scopus 로고
    • Adult hippocampal neurogenesis in depression
    • (PubMed: 17726477)
    • [9] Sahay, A., Hen, R., Adult hippocampal neurogenesis in depression. Nat. Neurosci. 10 (2007), 1110–1115 (PubMed: 17726477).
    • (2007) Nat. Neurosci. , vol.10 , pp. 1110-1115
    • Sahay, A.1    Hen, R.2
  • 11
    • 84921936492 scopus 로고    scopus 로고
    • Plasticity of brain and cognition in older adults
    • (PubMed: 25261907)
    • [11] Brehmer, Y., Kalpouzos, G., Wenger, E., Lovden, M., Plasticity of brain and cognition in older adults. Psychol. Res. 78 (2014), 790–802 (PubMed: 25261907).
    • (2014) Psychol. Res. , vol.78 , pp. 790-802
    • Brehmer, Y.1    Kalpouzos, G.2    Wenger, E.3    Lovden, M.4
  • 12
    • 79956209852 scopus 로고    scopus 로고
    • Adult neurogenesis in the mammalian brain: significant answers and significant questions
    • (PubMed: 21609825)
    • [12] Ming, G.L., Song, H., Adult neurogenesis in the mammalian brain: significant answers and significant questions. Neuron 70 (2011), 687–702 (PubMed: 21609825).
    • (2011) Neuron , vol.70 , pp. 687-702
    • Ming, G.L.1    Song, H.2
  • 13
    • 30644474606 scopus 로고    scopus 로고
    • Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus
    • (PubMed: 16399667)
    • [13] Zhao, C., Teng, E.M., Summers, R.G. Jr., Ming, G.L., Gage, F.H., Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus. J. Neurosci. 26 (2006), 3–11 (PubMed: 16399667).
    • (2006) J. Neurosci. , vol.26 , pp. 3-11
    • Zhao, C.1    Teng, E.M.2    Summers, R.G.3    Ming, G.L.4    Gage, F.H.5
  • 14
    • 84900001780 scopus 로고    scopus 로고
    • Physical exercise-induced adult neurogenesis: a good strategy to prevent cognitive decline in neurodegenerative diseases?
    • (PubMed: 24818140)
    • [14] Yau, S.Y., Gil-Mohapel, J., Christie, B.R., So, K.F., Physical exercise-induced adult neurogenesis: a good strategy to prevent cognitive decline in neurodegenerative diseases?. BioMed. Res. Int., 2014, 2014, 403120 (PubMed: 24818140).
    • (2014) BioMed. Res. Int. , vol.2014 , pp. 403120
    • Yau, S.Y.1    Gil-Mohapel, J.2    Christie, B.R.3    So, K.F.4
  • 15
    • 84936863942 scopus 로고    scopus 로고
    • Long-term mild, rather than intense, exercise enhances adult hippocampal neurogenesis and greatly changes the transcriptomic profile of the hippocampus
    • (PubMed: 26061528)
    • [15] Inoue, K., Okamoto, M., Shibato, J., Lee, M.C., Matsui, T., Rakwal, R., et al. Long-term mild, rather than intense, exercise enhances adult hippocampal neurogenesis and greatly changes the transcriptomic profile of the hippocampus. PLoS One, 10, 2015, e0128720 (PubMed: 26061528).
    • (2015) PLoS One , vol.10 , pp. e0128720
    • Inoue, K.1    Okamoto, M.2    Shibato, J.3    Lee, M.C.4    Matsui, T.5    Rakwal, R.6
  • 16
    • 84874380742 scopus 로고    scopus 로고
    • Voluntary resistance running induces increased hippocampal neurogenesis in rats comparable to load-free running
    • (PubMed: 23352660)
    • [16] Lee, M.C., Inoue, K., Okamoto, M., Liu, Y.F., Matsui, T., Yook, J.S., et al. Voluntary resistance running induces increased hippocampal neurogenesis in rats comparable to load-free running. Neurosci. Lett. 537 (2013), 6–10 (PubMed: 23352660).
    • (2013) Neurosci. Lett. , vol.537 , pp. 6-10
    • Lee, M.C.1    Inoue, K.2    Okamoto, M.3    Liu, Y.F.4    Matsui, T.5    Yook, J.S.6
  • 17
    • 84945546892 scopus 로고    scopus 로고
    • Effects of treadmill exercise on hippocampal neurogenesis in an MPTP/probenecid-induced Parkinson's disease mouse model
    • (PubMed: 26644675)
    • [17] Sung, Y.H., Effects of treadmill exercise on hippocampal neurogenesis in an MPTP/probenecid-induced Parkinson's disease mouse model. J. Phys. Sci. 27 (2015), 3203–3206 (PubMed: 26644675).
    • (2015) J. Phys. Sci. , vol.27 , pp. 3203-3206
    • Sung, Y.H.1
  • 18
    • 84949257529 scopus 로고    scopus 로고
    • Running rewires the neuronal network of adult-born dentate granule cells
    • (PubMed: 26589333)
    • [18] Vivar, C., Peterson, B.D., van Praag, H., Running rewires the neuronal network of adult-born dentate granule cells. Neuroimage 131 (2016), 29–41 (PubMed: 26589333).
    • (2016) Neuroimage , vol.131 , pp. 29-41
    • Vivar, C.1    Peterson, B.D.2    van Praag, H.3
  • 20
    • 77952475340 scopus 로고    scopus 로고
    • Murine features of neurogenesis in the human hippocampus across the lifespan from 0 to 100 years
    • (PubMed: 20126454)
    • [20] Knoth, R., Singec, I., Ditter, M., Pantazis, G., Capetian, P., Meyer, R.P., et al. Murine features of neurogenesis in the human hippocampus across the lifespan from 0 to 100 years. PLoS One, 5, 2010, e8809 (PubMed: 20126454).
    • (2010) PLoS One , vol.5 , pp. e8809
    • Knoth, R.1    Singec, I.2    Ditter, M.3    Pantazis, G.4    Capetian, P.5    Meyer, R.P.6
  • 21
    • 0034101536 scopus 로고    scopus 로고
    • In vitro neurogenesis by progenitor cells isolated from the adult human hippocampus
    • (PubMed: 10700228)
    • [21] Roy, N.S., Wang, S., Jiang, L., Kang, J., Benraiss, A., Harrison-Restelli, C., et al. In vitro neurogenesis by progenitor cells isolated from the adult human hippocampus. Nat. Med. 6 (2000), 271–277 (PubMed: 10700228).
    • (2000) Nat. Med. , vol.6 , pp. 271-277
    • Roy, N.S.1    Wang, S.2    Jiang, L.3    Kang, J.4    Benraiss, A.5    Harrison-Restelli, C.6
  • 22
    • 84861892457 scopus 로고    scopus 로고
    • Adult human brain neural progenitor cells (NPCs) and fibroblast-like cells have similar properties in vitro but only NPCs differentiate into neurons
    • (PubMed: 22675489)
    • [22] Park, T.I., Monzo, H., Mee, E.W., Bergin, P.S., Teoh, H.H., Montgomery, J.M., et al. Adult human brain neural progenitor cells (NPCs) and fibroblast-like cells have similar properties in vitro but only NPCs differentiate into neurons. PLoS One, 7, 2012, e37742 (PubMed: 22675489).
    • (2012) PLoS One , vol.7 , pp. e37742
    • Park, T.I.1    Monzo, H.2    Mee, E.W.3    Bergin, P.S.4    Teoh, H.H.5    Montgomery, J.M.6
  • 23
    • 84878831768 scopus 로고    scopus 로고
    • Dynamics of hippocampal neurogenesis in adult humans
    • (PubMed: 23746839)
    • [23] Spalding, K.L., Bergmann, O., Alkass, K., Bernard, S., Salehpour, M., Huttner, H.B., et al. Dynamics of hippocampal neurogenesis in adult humans. Cell 153 (2013), 1219–1227 (PubMed: 23746839).
    • (2013) Cell , vol.153 , pp. 1219-1227
    • Spalding, K.L.1    Bergmann, O.2    Alkass, K.3    Bernard, S.4    Salehpour, M.5    Huttner, H.B.6
  • 24
    • 36048970985 scopus 로고    scopus 로고
    • Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain
    • (PubMed: 17991865)
    • [24] Manganas, L.N., Zhang, X., Li, Y., Hazel, R.D., Smith, S.D., Wagshul, M.E., et al. Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain. Science 318 (2007), 980–985 (PubMed: 17991865).
    • (2007) Science , vol.318 , pp. 980-985
    • Manganas, L.N.1    Zhang, X.2    Li, Y.3    Hazel, R.D.4    Smith, S.D.5    Wagshul, M.E.6
  • 26
    • 84855946885 scopus 로고    scopus 로고
    • Could adult hippocampal neurogenesis be relevant for human behavior?
    • (PubMed: 21736900)
    • [26] Snyder, J.S., Cameron, H.A., Could adult hippocampal neurogenesis be relevant for human behavior?. Behav. Brain Res. 227 (2012), 384–390 (PubMed: 21736900).
    • (2012) Behav. Brain Res. , vol.227 , pp. 384-390
    • Snyder, J.S.1    Cameron, H.A.2
  • 27
    • 0029863342 scopus 로고    scopus 로고
    • Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation
    • (PubMed: 8604047)
    • [27] Kuhn, H.G., Dickinson-Anson, H., Gage, F.H., Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J. Neurosci. 16 (1996), 2027–2033 (PubMed: 8604047).
    • (1996) J. Neurosci. , vol.16 , pp. 2027-2033
    • Kuhn, H.G.1    Dickinson-Anson, H.2    Gage, F.H.3
  • 28
    • 36749037197 scopus 로고    scopus 로고
    • Diminished adult neurogenesis in the marmoset brain precedes old age
    • (PubMed: 17940008)
    • [28] Leuner, B., Kozorovitskiy, Y., Gross, C.G., Gould, E., Diminished adult neurogenesis in the marmoset brain precedes old age. Proc. Natl. Acad. Sci. U. S. A. 104 (2007), 17169–17173 (PubMed: 17940008).
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 17169-17173
    • Leuner, B.1    Kozorovitskiy, Y.2    Gross, C.G.3    Gould, E.4
  • 29
    • 52949147794 scopus 로고    scopus 로고
    • Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain
    • (PubMed: 18758458)
    • [29] Imayoshi, I., Sakamoto, M., Ohtsuka, T., Takao, K., Miyakawa, T., Yamaguchi, M., et al. Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain. Nat. Neurosci. 11 (2008), 1153–1161 (PubMed: 18758458).
    • (2008) Nat. Neurosci. , vol.11 , pp. 1153-1161
    • Imayoshi, I.1    Sakamoto, M.2    Ohtsuka, T.3    Takao, K.4    Miyakawa, T.5    Yamaguchi, M.6
  • 30
    • 79959949607 scopus 로고    scopus 로고
    • Maturation time of new granule cells in the dentate gyrus of adult macaque monkeys exceeds six months
    • (PubMed: 21646517)
    • [30] Kohler, S.J., Williams, N.I., Stanton, G.B., Cameron, J.L., Greenough, W.T., Maturation time of new granule cells in the dentate gyrus of adult macaque monkeys exceeds six months. Proc. Natl. Acad. Sci. U. S. A. 108 (2011), 10326–10331 (PubMed: 21646517).
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. 10326-10331
    • Kohler, S.J.1    Williams, N.I.2    Stanton, G.B.3    Cameron, J.L.4    Greenough, W.T.5
  • 32
    • 84928128189 scopus 로고    scopus 로고
    • Memory, scene construction, and the human hippocampus
    • (PubMed: 25825712)
    • [32] Kim, S., Dede, A.J., Hopkins, R.O., Squire, L.R., Memory, scene construction, and the human hippocampus. Proc. Natl. Acad. Sci. U. S. A. 112 (2015), 4767–4772 (PubMed: 25825712).
    • (2015) Proc. Natl. Acad. Sci. U. S. A. , vol.112 , pp. 4767-4772
    • Kim, S.1    Dede, A.J.2    Hopkins, R.O.3    Squire, L.R.4
  • 33
    • 84876204357 scopus 로고    scopus 로고
    • Hippocampal damage impairs recognition memory broadly, affecting both parameters in two prominent models of memory
    • (PubMed: 23576763)
    • [33] Dede, A.J., Wixted, J.T., Hopkins, R.O., Squire, L.R., Hippocampal damage impairs recognition memory broadly, affecting both parameters in two prominent models of memory. Proc. Natl. Acad. Sci. U. S. A. 110 (2013), 6577–6582 (PubMed: 23576763).
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , pp. 6577-6582
    • Dede, A.J.1    Wixted, J.T.2    Hopkins, R.O.3    Squire, L.R.4
  • 34
    • 48849105360 scopus 로고    scopus 로고
    • Hippocampal neurogenesis and depression
    • (discussion 60-4, 93-5. [PubMed: 18497101])
    • [34] Sahay, A., Hen, R., Hippocampal neurogenesis and depression. Novartis Found. Symp. 289 (2008), 152–160 (discussion 60-4, 93-5. [PubMed: 18497101]).
    • (2008) Novartis Found. Symp. , vol.289 , pp. 152-160
    • Sahay, A.1    Hen, R.2
  • 35
    • 26844457643 scopus 로고    scopus 로고
    • Hippocampal c-fos is necessary for long-term memory of a socially transmitted food preference
    • (PubMed: 16122949)
    • [35] Countryman, R.A., Kaban, N.L., Colombo, P.J., Hippocampal c-fos is necessary for long-term memory of a socially transmitted food preference. Neurobiol. Learn Mem. 84 (2005), 175–183 (PubMed: 16122949).
    • (2005) Neurobiol. Learn Mem. , vol.84 , pp. 175-183
    • Countryman, R.A.1    Kaban, N.L.2    Colombo, P.J.3
  • 36
    • 34249279806 scopus 로고    scopus 로고
    • Time-courses of Fos expression in rat hippocampus and neocortex following acquisition and recall of a socially transmitted food preference
    • (PubMed: 17448703)
    • [36] Smith, C.A., Countryman, R.A., Sahuque, L.L., Colombo, P.J., Time-courses of Fos expression in rat hippocampus and neocortex following acquisition and recall of a socially transmitted food preference. Neurobiol. Learn Mem. 88 (2007), 65–74 (PubMed: 17448703).
    • (2007) Neurobiol. Learn Mem. , vol.88 , pp. 65-74
    • Smith, C.A.1    Countryman, R.A.2    Sahuque, L.L.3    Colombo, P.J.4
  • 37
    • 33947498496 scopus 로고    scopus 로고
    • Experience-specific functional modification of the dentate gyrus through adult neurogenesis: a critical period during an immature stage
    • (PubMed: 16906136)
    • [37] Tashiro, A., Makino, H., Gage, F.H., Experience-specific functional modification of the dentate gyrus through adult neurogenesis: a critical period during an immature stage. J. Neurosci. 27 (2007), 3252–3259 (PubMed: 16906136).
    • (2007) J. Neurosci. , vol.27 , pp. 3252-3259
    • Tashiro, A.1    Makino, H.2    Gage, F.H.3
  • 38
    • 84872715007 scopus 로고    scopus 로고
    • Sustained transcription of the immediate early gene Arc in the dentate gyrus after spatial exploration
    • (PubMed: 23345235)
    • [38] Ramirez-Amaya, V., Angulo-Perkins, A., Chawla, M.K., Barnes, C.A., Rosi, S., Sustained transcription of the immediate early gene Arc in the dentate gyrus after spatial exploration. J. Neurosci. 33 (2013), 1631–1639 (PubMed: 23345235).
    • (2013) J. Neurosci. , vol.33 , pp. 1631-1639
    • Ramirez-Amaya, V.1    Angulo-Perkins, A.2    Chawla, M.K.3    Barnes, C.A.4    Rosi, S.5
  • 39
    • 11844289586 scopus 로고    scopus 로고
    • A role for adult neurogenesis in spatial long-term memory
    • (PubMed: 15652983)
    • [39] Snyder, J.S., Hong, N.S., McDonald, R.J., Wojtowicz, J.M., A role for adult neurogenesis in spatial long-term memory. Neurosci 130 (2005), 843–852 (PubMed: 15652983).
    • (2005) Neurosci , vol.130 , pp. 843-852
    • Snyder, J.S.1    Hong, N.S.2    McDonald, R.J.3    Wojtowicz, J.M.4
  • 40
    • 33751213392 scopus 로고    scopus 로고
    • Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus
    • (PubMed: 17088541)
    • [40] Saxe, M.D., Battaglia, F., Wang, J.W., Malleret, G., David, D.J., Monckton, J.E., et al. Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus. Proc. Natl. Acad. Sci. U. S. A. 103 (2006), 17501–17506 (PubMed: 17088541).
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 17501-17506
    • Saxe, M.D.1    Battaglia, F.2    Wang, J.W.3    Malleret, G.4    David, D.J.5    Monckton, J.E.6
  • 41
    • 84939262538 scopus 로고    scopus 로고
    • Increasing adult hippocampal neurogenesis is sufficient to reduce anxiety and depression-like behaviors
    • (PubMed: 25833129)
    • [41] Hill, A.S., Sahay, A., Hen, R., Increasing adult hippocampal neurogenesis is sufficient to reduce anxiety and depression-like behaviors. Neuropsychopharmacology 40 (2015), 2368–2378 (PubMed: 25833129).
    • (2015) Neuropsychopharmacology , vol.40 , pp. 2368-2378
    • Hill, A.S.1    Sahay, A.2    Hen, R.3
  • 42
    • 84055213663 scopus 로고    scopus 로고
    • Adult hippocampal neurogenesis and its role in Alzheimer's disease
    • (PubMed: 22192775)
    • [42] Mu, Y., Gage, F.H., Adult hippocampal neurogenesis and its role in Alzheimer's disease. Mol. Neurodegener., 6, 2011, 85 (PubMed: 22192775).
    • (2011) Mol. Neurodegener. , vol.6 , pp. 85
    • Mu, Y.1    Gage, F.H.2
  • 43
    • 84862128094 scopus 로고    scopus 로고
    • Activation of different neural precursor populations in the adult hippocampus: does this lead to new neurons with discrete functions?
    • (PubMed: 22505142)
    • [43] Jhaveri, D.J., Taylor, C.J., Bartlett, P.F., Activation of different neural precursor populations in the adult hippocampus: does this lead to new neurons with discrete functions?. Dev. Neurobiol. 72 (2012), 1044–1058 (PubMed: 22505142).
    • (2012) Dev. Neurobiol. , vol.72 , pp. 1044-1058
    • Jhaveri, D.J.1    Taylor, C.J.2    Bartlett, P.F.3
  • 44
    • 34247598445 scopus 로고    scopus 로고
    • Neural stem cells, neural progenitors, and neurotrophic factors
    • (PubMed: 17474295)
    • [44] Hsu, Y.C., Lee, D.C., Chiu, I.M., Neural stem cells, neural progenitors, and neurotrophic factors. Cell Transplant. 16 (2007), 133–150 (PubMed: 17474295).
    • (2007) Cell Transplant. , vol.16 , pp. 133-150
    • Hsu, Y.C.1    Lee, D.C.2    Chiu, I.M.3
  • 45
    • 39149107803 scopus 로고    scopus 로고
    • Mechanisms and functional implications of adult neurogenesis
    • (PubMed: 18295581)
    • [45] Zhao, C., Deng, W., Gage, F.H., Mechanisms and functional implications of adult neurogenesis. Cell 132 (2008), 645–660 (PubMed: 18295581).
    • (2008) Cell , vol.132 , pp. 645-660
    • Zhao, C.1    Deng, W.2    Gage, F.H.3
  • 46
    • 84865801305 scopus 로고    scopus 로고
    • Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision
    • (PubMed: 22842902)
    • [46] Song, J., Zhong, C., Bonaguidi, M.A., Sun, G.J., Hsu, D., Gu, Y., et al. Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision. Nature 489 (2012), 150–154 (PubMed: 22842902).
    • (2012) Nature , vol.489 , pp. 150-154
    • Song, J.1    Zhong, C.2    Bonaguidi, M.A.3    Sun, G.J.4    Hsu, D.5    Gu, Y.6
  • 47
    • 48149105674 scopus 로고    scopus 로고
    • Neurons born in the adult dentate gyrus form functional synapses with target cells
    • (PubMed: 18622400)
    • [47] Toni, N., Laplagne, D.A., Zhao, C., Lombardi, G., Ribak, C.E., Gage, F.H., et al. Neurons born in the adult dentate gyrus form functional synapses with target cells. Nat. Neurosci. 11 (2008), 901–907 (PubMed: 18622400).
    • (2008) Nat. Neurosci. , vol.11 , pp. 901-907
    • Toni, N.1    Laplagne, D.A.2    Zhao, C.3    Lombardi, G.4    Ribak, C.E.5    Gage, F.H.6
  • 48
    • 84888334128 scopus 로고    scopus 로고
    • Parvalbumin interneurons mediate neuronal circuitry-neurogenesis coupling in the adult hippocampus
    • (PubMed: 24212671)
    • [48] Song, J., Sun, J., Moss, J., Wen, Z., Sun, G.J., Hsu, D., et al. Parvalbumin interneurons mediate neuronal circuitry-neurogenesis coupling in the adult hippocampus. Nat. Neurosci. 16 (2013), 1728–1730 (PubMed: 24212671).
    • (2013) Nat. Neurosci. , vol.16 , pp. 1728-1730
    • Song, J.1    Sun, J.2    Moss, J.3    Wen, Z.4    Sun, G.J.5    Hsu, D.6
  • 49
    • 34249680733 scopus 로고    scopus 로고
    • Synapse formation on neurons born in the adult hippocampus
    • (PubMed: 17486101)
    • [49] Toni, N., Teng, E.M., Bushong, E.A., Aimone, J.B., Zhao, C., Consiglio, A., et al. Synapse formation on neurons born in the adult hippocampus. Nat. Neurosci. 10 (2007), 727–734 (PubMed: 17486101).
    • (2007) Nat. Neurosci. , vol.10 , pp. 727-734
    • Toni, N.1    Teng, E.M.2    Bushong, E.A.3    Aimone, J.B.4    Zhao, C.5    Consiglio, A.6
  • 50
    • 52949109794 scopus 로고    scopus 로고
    • Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brain
    • (PubMed: 18780780)
    • [50] Faulkner, R.L., Jang, M.H., Liu, X.B., Duan, X., Sailor, K.A., Kim, J.Y., et al. Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brain. Proc. Natl. Acad. Sci. U. S. A. 105 (2008), 14157–14162 (PubMed: 18780780).
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 14157-14162
    • Faulkner, R.L.1    Jang, M.H.2    Liu, X.B.3    Duan, X.4    Sailor, K.A.5    Kim, J.Y.6
  • 51
    • 0038301570 scopus 로고    scopus 로고
    • Short-term and long-term survival of new neurons in the rat dentate gyrus
    • (PubMed: 12717714)
    • [51] Dayer, A.G., Ford, A.A., Cleaver, K.M., Yassaee, M., Cameron, H.A., Short-term and long-term survival of new neurons in the rat dentate gyrus. J. Comp. Neurol. 460 (2003), 563–572 (PubMed: 12717714).
    • (2003) J. Comp. Neurol. , vol.460 , pp. 563-572
    • Dayer, A.G.1    Ford, A.A.2    Cleaver, K.M.3    Yassaee, M.4    Cameron, H.A.5
  • 52
    • 21344464438 scopus 로고    scopus 로고
    • Dynamics of neurogenesis in the dentate gyrus of adult rats
    • (PubMed: 15967575)
    • [52] McDonald, H.Y., Wojtowicz, J.M., Dynamics of neurogenesis in the dentate gyrus of adult rats. Neurosci. Lett. 385 (2005), 70–75 (PubMed: 15967575).
    • (2005) Neurosci. Lett. , vol.385 , pp. 70-75
    • McDonald, H.Y.1    Wojtowicz, J.M.2
  • 53
    • 2442642871 scopus 로고    scopus 로고
    • Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus
    • (PubMed: 15107864)
    • [53] Schmidt-Hieber, C., Jonas, P., Bischofberger, J., Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus. Nature 429 (2004), 184–187 (PubMed: 15107864).
    • (2004) Nature , vol.429 , pp. 184-187
    • Schmidt-Hieber, C.1    Jonas, P.2    Bischofberger, J.3
  • 54
    • 34248577303 scopus 로고    scopus 로고
    • A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain
    • (PubMed: 17521569)
    • [54] Ge, S., Yang, C.H., Hsu, K.S., Ming, G.L., Song, H., A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain. Neuron 54 (2007), 559–566 (PubMed: 17521569).
    • (2007) Neuron , vol.54 , pp. 559-566
    • Ge, S.1    Yang, C.H.2    Hsu, K.S.3    Ming, G.L.4    Song, H.5
  • 55
    • 33747827189 scopus 로고    scopus 로고
    • NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus
    • (PubMed: 16906136)
    • [55] Tashiro, A., Sandler, V.M., Toni, N., Zhao, C., Gage, F.H., NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus. Nature 442 (2006), 929–933 (PubMed: 16906136).
    • (2006) Nature , vol.442 , pp. 929-933
    • Tashiro, A.1    Sandler, V.M.2    Toni, N.3    Zhao, C.4    Gage, F.H.5
  • 56
    • 84925389871 scopus 로고    scopus 로고
    • A critical period for experience-dependent remodeling of adult-born neuron connectivity
    • (PubMed: 25661179)
    • [56] Bergami, M., Masserdotti, G., Temprana, S.G., Motori, E., Eriksson, T.M., Gobel, J., et al. A critical period for experience-dependent remodeling of adult-born neuron connectivity. Neuron 85 (2015), 710–717 (PubMed: 25661179).
    • (2015) Neuron , vol.85 , pp. 710-717
    • Bergami, M.1    Masserdotti, G.2    Temprana, S.G.3    Motori, E.4    Eriksson, T.M.5    Gobel, J.6
  • 57
    • 79955776987 scopus 로고    scopus 로고
    • Relationship of aerobic fitness and motor skills with memory and attention in preschoolers (Ballabeina): a cross-sectional and longitudinal study
    • (PubMed: 21569343)
    • [57] Niederer, I., Kriemler, S., Gut, J., Hartmann, T., Schindler, C., Barral, J., et al. Relationship of aerobic fitness and motor skills with memory and attention in preschoolers (Ballabeina): a cross-sectional and longitudinal study. BMC Pediatr., 11, 2011, 34 (PubMed: 21569343).
    • (2011) BMC Pediatr. , vol.11 , pp. 34
    • Niederer, I.1    Kriemler, S.2    Gut, J.3    Hartmann, T.4    Schindler, C.5    Barral, J.6
  • 58
    • 58449094251 scopus 로고    scopus 로고
    • Aerobic fitness and cognitive development: event-related brain potential and task performance indices of executive control in preadolescent children
    • (PubMed: 19209995)
    • [58] Hillman, C.H., Buck, S.M., Themanson, J.R., Pontifex, M.B., Castelli, D.M., Aerobic fitness and cognitive development: event-related brain potential and task performance indices of executive control in preadolescent children. Dev. Psychol. 45 (2009), 114–129 (PubMed: 19209995).
    • (2009) Dev. Psychol. , vol.45 , pp. 114-129
    • Hillman, C.H.1    Buck, S.M.2    Themanson, J.R.3    Pontifex, M.B.4    Castelli, D.M.5
  • 59
    • 80053959212 scopus 로고    scopus 로고
    • The effects of physical activity and physical fitness on children's achievement and cognitive outcomes: a meta-analysis
    • (PubMed: 21957711)
    • [59] Fedewa, A.L., Ahn, S., The effects of physical activity and physical fitness on children's achievement and cognitive outcomes: a meta-analysis. Res Q Exer Sport. 82 (2011), 521–535 (PubMed: 21957711).
    • (2011) Res Q Exer Sport. , vol.82 , pp. 521-535
    • Fedewa, A.L.1    Ahn, S.2
  • 61
    • 77951447854 scopus 로고    scopus 로고
    • Aerobic exercise and neurocognitive performance: a meta-analytic review of randomized controlled trials
    • (PubMed: 20223924)
    • [61] Smith, P.J., Blumenthal, J.A., Hoffman, B.M., Cooper, H., Strauman, T.A., Welsh-Bohmer, K., et al. Aerobic exercise and neurocognitive performance: a meta-analytic review of randomized controlled trials. Psychosom. Med. 72 (2010), 239–252 (PubMed: 20223924).
    • (2010) Psychosom. Med. , vol.72 , pp. 239-252
    • Smith, P.J.1    Blumenthal, J.A.2    Hoffman, B.M.3    Cooper, H.4    Strauman, T.A.5    Welsh-Bohmer, K.6
  • 62
    • 84986310084 scopus 로고    scopus 로고
    • Exercise and fitness modulate cognitive function in older adults
    • (PubMed: 26652724)
    • [62] Chu, C.H., Chen, A.G., Hung, T.M., Wang, C.C., Chang, Y.K., Exercise and fitness modulate cognitive function in older adults. Psychol. Aging 30 (2015), 842–848 (PubMed: 26652724).
    • (2015) Psychol. Aging , vol.30 , pp. 842-848
    • Chu, C.H.1    Chen, A.G.2    Hung, T.M.3    Wang, C.C.4    Chang, Y.K.5
  • 63
    • 84896709141 scopus 로고    scopus 로고
    • Tai Ji Quan and global cognitive function in older adults with cognitive impairment: a pilot study
    • (PubMed: 24398166)
    • [63] Li, F., Harmer, P., Liu, Y., Chou, L.S., Tai Ji Quan and global cognitive function in older adults with cognitive impairment: a pilot study. Arch. Gerontol. Geriatr. 58 (2014), 434–439 (PubMed: 24398166).
    • (2014) Arch. Gerontol. Geriatr. , vol.58 , pp. 434-439
    • Li, F.1    Harmer, P.2    Liu, Y.3    Chou, L.S.4
  • 64
    • 0033539607 scopus 로고    scopus 로고
    • Running enhances neurogenesis, learning, and long-term potentiation in mice
    • (PubMed: 10557337)
    • [64] van Praag, H., Christie, B.R., Sejnowski, T.J., Gage, F.H., Running enhances neurogenesis, learning, and long-term potentiation in mice. Proc. Natl. Acad. Sci. U. S. A. 96 (1999), 13427–13431 (PubMed: 10557337).
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 13427-13431
    • van Praag, H.1    Christie, B.R.2    Sejnowski, T.J.3    Gage, F.H.4
  • 65
    • 84922763017 scopus 로고    scopus 로고
    • Effect of high-intensity exercise on aged mouse brain mitochondria, neurogenesis, and inflammation
    • (PubMed: 25002036)
    • [65] L, E., Burns, J.M., Swerdlow, R.H., Effect of high-intensity exercise on aged mouse brain mitochondria, neurogenesis, and inflammation. Neurobiol. Aging 35 (2014), 2574–2583 (PubMed: 25002036).
    • (2014) Neurobiol. Aging , vol.35 , pp. 2574-2583
    • Burns, J.M.1    Swerdlow, R.H.2
  • 66
    • 25444533023 scopus 로고    scopus 로고
    • Exercise enhances learning and hippocampal neurogenesis in aged mice
    • (PubMed: 16177036)
    • [66] van Praag, H., Shubert, T., Zhao, C., Gage, F.H., Exercise enhances learning and hippocampal neurogenesis in aged mice. J. Neurosci. 25 (2005), 8680–8685 (PubMed: 16177036).
    • (2005) J. Neurosci. , vol.25 , pp. 8680-8685
    • van Praag, H.1    Shubert, T.2    Zhao, C.3    Gage, F.H.4
  • 67
    • 84892434560 scopus 로고    scopus 로고
    • Forced running exercise attenuates hippocampal neurogenesis impairment and the neurocognitive deficits induced by whole-brain irradiation via the BDNF-mediated pathway
    • (PubMed: 24333433)
    • [67] Ji, J.F., Ji, S.J., Sun, R., Li, K., Zhang, Y., Zhang, L.Y., et al. Forced running exercise attenuates hippocampal neurogenesis impairment and the neurocognitive deficits induced by whole-brain irradiation via the BDNF-mediated pathway. Biochem. Biophys. Res. Commun. 443 (2014), 646–651 (PubMed: 24333433).
    • (2014) Biochem. Biophys. Res. Commun. , vol.443 , pp. 646-651
    • Ji, J.F.1    Ji, S.J.2    Sun, R.3    Li, K.4    Zhang, Y.5    Zhang, L.Y.6
  • 68
    • 63849241816 scopus 로고    scopus 로고
    • Anatomical gradients of adult neurogenesis and activity: young neurons in the ventral dentate gyrus are activated by water maze training
    • (PubMed: 19004012)
    • [68] Snyder, J.S., Radik, R., Wojtowicz, J.M., Cameron, H.A., Anatomical gradients of adult neurogenesis and activity: young neurons in the ventral dentate gyrus are activated by water maze training. Hippocampus 19 (2009), 360–370 (PubMed: 19004012).
    • (2009) Hippocampus , vol.19 , pp. 360-370
    • Snyder, J.S.1    Radik, R.2    Wojtowicz, J.M.3    Cameron, H.A.4
  • 69
    • 45849151100 scopus 로고    scopus 로고
    • Spatial relational memory requires hippocampal adult neurogenesis
    • (PubMed: 18509506)
    • [69] Dupret, D., Revest, J.M., Koehl, M., Ichas, F., De Giorgi, F., Costet, P., et al. Spatial relational memory requires hippocampal adult neurogenesis. PLoS One, 3, 2008, e1959 (PubMed: 18509506).
    • (2008) PLoS One , vol.3 , pp. e1959
    • Dupret, D.1    Revest, J.M.2    Koehl, M.3    Ichas, F.4    De Giorgi, F.5    Costet, P.6
  • 70
    • 0035868717 scopus 로고    scopus 로고
    • Neurogenesis in the adult is involved in the formation of trace memories
    • (PubMed: 11268214)
    • [70] Shors, T.J., Miesegaes, G., Beylin, A., Zhao, M., Rydel, T., Gould, E., Neurogenesis in the adult is involved in the formation of trace memories. Nature 410 (2001), 372–376 (PubMed: 11268214).
    • (2001) Nature , vol.410 , pp. 372-376
    • Shors, T.J.1    Miesegaes, G.2    Beylin, A.3    Zhao, M.4    Rydel, T.5    Gould, E.6
  • 71
    • 65249124662 scopus 로고    scopus 로고
    • Recruitment of adult-generated neurons into functional hippocampal networks contributes to updating and strengthening of spatial memory
    • (PubMed: 19321751)
    • [71] [71].Trouche, S., Bontempi, B., Roullet, P., Rampon, C., Recruitment of adult-generated neurons into functional hippocampal networks contributes to updating and strengthening of spatial memory. Proc. Natl. Acad. Sci. U. S. A. 106 (2009), 5919–5924 (PubMed: 19321751).
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 5919-5924
    • Trouche, S.1    Bontempi, B.2    Roullet, P.3    Rampon, C.4
  • 72
    • 84964572490 scopus 로고    scopus 로고
    • Running rewires the neuronal network of adult-born dentate granule cells
    • (PubMed: 26589333])
    • [72] Vivar C, Peterson, B.D., van Praag, H., Running rewires the neuronal network of adult-born dentate granule cells. Neuroimage, 2015 (PubMed: 26589333]).
    • (2015) Neuroimage
    • Vivar C1    Peterson, B.D.2    van Praag, H.3
  • 73
    • 0036436191 scopus 로고    scopus 로고
    • Neurogenesis may relate to some but not all types of hippocampal-dependent learning
    • (PubMed: 12440573)
    • [73] Shors, T.J., Townsend, D.A., Zhao, M., Kozorovitskiy, Y., Gould, E., Neurogenesis may relate to some but not all types of hippocampal-dependent learning. Hippocampus 12 (2002), 578–584 (PubMed: 12440573).
    • (2002) Hippocampus , vol.12 , pp. 578-584
    • Shors, T.J.1    Townsend, D.A.2    Zhao, M.3    Kozorovitskiy, Y.4    Gould, E.5
  • 74
    • 84939838875 scopus 로고    scopus 로고
    • Experience-dependent regulation of dentate gyrus excitability by adult-born granule cells
    • (PubMed: 26290242)
    • [74] Park, E.H., Burghardt, N.S., Dvorak, D., Hen, R., Fenton, A.A., Experience-dependent regulation of dentate gyrus excitability by adult-born granule cells. J. Neurosci. 35 (2015), 11656–11666 (PubMed: 26290242).
    • (2015) J. Neurosci. , vol.35 , pp. 11656-11666
    • Park, E.H.1    Burghardt, N.S.2    Dvorak, D.3    Hen, R.4    Fenton, A.A.5
  • 75
    • 0034548865 scopus 로고    scopus 로고
    • Adult spinal cord stem cells generate neurons after transplantation in the adult dentate gyrus
    • (PubMed: 11102479)
    • [75] Shihabuddin, L.S., Horner, P.J., Ray, J., Gage, F.H., Adult spinal cord stem cells generate neurons after transplantation in the adult dentate gyrus. J. Neurosci. 20 (2000), 8727–8735 (PubMed: 11102479).
    • (2000) J. Neurosci. , vol.20 , pp. 8727-8735
    • Shihabuddin, L.S.1    Horner, P.J.2    Ray, J.3    Gage, F.H.4
  • 76
    • 36448982477 scopus 로고    scopus 로고
    • Brain micro-ecologies: neural stem cell niches in the adult mammalian brain
    • (PubMed: 17322003)
    • [76] Riquelme, P.A., Drapeau, E., Doetsch, F., Brain micro-ecologies: neural stem cell niches in the adult mammalian brain. Philos. Trans. R. Soc. Lond. B. Bio. Sci. 363 (2008), 123–137 (PubMed: 17322003).
    • (2008) Philos. Trans. R. Soc. Lond. B. Bio. Sci. , vol.363 , pp. 123-137
    • Riquelme, P.A.1    Drapeau, E.2    Doetsch, F.3
  • 78
    • 78149314205 scopus 로고    scopus 로고
    • Specification and morphogenesis of astrocytes
    • (PubMed: 21051628)
    • [78] Freeman, M.R., Specification and morphogenesis of astrocytes. Science 330 (2010), 774–778 (PubMed: 21051628).
    • (2010) Science , vol.330 , pp. 774-778
    • Freeman, M.R.1
  • 79
    • 0036234835 scopus 로고    scopus 로고
    • Neural stem cells from adult hippocampus develop essential properties of functional CNS neurons
    • (PubMed: 11953752)
    • [79] Song, H.J., Stevens, C.F., Gage, F.H., Neural stem cells from adult hippocampus develop essential properties of functional CNS neurons. Nat Nurosci. 5 (2002), 438–445 (PubMed: 11953752).
    • (2002) Nat Nurosci. , vol.5 , pp. 438-445
    • Song, H.J.1    Stevens, C.F.2    Gage, F.H.3
  • 80
    • 23444440818 scopus 로고    scopus 로고
    • Increased astrocyte proliferation in rats after running exercise
    • (PubMed: 16024173)
    • [80] Li, J., Ding, Y.H., Rafols, J.A., Lai, Q., McAllister, J.P., 2nd Ding, Y., Increased astrocyte proliferation in rats after running exercise. Neurosci. Lett. 386 (2005), 160–164 (PubMed: 16024173).
    • (2005) Neurosci. Lett. , vol.386 , pp. 160-164
    • Li, J.1    Ding, Y.H.2    Rafols, J.A.3    Lai, Q.4    McAllister, J.P.5    Ding, Y.6
  • 81
    • 84892366960 scopus 로고    scopus 로고
    • Physical exercise increases GFAP expression and induces morphological changes in hippocampal astrocytes
    • (PubMed: 23288255)
    • [81] Saur, L., Baptista, P.P., de Senna, P.N., Paim, M.F., do Nascimento, P., Ilha, J., et al. Physical exercise increases GFAP expression and induces morphological changes in hippocampal astrocytes. Brain Struct. Funct. 219 (2014), 293–302 (PubMed: 23288255).
    • (2014) Brain Struct. Funct. , vol.219 , pp. 293-302
    • Saur, L.1    Baptista, P.P.2    de Senna, P.N.3    Paim, M.F.4    do Nascimento, P.5    Ilha, J.6
  • 82
    • 84871379058 scopus 로고    scopus 로고
    • Plastic changes in the astrocyte GLUT1 glucose transporter and beta-tubulin microtubule protein following voluntary exercise in mice
    • (PubMed: 23201358)
    • [82] Allen, A., Messier, C., Plastic changes in the astrocyte GLUT1 glucose transporter and beta-tubulin microtubule protein following voluntary exercise in mice. Behav. Brain Res. 240 (2013), 95–102 (PubMed: 23201358).
    • (2013) Behav. Brain Res. , vol.240 , pp. 95-102
    • Allen, A.1    Messier, C.2
  • 83
    • 0035047718 scopus 로고    scopus 로고
    • Cerebral microvascular pathology in aging and Alzheimer's disease
    • (PubMed: 11311463)
    • [83] Farkas, E., Luiten, P.G., Cerebral microvascular pathology in aging and Alzheimer's disease. Prog. Neurobiol. 64 (2001), 575–611 (PubMed: 11311463).
    • (2001) Prog. Neurobiol. , vol.64 , pp. 575-611
    • Farkas, E.1    Luiten, P.G.2
  • 84
    • 0034597430 scopus 로고    scopus 로고
    • Vascular niche for adult hippocampal neurogenesis
    • (PubMed: 10975875)
    • [84] Palmer, T.D., Willhoite, A.R., Gage, F.H., Vascular niche for adult hippocampal neurogenesis. J. Comp. Neurol. 425 (2000), 479–494 (PubMed: 10975875).
    • (2000) J. Comp. Neurol. , vol.425 , pp. 479-494
    • Palmer, T.D.1    Willhoite, A.R.2    Gage, F.H.3
  • 85
    • 84900338737 scopus 로고    scopus 로고
    • Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors
    • (PubMed: 24797482)
    • [85] Katsimpardi, L., Litterman, N.K., Schein, P.A., Miller, C.M., Loffredo, F.S., Wojtkiewicz, G.R., et al. Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors. Science 344 (2014), 630–634 (PubMed: 24797482).
    • (2014) Science , vol.344 , pp. 630-634
    • Katsimpardi, L.1    Litterman, N.K.2    Schein, P.A.3    Miller, C.M.4    Loffredo, F.S.5    Wojtkiewicz, G.R.6
  • 86
    • 0037015059 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo
    • (PubMed: 12181492)
    • [86] Jin, K., Zhu, Y., Sun, Y., Mao, X.O., Xie, L., Greenberg, D.A., Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo. Proc. Natl. Acad. Sci. U. S. A. 99 (2002), 11946–11950 (PubMed: 12181492).
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 11946-11950
    • Jin, K.1    Zhu, Y.2    Sun, Y.3    Mao, X.O.4    Xie, L.5    Greenberg, D.A.6
  • 87
    • 3542999278 scopus 로고    scopus 로고
    • VEGF links hippocampal activity with neurogenesis, learning and memory
    • (PubMed: 15258583)
    • [87] Cao, L., Jiao, X., Zuzga, D.S., Liu, Y., Fong, D.M., Young, D., et al. VEGF links hippocampal activity with neurogenesis, learning and memory. Nat. Genet. 36 (2004), 827–835 (PubMed: 15258583).
    • (2004) Nat. Genet. , vol.36 , pp. 827-835
    • Cao, L.1    Jiao, X.2    Zuzga, D.S.3    Liu, Y.4    Fong, D.M.5    Young, D.6
  • 88
    • 0346751060 scopus 로고    scopus 로고
    • VEGF is necessary for exercise-induced adult hippocampal neurogenesis
    • (PubMed: 14656329)
    • [88] Fabel, K., Fabel, K., Tam, B., Kaufer, D., Baiker, A., Simmons, N., et al. VEGF is necessary for exercise-induced adult hippocampal neurogenesis. Eur. J. Neurosci. 18 (2003), 2803–2812 (PubMed: 14656329).
    • (2003) Eur. J. Neurosci. , vol.18 , pp. 2803-2812
    • Fabel, K.1    Fabel, K.2    Tam, B.3    Kaufer, D.4    Baiker, A.5    Simmons, N.6
  • 89
    • 67649386567 scopus 로고    scopus 로고
    • GABA-cAMP response element-binding protein signaling regulates maturation and survival of newly generated neurons in the adult hippocampus
    • (PubMed: 19553437)
    • [89] Jagasia, R., Steib, K., Englberger, E., Herold, S., Faus-Kessler, T., Saxe, M., et al. GABA-cAMP response element-binding protein signaling regulates maturation and survival of newly generated neurons in the adult hippocampus. J. Neurosci. 29 (2009), 7966–7977 (PubMed: 19553437).
    • (2009) J. Neurosci. , vol.29 , pp. 7966-7977
    • Jagasia, R.1    Steib, K.2    Englberger, E.3    Herold, S.4    Faus-Kessler, T.5    Saxe, M.6
  • 90
    • 70349454084 scopus 로고    scopus 로고
    • Running exercise-induced up-regulation of hippocampal brain-derived neurotrophic factor is CREB-dependent
    • (PubMed: 19294650)
    • [90] Chen, M.J., Russo-Neustadt, A.A., Running exercise-induced up-regulation of hippocampal brain-derived neurotrophic factor is CREB-dependent. Hippocampus 19 (2009), 962–972 (PubMed: 19294650).
    • (2009) Hippocampus , vol.19 , pp. 962-972
    • Chen, M.J.1    Russo-Neustadt, A.A.2
  • 91
    • 84946397354 scopus 로고    scopus 로고
    • The 5-HT3 receptor is essential for exercise-induced hippocampal neurogenesis and antidepressant effects
    • (PubMed: 25403840)
    • [91] Kondo, M., Nakamura, Y., Ishida, Y., Shimada, S., The 5-HT3 receptor is essential for exercise-induced hippocampal neurogenesis and antidepressant effects. Mol. Psychiatry 20 (2015), 1428–1437 (PubMed: 25403840).
    • (2015) Mol. Psychiatry , vol.20 , pp. 1428-1437
    • Kondo, M.1    Nakamura, Y.2    Ishida, Y.3    Shimada, S.4
  • 92
    • 0442307920 scopus 로고    scopus 로고
    • Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo
    • (PubMed: 14960340)
    • [92] Farmer, J., Zhao, X., van Praag, H., Wodtke, K., Gage, F.H., Christie, B.R., Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo. Neurosci 124 (2004), 71–79 (PubMed: 14960340).
    • (2004) Neurosci , vol.124 , pp. 71-79
    • Farmer, J.1    Zhao, X.2    van Praag, H.3    Wodtke, K.4    Gage, F.H.5    Christie, B.R.6
  • 93
    • 84876332735 scopus 로고    scopus 로고
    • Enhanced NMDA receptor-dependent LTP in the epileptic CA1 area via upregulation of NR2B
    • (PubMed: 23313317)
    • [93] Muller, L., Tokay, T., Porath, K., Kohling, R., Kirschstein, T., Enhanced NMDA receptor-dependent LTP in the epileptic CA1 area via upregulation of NR2B. Neurobiol. Dis. 54 (2013), 183–193 (PubMed: 23313317).
    • (2013) Neurobiol. Dis. , vol.54 , pp. 183-193
    • Muller, L.1    Tokay, T.2    Porath, K.3    Kohling, R.4    Kirschstein, T.5
  • 94
    • 27744484327 scopus 로고    scopus 로고
    • Neuronal differentiation in the adult hippocampus recapitulates embryonic development
    • (PubMed: 16267214)
    • [94] Esposito, M.S., Piatti, V.C., Laplagne, D.A., Morgenstern, N.A., Ferrari, C.C., Pitossi, F.J., et al. Neuronal differentiation in the adult hippocampus recapitulates embryonic development. J. Neurosci. 25 (2005), 10074–10086 (PubMed: 16267214).
    • (2005) J. Neurosci. , vol.25 , pp. 10074-10086
    • Esposito, M.S.1    Piatti, V.C.2    Laplagne, D.A.3    Morgenstern, N.A.4    Ferrari, C.C.5    Pitossi, F.J.6
  • 95
    • 80255127361 scopus 로고    scopus 로고
    • Neurogenesis, cellular plasticity and cognition: the impact of stem cells in the adult and aging brain–a mini-review
    • (PubMed: 21311170)
    • [95] Couillard-Despres, S., Iglseder, B., Aigner, L., Neurogenesis, cellular plasticity and cognition: the impact of stem cells in the adult and aging brain–a mini-review. Gerontology 57 (2011), 559–564 (PubMed: 21311170).
    • (2011) Gerontology , vol.57 , pp. 559-564
    • Couillard-Despres, S.1    Iglseder, B.2    Aigner, L.3
  • 96
    • 65649125633 scopus 로고    scopus 로고
    • Neurogenesis-dependent and −independent effects of fluoxetine in an animal model of anxiety/depression
    • (PubMed: 19477151)
    • [96] David, D.J., Samuels, B.A., Rainer, Q., Wang, J.W., Marsteller, D., Mendez, I., et al. Neurogenesis-dependent and −independent effects of fluoxetine in an animal model of anxiety/depression. Neuron 62 (2009), 479–493 (PubMed: 19477151).
    • (2009) Neuron , vol.62 , pp. 479-493
    • David, D.J.1    Samuels, B.A.2    Rainer, Q.3    Wang, J.W.4    Marsteller, D.5    Mendez, I.6
  • 97
    • 67650450542 scopus 로고    scopus 로고
    • A functional role for adult hippocampal neurogenesis in spatial pattern separation
    • (PubMed: 19590004)
    • [97] Clelland, C.D., Choi, M., Romberg, C., Clemenson, G.D. Jr., Fragniere, A., Tyers, P., et al. A functional role for adult hippocampal neurogenesis in spatial pattern separation. Science 325 (2009), 210–213 (PubMed: 19590004).
    • (2009) Science , vol.325 , pp. 210-213
    • Clelland, C.D.1    Choi, M.2    Romberg, C.3    Clemenson, G.D.4    Fragniere, A.5    Tyers, P.6
  • 98
    • 0034736218 scopus 로고    scopus 로고
    • Conditionally immortal neuroepithelial stem cell grafts reverse age-associated memory impairments in rats
    • (PubMed: 11113344)
    • [98] Hodges, H., Veizovic, T., Bray, N., French, S.J., Rashid, T.P., Chadwick, A., et al. Conditionally immortal neuroepithelial stem cell grafts reverse age-associated memory impairments in rats. Neurosci 101 (2000), 945–955 (PubMed: 11113344).
    • (2000) Neurosci , vol.101 , pp. 945-955
    • Hodges, H.1    Veizovic, T.2    Bray, N.3    French, S.J.4    Rashid, T.P.5    Chadwick, A.6
  • 99
    • 57049122251 scopus 로고    scopus 로고
    • Behavior of hippocampal stem/progenitor cells following grafting into the injured aged hippocampus
    • (PubMed: 18618674)
    • [99] Shetty, A.K., Rao, M.S., Hattiangady, B., Behavior of hippocampal stem/progenitor cells following grafting into the injured aged hippocampus. J. Neurosci. Res. 86 (2008), 3062–3074 (PubMed: 18618674).
    • (2008) J. Neurosci. Res. , vol.86 , pp. 3062-3074
    • Shetty, A.K.1    Rao, M.S.2    Hattiangady, B.3
  • 100
    • 0035826914 scopus 로고    scopus 로고
    • Human neural stem cells improve cognitive function of aged brain
    • (PubMed: 11338178)
    • [100] Qu, T., Brannen, C.L., Kim, H.M., Sugaya, K., Human neural stem cells improve cognitive function of aged brain. Neuroreport 12 (2001), 1127–1132 (PubMed: 11338178).
    • (2001) Neuroreport , vol.12 , pp. 1127-1132
    • Qu, T.1    Brannen, C.L.2    Kim, H.M.3    Sugaya, K.4
  • 101
    • 84931576897 scopus 로고    scopus 로고
    • Human neural stem cells improve cognition and promote synaptic growth in two complementary transgenic models of Alzheimer's disease and neuronal loss
    • (PubMed: 25530343)
    • [101] Ager, R.R., Davis, J.L., Agazaryan, A., Benavente, F., Poon, W.W., LaFerla, F.M., et al. Human neural stem cells improve cognition and promote synaptic growth in two complementary transgenic models of Alzheimer's disease and neuronal loss. Hippocampus 25 (2015), 813–826 (PubMed: 25530343).
    • (2015) Hippocampus , vol.25 , pp. 813-826
    • Ager, R.R.1    Davis, J.L.2    Agazaryan, A.3    Benavente, F.4    Poon, W.W.5    LaFerla, F.M.6
  • 103
    • 84975796456 scopus 로고    scopus 로고
    • Drug and exercise treatment of Alzheimer disease and mild cognitive impairment: a systematic review and meta-analysis of effects on cognition in randomized controlled trials
    • (PubMed: 27492909)
    • [103] Strohle, A., Schmidt, D.K., Schultz, F., Fricke, N., Staden, T., Hellweg, R., Drug and exercise treatment of Alzheimer disease and mild cognitive impairment: a systematic review and meta-analysis of effects on cognition in randomized controlled trials. Am. J. Geriatr. Psychiatry 23 (2015), 1234–1249 (PubMed: 27492909).
    • (2015) Am. J. Geriatr. Psychiatry , vol.23 , pp. 1234-1249
    • Strohle, A.1    Schmidt, D.K.2    Schultz, F.3    Fricke, N.4    Staden, T.5    Hellweg, R.6
  • 104
    • 84966295015 scopus 로고    scopus 로고
    • Physical activity delays hippocampal neurodegeneration and rescues memory deficits in an Alzheimer disease mouse model
    • (PubMed: 27138799)
    • [104] Huttenrauch, M., Brauss, A., Kurdakova, A., Borgers, H., Klinker, F., Liebetanz, D., et al. Physical activity delays hippocampal neurodegeneration and rescues memory deficits in an Alzheimer disease mouse model. Transl Psychiatry., 6, 2016, e800 (PubMed: 27138799).
    • (2016) Transl Psychiatry. , vol.6 , pp. e800
    • Huttenrauch, M.1    Brauss, A.2    Kurdakova, A.3    Borgers, H.4    Klinker, F.5    Liebetanz, D.6
  • 105
    • 84914689471 scopus 로고    scopus 로고
    • Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model
    • (PubMed: 25125468)
    • [105] Dunn, H.C., Ager, R.R., Baglietto-Vargas, D., Cheng, D., Kitazawa, M., Cribbs, D.H., et al. Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model. J. Alzheimers Dis. 43 (2015), 893–903 (PubMed: 25125468).
    • (2015) J. Alzheimers Dis. , vol.43 , pp. 893-903
    • Dunn, H.C.1    Ager, R.R.2    Baglietto-Vargas, D.3    Cheng, D.4    Kitazawa, M.5    Cribbs, D.H.6


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