Conditionally immortal neuroepithelial stem cell grafts reverse age-associated memory impairments in rats

Neuroscience

Volumn 101, Issue 4, 2000, Pages 945-955

  Hodges, H ^a,b,c   Veizovic, T ^b   Bray, N ^a   French, S J ^b   Rashid, T P ^b   Chadwick, A ^b   Patel, S ^b   Gray, J A ^a,b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b RENEURON LTD   (United Kingdom)

^c NONE   (United Kingdom)

Author keywords

Aged rats; Intracerebral transplantation; MHP36 cell line; Spatial learning; Water maze

Indexed keywords

AGE; AGED; AMNESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL IMMORTALIZATION; CELL TRANSPLANTATION; COGNITION; CONTROLLED STUDY; HIPPOCAMPUS; HISTOLOGY; LEARNING; MALE; NEUROEPITHELIUM; NONHUMAN; PRIORITY JOURNAL; RAT; SPATIAL MEMORY; STEM CELL;

AGING; ANIMALS; CELL LINE, TRANSFORMED; CELL MOVEMENT; CEREBRAL CORTEX; CORPUS STRIATUM; DISEASE PROGRESSION; HIPPOCAMPUS; MALE; MAZE LEARNING; MEMORY DISORDERS; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; STEM CELL TRANSPLANTATION; STEM CELLS; SWIMMING;

EID: 0034736218     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(00)00408-5     Document Type: Article

References (28)

1. Importance of forebrain cholinergic and GABAergic systems to age-related deficits in water maze performance of rats
2. Cholinergic markers in aged cognitively impaired Long-Evans rats
3. Astrocyte transplants alleviate lesion induced memory deficits independently of cholinergic recovery
4. Somatic gene transfer of NGF to the aged brain: behavioural and morphological amelioration
5. Cholinergic grafts in the neocortex or hippocampus of aged rats: reduction of delay-dependent deficits in the delayed non-matching to position task
6. Two functional components of the hippocampal memory system
7. Ageing: the cholinergic hypothesis of cognitive decline
8. Prospects for the clinical application of neural transplantation with the use of conditionally immortalized neuroepithelial stem cells
9. Conditionally immortalized, multipotential and multifunctional neural stem cell lines as an approach to clinical transplantation
10. Functional reconstruction of the hippocampus: foetal versus conditionally immortal neuroepithelial stem cell grafts
11. Age and neurochemical correlates of radial maze performance in rats
12. Spatial memory deficits in aged rats: contributions of the cholinergic system assessed by ChAT
13. Survival, integration and differentiation of neural stem cell lines after transplantation to the adult rat striatum
14. Individual differences in aging: behavioural and neurobiological correlates
15. Reversal of age-dependent cognitive impairments and cholinergic neuron atrophy by NGF-secreting neural progenitors grafted to the basal forebrain
16. Long-term functional recovery from age-induced spatial memory impairments by nerve growth factor gene transfer to the rat basal forebrain
17. Ex vivo nerve growth factor gene transfer to the basal forebrain in presymptomatic middle-aged rats prevents the development of cholinergic neuron atrophy and cognitive impairment during aging
18. Comparison of the effects of global cerebal ischaemia on spatial learning in the standard and radial water maze: relationship of hippocampal damage to performance
19. Metabotropic glutamate receptor-mediated hippocampal phosphoinositide turnover is blunted in spatial learning-impaired rats
20. Altered sensitivity of α2 adrenoreceptors in the brain during aging in rats
21. Preserved neuron number in the hippocampus of aged rats with spatial learning deficits
22. Memory impaired aged rats: no loss of principal hippocampal and subicular neurons
23. The effect of aging on experience-dependent plasticity of hippocampal place cells
24. The adult CNS retains the potential to direct region-specific differentiation of a transplanted neuronal precursor cell line
25. Neural transplantation and recovery of cognitive function
26. Recovery of spatial learning by grafts of a conditionally-immortalised hippocampal neuroepithelial cell line into the ischaemia-lesioned hippocampus
27. Primary CA1 and conditionally immortal MHP36 cells restore conditional discrimination learning and recall in marmosets after excitotoxic lesions of the hippocampal CA1 field
28. Polymer-encapsulated genetically modified cells continue to secrete human nerve growth factor for over one year in rat ventricles: behavioural and anatomical consequences