Tocotrienol Rich Palm Oil Extract Is More Effective Than Pure Tocotrienols at Improving Endothelium-Dependent Relaxation in the Presence of Oxidative Stress

Oxidative Medicine and Cellular Longevity

Volumn 2015, Issue , 2015, Pages

  Ali, Saher F ^a   Woodman, Owen L ^a  

^a RMIT UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANTS; BLOOD VESSELS; DELTA FUNCTIONS; OIL SHALE; OXIDANTS; OXIDATIVE STRESS; OXYGEN; RATS;

ANTI-OXIDANT ACTIVITIES; ENDOTHELIAL DYSFUNCTION; ENDOTHELIAL FUNCTION; ENHANCED CHEMILUMINESCENCES; OXIDANT STRESS; PROTECTIVE EFFECTS; TOCOTRIENOLS; VASCULAR DISEASE;

PALM OIL;

ALPHA TOCOPHEROL; ALPHA TOCOTRIENOL; ANTIOXIDANT; DELTA TOCOTRIENOL; ENDOTHELIUM DERIVED RELAXING FACTOR; GAMMA TOCOTRIENOL; LUCIGENIN; PYROGALLOL; SUPEROXIDE; UNCLASSIFIED DRUG; ACETYLCHOLINE; NITROPRUSSIDE SODIUM; PALM OIL; PLANT EXTRACT; SCAVENGER; TOCOMIN; VEGETABLE OIL; XANTHINE OXIDASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; AORTA; ARTICLE; CELL MEMBRANE; CHEMOLUMINESCENCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; EC50; ENZYME INHIBITION; ISOMER; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; VASODILATATION; ANIMAL; DRUG EFFECTS; IN VITRO STUDY; METABOLISM; PATHOPHYSIOLOGY; VASCULAR ENDOTHELIUM; WISTAR RAT;

RATTUS;

ACETYLCHOLINE; ALPHA-TOCOPHEROL; ANIMALS; AORTA; ENDOTHELIUM, VASCULAR; FREE RADICAL SCAVENGERS; IN VITRO TECHNIQUES; MALE; NITROPRUSSIDE; OXIDATIVE STRESS; PLANT EXTRACTS; PLANT OILS; PYROGALLOL; RATS, WISTAR; SUPEROXIDES; TOCOTRIENOLS; VASODILATION; XANTHINE OXIDASE;

EID: 84930965626     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2015/150829     Document Type: Article

References (28)

1. st century: its potential against cancer and other chronic diseases," Biochemical Pharmacology,vol. 80, no. 11, pp. 1613-1631, 2010.
2. R. A. Parker, B. C. Pearce, R. W. Clark, D. A. Gordon, andJ. J. K. Wright, "Tocotrienols regulate cholesterol productionin mammalian cells by post- transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase," Journal of Biological Chemistry, vol. 268, no. 15, pp. 11230-11238, 1993.
3. A. J. Esterhuyse, E. F. du Toit, A. J. S. Benadeè, and J. van Rooyen,"Dietary red palm oil improves reperfusion cardiac function inthe isolated perfused rat heart of animals fed a high cholesteroldiet," Prostaglandins Leukotrienes and Essential Fatty Acids, vol.72, no. 3, pp. 153-161, 2005.
4. M. Berbee, Q. Fu, M. Boerma et al., "Reduction of radiation-inducedvascular nitrosative stress by the vitamin e analog γ-tocotrienol: evidence of a role for tetrahydrobiopterin," International Journal of Radiation Oncology, Biology, Physics, vol. 79,no. 3, pp. 884-891, 2011.
5. M. A. Newaz, Z. Yousefipour, N. Nawal, and N. Adeeb, "Nitricoxide synthase activity in blood vessels of spontaneously hypertensiverats: antioxidant protection by gamma-tocotrienol,"Journal of Physiology and Pharmacology, vol. 54, no. 3, pp. 319-327, 2003.
6. A. Kuhad and K. Chopra, "Tocotrienol attenuates oxidativenitrosativestress and inflammatory cascade in experimental model of diabetic neuropathy," Neuropharmacology, vol. 57, no.4, pp. 456-462, 2009.
7. K.-Z. Norsidah, A. Y. Asmadi, A. Azizi, O. Faizah, and Y. Kamisah, "Palm tocotrienol-rich fraction improves vascular proatherosclerotic changes in hyperhomocysteinemic rats,"Evidence-Based Complementary and Alternative Medicine, vol.2013, Article ID 976967, 10 pages, 2013.
8. S. P. Muharis, A. G. M. Top, D. Murugan, and M. R. Mustafa,"Palm oil tocotrienol fractions restore endothelium dependentrelaxation in aortic rings of streptozotocin-induced diabeticand spontaneously hypertensive rats," Nutrition Research, vol.30, no. 3, pp. 209-216, 2010.
9. S. B. Budin, F. Othman, S. R. Louis, M. A. Bakar, S. Das, and J. Mohamed, "The effects of palm oil tocotrienol-rich fraction supplementation on biochemical parameters, oxidative stressand the vascular wall of streptozotocin-induced diabetic rats,"Clinics, vol. 64, no. 3, pp. 235-244, 2009.
10. A. H. G. Rasool, A. R. A. Rahman, K. H. Yuen, and A. R. Wong,"Arterial compliance and vitamin E blood levels with a self emulsifying preparation of tocotrienol rich vitamin E," Archivesof Pharmacal Research, vol. 31, no. 9, pp. 1212-1217, 2008.
11. C.-H. Leo, J. L. Hart, and O. L. Woodman, "3′,4′-dihydroxyflavonolrestores endothelium-dependent relaxation in small mesenteric artery from rats with type 1 and type 2 diabetes,"European Journal of Pharmacology, vol. 659, no. 2-3, pp. 193-198, 2011.
12. C. H. Leo, A. Joshi, and O. L. Woodman, "Short-term type1 diabetes alters the mechanism of endothelium-dependent relaxation in the rat carotid artery," The American Journal ofPhysiology - Heart and Circulatory Physiology, vol. 299, no. 2,pp. H502-H511, 2010.
13. Y. Saito, K. Nishio, Y. O. Akazawa et al., "Cytoprotective effectsof vitamin E homologues against glutamate-induced cell death in immature primary cortical neuron cultures: Tocopherols andtocotrienols exert similar effects by antioxidant function," Free Radical Biology and Medicine, vol. 49, no. 10, pp. 1542-1549,2010.
14. Y. Saito, Y. Yoshida, T. Akazawa, K. Takahashi, and E. Niki, "Cell death caused by selenium deficiency and protective effect of antioxidants," Journal of Biological Chemistry, vol. 278, no. 41,pp. 39428-39434, 2003.
15. Y. Saito, Y. Yoshida, K. Nishio, M. Hayakawa, and E. Niki,"Characterization of cellular uptake and distribution of vitamin E," Annals of the New York Academy of Sciences, vol. 1031, pp.368-375, 2004.
16. E. C. H. Chan, G. R. Drummond, and O. L. Woodman, "3′,4′-dihydroxyflavonol enhances nitric oxide bioavailability and improves vascular function after ischemia and reperfusion injury in the rat," Journal of Cardiovascular Pharmacology, vol.42, no. 6, pp. 727-735, 2003.
17. L. J. Ignarro, R. E. Byrns, G. M. Buga, K. S. Wood, and G. Chaudhuri, "Pharmacological evidence that endothelium-derivedrelaxing factor is nitric oxide: use of pyrogallol andsuperoxide dismutase to study endothelium-dependent andnitric oxide-elicited vascular smooth muscle relaxation," TheJournal of Pharmacology and Experimental Therapeutics, vol.244, no. 1, pp. 181-189, 1988.
18. A. Ellis, C. G. Li, and M. J. Rand, "Effect of xanthine oxidase inhibition on endothelium-dependent and nitrergicrelaxations," European Journal of Pharmacology, vol. 356, no. 1,pp. 41-47, 1998.
19. N. Cantu-Medellin and E. E. Kelley, "Xanthine oxidoreductase-catalyzed reactive species generation: a process in critical need of reevaluation," Redox Biology, vol. 1, no. 1, pp. 353-358, 2013.
20. M.-C. Desco, M. Asensi, R. Márquez et al., "Xanthine oxidase isinvolved in free radical production in type 1 diabetes: protection by allopurinol," Diabetes, vol. 51, no. 4, pp. 1118-1124, 2002.
21. A. Kamal-Eldin and L.-Å. Appelqvist, "The chemistry and antioxidant properties of tocopherols and tocotrienols," Lipids,vol. 31, no. 7, pp. 671-701, 1996.
22. Y. Yoshida, E. Niki, and N. Noguchi, "Comparative study on the action of tocopherols and tocotrienols as antioxidant: chemical and physical effects," Chemistry and Physics of Lipids, vol. 123,no. 1, pp. 63-75, 2003.
23. R. Kissner, T. Nauser, P. Bugnon, P. G. Lye, and W. H. Koppenol,"Formation and properties of peroxynitrite as studied by laser flash photolysis, high-pressure stopped-flow technique, andpulse radiolysis," Chemical Research in Toxicology, vol. 10, no.11, pp. 1285-1292, 1997.
24. G. Ferrer-Sueta, C. Quijano, B. Alvarez, and R. Radi, "Reactions of manganese porphyrins and manganese-superoxide dismutase with peroxynitrite," Methods in Enzymology, vol. 349, pp.23-37, 2002.
25. T. S. Jackson, A. Xu, J. A. Vita, and J. F. Keaney Jr., "Ascorbate prevents the interaction of superoxide and nitric oxide only at very high physiological concentrations," Circulation Research,vol. 83, no. 9, pp. 916-922, 1998.
26. N. Gotoh and E. Niki, "Rates of interactions of superoxide with vitamin E, vitamin C and related compounds as measured by chemiluminescence," Biochimica et Biophysica Acta, vol. 1115, no. 3, pp. 201-207, 1992.
27. G. Upadhyay, S. P. Gupta, O. Prakash, and M. P. Singh,"Pyrogallol-mediated toxicity and natural antioxidants: triumphs and pitfalls of preclinical findings and their translation all imitations," Chemico-Biological Interactions, vol. 183, no. 3, pp.333-340, 2010.
28. H. Ahsan, A. Ahad, J. Iqbal, and W. A. Siddiqui, "Pharmacological potential of tocotrienols: a review," Nutrition & Metabolism,vol. 11, no. 1, article 52, 2014.