Triazine-based tool box for developing peptidic PET imaging probes: Syntheses, microfluidic radiolabeling, and structure-activity evaluation

Bioconjugate Chemistry

Volumn 25, Issue 4, 2014, Pages 761-772

  Li, Hairong ^a   Zhou, Haiying ^a   Krieger, Stephanie ^b   Parry, Jesse J ^b   Whittenberg, Joseph J ^c   Desai, Amit V ^c   Rogers, Buck E ^b   Kenis, Paul J A ^c   Reichert, David E ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; MICROFLUIDICS; MOLECULES; PEPTIDES; SYNTHESIS (CHEMICAL);

ACTIVITY EVALUATIONS; BI-FUNCTIONAL; CORE MOLECULES; IMAGING PROBE; MODULAR PLATFORM; PET IMAGING; RADIOLABELLING; STRUCTURE ACTIVITY; SYNTHESISED; TOOL BOXES;

CHELATION;

DOTA TZ BIS CYCLO (RGDFK) 13 CU 64; DOTA TZ CYCLO (RGDFK) 14 CONJUGATE; ECHISTATIN; RADIOPHARMACEUTICAL AGENT; TETRAXETAN; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR; COPPER; CYCLIC (ARGINYL-GLYCYL-ASPARTYL-PHENYLALANYL-LYSYL); CYCLOPEPTIDE; MOLECULAR PROBE; RADIOACTIVE IODINE;

AMIDATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BINDING ASSAY; CHEMICAL BOND; CLICK CHEMISTRY; CONTROLLED STUDY; DRUG CONJUGATION; DRUG DISTRIBUTION; DRUG TUMOR LEVEL; FEMALE; GLIOMA CELL; HUMAN; HUMAN CELL; IC 50; ISOTOPE LABELING; MICROFLUIDIC ANALYSIS; MOLECULAR IMAGING; MOUSE; NONHUMAN; PEPTIDE SYNTHESIS; POSITRON EMISSION TOMOGRAPHY; PROTEIN REFOLDING; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; EXPERIMENTAL NEOPLASM; GLIOBLASTOMA; METABOLISM; MOLECULAR PROBE; NUDE MOUSE; PHARMACOKINETICS; PROCEDURES; RAT; TISSUE DISTRIBUTION; TUMOR CELL CULTURE;

ANIMALS; CLICK CHEMISTRY; COPPER RADIOISOTOPES; FEMALE; GLIOBLASTOMA; HUMANS; INTEGRIN ALPHAVBETA3; IODINE RADIOISOTOPES; ISOTOPE LABELING; MICE; MICE, NUDE; MICROFLUIDIC ANALYTICAL TECHNIQUES; MOLECULAR IMAGING; MOLECULAR PROBES; MOLECULAR STRUCTURE; NEOPLASMS, EXPERIMENTAL; PEPTIDES, CYCLIC; POSITRON-EMISSION TOMOGRAPHY; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION; TRIAZINES; TUMOR CELLS, CULTURED;

EID: 84898955500     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc500034n     Document Type: Article

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