Therapeutic uses of somatostatin and its analogues: Current view and potential applications

Pharmacology and Therapeutics

Volumn 152, Issue , 2015, Pages 98-110

  Rai, Uma ^a   Thrimawithana, Thilini R ^a   Valery, Celine ^a   Young, Simon A ^a  

^a RMIT UNIVERSITY   (Australia)

Author keywords

Acromegaly; Cancer; Diabetes; Inflammation; Somatostatin; Somatostatin analogues

Indexed keywords

ANGIOPEPTIN; OCTREOTIDE; PASIREOTIDE; SOMATOSTATIN; SOMATOSTATIN RECEPTOR 1; SOMATOSTATIN RECEPTOR 2; SOMATOSTATIN RECEPTOR 3; SOMATOSTATIN RECEPTOR 4; SOMATOSTATIN RECEPTOR 5; VAPREOTIDE; SOMATOSTATIN RECEPTOR;

ACTH SECRETING ADENOMA; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BREAST CANCER; DIABETIC NEPHROPATHY; DIABETIC RETINOPATHY; DRUG EFFICACY; DRUG MARKETING; GASTROENTEROPANCREATIC NEUROENDOCRINE TUMOR; GROWTH HORMONE SECRETING ADENOMA; HUMAN; INFLAMMATION; INSULIN DEPENDENT DIABETES MELLITUS; LIVER CELL CARCINOMA; MELANOMA; NOCICEPTION; NONFUNCTIONING PITUITARY ADENOMA; NONHUMAN; OBESITY; OVARY TUMOR; PANCREATITIS; POSTMARKETING SURVEILLANCE; PRIORITY JOURNAL; PROLACTINOMA; PROLIFERATIVE RETINOPATHY; PROSTATE CANCER; RETINA MACULA CYSTOID EDEMA; SECRETORY PATHWAY; SENSORY NERVE; SIGNAL TRANSDUCTION; THYROID TUMOR; ANALOGS AND DERIVATIVES; ANIMAL; DIABETES MELLITUS; DRUG EFFECTS; METABOLISM; NEOPLASMS; PHYSIOLOGY; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM;

ANIMALS; DIABETES MELLITUS; HUMANS; NEOPLASMS; RECEPTORS, SOMATOSTATIN; RENIN-ANGIOTENSIN SYSTEM; SOMATOSTATIN;

EID: 84933677744     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2015.05.007     Document Type: Review

References (213)

1. J. Ambati, K.V. Chalam, D.K. Chawla, C.T. D'Angio, E.G. Guillet, and S.J. Rose Elevated gamma-aminobutyric acid, glutamate, and vascular endothelial growth factor levels in the vitreous of patients with proliferative diabetic retinopathy Arch Ophthalmol 115 1997 1161 1166
2. S. Arena, A. Pattarozzi, A. Corsaro, G. Schettini, and T. Florio Somatostatin receptor subtype-dependent regulation of nitric oxide release: involvement of different intracellular pathways Mol Endocrinol 19 2005 255 267
3. E. Averbukh, M. Halpert, R. Yanko, L. Yanko, J. Peer, and S. Levinger Octreotide, a somatostatin analogue, fails to inhibit hypoxia-induced retinal neovascularization in the neonatal rat Int J Exp Diabetes Res 1 2000 39 47
4. A. Baldysiak-Figiel, G.K. Lang, J. Kampmeier, and G.E. Lang Octreotide prevents growth factor-induced proliferation of bovine retinal endothelial cells under hypoxia J Endocrinol 180 2004 417 424
5. D.A. Balster, M.S. O'Dorisio, M.A. Summers, and M.A. Turman Segmental expression of somatostatin receptor subtypes sst(1) and sst(2) in tubules and glomeruli of human kidney Am J Physiol Renal Physiol 280 2001 F457 F465
6. P. Barnett Somatostatin and somatostatin receptor physiology Endocrine 20 2003 255 264
7. T. Bartsch, M.J. Levy, Y.E. Knight, and P.J. Goadsby Inhibition of nociceptive dural input in the trigeminal nucleus caudalis by somatostatin receptor blockade in the posterior hypothalamus Pain 117 2005 30 39
8. J. Basivireddy, R.K. Somvanshi, I.A. Romero, B.B. Weksler, P.O. Couraud, and J. Oger Somatostatin preserved blood brain barrier against cytokine induced alterations: possible role in multiple sclerosis Biochem Pharmacol 86 2013 497 507
9. L. Baud, B. Fouqueray, A. Bellocq, S. Doublier, and A. Dumoulin Growth hormone and somatostatin in glomerular injury J Nephrol 12 1999 18 23
10. N. Benali, P. Cordelier, D. Calise, P. Pages, P. Rochaix, and A. Nagy Inhibition of growth and metastatic progression of pancreatic carcinoma in hamster after somatostatin receptor subtype 2 (sst2) gene expression and administration of cytotoxic somatostatin analog AN-238 Proceedings of the National Academy of Sciences of the United States of America 97 2000 9180 9185
11. R. Benko, A. Antwi, and L. Bartho The putative somatostatin antagonist cyclo-somatostatin has opioid agonist effects in gastrointestinal preparations Life Sci 90 2012 728 732
12. M. Benuck, and N. Marks Differences in the degradation of hypothalamic releasing factors by rat and human serum Life Sci 19 1976 1271 1276
13. N. Berenger, J.L. Moretti, C. Boaziz, N. Vigneron, J.F. Morere, and J.L. Breau Somatostatin receptor imaging in small cell lung cancer Eur J Cancer 32A 1996 1429 1431
14. A. Bigiani, C. Petrucci, V. Ghiaroni, M. Dal Monte, A. Cozzi, and H.J. Kreienkamp Functional correlates of somatostatin receptor 2 overexpression in the retina of mice with genetic deletion of somatostatin receptor 1 Brain Res 1025 2004 177 185
15. B.O. Boehm, G.K. Lang, P.M. Jehle, B. Feldman, and G.E. Lang Octreotide reduces vitreous hemorrhage and loss of visual acuity risk in patients with high-risk proliferative diabetic retinopathy Horm Metab Res Hormon- und Stoffwechselforschung = Hormones et metabolisme 33 2001 300 306
16. B.O. Boehm, and R.H. Lustig Use of somatostatin receptor ligands in obesity and diabetic complications Best Pract Res Clin Gastroenterol 16 2002 493 509
17. M. Boscaro, W.H. Ludlam, B. Atkinson, J.E. Glusman, S. Petersenn, and M. Reincke Treatment of pituitary-dependent Cushing's disease with the multireceptor ligand somatostatin analog pasireotide (SOM230): a multicenter, phase II trial J Clin Endocrinol Metab 94 2009 115 122
18. P. Brazeau, W. Vale, R. Burgus, N. Ling, M. Butcher, and J. Rivier Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone Science 179 1973 77 79
19. A.M.J. Buchan, C.-Y. Lin, J. Choi, and D.L. Barber Somatostatin, acting at receptor subtype 1, inhibits rho activity, the assembly of actin stress fibers, and cell migration J Biol Chem 277 2002 28431 28438
20. M.W. Buchler, M. Binder, and H. Friess Role of somatostatin and its analogues in the treatment of acute and chronic pancreatitis Gut 35 1994 S15 S19
21. L. Buscail, N. Delesque, J.P. Estève, N. Saint-Laurent, H. Prats, and P. Clerc Stimulation of tyrosine phosphatase and inhibition of cell proliferation by somatostatin analogues: mediation by human somatostatin receptor subtypes SSTR1 and SSTR2 Proceedings of the National Academy of Sciences 91 1994 2315 2319
22. R.M. Campbell, and C.G. Scanes Inhibition of growth hormone-stimulated lipolysis by somatostatin, insulin, and insulin-like growth factors (somatomedins) in vitro Proceedings of the Society for Experimental Biology and Medicine Society for Experimental Biology and Medicine 189 1988 362 366
23. M. Caplin, P. Ruszniewski, M. Pavel, J. Cwikla, A. Phan, and M. Raderer A randomized, double-blind, placebo-Controlled study of Lanreotide Antiproliferative Response in patients with gastroenteropancreatic NeuroEndocrine Tumors (CLARINET) The European Cancer Congress 2013
24. S.M. Carlton, J. Du, S. Zhou, and R.E. Coggeshall Tonic control of peripheral cutaneous nociceptors by somatostatin receptors J Neurosci Off J Soc Neurosci 21 2001 4042 4049
25. S.M. Carlton, S. Zhou, J. Du, G.L. Hargett, G. Ji, and R.E. Coggeshall Somatostatin modulates the transient receptor potential vanilloid 1 (TRPV1) ion channel Pain 110 2004 616 627
26. A. Caroli, N. Perico, A. Perna, L. Antiga, P. Brambilla, and A. Pisani Effect of longacting somatostatin analogue on kidney and cyst growth in autosomal dominant polycystic kidney disease (ALADIN): a randomised, placebo-controlled, multicentre trial Lancet 382 2013 1485 1495
27. E. Carrasco, C. Hernandez, A. Miralles, P. Huguet, J. Farres, and R. Simo Lower somatostatin expression is an early event in diabetic retinopathy and is associated with retinal neurodegeneration Diabetes Care 30 2007 2902 2908
28. M.G. Cattaneo, D. Gentilini, and L.M. Vicentini Deregulated human glioma cell motility: inhibitory effect of somatostatin Mol Cell Endocrinol 256 2006 34 39
29. K. Cejvan, D.H. Coy, and S. Efendic Intra-islet somatostatin regulates glucagon release via type 2 somatostatin receptors in rats Diabetes 52 2003 1176 1181
30. D. Cervia, G. Casini, and P. Bagnoli Physiology and pathology of somatostatin in the mammalian retina: a current view Mol Cell Endocrinol 286 2008 112 122
31. D. Cervia, E. Catalani, M. Dal Monte, and G. Casini Vascular endothelial growth factor in the ischemic retina and its regulation by somatostatin J Neurochem 120 2012 818 829
32. D. Cervia, D. Martini, C. Ristori, E. Catalani, A.M. Timperio, and P. Bagnoli Modulation of the neuronal response to ischaemia by somatostatin analogues in wild-type and knock-out mouse retinas J Neurochem 106 2008 2224 2235
33. D. Cervia, C. Petrucci, M.T. Bluet-Pajot, J. Epelbaum, and P. Bagnoli Inhibitory control of growth hormone secretion by somatostatin in rat pituitary GC cells: sst(2) but not sst(1) receptors are coupled to inhibition of single-cell intracellular free calcium concentrations Neuroendocrinology 76 2002 99 110
34. M. Chalabi, C. Duluc, P. Caron, D. Vezzosi, J. Guillermet-Guibert, and S. Pyronnet Somatostatin analogs: does pharmacology impact antitumor efficacy? Trends Endocrinol Metab 25 2014 115 127
35. N.W. Cheung, and S.C. Boyages Somatostatin-14 and its analog octreotide exert a cytostatic effect on GH3 rat pituitary tumor cell proliferation via a transient G0/G1 cell cycle block Endocrinology 136 1995 4174 4181
36. C. Chisholm, and G.R. Greenberg Somatostatin-28 regulates GLP-1 secretion via somatostatin receptor subtype 5 in rat intestinal cultures Am J Physiol Endocrinol Metab 283 2002 E311 E317
37. J. Chrubasik, J. Meynadier, S. Blond, P. Scherpereel, E. Ackerman, and M. Weinstock Somatostatin, a potent analgesic Lancet 2 1984 1208 1209
38. A. Clemens, M.S. Klevesath, M. Hofmann, F. Raulf, M. Henkels, and J. Amiral Octreotide (somatostatin analog) treatment reduces endothelial cell dysfunction in patients with diabetes mellitus Metabolism 48 1999 1236 1240
39. A. Colao, M.D. Bronstein, P. Freda, F. Gu, C.-C. Shen, and M. Gadelha Pasireotide versus octreotide in acromegaly: a head-to-head superiority study J Clin Endocrinol Metab 99 2014 791 799
40. A. Colao, S. Petersenn, J. Newell-Price, J.W. Findling, F. Gu, and M. Maldonado A 12-month phase 3 study of pasireotide in Cushing's disease N Engl J Med 366 2012 914 924
41. M. Dal Monte, M. Cammalleri, D. Martini, G. Casini, and P. Bagnoli Antiangiogenic role of somatostatin receptor 2 in a model of hypoxia-induced neovascularization in the retina: results from transgenic mice Invest Ophthalmol Vis Sci 48 2007 3480 3489
42. V.A. Dalm, P.M. van Hagen, P.M. van Koetsveld, S. Achilefu, A.B. Houtsmuller, and D.H. Pols Expression of somatostatin, cortistatin, and somatostatin receptors in human monocytes, macrophages, and dendritic cells Am J Physiol Endocrinol Metab 285 2003 E344 E353
43. M.I. Davis, S.H. Wilson, and M.B. Grant The therapeutic problem of proliferative diabetic retinopathy: targeting somatostatin receptors Horm Metab Res Hormon- und Stoffwechselforschung = Hormones et metabolisme 33 2001 295 299
44. W.W. de Herder, L.J. Hofland, A.J. van der Lely, and S.W. Lamberts Somatostatin receptors in gastroentero-pancreatic neuroendocrine tumours Endocr Relat Cancer 10 2003 451 458
45. Debiopharm Sanvar Product Information. In www.debiopharm.com 2015
46. T.R. Deer, C.K. Kim, R.G. Bowman II, C.D. Stewart, M. Norris, and Y. Khan The Use of Continuous Intrathecal Infusion of Octreotide in Patients with Chronic Pain of Noncancer Origin: An Evaluation of Side-effects and Toxicity in a Prospective Double-blind Fashion Neuromodulation: Journal of the International Neuromodulation Society 8 2005 171 175
47. N. Delesque, L. Buscail, J.P. Estève, I. Rauly, M. Zeggari, and N. Saint-Laurent A tyrosine phosphatase is associated with the somatostatin receptor Ciba Found Symp 190 1995 187 196 (discussion 196)
48. P. Dent, D.B. Reardon, S.L. Wood, M.A. Lindorfer, S.G. Graber, and J.C. Garrison Inactivation of Raf-1 by a protein-tyrosine phosphatase stimulated by GTP and reconstituted by G subunits J Biol Chem 271 1996 3119 3123
49. M.L. Diez-Marques, C. Garcia-Escribano, J. Medina, M.C. Boyano-Adanez, E. Arilla, and G. Torrecilla Effects of somatostatin on cultured human mesangial cells Endocrinology 136 1995 3444 3451
50. J.W. Ensinck, E.C. Laschansky, R.E. Vogel, D.A. Simonowitz, B.A. Roos, and B.H. Francis Circulating prosomatostatin-derived peptides. Differential responses to food ingestion J Clin Invest 83 1989 1580 1589
51. E. Ferrante, C. Pellegrini, S. Bondioni, E. Peverelli, M. Locatelli, and P. Gelmini Octreotide promotes apoptosis in human somatotroph tumor cells by activating somatostatin receptor type 2 Endocr Relat Cancer 13 2006 955 962
52. T. Fischer, C. Doll, S. Jacobs, A. Kolodziej, R. Stumm, and S. Schulz Reassessment of sst2 somatostatin receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-1 J Clin Endocrinol Metab 93 2008 4519 4524
53. T. Florio, S. Arena, S. Thellung, R. Iuliano, A. Corsaro, and A. Massa The activation of the phosphotyrosine phosphatase eta (r-PTP eta) is responsible for the somatostatin inhibition of PC Cl3 thyroid cell proliferation Mol Endocrinol 15 2001 1838 1852
54. T. Florio, M. Morini, V. Villa, S. Arena, A. Corsaro, and S. Thellung Somatostatin inhibits tumor angiogenesis and growth via somatostatin receptor-3-mediated regulation of endothelial nitric oxide synthase and mitogen-activated protein kinase activities Endocrinology 144 2003 1574 1584
55. T. Florio, and G. Schettini Multiple intracellular effectors modulate physiological functions of the cloned somatostatin receptors J Mol Endocrinol 17 1996 89 100
56. J. Freedman, C. Post, J. Kahrstrom, A. Ohlen, P. Mollenholt, and C. Owman Vasoconstrictor effects in spinal cord of the substance P antagonist [D-Arg, D-Trp7,9 Leu11]-substance P (Spantide) and somatostatin and interaction with thyrotropin releasing hormone Neuroscience 27 1988 267 278
57. Fujii, Y., Gonoi, T., Yamada, Y., Chihara, K., Inagaki, N., & Seino, S. Somatostatin receptor subtype SSTR2 mediates the inhibition of high-voltage-activated calcium channels by somatostatin and its analogue SMS 201-995. FEBS Lett, 355, 117-120.
58. M.B. Grant, and S. Caballero Somatostatin analogues as drug therapies for retinopathies Drugs Today (Barc) 38 2002 783 791
59. M.B. Grant, R. Mames, R. Cooper, S. Caballero, and C. Fitzgerald Octreotide (OCT) does not prevent progression of Diabetic Retinopathy (DR) Investig Ophthalmol Vis Sci 37 1996
60. M.B. Grant, R.N. Mames, C. Fitzgerald, K.M. Hazariwala, R. Cooper-DeHoff, and S. Caballero The efficacy of octreotide in the therapy of severe nonproliferative and early proliferative diabetic retinopathy: a randomized controlled study Diabetes Care 23 2000 504 509
61. P.G. Green, A.I. Basbaum, and J.D. Levine Sensory neuropeptide interactions in the production of plasma extravasation in the rat Neuroscience 50 1992 745 749
62. J. Gromada, M. Hoy, K. Buschard, A. Salehi, and P. Rorsman Somatostatin inhibits exocytosis in rat pancreatic alpha-cells by G(i2)-dependent activation of calcineurin and depriming of secretory granules J Physiol 535 2001 519 532
63. J. Gromada, M. Høy, K. Buschard, A. Salehi, and P. Rorsman Somatostatin inhibits exocytosis in rat pancreatic α-cells by Gi2-dependent activation of calcineurin and depriming of secretory granules J Physiol 535 2001 519 532
64. S. Grozinsky-Glasberg, I. Shimon, M. Korbonits, and A.B. Grossman Somatostatin analogues in the control of neuroendocrine tumours: efficacy and mechanisms Endocr Relat Cancer 15 2008 701 720
65. R. Guillemin Somatostatin: the beginnings, 1972 Mol Cell Endocrinol 286 2008 3 4
66. J. Guillermet-Guibert, N. Saint-Laurent, L. Davenne, P. Rochaix, O. Cuvillier, and M.D. Culler Novel synergistic mechanism for sst2 somatostatin and TNF[alpha] receptors to induce apoptosis: crosstalk between NF-[kappa]B and JNK pathways Cell Death Differ 14 2006 197 208
67. J. Guillermet, N. Saint-Laurent, P. Rochaix, O. Cuvillier, T. Levade, and A.V. Schally Somatostatin receptor subtype 2 sensitizes human pancreatic cancer cells to death ligand-induced apoptosis Proceedings of the National Academy of Sciences 100 2003 155 160
68. S.A. Gulec, G.J. Drouant, J. Fuselier, C.T. Anthony, J. Heneghan, and J.B. DelCarpio Antitumor and antiangiogenic effects of somatostatin receptor-targeted in situ radiation with (111)In-DTPA-JIC 2DL J Surg Res 97 2001 131 137
69. V. Gupta, and P.P. Toskes Diagnosis and management of chronic pancreatitis Postgrad Med J 81 2005 491 497
70. K. Gyr, C. Beglinger, E. Kohler, U. Trautzl, U. Keller, and S.R. Bloom Circulating somatostatin. Physiological regulator of pancreatic function? J Clin Invest 79 1987 1595 1600
71. J.P. Hannon, C. Nunn, B. Stolz, C. Bruns, G. Weckbecker, and I. Lewis Drug design at peptide receptors: somatostatin receptor ligands J Mol Neurosci: MN 18 2002 15 27
72. J. Hasskarl, M. Kaufmann, and H.A. Schmid Somatostatin receptors in non-neuroendocrine malignancies: the potential role of somatostatin analogs in solid tumors Future Oncol 7 2011 895 913
73. Z. Helyes, E. Pinter, J. Nemeth, G. Keri, M. Than, and G. Oroszi Anti-inflammatory effect of synthetic somatostatin analogues in the rat Br J Pharmacol 134 2001 1571 1579
74. B. Heppelmann, and M. Pawlak Inhibitory effect of somatostatin on the mechanosensitivity of articular afferents in normal and inflamed knee joints of the rat Pain 73 1997 377 382
75. M.C. Hernaez-Ortega, E. Soto-Pedre, and J.A. Pinies Lanreotide autogel for persistent diabetic macular edema Diabetes Res Clin Pract 80 2008 e8 e10
76. C. Hernandez, E. Carrasco, R. Casamitjana, R. Deulofeu, J. Garcia-Arumi, and R. Simo Somatostatin molecular variants in the vitreous fluid: a comparative study between diabetic patients with proliferative diabetic retinopathy and nondiabetic control subjects Diabetes Care 28 2005 1941 1947
77. C. Hernandez, M. Garcia-Ramirez, L. Corraliza, J. Fernandez-Carneado, J. Farrera-Sinfreu, and B. Ponsati Topical administration of somatostatin prevents retinal neurodegeneration in experimental diabetes Diabetes 62 2013 2569 2578
78. C. Hernandez, O. Simo-Servat, and R. Simo Somatostatin and diabetic retinopathy: current concepts and new therapeutic perspectives Endocrine 46 2014 209 214
79. C. Hernandez, R. Simo, European Consortium for the Early Treatment of Diabetic, and R. Somatostatin replacement: a new strategy for treating diabetic retinopathy Curr Med Chem 20 2013 3251 3257
80. R.D. Higgins, Y. Yan, and B.K. Schrier Somatostatin analogs inhibit neonatal retinal neovascularization Exp Eye Res 74 2002 553 559
81. L.J. Hofland, and S.W. Lamberts The pathophysiological consequences of somatostatin receptor internalization and resistance Endocr Rev 24 2003 28 47
82. L.J. Hofland, J. van der Hoek, R. Feelders, M.O. van Aken, P.M. van Koetsveld, and M. Waaijers The multi-ligand somatostatin analogue SOM230 inhibits ACTH secretion by cultured human corticotroph adenomas via somatostatin receptor type 5 Eur J Endocrinol 152 2005 645 654
83. T. Hokfelt, R. Elde, O. Johansson, R. Luft, G. Nilsson, and A. Arimura Immunohistochemical evidence for separate populations of somatostatin-containing and substance P-containing primary afferent neurons in the rat Neuroscience 1 1976 131 136
84. C. Hou, R.L. Gilbert, and D.L. Barber Subtype-specific signaling mechanisms of somatostatin receptors SSTR1 and SSTR2 J Biol Chem 269 1994 10357 10362
85. 2+ channels in the beta cell J Biol Chem 266 1991 837 843
86. S.L. Hyer, P.S. Sharp, R.A. Brooks, J.M. Burrin, and E.M. Kohner Continuous subcutaneous octreotide infusion markedly suppresses IGF-I levels whilst only partially suppressing GH secretion in diabetics with retinopathy Acta Endocrinol (Copenh) 120 1989 187 194
87. I.D. Ionov, and N.N. Severtsev Somatostatin antagonist potentiates haloperidol-induced catalepsy in the aged rat Pharmacol Biochem Behav 103 2012 295 298
88. Ipsen Somatuline Product Information. In (Vol. 2015) www.ipsen.com 2015
89. H. Kashiba, Y. Ueda, and E. Senba Coexpression of preprotachykinin-A, alpha-calcitonin gene-related peptide, somatostatin, and neurotrophin receptor family messenger RNAs in rat dorsal root ganglion neurons Neuroscience 70 1996 179 189
90. C. Kirkegaard, K. Norgaard, O. Snorgaard, T. Bek, M. Larsen, and H. Lund-Andersen Effect of one year continuous subcutaneous infusion of a somatostatin analogue, octreotide, on early retinopathy, metabolic control and thyroid function in Type I (insulin-dependent) diabetes mellitus Acta Endocrinol (Copenh) 122 1990 766 772
91. C. Kleuss, J. Hescheler, C. Ewel, W. Rosenthal, G. Schultz, and B. Wittig Assignment of G-protein subtypes to specific receptors inducing inhibition of calcium currents Nature 353 1991 43 48
92. D.D. Klisovic, M.S. O'Dorisio, S.E. Katz, J.W. Sall, D. Balster, and T.M. O'Dorisio Somatostatin receptor gene expression in human ocular tissues: RT-PCR and immunohistochemical study Invest Ophthalmol Vis Sci 42 2001 2193 2201
93. B.D. Koch, J.B. Blalock, and A. Schonbrunn Characterization of the cyclic AMP-independent actions of somatostatin in GH cells. I. An increase in potassium conductance is responsible for both the hyperpolarization and the decrease in intracellular free calcium produced by somatostatin J Biol Chem 263 1988 216 225
94. D. Kokona, N. Mastrodimou, I. Pediaditakis, I. Charalampopoulos, H.A. Schmid, and K. Thermos Pasireotide (SOM230) protects the retina in animal models of ischemia induced retinopathies Exp Eye Res 103 2012 90 98
95. R.A. Kowluru, R.L. Engerman, G.L. Case, and T.S. Kern Retinal glutamate in diabetes and effect of antioxidants Neurochem Int 38 2001 385 390
96. R.W. Kuijpers, S. Baarsma, and P.M. van Hagen Treatment of cystoid macular edema with octreotide N Engl J Med 338 1998 624 626
97. U. Kumar, and M. Grant Somatostatin and somatostatin receptors Results Probl Cell Differ 50 2010 137 184
98. L.K. Kvols, K.E. Oberg, T.M. O'Dorisio, P. Mohideen, W.W. de Herder, and R. Arnold Pasireotide (SOM230) shows efficacy and tolerability in the treatment of patients with advanced neuroendocrine tumors refractory or resistant to octreotide LAR: results from a phase II study Endocr Relat Cancer 19 2012 657 666
99. H. Lahlou, M. Fanjul, L. Pradayrol, C. Susini, and S. Pyronnet Restoration of functional gap junctions through internal ribosome entry site-dependent synthesis of endogenous connexins in density-inhibited cancer cells Mol Cell Biol 25 2005 4034 4045
100. H. Laklai, S. Laval, L. Dumartin, P. Rochaix, M. Hagedorn, and A. Bikfalvi Thrombospondin-1 is a critical effector of oncosuppressive activity of sst2 somatostatin receptor on pancreatic cancer Proceedings of the National Academy of Sciences 106 2009 17769 17774
101. S.W. Lamberts, A.J. van der Lely, and L.J. Hofland New somatostatin analogs: will they fulfil old promises? European journal of endocrinology / European Federation of Endocrine Societies 146 2002 701 705
102. A.C. Lambooij, R.W. Kuijpers, E.G. van Lichtenauer-Kaligis, M. Kliffen, G.S. Baarsma, and P.M. van Hagen Somatostatin receptor 2A expression in choroidal neovascularization secondary to age-related macular degeneration Invest Ophthalmol Vis Sci 41 2000 2329 2335
103. S.N. Lawson Neuropeptides in morphologically and functionally identified primary afferent neurons in dorsal root ganglia: substance P, CGRP and somatostatin Prog Brain Res 104 1995 161 173
104. H.K. Lee, K.I. Suh, C.S. Koh, H.K. Min, J.H. Lee, and H. Chung Effect of SMS 201-995 in rapidly progressive diabetic retinopathy Diabetes Care 11 1988 441 443
105. F. Lembeck, J. Donnerer, and L. Bartho Inhibition of neurogenic vasodilation and plasma extravasation by substance P antagonists, somatostatin and [D-Met2, Pro5]enkephalinamide Eur J Pharmacol 85 1982 171 176
106. A.S. Levine, and J.E. Morley Peripherally administered somatostatin reduces feeding by a vagal mediated mechanism Pharmacol Biochem Behav 16 1982 897 902
107. L. Li, R. Luo, Y. Guo, F. Yao, D. Cao, and S. Ma The Inhibitory Effect of Somatostatin Receptor Activation on Bee Venom-Evoked Nociceptive Behavior and pCREB Expression in Rats BioMed Research International 2014 2014 11
108. E.G. Lichtenauer-Kaligis, V.A. Dalm, S.P. Oomen, D.M. Mooij, P.M. van Hagen, and S.W. Lamberts Differential expression of somatostatin receptor subtypes in human peripheral blood mononuclear cell subsets Eur J Endocrinol 150 2004 565 577
109. E. Lieth, K.F. LaNoue, D.A. Antonetti, and M. Ratz Diabetes reduces glutamate oxidation and glutamine synthesis in the retina. The Penn State Retina Research Group Exp Eye Res 70 2000 723 730
110. C.-Y. Lin, M.G. Varma, A. Joubel, S. Madabushi, O. Lichtarge, and D.L. Barber Conserved motifs in somatostatin, D2-dopamine, and α2B-adrenergic receptors for inhibiting the Na-H exchanger, NHE1 J Biol Chem 278 2003 15128 15135
111. + exchanger isoforms J Biol Chem 271 1996 22604 22610
112. F. Lopez, J.-P. Estève, L. Buscail, N. Delesque, N. Saint-Laurent, and M. Théveniau The tyrosine phosphatase SHP-1 associates with the sst2 somatostatin receptor and is an essential component of sst2-mediated inhibitory growth signaling J Biol Chem 272 1997 24448 24454
113. Lopez, F., Estève, J. P., Buscail, L., Delesque, N., Saint-Laurent, N., Vaysse, N., & Susini, C. Molecular mechanisms of antiproliferative effect of somatostatin: Involvement of a tyrosine phosphatase. Metabolism - Clinical and Experimental, 45, 14-16.
114. F. Lopez, G. Ferjoux, P. Cordelier, N. Saint-Laurent, J.P. Estève, and N. Vaysse Neuronal nitric oxide synthase: a substrate for SHP-1 involved in sst2 somatostatin receptor growth inhibitory signaling The FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology 15 2001 2300 2302
115. E.C. Lotter, R. Krinsky, J.M. McKay, C.M. Treneer, D. Porter Jr., and S.C. Woods Somatostatin decreases food intake of rats and baboons J Comp Physiol Psychol 95 1981 278 287
116. B. Mallet, B. Vialettes, S. Haroche, P. Escoffier, P. Gastaut, and J.P. Taubert Stabilization of severe proliferative diabetic retinopathy by long-term treatment with SMS 201-995 Diabete Metab 18 1992 438 444
117. P. Martin-Gago, R. Ramon, E. Aragon, J. Fernandez-Carneado, P. Martin-Malpartida, and X. Verdaguer A tetradecapeptide somatostatin dicarba-analog: synthesis, structural impact and biological activity Bioorg Med Chem Lett 24 2014 103 107
118. A. Massa, F. Barbieri, C. Aiello, S. Arena, A. Pattarozzi, and P. Pirani The expression of the phosphotyrosine phosphatase DEP-1/PTPη dictates the responsivity of glioma cells to somatostatin inhibition of cell proliferation J Biol Chem 279 2004 29004 29012
119. N. Mastrodimou, G.N. Lambrou, and K. Thermos Effect of somatostatin analogues on chemically induced ischaemia in the rat retina Naunyn Schmiedeberg's Arch Pharmacol 371 2005 44 53
120. M. McCombe, S. Lightman, D.J. Eckland, A.M. Hamilton, and S.L. Lightman Effect of a long-acting somatostatin analogue (BIM23014) on proliferative diabetic retinopathy: a pilot study Eye (Lond) 5 Pt 5 1991 569 575
121. 2+ current modulated by cGMP-dependent protein kinase Nature 369 1994 336 339
122. J. Meynadier, J. Chrubasik, M. Dubar, and E. Wunsch Intrathecal somatostatin in terminally ill patients. A report of two cases Pain 23 1985 9 12
123. E.I. Mikhaevich, and M.A. Krasil'nikov The mechanism of cytostatic effect of a new somatostatin analog cifetrelin on in vitro cultured MCF-7 breast carcinoma cells Bull Exp Biol Med 154 2013 669 672
124. G. Mizutani, Y. Nakanishi, N. Watanabe, T. Honma, Y. Obana, and T. Seki Expression of Somatostatin Receptor (SSTR) Subtypes (SSTR-1, 2A, 3, 4 and 5) in Neuroendocrine Tumors Using Real-time RT-PCR Method and Immunohistochemistry Acta histochemica et cytochemica 45 2012 167 176
125. I.M. Modlin, M. Pavel, M. Kidd, and B.I. Gustafsson Review article: somatostatin analogues in the treatment of gastroenteropancreatic neuroendocrine (carcinoid) tumours Aliment Pharmacol Ther 31 2010 169 188
126. L.N. Moller, C.E. Stidsen, B. Hartmann, and J.J. Holst Somatostatin receptors Biochim Biophys Acta 1616 2003 1 84
127. A. Mulak, M. Larauche, M. Biraud, M. Million, J. Rivier, and Y. Taché Selective agonists of somatostatin receptor subtype 1 or 2 injected peripherally induce antihyperalgesic effect in two models of visceral hypersensitivity in mice Peptides 63 2015 71 80
128. K. Nagata, Y. Kihara, R. Eguchi, H. Nakamura, I. Yoshikawa, and M. Otsuki A case of octreotide acetate-induced acute pancreatitis Nihon Shokakibyo Gakkai zasshi The Japanese journal of gastro-enterology 104 2007 1652 1657
129. S.J. Neggers, and A.J. van der Lely Combination treatment with somatostatin analogues and pegvisomant in acromegaly Growth Hormon IGF Res 21 2011 129 133
130. Y.K. Ng, X.X. Zeng, and E.A. Ling Expression of glutamate receptors and calcium-binding proteins in the retina of streptozotocin-induced diabetic rats Brain Res 1018 2004 66 72
131. NovartisEuropharm SIGNIFOR 0.3 mg solution for injection. In Novartis Europharm www.novartis.com 2012
132. Y. Oh The Insulin-like Growth Factor System in Chronic Kidney Disease: Pathophysiology and Therapeutic Opportunities Kidney Research and Clinical Practice 31 2012 26 37
133. C.S. Pace, and J.T. Tarvin Somatostatin: mechanism of action in pancreatic islet β-cells Diabetes 30 1981 836 842
134. P. Pagès, N. Benali, N. Saint-Laurent, J.-P. Estève, A.V. Schally, and J. Tkaczuk SST2 somatostatin receptor mediates cell cycle arrest and induction of p27 Kip1: evidence for the role of SHP-1 J Biol Chem 274 1999 15186 15193
135. M.G. Pan, T. Florio, and P.J.S. Stork G protein activation of a hormone-stimulated phosphatase in human tumor cells Science 256 1992 1215 1217
136. C. Parkinson, W.M. Drake, M.E. Roberts, K. Meeran, G.M. Besser, and P.J. Trainer A comparison of the effects of pegvisomant and octreotide on glucose, insulin, gastrin, cholecystokinin, and pancreatic polypeptide responses to oral glucose and a standard mixed meal J Clin Endocrinol Metab 87 2002 1797 1804
137. D. Patch, and A. Burroughs Vapreotide in variceal bleeding J Hepatol 37 2002 167 168
138. Y.C. Patel Somatostatin and its receptor family Front Neuroendocrinol 20 1999 157 198
139. Y.C. Patel Somatostatin and its receptor family Front Neuroendocrinol 20 1999 157 198
140. Y.C. Patel, M.T. Greenwood, A. Warszynska, R. Panetta, and C.B. Srikant All five cloned human somatostatin receptors (hSSTR1-5) are functionally coupled to adenylyl cyclase Biochem Biophys Res Commun 198 1994 605 612
141. T.L. Peeters, Y. Depraetere, and G.R. Vantrappen Simple extraction method and radioimmunoassay for somatostatin in human plasma Clin Chem 27 1981 888 891
142. E. Penman, J.A. Wass, S. Medbak, L. Morgan, J.M. Lewis, and G.M. Besser Response of circulating immunoreactive somatostatin to nutritional stimuli in normal subjects Gastroenterology 81 1981 692 699
143. S. Petersenn, A. Farrall, C. Block, S. Melmed, J. Schopohl, and P. Caron Long-term efficacy and safety of subcutaneous pasireotide in acromegaly: results from an open-ended, multicenter, Phase II extension study Pituitary 17 2014 132 140
144. S. Petersenn, J. Schopohl, A. Barkan, P. Mohideen, A. Colao, and R. Abs Pasireotide (SOM230) demonstrates efficacy and safety in patients with acromegaly: a randomized, multicenter, Phase II trial J Clin Endocrinol Metab 95 2010 2781 2789
145. E. Pinter, Z. Helyes, J. Nemeth, R. Porszasz, G. Petho, and M. Than Pharmacological characterisation of the somatostatin analogue TT-232: effects on neurogenic and non-neurogenic inflammation and neuropathic hyperalgesia Naunyn Schmiedeberg's Arch Pharmacol 366 2002 142 150
146. E. Pinter, Z. Helyes, and J. Szolcsanyi Inhibitory effect of somatostatin on inflammation and nociception Pharmacol Ther 112 2006 440 456
147. L. Poitout, P. Roubert, M.O. Contour-Galcera, C. Moinet, J. Lannoy, and J. Pommier Identification of potent non-peptide somatostatin antagonists with sst(3) selectivity J Med Chem 44 2001 2990 3000
148. S. Pola, M.G. Cattaneo, and L.M. Vicentini Anti-migratory and anti-invasive effect of somatostatin in human neuroblastoma cells: involvement of Rac and MAP kinase activity J Biol Chem 278 2003 40601 40606
149. G. Prevost, Y. Bourgeois, C. Mormont, Y. Lerrant, N. Veber, and M.F. Poupon Characterization of somatostatin receptors and growth inhibition by the somatostatin analogue BIM23014 in small cell lung carcinoma xenograft: SCLC-6 Life Sci 55 1994 155 162
150. T.A. Pugsley, and W. Lippmann Effect of somatostatin analogues and 17-alpha-dihydroequilin on rat brain opiate receptors Res Commun Chem Pathol Pharmacol 21 1978 153 156
151. J.E. Pulido, J.S. Pulido, J.C. Erie, J. Arroyo, K. Bertram, and M.J. Lu A role for excitatory amino acids in diabetic eye disease Exp Diabetes Res 2007 2007 36150
152. S. Pyronnet, C. Bousquet, S. Najib, R. Azar, H. Laklai, and C. Susini Antitumor effects of somatostatin Mol Cell Endocrinol 286 2008 230 237
153. D. Ramos, A. Carretero, M. Navarro, L. Mendes-Jorge, V. Nacher, and A. Rodriguez-Baeza Mimicking microvascular alterations of human diabetic retinopathy: a challenge for the mouse models Curr Med Chem 20 2013 3200 3217
154. D.B. Reardon, P. Dent, S.L. Wood, T. Kong, and T.W. Sturgill Activation in vitro of somatostatin receptor subtypes 2, 3, or 4 stimulates protein tyrosine phosphatase activity in membranes from transfected Ras-transformed NIH 3T3 cells: coexpression with catalytically inactive SHP-2 blocks responsiveness Mol Endocrinol 11 1997 1062 1069
155. D.B. Reardon, S.L. Wood, D.L. Brautigan, G.I. Bell, P. Dent, and T.W. Sturgill Activation of a protein tyrosine phosphatase and inactivation of Raf-1 by somatostatin Biochem J 314 1996 401 404
156. Renström, E., Ding, W.-G., Bokvist, K., & Rorsman, P. Neurotransmitter-Induced Inhibition of Exocytosis in Insulin-Secreting β Cells by Activation of Calcineurin. Neuron, 17, 513-522.
157. J.C. Reubi, U. Horisberger, U.E. Studer, B. Waser, and J.A. Laissue Human kidney as target for somatostatin: high affinity receptors in tubules and vasa recta J Clin Endocrinol Metab 77 1993 1323 1328
158. A. Rinke, H.-H. Müller, C. Schade-Brittinger, K.-J. Klose, P. Barth, and M. Wied Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: a report from the PROMID study group J Clin Oncol 27 2009 4656 4663
159. A.S. Rocca, and P.L. Brubaker Role of the vagus nerve in mediating proximal nutrient-induced glucagon-like peptide-1 secretion Endocrinology 140 1999 1687 1694
160. M. Ruscica, P. Magni, L. Steffani, F. Gatto, M. Albertelli, and R. Rametta Characterization and sub-cellular localization of SS1R, SS2R, and SS5R in human late-stage prostate cancer cells: effect of mono- and bi-specific somatostatin analogs on cell growth Mol Cell Endocrinol 382 2014 860 870
161. L. Sandostatin Depot (Octreotide Acetate for Injectable Suspension) Prescribing Information 2000 Novartis Pharmaceuticals Corp East Hanover, NJ
162. A.R. Santiago, J.M. Gaspar, F.I. Baptista, A.J. Cristovao, P.F. Santos, and W. Kamphuis Diabetes changes the levels of ionotropic glutamate receptors in the rat retina Mol Vis 15 2009 1620 1630
163. W. Schlegel, F. Wuarin, C. Zbaren, C.B. Wollheim, and G.R. Zahnd Pertussis toxin selectively abolishes hormone induced lowering of cytosolic calcium in GH3 cells FEBS Lett 189 1985 27 32
164. N. Schuelert, S. Just, R. Kuelzer, L. Corradini, L.C.J. Gorham, and H. Doods The somatostatin receptor 4 agonist J-2156 reduces mechanosensitivity of peripheral nerve afferents and spinal neurons in an inflammatory pain model Eur J Pharmacol 746 2015 274 281
165. R. Seger, and E.G. Krebs The MAPK signaling cascade FASEB J 9 1995 726 735
166. O. Serri, H. Beauregard, and P. Brazeau Somatostatin analogue, octreotide, reduces increased glomerular filtration rate and kidney size in insulin-dependent diabetes J Am Med Assoc 265 1991 888 892
167. K. Sharma, Y.C. Patel, and C.B. Srikant Subtype-selective induction of wild-type p53 and apoptosis, but not cell cycle arrest, by human somatostatin receptor 3 Mol Endocrinol 10 1996 1688 1696
168. T.J. Shi, Q. Xiang, M.D. Zhang, S. Barde, Y. Kai-Larsen, and K. Fried Somatostatin and its 2A receptor in dorsal root ganglia and dorsal horn of mouse and human: expression, trafficking and possible role in pain Mol Pain 10 2014 12
169. S.E. Shoelson, K.S. Polonsky, T. Nakabayashi, J.B. Jaspan, and H.S. Tager Circulating forms of somatostatin-like immunoreactivity in human plasma Am J Physiol 250 1986 E428 E434
170. F. Sicuteri, L. Raino, and P. Geppetti Substance P and endogenous opioids: how and where they could play a role in cluster headache Cephalalgia: An International Journal of Headache 3 Suppl. 1 1983 143 145
171. R. Simo, C. Hernandez, European Consortium for the Early Treatment of Diabetic, and R. Neurodegeneration is an early event in diabetic retinopathy: therapeutic implications Br J Ophthalmol 96 2012 1285 1290
172. R. Simo, A. Lecube, L. Sararols, J. Garcia-Arumi, R.M. Segura, and R. Casamitjana Deficit of somatostatin-like immunoreactivity in the vitreous fluid of diabetic patients: possible role in the development of proliferative diabetic retinopathy Diabetes Care 25 2002 2282 2286
173. M.A. Simon, B. Romero, and C. Calle Characterization of somatostatin binding sites in isolated rat adipocytes Regul Pept 23 1988 261 270
174. + conductance in freshly dispersed rat somatotrophs J Physiol 441 1991 615 637
175. R.B. Simsolo, S. Ezzat, J.M. Ong, M. Saghizadeh, and P.A. Kern Effects of acromegaly treatment and growth hormone on adipose tissue lipoprotein lipase J Clin Endocrinol Metab 80 1995 3233 3238
176. A. Skamene, and Y.C. Patel Infusion of graded concentrations of somatostatin in man: pharmacokinetics and differential inhibitory effects on pituitary and islet hormones Clin Endocrinol (Oxf) 20 1984 555 564
177. M. ͆liwińska-Mossoń, M. Veselý, and H. Milnerowicz The clinical significance of somatostatin in pancreatic diseases. La signification clinique de la somatostatine dans les maladies du pancréas Annales d'Endocrinologie 75 4 2014 232 240
178. L.E. Smith, J.J. Kopchick, W. Chen, J. Knapp, F. Kinose, and D. Daley Essential role of growth hormone in ischemia-induced retinal neovascularization Science 276 1997 1706 1709
179. 2+-channels in murine pancreatic β-cells are inhibited by an exclusive coupling with somatostatin receptor subtype 1 Endocrinology 150 2009 741 748
180. U. Sprecher, P. Mohr, R.E. Martin, H.P. Maerki, R.A. Sanchez, and A. Binggeli Novel, non-peptidic somatostatin receptor subtype 5 antagonists improve glucose tolerance in rodents Regul Pept 159 2010 19 27
181. C.B. Srikant Cell cycle dependent induction of apoptosis by somatostatin analog SMS 201-995 in AtT-20 mouse pituitary cells Biochem Biophys Res Commun 209 1995 400 406
182. C.B. Srikant, and S.H. Shen Octapeptide somatostatin analog SMS 201-995 induces translocation of intracellular PTP1C to membranes in MCF-7 human breast adenocarcinoma cells Endocrinology 137 1996 3461 3468
183. M.Z. Strowski, M.P. Dashkevicz, R.M. Parmar, H. Wilkinson, M. Kohler, and J.M. Schaeffer Somatostatin receptor subtypes 2 and 5 inhibit corticotropin-releasing hormone-stimulated adrenocorticotropin secretion from AtT-20 cells Neuroendocrinology 75 2002 339 346
184. M.Z. Strowski, M. Kohler, H.Y. Chen, M.E. Trumbauer, Z. Li, and D. Szalkowski Somatostatin receptor subtype 5 regulates insulin secretion and glucose homeostasis Mol Endocrinol 17 2003 93 106
185. Y.D. Sun, Y. Ma, Y.J. Jiang, Q.D. Zhao, H. Guan, and Y. Han Effect of somatostatin on early electroretinogram in diabetic rats Journal of Jilin University Medicine Edition 40 2014 1192 1196
186. J. Szolcsanyi, Z. Helyes, G. Oroszi, J. Nemeth, and E. Pinter Release of somatostatin and its role in the mediation of the anti-inflammatory effect induced by antidromic stimulation of sensory fibres of rat sciatic nerve Br J Pharmacol 123 1998 936 942
187. J. Szolcsanyi, E. Pinter, Z. Helyes, G. Oroszi, and J. Nemeth Systemic anti-inflammatory effect induced by counter-irritation through a local release of somatostatin from nociceptors Br J Pharmacol 125 1998 916 922
188. 2+ current in the pituitary cell line AtT-20 Neuroscience 71 1996 1073 1081
189. Y. Taniyama, T. Suzuki, Y. Mikami, T. Moriya, S. Satomi, and H. Sasano Systemic distribution of somatostatin receptor subtypes in human: an immunohistochemical study Endocr J 52 2005 605 611
190. R. Teijeiro, R. Rios, J.A. Costoya, R. Castro, J.L. Bello, and J. Devesa Activation of human somatostatin receptor 2 promotes apoptosis through a mechanism that is independent from induction of p53 Cellular Physiology and Biochemistry: International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology 12 2002 31 38
191. A.M. ten Bokum, L.J. Hofland, and P.M. van Hagen Somatostatin and somatostatin receptors in the immune system: a review Eur Cytokine Netw 11 2000 161 176
192. A.M. ten Bokum, E.G. Lichtenauer-Kaligis, M.J. Melief, P.M. van Koetsveld, C. Bruns, and P.M. van Hagen Somatostatin receptor subtype expression in cells of the rat immune system during adjuvant arthritis J Endocrinol 161 1999 167 175
193. M. Thangaraju, K. Sharma, B. Leber, D.W. Andrews, S.H. Shen, and C.B. Srikant Regulation of acidification and apoptosis by SHP-1 and Bcl-2 J Biol Chem 274 1999 29549 29557
194. M. Theodoropoulou, and G.K. Stalla Somatostatin receptors: From signaling to clinical practice Frontiers in Neuroendocrinology 34 3 2013 228 252
195. T. Troxler, K. Hurth, K.-H. Schuh, P. Schoeffter, D. Langenegger, and A. Enz Decahydroisoquinoline derivatives as novel non-peptidic, potent and subtype-selective somatostatin sst3 receptor antagonists Bioorg Med Chem Lett 20 2010 1728 1734
196. K. Tsuda, H. Sakurai, Y. Seino, S. Seino, K. Tanigawa, and H. Kuzuya Somatostatin-like immunoreactivity in human peripheral plasma measured by radioimmunoassay following affinity chromatography Diabetes 30 1981 471 474
197. M.A. Turman, M.S. O'Dorisio, T.M. O'Dorisio, C.A. Apple, and A.R. Albers Somatostatin expression in human renal cortex and mesangial cells Regul Pept 68 1997 15 21
198. C. Valéry, M. Paternostre, B. Robert, T. Gulik-Krzywicki, T. Narayanan, and J.C. Dedieu Biomimetic organization: octapeptide self-assembly into nanotubes of viral capsid-like dimension Proceedings of the National Academy of Sciences of the United States of America 100 2003 10258 10262
199. J. van der Hoek, L.J. Hofland, and S.W. Lamberts Novel subtype specific and universal somatostatin analogues: clinical potential and pitfalls Curr Pharm Des 11 2005 1573 1592
200. Vapreotide Drugs in R & D 4 2003 326 330
201. B. Vasquez, V. Harris, and R.H. Unger Extraction of somatostatin from human plasma on octadecylsilyl silica J Clin Endocrinol Metab 55 1982 807 809
202. G. Weckbecker, I. Lewis, R. Albert, H.A. Schmid, D. Hoyer, and C. Bruns Opportunities in somatostatin research: biological, chemical and therapeutic aspects Nat Rev Drug Discov 2 2003 999 1017
203. G. Weckbecker, F. Raulf, B. Stolz, and C. Bruns Somatostatin analogs for diagnosis and treatment of cancer Pharmacol Ther 60 1993 245 264
204. J.V. Weinstock Production of neuropeptides by inflammatory cells within the granulomas of murine schistosomiasis mansoni Eur J Clin Investig 21 1991 145 153
205. S.H. Wilson, M.I. Davis, S. Caballero, and M.B. Grant Modulation of retinal endothelial cell behaviour by insulin-like growth factor I and somatostatin analogues: implications for diabetic retinopathy Growth Hormone IGF Res: Official Journal of the Growth Hormone Research Society and the International IGF Research Society 11 Suppl. A 2001 S53 S59
206. P.C. Wu, C.C. Liu, C.H. Chen, H.K. Kou, S.C. Shen, and C.Y. Lu Inhibition of experimental angiogenesis of cornea by somatostatin Graefes Arch Clin Exp Ophthalmol Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 241 2003 63 69
207. N. Yamashita, N. Shibuya, and E. Ogata Hyperpolarization of the membrane potential caused by somatostatin in dissociated human pituitary adenoma cells that secrete growth hormone Proceedings of the National Academy of Sciences 83 1986 6198 6202
208. + currents in GH3 cells through activation of multiple somatostatin receptors Endocrinology 146 2005 4975 4984
209. + channels by isolated GK protein in clonal rat anterior pituitary cell membranes Mol Endocrinol 1 1987 283 289
210. M. Yeung, and D. Treit The anxiolytic effects of somatostatin following intra-septal and intra-amygdalar microinfusions are reversed by the selective sst2 antagonist PRL2903 Pharmacol Biochem Behav 101 2012 88 92
211. K. Zarogoulidis, E. Eleftheriadou, T. Kontakiotis, G. Gerasimou, P. Zarogoulidis, and I. Sapardanis Long acting somatostatin analogues in combination to antineoplastic agents in the treatment of small cell lung cancer patients Lung Cancer 76 2012 84 88
212. M.C. Zatelli, F. Tagliati, D. Piccin, J.E. Taylor, M.D. Culler, and M. Bondanelli Somatostatin receptor subtype 1-selective activation reduces cell growth and calcitonin secretion in a human medullary thyroid carcinoma cell line Biochem Biophys Res Commun 297 2002 828 834
213. L. Zhang, X. Wu, Y. Yan, J. Qian, Y. Lu, and C. Luo Preoperative somatostatin analogs treatment in acromegalic patients with macroadenomas. A meta-analysis Brain Dev 2015 37 2015 181 190